Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.

The Journal of pharmacology and experimental therapeutics 20120701

Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians.

The Journal of physiology 20120601

Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.

Urology 20120601

Enantioselective drug-protein interaction between mexiletine and plasma protein.

The Journal of pharmacy and pharmacology 20120601

Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains.

Acta pharmacologica Sinica 20120501

Asymmetric hydrolytic kinetic resolution with recyclable macrocyclic Co(III)-salen complexes: a practical strategy in the preparation of (R)-mexiletine and (S)-propranolol.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120423

Wide QRS Tachycardia in a young patient.

Archives of internal medicine 20120409

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.

Journal of medicinal chemistry 20120209

Drug-induced hypersensitivity syndrome followed by persistent arthritis.

The Journal of dermatology 20120201

High-dose intravenous immunoglobulin monotherapy for drug-induced hypersensitivity syndrome.

Acta dermato-venereologica 20120101

Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.

International heart journal 20120101

Long QT syndrome with nocturnal cardiac events caused by a KCNH2 missense mutation (G604S).

Internal medicine (Tokyo, Japan) 20120101

Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel.

PloS one 20120101

Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks.

Pacing and clinical electrophysiology : PACE 20111201

Hemodialysis as an alternative treatment of mexiletine intoxication.

The American journal of emergency medicine 20111101

Enantiomeric purity of chiral derivatizing reagents for enantioresolution.

Bioanalysis 20110901

Indirect enantioresolution of (R,S)-mexiletine by reversed-phase high-performance liquid chromatography via diastereomerization with [(S,S)-O,O'-di-p-toluoyl tartaric acid anhydride], (S)-naproxen and nine chiral reagents synthesized as variants of Marfey's reagent.

Biomedical chromatography : BMC 20110301

High performance liquid chromatography enantioseparation of the novel designed mexiletine derivatives and its analogs.

Chirality 20110201

Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.

Neurology 20110125

Functional atrioventricular conduction block in an elderly patient with acquired long QT syndrome: elucidation of the mechanism of block.

Journal of electrocardiology 20110101

Refractory erythromelalgia of the ears: response to mexiletine.

American journal of otolaryngology 20110101

Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical.

Journal of pharmacological and toxicological methods 20110101

Highly sensitive determination and validation of gabapentin in pharmaceutical preparations by HPLC with 4-fluoro-7-nitrobenzofurazan derivatization and fluorescence detection.

Journal of chromatographic science 20110101

Reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-mexiletine prepared by microwave irradiation with four new chiral derivatizing reagents based on trichloro-s-triazine having amino acids as chiral auxiliaries and 10 others having amino acid amides.

Journal of chromatography. A 20101203

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug metabolism and disposition: the biological fate of chemicals 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20100801

Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.

British journal of pharmacology 20100701

Congenital long QT syndrome and 2:1 atrioventricular block: an optimistic outcome in the current era.

Heart rhythm 20100601

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity.

Archiv der Pharmazie 20100601

Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.

Neurology 20100504

Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords.

Neuroscience research 20100501

Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20100501

Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3.

Circulation research 20100430

Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias.

Current pain and headache reports 20100401

Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.

Chirality 20100301

Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.

Journal of clinical pharmacology 20100301

Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge.

Pacing and clinical electrophysiology : PACE 20100301

Polymyositis presenting with cardiac manifestations: Report of two cases and review of the literature.

Clinical neurology and neurosurgery 20100201

Fabrication and evaluation of chiral monolithic column modified by beta-cyclodextrin derivatives.

Talanta 20100115

A case of mexiletine-induced hypersensitivity syndrome presenting as eosinophilic pneumonia.

Journal of Korean medical science 20100101

Comparison of the effect of mexiletine and methylprednisolone on neural function and histopathological damage after transient spinal cord ischemia in rabbits.

Turkish neurosurgery 20100101

Mexiletine reverses oxaliplatin-induced neuropathic pain in rats.

Journal of pharmacological sciences 20100101

Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp.

Journal of pharmacological and toxicological methods 20100101

Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation.

Journal of AOAC International 20100101

Column-switching HPLC determination of mexiletine using tris(bipyridine)ruthenium(III) electrogenerated chemiluminescence and precolumn derivatization with divinylsulfone.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101

Deracemization of mexiletine biocatalyzed by omega-transaminases.

Organic letters 20091105

Design and assessment of a potent sodium channel blocking derivative of mexiletine for minimizing experimental neuropathic pain in several rat models.

