Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-
| Title | Journal |
|---|---|
| Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors. | Journal of medicinal chemistry 20111124 |
| Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. | Neuron 20100909 |
| Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease. | Journal of medicinal chemistry 20091022 |
| Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. | Xenobiotica; the fate of foreign compounds in biological systems 20090701 |
| The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. | The Journal of biological chemistry 20080822 |
| Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay. | Journal of neuroscience methods 20080315 |
| Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. | The Journal of biological chemistry 20071221 |
| Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20070411 |
| In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor. | Current drug metabolism 20061201 |
| Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. | Bioorganic & medicinal chemistry letters 20060815 |
| Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. | Biochemical pharmacology 20050215 |