Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

Lancet (London, England) 20120728

How effective is citicoline for acute ischaemic stroke?

Lancet (London, England) 20120728

Citicoline enhances neuroregenerative processes after experimental stroke in rats.

Stroke 20120701

Improvements in quantitative EEG following consumption of a natural citicoline-enhanced beverage.

International journal of food sciences and nutrition 20120601

Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury.

Neurological research 20120401

Efficacy of cytidine-5'-diphosp-bocholine combined with compound anisodine in the treatment of early optic nerve contusion.

Eye science 20120301

Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion.

Brain research bulletin 20120210

CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke.

Neurochemistry international 20120201

Probably role of citicoline in stroke rehabilitation: review of the literature.

Revista de neurologia 20120201

Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome.

Clinical interventions in aging 20120101

[Neuroprotective treatment with citicoline (ceraxon) in patients with ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101

[Influence of neuroprotectors with choline-positive action on the level of brain-injury markers during acute ischemic stroke].

Eksperimental'naia i klinicheskaia farmakologiia 20120101

Prevention of epidural fibrosis in rats by local or systemic administration of citicoline.

Turkish neurosurgery 20120101

Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis.

Biochimica et biophysica acta 20111201

CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves.

Neurological research 20110901

The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models.

Behavioural pharmacology 20110901

Investigational therapies for ischemic stroke: neuroprotection and neurorecovery.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20110701

CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke.

Neurological research 20110701

Eight weeks of citicoline treatment does not perturb sleep/wake cycles in cocaine-dependent adults.

Pharmacology, biochemistry, and behavior 20110601

CDP-choline as a biological supplement during neurorecovery: a focused review.

PM & R : the journal of injury, function, and rehabilitation 20110601

Effect of choline-containing phospholipids on brain cholinergic transporters in the rat.

Journal of the neurological sciences 20110315

CDP-choline-induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho-kinase signalling.

Life sciences 20110314

Citicoline: pharmacological and clinical review, 2010 update.

Revista de neurologia 20110314

Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia.

Science China. Life sciences 20110301

Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers.

Journal of addiction medicine 20110301

Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia.

International journal of pharmaceutics 20110227

Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo.

Journal of lipid research 20110201

Citicoline preclinical and clinical update 2009-2010.

Stroke 20110101

Citicoline in vascular cognitive impairment and vascular dementia after stroke.

Stroke 20110101

Neuroprotection and recovery: recent data at the bench on citicoline.

Stroke 20110101

A random effects variance shift model for detecting and accommodating outliers in meta-analysis.

BMC medical research methodology 20110101

Human tissue kallikrein promoted activation of the ipsilesional sensorimotor cortex after acute cerebral infarction.

European neurology 20110101

Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia.

Journal of pharmacological sciences 20110101

Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury.

Drug delivery 20110101

[The effect of parenteral citicoline on visual functions and life quality of patients with primary open-angle glaucoma].

Vestnik oftalmologii 20110101

[Comparative aspects of using neuroprotectors in the management of patients with ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

[Ceraxon (citicoline) in the treatment of the mild cognitive impairment syndrome].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

[Comparison of efficacy of different neurometabolic and vasoactive medicines in ischemic stroke patients's rehabilitation].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Mannosylated liposomal cytidine 5' diphosphocholine prevent age related global moderate cerebral ischemia reperfusion induced mitochondrial cytochrome c release in aged rat brain.

Neuroscience 20101229

Citicoline, use in cognitive decline: vascular and degenerative.

Journal of the neurological sciences 20101215

Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.

Bipolar disorders 20101201

Production of cytidine 5'-diphosphorylcholine with high utilization of ATP by whole cells of Saccharomyces cerevisiae.

Bioresource technology 20101101

Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury.

Acta neurochirurgica 20100601

Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100601

Citicoline for acute ischemic stroke in Mexican hospitals: a retrospective postmarketing analysis.

Methods and findings in experimental and clinical pharmacology 20100601

Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse.