Neurochemical research 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

The preventive effect of mexiletine on cerebral ischemic injury following experimental middle cerebral artery occlusion.

Turkish neurosurgery 20091001

Synthesis of dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and four new variants of Sanger's reagent having chiral amines and their application for enantioresolution of mexiletine using reversed-phase high-performance liquid chromatography.

Journal of chromatography. A 20090724

Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.

Chirality 20090701

Mexiletine and lidocaine suppress the excitability of dorsal horn neurons.

Anesthesia and analgesia 20090701

Effect of mexiletine on dynamic allodynia induced by chronic constriction injury of the sciatic nerve in rats.

The Journal of veterinary medical science 20090701

A case of myotonic dystrophy presenting with ventricular tachycardia and atrial fibrillation.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090701

2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.

European journal of medicinal chemistry 20090401

Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.

Experimental neurology 20090401

Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report.

Headache 20090201

Evaluation of pressor and visceromotor reflex responses to bladder distension in urethane anesthetized rats.

Neurourology and urodynamics 20090101

Experience with oral mexiletine in primary erythromelalgia in children.

Annals of Saudi medicine 20090101

Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution.

Journal of pharmaceutical and biomedical analysis 20081201

Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel.

Circulation. Arrhythmia and electrophysiology 20081201

A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel beta-thiophenoxy and pyridyl ethers.

The Journal of organic chemistry 20080905

One from column A and one from column B: may I take your order?

Anesthesiology 20080801

Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.

Anesthesiology 20080801

Studies on somnolence in the daytime caused by drugs used for neuropathic pain.

Journal of pharmacological sciences 20080701

[Central and peripheral mechanisms in antinociception: current and future perspectives].

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20080601

Development and validation of HPLC method for the resolution of drug intermediates: DL-3-Phenyllactic acid, DL-O-acetyl-3-phenyllactic acid and (+/-)-mexiletine acetamide enantiomers.

Talanta 20080315

Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success.

Journal of pain and symptom management 20080301

Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome.

Heart rhythm 20080301

Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.

Behavioural pharmacology 20080201

Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.

Journal of medicinal chemistry 20080124

Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.

Neurourology and urodynamics 20080101

Selective and stability-indicating methods for the simultaneous determination of mexiletine hydrochloride and/or its related substance: 2,6-dimethylphenol.

Journal of AOAC International 20080101

Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies.

Pain medicine (Malden, Mass.) 20080101

Mexiletine for refractory chronic daily headache: a report of nine cases.

Headache 20080101

[Determination of mexiletine in human blood by liquid chromatography-tandem mass spectrometry].

Fa yi xue za zhi 20071201

Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001

Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients.

Circulation 20070904

Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers.

Anesthesiology 20070901

Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070701

Burning mouth syndrome: will better understanding yield better management?

Pain practice : the official journal of World Institute of Pain 20070601

Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.

British journal of neurosurgery 20070601

Ventricular ectopy during REM sleep: implications for nocturnal sudden cardiac death.

Nature clinical practice. Cardiovascular medicine 20070501

A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.

Journal of cardiovascular electrophysiology 20070401

The cutaneous analgesic effect of class I antiarrhythmic drugs.

Anesthesia and analgesia 20070401

Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode.

Analytical and bioanalytical chemistry 20070301

Intravenous lidocaine for neuropathic pain: diagnostic utility and therapeutic efficacy.

Current pain and headache reports 20070201

Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.

Biochemical and biophysical research communications 20070126

Simultaneous separation of 14 antiarrhythmic drugs and determination of mexiletine and flecainide by capillary zone electrophoresis.

Journal of AOAC International 20070101

The effect of intravenously administered mexiletine on tinnitus - a pilot study.

International journal of audiology 20061201

The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage.

Neurological research 20061201

Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population.

Biological & pharmaceutical bulletin 20061101

Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine.

American journal of physiology. Heart and circulatory physiology 20061001

Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.

British journal of pharmacology 20061001

Acetazolamide acts directly on the human skeletal muscle chloride channel.

Muscle & nerve 20060901

Evaluation of patients with paramyotonia at 23Na MR imaging during cold-induced weakness.

Radiology 20060801

Successful parental use of an automated external defibrillator for an infant with long-QT syndrome.

Pediatrics 20060801

Systemic lidocaine or mexiletine for neuropathic pain.

American family physician 20060701

Myotonia congenita--a cause of muscle weakness and stiffness.

