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Scoparone

CAS No.:
120-08-1
Catalog Number:
AG000Q0C
Molecular Formula:
C11H10O4
Molecular Weight:
206.1947
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
≥98%
1 week
United States
$91
- +
25mg
≥98%
1 week
United States
$187
- +
50mg
≥98%
1 week
United States
$300
- +
250mg
≥98%
1 week
United States
$621
- +
Product Description
Catalog Number:
AG000Q0C
Chemical Name:
Scoparone
CAS Number:
120-08-1
Molecular Formula:
C11H10O4
Molecular Weight:
206.1947
MDL Number:
MFCD00006871
IUPAC Name:
6,7-dimethoxychromen-2-one
InChI:
InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3
InChI Key:
GUAFOGOEJLSQBT-UHFFFAOYSA-N
SMILES:
COc1cc2oc(=O)ccc2cc1OC
EC Number:
204-369-0
UNII:
H5841PDT4Y
Properties
Complexity:
274  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
206.058g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
206.197g/mol
Monoisotopic Mass:
206.058g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
44.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.9  
Literature
Title Journal
Scoparone attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130701
Citrus phenylpropanoids and defence against pathogens. Part II: gene expression and metabolite accumulation in the response of fruits to Penicillium digitatum infection. Food chemistry 20130101
Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment. Chinese journal of integrative medicine 20121101
Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. Bioorganic & medicinal chemistry 20120915
Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples. Biomedical chromatography : BMC 20120701
Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry. Fitoterapia 20120601
Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. Archives of pharmacal research 20120601
Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120115
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor. Bioorganic & medicinal chemistry 20120115
Simultaneous determination of five active compounds in chimonanthus nitens by double-development HPTLC and scanning densitometry. Chemistry Central journal 20120101
Evaluation of melanogenesis in A-375 cells in the presence of DMSO and analysis of pyrolytic profile of isolated melanin. TheScientificWorldJournal 20120101
The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats. Journal of physiology and biochemistry 20111201
Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor. British journal of pharmacology 20111101
Biologically active constituents of Aglaia erythrosperma. Natural product research 20111001
[Study on antibacterial active components from Viola yedoensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001
Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents. Archives of pharmacal research 20110901
Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110701
Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110501
Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities. Archives of pharmacal research 20110501
Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110201
Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats. Evidence-based complementary and alternative medicine : eCAM 20110101
Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo. Evidence-based complementary and alternative medicine : eCAM 20110101
Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators. Frontiers in pharmacology 20110101
Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
[Studies on the chemical constituents from Lobelia chinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101101
Effects of scoparone on dopamine release in PC12 cells. Fitoterapia 20100901
Immunosuppressive constituents from Urtica dentata Hand. Journal of Asian natural products research 20100801
Sodium bicarbonate induces crystalline wax generation, activates host-resistance, and increases imazalil level in rind wounds of oranges, improving the control of green mold during storage. Journal of agricultural and food chemistry 20100623
Chemical constituents and antimicrobial activities of Canthium horridum. Natural product communications 20100601
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr. Bioorganic & medicinal chemistry 20100515
A simple RP-HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study. Biomedical chromatography : BMC 20100401
Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells. Journal of enzyme inhibition and medicinal chemistry 20100401
[Main chemical components for clearing heat and relieving sore throat in different germplasm of Canarium album]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301
Effect of mobile phase additives on the resolution of four bioactive compounds by RP-HPLC. International journal of molecular sciences 20100101
A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. BMC plant biology 20100101
Tyrosinase small interfering RNA effectively suppresses tyrosinase gene expression in vitro and in vivo. Molecular biology international 20100101
Anti-allergic effects of scoparone on mast cell-mediated allergy model. Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201
[Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B. Chang]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20091018
Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells. Chemico-biological interactions 20090914
Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Journal of neuroscience research 20090601
Benzophenone derivatives from the fruits of Garcinia multiflora and their anti-inflammatory activity. Journal of natural products 20090227
Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Analytica chimica acta 20090202
MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. The Plant journal : for cell and molecular biology 20090201
Amides and benzenoids from Zanthoxylum ailanthoides with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of natural products 20090101
Hypoglycemic herbs and their action mechanisms. Chinese medicine 20090101
Abiotic stresses sequentially applied enhance natural resistance and reduce postharvest decay. Communications in agricultural and applied biological sciences 20090101
Host-pathogen-biocontrol agent interaction as affected by sequential application of Na2CO3 and CaCl2. Communications in agricultural and applied biological sciences 20090101
Pharmacokinetic studies of a Chinese triple herbal drug formula. Phytomedicine : international journal of phytotherapy and phytopharmacology 20081101
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of natural products 20081001
[Studies on chemical constituents of Ranunculus japonicus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001
Simultaneous determination of 13 bioactive compounds in Herba Artemisiae Scopariae (Yin Chen) from different harvest seasons by HPLC-DAD. Journal of pharmaceutical and biomedical analysis 20080805
Effect of scoparone on neurite outgrowth in PC12 cells. Neuroscience letters 20080725
Minor compounds from the stem bark of Chinese mangrove associate Catunaregam spinosa. Die Pharmazie 20080701
Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica. Journal of natural products 20080601
Anticomplementary principles of a Chinese multiherb remedy for the treatment and prevention of SARS. Journal of ethnopharmacology 20080508
A new oxygenated ursane derivative from Canthium multiflorum. Planta medica 20080401
[Studies on chemical constituents of Sarcandra glabra]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401
Involvement of limonene hydroperoxides formed after oil gland injury in the induction of defense response against Penicillium digitatum in lemon fruit. Journal of agricultural and food chemistry 20080326
Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. Journal of separation science 20080301
Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae. Journal of natural products 20080201
A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus. Archives of pharmacal research 20080101
Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation. Arzneimittel-Forschung 20080101
New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum. Journal of natural products 20070901
Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. Memorias do Instituto Oswaldo Cruz 20070901
Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang. Journal of chromatographic science 20070901
Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. Journal of ethnopharmacology 20070815
Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone. Biological & pharmaceutical bulletin 20070201
[Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101
Scoparone inhibits ultraviolet radiation-induced lipid peroxidation. Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101
Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20070101
[Studies on chemical constituents from fruits of Paliurus ramosissimus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201
Stimulation of melanogenesis by scoparone in B16 melanoma cells. Acta pharmacologica Sinica 20061101
Biocontrol of aflatoxins B1, B2, G1, G2, and fumonisin B1 with 6,7-dimethoxycoumarin, a phytoalexin from Citrus sinensis. Journal of food protection 20060901
Simultaneous analysis of trans- and cis-isomers of 2-glucosyloxycinnamic acids and coumarin derivatives in Dendrobium thyrsiflorum by high-performance liquid chromatography (HPLC)-photodiode array detection (DAD)-electrospray ionization (ESI)-tandem mass spectrometry (MS). Analytica chimica acta 20060630
[Studies on the chemical constituents in herb of Ranunculus japonicus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060601
Investigations of the Malagasy species Tachiadenus longiflorus Grisebach (Gentianaceae): linking chemical finding and traditional usage. Journal of ethnopharmacology 20060524
Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells. Life sciences 20060515
Production of three O-methhylated esculetins with Escherichia coli expressing O-methyltransferase from poplar. Bioscience, biotechnology, and biochemistry 20060501
Yb(OTf)3-catalyzed reactions of 5-alkylidene Meldrum's acids with phenols: one-pot assembly of 3,4-dihydrocoumarins, 4-chromanones, coumarins, and chromones. The Journal of organic chemistry 20060106
The structural elucidation of a novel iridoid derivative from Tachiadenus longiflorus (Gentianaceae) using the LSD programme and quantum chemical computations. Phytochemical analysis : PCA 20060101
Induction of phytoalexins biosynthesis in orange fruit by the biocontrol yeast Rhodotorula glutinis. Communications in agricultural and applied biological sciences 20060101
Microstructured scaffolds for liver tissue cultures of high cell density: morphological and biochemical characterization of tissue aggregates. Journal of cellular biochemistry 20050515
Sodium carbonate treatment induces scoparone accumulation, structural changes, and alkalinization in the albedo of wounded citrus fruits. Journal of agricultural and food chemistry 20050504
Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS. Archives of pharmacal research 20050201
[Studies on the chemical constituents in herb of Ranunculus sceleratus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101
IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein. Biological research 20050101
Biological and physical approaches to improve induced resistance against green mold of stored citrus fruit. Communications in agricultural and applied biological sciences 20050101
Antifungal constituents of Melicope borbonica. Phytotherapy research : PTR 20040701
[Studies on chemical constituents in bud of Artemisia scoparia (III)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040501
A modern examination of an ancient cure. Lab animal 20040201
New coumarins from Cedrelopsis grevei. Fitoterapia 20031201
Secondary metabolites from Cedrelopsis grevei (Ptaeroxylaceae). Phytochemistry 20030901
Pharmacokinetics of a novel anti-asthmatic, scoparone, in the rabbit serum assessed by a simple HPLC method. Journal of ethnopharmacology 20030501
Vasorelaxing properties and bio-guided fractionation of Cedrelopsis grevei. Planta medica 20030201
Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells. Journal of biomedical science 20030101
Coumarins from Cedrelopsis grevei (Ptaeroxylaceae). Phytochemistry 20021201
Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus. Planta medica 20021001
Effects of the chestnut inner shell extract on the expression of adhesion molecules, fibronectin and vitronectin, of skin fibroblasts in culture. Archives of pharmacal research 20020801
Arteminin, a new coumarin from Artemisia apiacea. Fitoterapia 20020601
Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. Archives of pharmacal research 20020601
Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit. The Journal of biological chemistry 20020503
Enzyme inhibitory constituents from Duranta repens. Chemical & pharmaceutical bulletin 20020401
Alpha-glucosidase inhibitory constituents from Cuscuta reflexa. Chemical & pharmaceutical bulletin 20020101
Signal transduction in lemon seedlings in the hypersensitive response against Alternaria alternata: participation of calmodulin, G-protein and protein kinases. Biological research 20020101
Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway. Journal of medicinal chemistry 20010927
Determinations of morin, quercetin and their conjugate metabolites in serum. Biological & pharmaceutical bulletin 20010801
Oxidative hydrolysis of scoparone by cytochrome p450 CYP2C29 reveals a novel metabolite. Biochemical and biophysical research communications 20010706
A new phorbol diester from Aleurites moluccana. Fitoterapia 20010301
Mode of action of hot-water dip in reducing decay of lemon fruit. Journal of agricultural and food chemistry 20010101
Two new germacranolides from Magnolia grandiflora. Journal of Asian natural products research 20010101
Participation of the phosphoinositide metabolism in the hypersensitive response of Citrus limon against Alternaria alternata. Biological research 20010101
A new diprenyl coumarin and alkaloids from the bark of Zanthoxylum dimorphophyllum (Rutaceae). Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101
Properties