Home Sulfos Acetic acid, 2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-

Acetic acid, 2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-

CAS No.:
151606-29-0
Catalog Number:
AG001NG7
Molecular Formula:
C19H18N2O5S
Molecular Weight:
386.4216
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Product Description
Catalog Number:
AG001NG7
Chemical Name:
Acetic acid, 2-[[2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]-
CAS Number:
151606-29-0
Molecular Formula:
C19H18N2O5S
Molecular Weight:
386.4216
MDL Number:
MFCD00797629
IUPAC Name:
2-[2-methyl-8-[(4-methylphenyl)sulfonylamino]quinolin-6-yl]oxyacetic acid
InChI:
InChI=1S/C19H18N2O5S/c1-12-3-7-16(8-4-12)27(24,25)21-17-10-15(26-11-18(22)23)9-14-6-5-13(2)20-19(14)17/h3-10,21H,11H2,1-2H3,(H,22,23)
InChI Key:
CGNKOBNGEFZRQU-UHFFFAOYSA-N
SMILES:
OC(=O)COc1cc(NS(=O)(=O)c2ccc(cc2)C)c2c(c1)ccc(n2)C
UNII:
Z74RD6XLAC
Properties
Complexity:
612  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
386.094g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
386.422g/mol
Monoisotopic Mass:
386.094g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
114A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3  
Literature
Title Journal
Sensor specific imaging of proteomic Zn2+ with zinquin and TSQ after cellular exposure to N-ethylmaleimide. Metallomics : integrated biometal science 20120502
Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation. Nutrients 20111101
Reactions of the fluorescent sensor, Zinquin, with the zinc-proteome: adduct formation and ligand substitution. Inorganic chemistry 20111017
Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma. Cancer biology & therapy 20110815
Sputum zinc concentration and clinical outcome in older asthmatics. Respirology (Carlton, Vic.) 20110401
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. The EMBO journal 20110202
Zinc signals promote IL-2-dependent proliferation of T cells. European journal of immunology 20100501
Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells. Journal of food science 20100501
3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts. Molecular nutrition & food research 20100201
Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PloS one 20090101
Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Investigative ophthalmology & visual science 20080301
Trichomes of tobacco excrete zinc as zinc-substituted calcium carbonate and other zinc-containing compounds. Plant physiology 20060701
Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment. Brain research 20060426
Apoptosis may underlie the pathology of zinc-deficient skin. Immunology and cell biology 20060201
Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons. Brain research 20051102
S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils. The international journal of biochemistry & cell biology 20050601
Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood. Proceedings of the National Academy of Sciences of the United States of America 20050517
The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. The Journal of biological chemistry 20050415
Zinc has ambiguous effects on chromium (VI)-induced oxidative stress and apoptosis. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20050101
Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20050101
Exchangeable zinc ions transiently accumulate in a vesicular compartment in the yeast Saccharomyces cerevisiae. Biochemical and biophysical research communications 20041008
S-Nitroso compounds interfere with zinc probing by Zinquin. Analytical biochemistry 20040901
Monitoring apoptosis with fluorescent Zn2+-indicators. Science's STKE : signal transduction knowledge environment 20040302
Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation. Biochemical pharmacology 20031015
Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes. Journal of the American Chemical Society 20030402
Intracellular zinc fluxes associated with apoptosis in growth plate chondrocytes. Journal of cellular biochemistry 20030401
Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells. American journal of physiology. Renal physiology 20021201
Intracellular zinc distribution and transport in C6 rat glioma cells. Biochemical and biophysical research communications 20020830
DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells. American journal of physiology. Cell physiology 20020801
Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. The Biochemical journal 20020515
pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons. American journal of physiology. Cell physiology 20020201
Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. American journal of physiology. Lung cellular and molecular physiology 20020201
Localization of zinc after in vitro mineralization in osteoblastic cells. Biological trace element research 20011001
Spatial organization of Ca(2+) entry and exocytosis in mouse pancreatic beta-cells. Biochemical and biophysical research communications 20010817
A decrease in intracellular zinc level precedes the detection of early indicators of apoptosis in HL-60 cells. Apoptosis : an international journal on programmed cell death 20010601
Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments. Biophysical journal 20010301
Zinc inhibits interleukin-1-dependent T cell stimulation. European journal of immunology 19971001
Properties