Home Sulfos 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole

CAS No.:
131926-99-3
Catalog Number:
AG000ZXL
Molecular Formula:
C16H14F3N3O3S
Molecular Weight:
385.3609
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$97
- +
5mg
≥98%
1 week
United States
$239
- +
10mg
≥98%
1 week
United States
$379
- +
Product Description
Catalog Number:
AG000ZXL
Chemical Name:
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole
CAS Number:
131926-99-3
Molecular Formula:
C16H14F3N3O3S
Molecular Weight:
385.3609
MDL Number:
MFCD08063665
IUPAC Name:
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfonyl]-1H-benzimidazole
InChI:
InChI=1S/C16H14F3N3O3S/c1-10-13(20-7-6-14(10)25-9-16(17,18)19)8-26(23,24)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChI Key:
TVMJMCGRSSSSDJ-UHFFFAOYSA-N
SMILES:
Cc1c(ccnc1CS(=O)(=O)c1nc2c([nH]1)cccc2)OCC(F)(F)F
UNII:
A62FAW18P1
Properties
Complexity:
582  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
385.071g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
385.361g/mol
Monoisotopic Mass:
385.071g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
93.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3  
Literature
Title Journal
Pharmacokinetics of lansoprazole and its main metabolites after single intravenous doses in healthy Chinese subjects. Xenobiotica; the fate of foreign compounds in biological systems 20121101
Effects of CYP2C19 polymorphism on the pharmacokinetics of lansoprazole and its main metabolites in healthy Chinese subjects. Xenobiotica; the fate of foreign compounds in biological systems 20110601
The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharmaceutical biology 20100801
Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes. Biological & pharmaceutical bulletin 20090801
Simultaneous determination of lansoprazole and its metabolites 5'-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC-MS/MS: application to a pharmacokinetic study in healthy volunteers. Journal of pharmaceutical and biomedical analysis 20081201
Intestinal CYP3A4 is not involved in the enantioselective disposition of lansoprazole. Xenobiotica; the fate of foreign compounds in biological systems 20060101
Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine. British journal of clinical pharmacology 20050701
Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes. British journal of clinical pharmacology 20050301
Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography: application to measuring CYP2C19 activity. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225
Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes. European journal of clinical pharmacology 20041101
Effects of fluvoxamine on lansoprazole pharmacokinetics in relation to CYP2C19 genotypes. Journal of clinical pharmacology 20041101
Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040525
A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. The Journal of biological chemistry 20030328
Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobacter pylori eradication therapy assessed by changes in plasma lansoprazole levels and partial cortisol clearance to 6beta-hydroxycortisol. Clinical pharmacology and therapeutics 20020701
Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes. European journal of clinical pharmacology 20011201
High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes. Journal of chromatography. B, Biomedical sciences and applications 20010605
Pharmacokinetic differences between lansoprazole enantiomers and contribution of cytochrome P450 isoforms to enantioselective metabolism of lansoprazole in dogs. Biological & pharmaceutical bulletin 20010301
Identification of the human P450 enzymes involved in lansoprazole metabolism. The Journal of pharmacology and experimental therapeutics 19960501
Properties