Nature clinical practice. Neurology 20060701

Neuroprotective effect of mexiletine in the central nervous system of diabetic rats.

Molecular and cellular biochemistry 20060601

Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.

European journal of pharmacology 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae.

Biochemical pharmacology 20060428

Effect of mexiletine on vincristine-induced painful neuropathy in mice.

European journal of pharmacology 20060424

Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.

Neuroscience letters 20060313

[An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman].

Deutsche medizinische Wochenschrift (1946) 20060303

Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation.

European journal of pharmacology 20060217

A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.

The Journal of clinical investigation 20060201

Influence of mexiletine on action potential discharge and conduction in nodose Adelta afferent neurons innervating guinea pig isolated trachea.

Pulmonary pharmacology & therapeutics 20060101

Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation.

Journal of veterinary internal medicine 20060101

Effects of mexiletine on electrical field stimulation-induced contractile responses in the ipsilateral and contralateral vasa deferentia after unilateral testicular torsion/detorsion.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20060101

Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7.

Dermatology (Basel, Switzerland) 20060101

Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells.

European journal of pharmacology 20051228

The effect of stationary phase on lipophilicity determination of beta-blockers using reverse-phase chromatographic systems.

Biomedical chromatography : BMC 20051201

Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis.

Anesthesia and analgesia 20051201

Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice.

Journal of cardiovascular electrophysiology 20051201

Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.

Pain 20051101

Systemic administration of local anesthetic agents to relieve neuropathic pain.

The Cochrane database of systematic reviews 20051019

Double-blind, placebo-controlled pilot study of mexiletine for acute mania or hypomania.

Journal of clinical psychopharmacology 20051001

Drug therapy in Brugada syndrome.

Current drug targets. Cardiovascular & haematological disorders 20051001

Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.

Pain 20050901

Prevention of ventricular extrasystole by mexiletine in patients with normal QT intervals is associated with a reduction of transmural dispersion of repolarization.

International journal of cardiology 20050803

Mexiletine treatment-induced inhibition of caspase-3 activation and improvement of behavioral recovery after spinal cord injury.

Journal of neurosurgery. Spine 20050701

[Symptomatic treatment of painful diabetic neuropathy].

Nihon rinsho. Japanese journal of clinical medicine 20050601

Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes: prediction of in vivo drug interactions.

Xenobiotica; the fate of foreign compounds in biological systems 20050601

Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20050501

Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment.

Pediatrics 20050401

Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.

Bioorganic & medicinal chemistry letters 20050401

Drug-induced hypersensitivity syndrome due to mexiletine associated with human herpes virus 6 and cytomegalovirus reactivation.

The Journal of dermatology 20050401

Preferred mexiletine block of human sodium channels with IVS4 mutations and its pH-dependence.

Pharmacogenetics and genomics 20050401

Fiction: the Christmas card.

Neurology 20050308

Systemic lidocaine and mexiletine for the treatment of a patient with total ulcerative colitis.

Gut 20050301

Inhibitory effects of lidocaine and mexiletine on vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels and the role of kinases in the porcine coronary artery.

Anesthesiology 20050301

A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.

Molecular pharmacology 20050201

The effects of mexiletine on excitability properties of human median motor axons.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20050201

Mexiletine protects myocardium during acute ischemia by opening sarcolemmal K-ATP channel: studies in closed-chest acute ischemia model in rabbits.

Journal of cardiovascular pharmacology 20041201

Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice.

Journal of pharmacological sciences 20041101

[The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].

[Hokkaido igaku zasshi] The Hokkaido journal of medical science 20041101

A case of fulminant Type 1 diabetes associated with mexiletine hypersensitivity syndrome.

Diabetic medicine : a journal of the British Diabetic Association 20041001

Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man.

Therapeutic drug monitoring 20041001

Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20041001

A case of primary erythromelalgia improved by mexiletine.

The British journal of dermatology 20040901

Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.

Molecular pharmacology 20040801

New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.

Neuromuscular disorders : NMD 20040701

Rate-dependent QRS prolongation during exercise testing associated with hyperkalemia.

Journal of electrocardiology 20040701

Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine.

Acta neurochirurgica 20040601

Images in cardiovascular medicine. Life-threatening neonatal arrhythmia: successful treatment and confirmation of clinically suspected extreme long QT-syndrome-3.

Circulation 20040511

Effects of antiarrhythmic agents on left ventricular function during exercise in patients with chronic left ventricular dysfunction.