Biochimica et biophysica acta 20100401

Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100401

Effect of repeatedly given CDP-choline on cardiovascular and tissue injury in spinal shock conditions: investigation of the acute phase.

The Journal of pharmacy and pharmacology 20100401

Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100201

Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100201

Molecular mechanisms involved in farnesol-induced apoptosis.

Cancer letters 20100128

Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods.

The International journal of eating disorders 20100101

The protective effects of propofol and citicoline combination in experimental head injury in rats.

Turkish neurosurgery 20100101

Effect of recombinant human erythropoietin on serum S100B protein and interleukin-6 levels after traumatic brain injury in the rat.

Neurologia medico-chirurgica 20100101

[Efficacy and safety of the combined therapy with citicholine and actovegin in the acute period of ischemic stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

The citicoline brain injury treatment (COBRIT) trial: design and methods.

Journal of neurotrauma 20091201

Effect of NH4+ and glycerol on cytidine 5'-diphosphocholine synthesis in Saccharomyces cerevisiae.

Bioresource technology 20091001

Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors.

Shock (Augusta, Ga.) 20090901

Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.

The international journal of biochemistry & cell biology 20090701

ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.

Journal of cell science 20090515

Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice.

Biochimica et biophysica acta 20090501

The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.

Anesthesia and analgesia 20090501

A robust quantitative solid phase immunoassay for the acute phase protein C-reactive protein (CRP) based on cytidine 5'-diphosphocholine coupled dendrimers.

Journal of immunological methods 20090415

Efficacy of citicoline as an acute stroke treatment.

Expert opinion on pharmacotherapy 20090401

Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases.

Methods and findings in experimental and clinical pharmacology 20090401

Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

Pharmaceutical statistics 20090101

Multifunctional actions of approved and candidate stroke drugs.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20090101

Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats.

International journal of toxicology 20090101

[The use of citicoline in the acute cerebral stroke].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Effects of cytidine 5'-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice.

European journal of pharmacology 20081119

Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats.

Life sciences 20081107

Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy.

NMR in biomedicine 20081101

Effect of choline-containing phospholipids on transglutaminase activity in primary astroglial cell cultures.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20081101

CDP-choline prevents cardiac arrhythmias and lethality induced by short-term myocardial ischemia-reperfusion injury in the rat: involvement of central muscarinic cholinergic mechanisms.

Naunyn-Schmiedeberg's archives of pharmacology 20080901

Central choline suppresses plasma renin response to graded haemorrhage in rats.

Clinical and experimental pharmacology & physiology 20080901

Cytidine-5-diphosphocholine supplement in early life induces stable increase in dendritic complexity of neurons in the somatosensory cortex of adult rats.

Neuroscience 20080813

Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system.

European journal of pharmacology 20080728

Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.

The Biochemical journal 20080701

Cholinomimetic agents and neurocognitive impairment following head injury: a systematic review.

Brain injury 20080701

[Clinical effect of ligustrazine combined with citicoline for treatment of diabetic peripheral neuropathy].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080701

Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy.

European journal of neurology 20080501

Citicoline. Monograph.

Alternative medicine review : a journal of clinical therapeutic 20080301

Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080201

Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions.

Neuroscience letters 20080124

Effect of oral CDP-choline on visual function in young amblyopic patients.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080101

Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke.

Neurobiology of disease 20080101

Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.

Autonomic & autacoid pharmacology 20080101

First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy.

Clinical neuropharmacology 20080101

Efficiency of citicoline in increasing muscular strength of patients with nontraumatic cerebral hemorrhage: a double-blind randomized clinical trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20080101

CDP-choline protects motor neurons against apoptotic changes in a model of chronic glutamate excitotoxicity in vitro.

Folia neuropathologica 20080101

CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia.

Acta neurobiologiae experimentalis 20080101

Evidence of the neuroprotective role of citicoline in glaucoma patients.

Progress in brain research 20080101

Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair.

Reviews in neurological diseases 20080101

Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system.

