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Azd2014

CAS No.:
1009298-59-2
Catalog Number:
AG000382
Molecular Formula:
C25H30N6O3
Molecular Weight:
462.5441
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
5mg
≥98%
1 week
United States
$161
- +
10mg
≥98%
1 week
United States
$223
- +
25mg
≥98%
1 week
United States
$404
- +
Product Description
Catalog Number:
AG000382
Chemical Name:
Azd2014
CAS Number:
1009298-59-2
Molecular Formula:
C25H30N6O3
Molecular Weight:
462.5441
MDL Number:
MFCD22628784
IUPAC Name:
3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide
InChI:
InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
InChI Key:
JUSFANSTBFGBAF-IRXDYDNUSA-N
SMILES:
CNC(=O)c1cccc(c1)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
UNII:
0BSC3P4H5X
Properties
Complexity:
698  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
462.238g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
462.554g/mol
Monoisotopic Mass:
462.238g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
92.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20180901
Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models. Oncotarget 20171226
mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection. Virology 20140301
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014. Bioorganic & medicinal chemistry letters 20130301
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell metabolism 20120502
Mammalian autophagy: core molecular machinery and signaling regulation. Current opinion in cell biology 20100401
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 20090716
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Current biology : CB 20040727
Regulation of longevity and stress resistance by Sch9 in yeast. Science (New York, N.Y.) 20010413
Properties