Home Other Building Blocks DICHLOROTRICARBONYLRUTHENIUM (II) DIMER

DICHLOROTRICARBONYLRUTHENIUM (II) DIMER

CAS No.:
22594-69-0
Catalog Number:
AG003PDY
Molecular Formula:
C6Cl4O6Ru2
Molecular Weight:
512.0126
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Product Description
Catalog Number:
AG003PDY
Chemical Name:
DICHLOROTRICARBONYLRUTHENIUM (II) DIMER
CAS Number:
22594-69-0
Molecular Formula:
C6Cl4O6Ru2
Molecular Weight:
512.0126
MDL Number:
MFCD00011528
IUPAC Name:
carbon monoxide;dichlororuthenium
InChI:
InChI=1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4
InChI Key:
JYHHJVKGDCZCCL-UHFFFAOYSA-J
SMILES:
[O]#C[Ru+2]1([Cl-])(C#[O])(C#[O])[Cl-][Ru+2]([Cl-]1)([Cl-])(C#[O])(C#[O])C#[O]
Properties
Complexity:
12.8  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
8  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
515.652g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
512g/mol
Monoisotopic Mass:
511.654g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells. Environmental toxicology 20180301
Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells. Environmental toxicology 20170301
Carbon monoxide releasing molecule-2 ameliorates IL-1β-induced IL-8 in human gastric cancer cells. Toxicology 20160615
Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes. Toxicology and applied pharmacology 20151201
Carbon Monoxide (CO) Released from Tricarbonyldichlororuthenium (II) Dimer (CORM-2) in Gastroprotection against Experimental Ethanol-Induced Gastric Damage. PloS one 20150101
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide. Toxicology and applied pharmacology 20140101
Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway. Toxicology and applied pharmacology 20131115
Treatment with carbon monoxide-releasing molecules and an HO-1 inducer enhances the effects and expression of µ-opioid receptors during neuropathic pain. Anesthesiology 20130501
Divergent molecular mechanisms underlay CO- and CORM-2-induced relaxation of corpora cavernosa. The journal of sexual medicine 20120901
Cell damage following carbon monoxide releasing molecule exposure: implications for therapeutic applications. Basic & clinical pharmacology & toxicology 20120701
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circulation research 20120427
Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis. Journal of cellular biochemistry 20120201
Therapeutic potential of carbon monoxide in multiple sclerosis. Clinical and experimental immunology 20120201
Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation. European journal of pharmacology 20120115
Carbon monoxide protects against ischemia-reperfusion injury in vitro via antioxidant properties. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
The carbon monoxide releasing molecule CORM-2 attenuates Pseudomonas aeruginosa biofilm formation. PloS one 20120101
Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice. PloS one 20120101
Redox-based thrombelastographic method to detect carboxyhemefibrinogen-mediated hypercoagulability. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201
Carbon monoxide-releasing molecule-2 enhances coagulation in rabbit plasma and decreases bleeding time in clopidogrel/aspirin-treated rabbits. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201
Carbon monoxide and nitric oxide modulate α₂-antiplasmin and plasmin activity: role of heme. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201
p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro. European journal of pharmacology 20111116
Carbon monoxide releasing molecule-2 improves coagulation in patient plasma in vitro following cardiopulmonary bypass. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110701
Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110701
Wound healing activity of carbon monoxide liberated from CO-releasing molecule (CO-RM). Naunyn-Schmiedeberg's archives of pharmacology 20110701
Beneficial effects of carbon monoxide-releasing molecule-2 (CORM-2) on acute doxorubicin cardiotoxicity in mice: role of oxidative stress and apoptosis. Toxicology and applied pharmacology 20110515
Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1. American journal of respiratory cell and molecular biology 20110501
Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation. Kidney international 20110501
Effects of carbon monoxide on ion transport across rat distal colon. American journal of physiology. Gastrointestinal and liver physiology 20110201
Carbon monoxide releasing molecule-2 enhances coagulation and attenuates fibrinolysis by two mechanisms: insights gained with colloid dilution. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110101
Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes. PloS one 20110101
Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages. Shock (Augusta, Ga.) 20101201
Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes. International immunopharmacology 20101201
Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban. Anesthesia and analgesia 20101201
Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells. Toxicology and applied pharmacology 20101115
Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in subjects exposed to warfarin. Thrombosis research 20100701
Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100601
Carbon monoxide liberated from CO-releasing molecule (CORM-2) attenuates ischemia/reperfusion (I/R)-induced inflammation in the small intestine. Inflammation 20100401
Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Molecular pharmacology 20100401
Effects of carbon monoxide releasing molecule-liberated CO on severe acute pancreatitis in rats. Cytokine 20100101
Cardioprotective effect with carbon monoxide releasing molecule-2 (CORM-2) in isolated perfused rat heart: Role of coronary endothelium and underlying mechanism. Vascular pharmacology 20100101
Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats. BMC gastroenterology 20100101
Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells. Atherosclerosis 20091201
Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages. Inflammation 20091201
Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo. Molecular pharmacology 20090701
The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage. American journal of physiology. Gastrointestinal and liver physiology 20090601
Carbon monoxide produced by intrasinusoidally located haem-oxygenase-1 regulates the vascular tone in cirrhotic rat liver. Liver international : official journal of the International Association for the Study of the Liver 20090501
Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice. Cardiovascular research 20090401
Protection of carbon monoxide-releasing molecule against lung injury induced by limb ischemia-reperfusion. Chinese journal of traumatology = Zhonghua chuang shang za zhi 20090401
[Inhibitive effect of exogenous carbon monoxide-releasing molecules 2 on tissue factor expression in sepsis]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20090401
Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coli. Microbiology (Reading, England) 20090301
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus. Naunyn-Schmiedeberg's archives of pharmacology 20081101
The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes. Rheumatology (Oxford, England) 20080901
Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing. European journal of pharmacology 20080820
Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum. European journal of pharmacology 20080820
Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits. Journal of applied physiology (Bethesda, Md. : 1985) 20080701
Carbon monoxide-releasing molecule tricarbonyldichlororuthenium (II) dimer induces concentration-dependent alterations in the electrophysiological properties of axons in mammalian spinal cord. Neuroscience 20080219
Modulation of hTREK-1 by carbon monoxide. Neuroreport 20080212
Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Free radical biology & medicine 20080201
Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation. Current pharmaceutical design 20080101
Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC. International journal of biological sciences 20080101
Mechanisms of relaxation by carbon monoxide-releasing molecule-2 in murine gastric fundus and jejunum. European journal of pharmacology 20071031
[The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20070601
Attenuation of leukocytes sequestration by carbon monoxide-releasing molecules: liberated carbon monoxide in the liver of thermally injured mice. Journal of burn care & research : official publication of the American Burn Association 20070101
CO from enhanced HO activity or from CORM-2 inhibits both O2- and NO production and downregulates HO-1 expression in LPS-stimulated macrophages. Biochemical pharmacology 20060112
The inhibitory effects of roflumilast on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells are mediated by heme oxygenase-1 and its product carbon monoxide. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20051201
Carbon monoxide reduces the expression and activity of matrix metalloproteinases 1 and 2 in alveolar epithelial cells. Cellular and molecular biology (Noisy-le-Grand, France) 20050930
Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. The Journal of biological chemistry 20050708
Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. British journal of pharmacology 20050701
Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochemical pharmacology 20050615
Protective effect of carbon monoxide-releasing compounds in ischemia-induced acute renal failure. Journal of the American Society of Nephrology : JASN 20050401
The effect of a carbon monoxide-releasing molecule on the immunological activation of guinea-pig mast cells and human basophils. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040301
Heme oxygenase-1 attenuates interleukin-1beta-induced nitric oxide synthase expression in vascular smooth muscle cells. Journal of biomedical science 20040101
Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2. The Journal of biological chemistry 20030523
Properties