Home Aminos 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

CAS No.:
1211441-98-3
Catalog Number:
AG003AC4
Molecular Formula:
C23H30N8O
Molecular Weight:
434.5373
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
99%(HPLC)
In Stock USA
United States
$119
- +
5mg
99%(HPLC)
In Stock USA
United States
$154
- +
10mg
99%(HPLC)
In Stock USA
United States
$180
- +
Product Description
Catalog Number:
AG003AC4
Chemical Name:
7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS Number:
1211441-98-3
Molecular Formula:
C23H30N8O
Molecular Weight:
434.5373
MDL Number:
MFCD27976795
IUPAC Name:
7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
InChI:
InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChI Key:
RHXHGRAEPCAFML-UHFFFAOYSA-N
SMILES:
CN(C(=O)c1cc2c(n1C1CCCC1)nc(nc2)Nc1ccc(cn1)N1CCNCC1)C
EC Number:
807-111-0
UNII:
TK8ERE8P56
Properties
Complexity:
636  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
434.254g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
434.548g/mol
Monoisotopic Mass:
434.254g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
91.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicology letters 20180701
Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial. The Lancet. Oncology 20180701
A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas. Clinical cancer research : an official journal of the American Association for Cancer Research 20161201
Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer. The New England journal of medicine 20161103
Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 20131115
A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer biology & therapy 20130701
The requirement for cyclin D function in tumor maintenance. Cancer cell 20121016
Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer cell 20121016
Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Cell cycle (Georgetown, Tex.) 20120715
Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. Biochimica et biophysica acta 20110801
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer cell 20100713
The landscape of somatic copy-number alteration across human cancers. Nature 20100218
Requirement for CDK4 kinase function in breast cancer. Cancer cell 20060101
Properties