European journal of pharmacology 20071222

Citicoline is not protective in experimental models of Huntington's disease.

Neurobiology of aging 20071201

Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats.

Surgical neurology 20071201

Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina.

Current eye research 20071201

A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence.

Journal of clinical psychopharmacology 20071001

Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase.

Eukaryotic cell 20070901

CDP-choline reduces dopaminergic cell loss induced by MPP(+) and glutamate in primary mesencephalic cell culture.

The International journal of neuroscience 20070701

Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?

Journal of the neurological sciences 20070615

Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats.

Neuroscience letters 20070613

Interventions for preventing delirium in hospitalised patients.

The Cochrane database of systematic reviews 20070418

A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke.

Neurobiology of disease 20070401

Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system.

Archives of physiology and biochemistry 20070101

Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat.

Experimental eye research 20061101

The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system.

Brain research 20061030

Citicoline--the first effective neuroprotectant to be combined with thrombolysis in acute ischemic stroke?

Journal of the neurological sciences 20060925

Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke.

Journal of the neurological sciences 20060925

Citicoline: pharmacological and clinical review, 2006 update.

Methods and findings in experimental and clinical pharmacology 20060901

Citicoline (Cognizin) in the treatment of cognitive impairment.

Clinical interventions in aging 20060901

Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.

The Journal of biological chemistry 20060728

Medical treatment of amblyopia: present state and perspectives.

Strabismus 20060601

Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: improved behavioral and neuroanatomical recovery.

Neurochemical research 20060601

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Action of citicoline on rat retinal expression of extracellular-signal-regulated kinase (ERK1/2).

Brain research 20060407

CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke.

The Journal of biological chemistry 20060310

Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of sea bream (Sparus aurata).

The British journal of nutrition 20060301

[Effect of citicoline on spatial learning and memory of rats after focal cerebral ischemia].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201

Intravenous administration of choline or cdp-choline improves platelet count and platelet closure times in endotoxin-treated dogs.

Shock (Augusta, Ga.) 20060101

Citicoline in intracerebral haemorrhage: a double-blind, randomized, placebo-controlled, multi-centre pilot study.

Cerebrovascular diseases (Basel, Switzerland) 20060101

Radioprotective effect of transferrin targeted citicoline liposomes.

Journal of drug targeting 20060101

Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release.

Cellular and molecular neurobiology 20060101

Targets of cytoprotection in acute ischemic stroke: present and future.

Cerebrovascular diseases (Basel, Switzerland) 20060101

Neurorepair versus neuroprotection in stroke.

Cerebrovascular diseases (Basel, Switzerland) 20060101

Thrombolysis and neuroprotection in cerebral ischemia.

Cerebrovascular diseases (Basel, Switzerland) 20060101

Cytidine 5'-diphosphocholine restores blood flow of superior mesenteric and renal arteries and prolongs survival time in haemorrhaged anaesthetized rats.

Clinical and experimental pharmacology & physiology 20060101

Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.

The Journal of biological chemistry 20051118

Effects of citicoline on experimental spinal cord injury.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20051101

Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils.

Brain research 20051005

CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke.

Brain research 20051005

Neuroprotective effect of citicoline against KA-induced neurotoxicity in the rat retina.

Experimental eye research 20050901

Neuroprotective effect of citicoline on retinal cell damage induced by kainic acid in rats.

Korean journal of ophthalmology : KJO 20050901

Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.

The Journal of biological chemistry 20050805

Effects of simvastatin on the expression of intercellular adhesion molecule-1 mRNA in neonatal brain with hypoxic-ischemic damage.

Journal of nanoscience and nanotechnology 20050801

Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia.

Neurochemical research 20050801

Effect of Xuesaitong soft capsule on hemorrheology and in auxiliarily treating patients with acute cerebral infarction.

Chinese journal of integrative medicine 20050601

[A case of interval form of carbon monoxide poisoning with a remarkable recovery].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050501

Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.

The Cochrane database of systematic reviews 20050418

Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells.

