2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride
| Title | Journal |
|---|---|
| B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals. | Toxicology 20170701 |
| Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness. | Toxicology 20170501 |
| Liver X receptor activation promotes differentiation of regulatory T cells. | PloS one 20170101 |
| Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content. | Molecular membrane biology 20121101 |
| Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors. | Molecular pharmacology 20121001 |
| Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner. | Antiviral research 20120901 |
| Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2. | Arteriosclerosis, thrombosis, and vascular biology 20120901 |
| Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin. | Prostaglandins, leukotrienes, and essential fatty acids 20120701 |
| ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells. | Biochemical and biophysical research communications 20120427 |
| Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. | Brain pathology (Zurich, Switzerland) 20120301 |
| Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | American journal of physiology. Renal physiology 20120301 |
| Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. | PloS one 20120101 |
| Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111102 |
| Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism. | The Journal of biological chemistry 20110923 |
| Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRα. | The American journal of pathology 20110701 |
| LXR as a novel antithrombotic target. | Blood 20110526 |
| Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4. | Journal of immunology (Baltimore, Md. : 1950) 20110415 |
| Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. | British journal of pharmacology 20110401 |
| Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity. | Journal of lipid research 20101201 |
| ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. | The Journal of biological chemistry 20101029 |
| Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100908 |
| Recent progress in liver X receptor-selective modulators. | Current opinion in drug discovery & development 20100701 |
| The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. | The Journal of biological chemistry 20100625 |
| X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. | Journal of molecular biology 20100528 |
| Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model. | Journal of lipid research 20100401 |
| The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation. | Journal of cellular physiology 20100401 |
| Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. | Arteriosclerosis, thrombosis, and vascular biology 20100401 |
| Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. | The Journal of biological chemistry 20100219 |
| Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages. | Shock (Augusta, Ga.) 20091101 |
| LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | Atherosclerosis 20091101 |
| Activation of liver X receptor regulates substrate oxidation in white adipocytes. | Endocrinology 20090901 |
| The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro. | Diabetologia 20090701 |
| Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. | Cell metabolism 20081201 |
| Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. | Journal of immunology (Baltimore, Md. : 1950) 20081115 |
| Treatment with LXR agonists after focal cerebral ischemia prevents brain damage. | FEBS letters 20081015 |
| Intestine-specific regulation of PPARalpha gene transcription by liver X receptors. | Endocrinology 20081001 |
| Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke. | Circulation 20080930 |
| Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth. | Journal of immunology (Baltimore, Md. : 1950) 20080915 |
| Androgen deprivation by activating the liver X receptor. | Endocrinology 20080801 |
| PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine. | Biochemical and biophysical research communications 20080711 |
| Ligand specificity and evolution of liver X receptors. | The Journal of steroid biochemistry and molecular biology 20080501 |
| Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators. | Journal of medicinal chemistry 20080410 |
| Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice. | Arteriosclerosis, thrombosis, and vascular biology 20080301 |
| The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation. | Atherosclerosis 20080101 |
| Liver X receptors (LXR) as therapeutic targets in dyslipidemia. | Cardiovascular therapeutics 20080101 |
| Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965). | Molecular pharmacology 20071001 |
| GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. | British journal of pharmacology 20070601 |
| Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists. | Molecular human reproduction 20070601 |
| [Advances in the study of anti-atherosclerosis drugs]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070301 |
| Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2. | Infection and immunity 20070201 |
| The nuclear receptor LXR is a glucose sensor. | Nature 20070111 |
| Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. | Circulation research 20060929 |
| Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study. | Journal of lipid research 20060601 |
| A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. | The Journal of biological chemistry 20060224 |
| Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. | Neuroreport 20060206 |
| Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation. | Shock (Augusta, Ga.) 20060201 |
| Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. | Circulation 20060103 |
| Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice. | American journal of physiology. Endocrinology and metabolism 20051101 |
| Synthetic LXR agonists increase LDL in CETP species. | Journal of lipid research 20051001 |
| Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. | Circulation research 20041210 |
| Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator. | Journal of lipid research 20040801 |
| Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptors. | Assay and drug development technologies 20031201 |
| FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene. | FEBS letters 20031023 |