Toxicological sciences : an official journal of the Society of Toxicology 20050301

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport.

Neurobiology of disease 20050301

Progressive morphometric and cognitive changes in vascular dementia.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 20050301

Effects of cataractogenesis on the CDP-choline pathway: increased phospholipid synthesis in lenses from galactosemic rats and 13/N guinea pigs.

Ophthalmic research 20050101

Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats.

Learning & memory (Cold Spring Harbor, N.Y.) 20050101

Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders.

Neurochemical research 20050101

Electrophysiological assessment of glaucomatous visual dysfunction during treatment with cytidine-5'-diphosphocholine (citicoline): a study of 8 years of follow-up.

Documenta ophthalmologica. Advances in ophthalmology 20050101

The new approaches to preservation of graft cell integrity in preservation for transplantation.

Annals of transplantation 20050101

CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement.

Fundamental & clinical pharmacology 20041001

Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia.

Nucleosides, nucleotides & nucleic acids 20041001

Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster.

Biochimica et biophysica acta 20040705

A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion.

The Journal of biological chemistry 20040604

Chronic treatment with a precursor of cellular phosphatidylcholine ameliorates morphological and behavioral effects of aging in the mouse [correction of rat] hippocampus.

Annals of the New York Academy of Sciences 20040601

Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana.

FEBS letters 20040521

Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia.

Journal of neuroscience research 20040501

Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature.

Alternative medicine review : a journal of clinical therapeutic 20040301

The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats.

The International journal of neuroscience 20040201

Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation.

Fundamental & clinical pharmacology 20040201

Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201

Phospholipid biosynthesis in mammalian cells.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20040201

A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola.

Molecular microbiology 20040101

Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly.

The Cochrane database of systematic reviews 20040101

Brain cholinesterases: III. Future perspectives of AD research and clinical practice.

Medical hypotheses 20040101

Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia.

Journal of geriatric psychiatry and neurology 20031201

Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells.

Journal of the neurological sciences 20031115

Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia.

Antioxidants & redox signaling 20031001

Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia.

Journal of neuroscience research 20030801

Phosphorylation of Saccharomyces cerevisiae CTP synthetase at Ser424 by protein kinases A and C regulates phosphatidylcholine synthesis by the CDP-choline pathway.

The Journal of biological chemistry 20030627

Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.

The Biochemical journal 20030615

Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats.

Progress in neuro-psychopharmacology & biological psychiatry 20030601

Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells.

Brain research 20030509

Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation.

European journal of pharmacology 20030509

Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats.

Journal of neurosurgery 20030401

The two biosynthetic routes leading to phosphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling.

Biochemistry 20030318

Oral citicoline treatment improves visual pathway function in glaucoma.

Medical science monitor : international medical journal of experimental and clinical research 20030301

Clinical correlates of cognitive decline in vascular dementia.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20030301

Effects of cytidine 5'-diphosphocholine on plasma homocysteine levels in rat.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030201

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

Journal of molecular neuroscience : MN 20030201

Effects of citicholine and dimethylsulfoxide on transepithelial transport of passively diffused drugs in the Caco-2 cell culture model.

International journal of pharmaceutics 20030130

Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia.

Neuroscience 20030101

Effect of CDP-choline on hippocampal acetylcholinesterase and Na+,K(+)-ATPase in adult and aged rats.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Effects of cataractogenesis on the CDP-choline pathway: changes in ATP concentration and phosphocholine synthesis during and after exposure of rat lenses to sugars in vitro and in vivo.

Ophthalmic research 20030101

Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes.

Cerebrovascular diseases (Basel, Switzerland) 20030101

'Brain-specific' nutrients: a memory cure?

Nutrition (Burbank, Los Angeles County, Calif.) 20030101

Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells.

Brain research 20021206

Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials.

Stroke 20021201

Citicoline has a protective effect on damaged retinal ganglion cells in mouse culture retina.

Neuroreport 20021115

Citicoline mechanisms and clinical efficacy in cerebral ischemia.

Journal of neuroscience research 20021015

[Treatment of mild cognitive impairment: value of citicoline].

Revista de neurologia 20021001

Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway.

The Journal of biological chemistry 20020920

Clinical use of cholinomimetic agents: a review.

The Journal of head trauma rehabilitation 20020801

Effects of ganglioside GM3 on phospholipid turnover of human leukemic J6-2 cells.

Neurochemical research 20020801

Argipressin(4-8) upregulate CTP: phosphocholine cytidylyltransferase in rat hippocampal neurons.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20020701

Quantifying heterogeneity in a meta-analysis.

Statistics in medicine 20020615

Antidepressant-like effects of cytidine in the forced swim test in rats.

Biological psychiatry 20020601

Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system.

Naunyn-Schmiedeberg's archives of pharmacology 20020501

CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat.

Neuropharmacology 20020501

Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study.

Psychopharmacology 20020501

The serial position effect in mild and moderately severe vascular dementia.

Journal of the International Neuropsychological Society : JINS 20020501

[Perspectives on the treatment of organic mental disorders by the use of nootropic agents].

Voenno-meditsinskii zhurnal 20020501

News about neuroprotectants for the treatment of stroke.

JAMA 20020313

Pharmacodynamics of citicoline relevant to the treatment of glaucoma.

Journal of neuroscience research 20020115

Citicoline: neuroprotective mechanisms in cerebral ischemia.

Journal of neurochemistry 20020101

Citicoline treatment increases retinal dopamine content in rabbits.

Ophthalmic research 20020101

Membrane stabilizer: citicoline.

Current medical research and opinion 20020101

[Reaction times during citicoline treatment].

La Clinica terapeutica 20020101

Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs.

Molecular and biochemical parasitology 20020101

Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter.

Biological & pharmaceutical bulletin 20011201

Citicoline. Ferrer Internacional.

Current opinion in investigational drugs (London, England : 2000) 20011201

A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients.

Neurology 20011113

[Curative effect of soybean lecithin on cerebral infarction].

Zhonghua yi xue za zhi 20011110

Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia.

Stroke 20011001

The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20011001

[Use of procholinergics in the prevention of postoperative delirium in hip fracture surgery in the elderly. A randomized controlled trial].

Revista de neurologia 20011001

Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects.

Psychopharmacology 20010901

Choline deficiency induced by Mycoplasma fermentans enhances apoptosis of rat astrocytes.

FEMS microbiology letters 20010724

[Neuroprotection in acute ischemic stroke. Practicability of guidelines for treatment].

Revista de neurologia 20010501

Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline.

Archives of physiology and biochemistry 20010401

Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes.

The Journal of biological chemistry 20010316

Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

Brain research 20010302

Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats.

Neuroscience letters 20010223

Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway.

The Journal of biological chemistry 20010209

Delayed administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain.

Clinical and experimental pharmacology & physiology 20010101

Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease.

Neuroscience 20010101

Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver: influence of ethanol on the microsomal cholinephosphotransferase activity.

Molecular and cellular biochemistry 20010101

Performance on the Hooper Visual Organizational Test in patients diagnosed with subcortical vascular dementia: relation to naming performance.

Neuropsychiatry, neuropsychology, and behavioral neurology 20010101

CDP-choline, but not cytidine, protects hippocampal CA1 neurones in the gerbil following transient forebrain ischaemia.

Folia neuropathologica 20010101

Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report.

Psychopharmacology 19990201

A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group.

Neurology 19970901

Characterization of 2',3'-dideoxycytidine diphosphocholine and 2',3'-dideoxycytidine diphosphoethanolamine. Prominent phosphodiester metabolites of the anti-HIV nucleoside 2',3'-dideoxycytidine.

Drug metabolism and disposition: the biological fate of chemicals 19930101

Effects of citicholine and of the combination citicholine + piracetam on the memory (experiments on mice).

Acta physiologica et pharmacologica Bulgarica 19900101

Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in rats.

Arzneimittel-Forschung 19890901