Annals of nuclear medicine 20040501

A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs.

Cardiovascular research 20040401

Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors.

Biochemical pharmacology 20040301

Frequent ventricular extrasystole treated by needling neiguan (PC 6) plus oral administration of mexiletine--a report of 30 cases.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20040301

Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.

The Journal of physiology 20040201

Stereospecific synthesis of 'para-hydroxymexiletine' and sodium channel blocking activity evaluation.

Chirality 20040201

Systemic lidocaine in pain due to peripheral nerve injury and predictors of response.

Neurology 20040127

Novel antiarrhythmic compounds with combined class IB and class III mode of action.

Current medicinal chemistry 20040101

Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy.

Clinical and experimental pharmacology & physiology 20040101

Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.

Receptors & channels 20040101

Comparison of classical and derivative UV-spectrophotometric methods for the quantification of diltiazem and mexiletine.

Acta poloniae pharmaceutica 20040101

Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na(+) channels.

Journal of medicinal chemistry 20031120

Akt activation induced by an antioxidant compound during ischemia-reperfusion.

Free radical biology & medicine 20031101

Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury.

Neurosurgical review 20031001

Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus.

The Journal of pharmacy and pharmacology 20031001

Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers.

European journal of clinical pharmacology 20030901

Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.

European journal of pharmacology 20030822

Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.

Circulation journal : official journal of the Japanese Circulation Society 20030801

Mexiletine carbonyloxy beta-D-glucuronide: a novel metabolite in human urine.

Xenobiotica; the fate of foreign compounds in biological systems 20030801

Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine.

Biological & pharmaceutical bulletin 20030601

Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.

Brain : a journal of neurology 20030401

Effect of mexiletine on long QT syndrome model.

Acta pharmacologica Sinica 20030401

[Treatment of familial erythermalgia with the association of lidocaine and mexiletine].

Annales de dermatologie et de venereologie 20030401

Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits.

European journal of pharmacology 20030328

Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice.

Cardiovascular research 20030315

Mexiletine differentially modulates vasorelaxation mediated by adenosine triphosphate-sensitive K+ channels in aortas from normotensive and hypertensive rats.

Anesthesia and analgesia 20030301

Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine.

Circulation journal : official journal of the Japanese Circulation Society 20030301

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.

Naunyn-Schmiedeberg's archives of pharmacology 20030301

[HPLC-fluorescent spectrometric determination of serum mexiletine concentration after derivatization with fluram].

Yao xue xue bao = Acta pharmaceutica Sinica 20030301

[Intractable hiccups treated with mexiletine hydrochloride].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20030210

A case of a short-coupled variant of torsades de Pointes with electrical storm.

Pacing and clinical electrophysiology : PACE 20030201

A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.

European journal of pharmacology 20030105

Storms of ventricular tachyarrhythmias associated with primary hyperparathyroidism in a patient with dilated cardiomyopathy.

International journal of cardiology 20030101

Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine.

Xenobiotica; the fate of foreign compounds in biological systems 20030101

The effect of commonly used drugs on angiogenesis.

Anticancer research 20030101

The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats.

Neurotoxicity research 20030101

Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.

Neurotoxicity research 20030101

Down regulation of sodium channel Na(v)1.1 expression by veratridine and its reversal by a novel sodium channel blocker, RS100642, in primary neuronal cultures.

Neurotoxicity research 20030101

Long-term follow-up of sudden cardiac arrest survivors and electrophysiologically guided antiarrhythmic therapy.

Cardiology 20030101

A patient with seizures and a positive drug screen: three wrongs don't make a right.

The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20030101

Stable expression and characterization of human PN1 and PN3 sodium channels.

Receptors & channels 20030101

Persistent pain management for improved quality of life.

Journal of the American Pharmacists Association : JAPhA 20030101

[Differential diagnosis of idiopathic ventricular fibrillation].

Deutsche medizinische Wochenschrift (1946) 20021122

The analgesic effect of gabapentin and mexiletine after breast surgery for cancer.

Anesthesia and analgesia 20021001

[Diabetic neuropathy--concept, staging, diagnosis, treatment].

Nihon rinsho. Japanese journal of clinical medicine 20021001

Modification of the fenvalerate-induced nociceptive response in mice by diabetes.

Brain research 20020906

Mexiletine on segmental hyperhidrosis.

Journal of neurology, neurosurgery, and psychiatry 20020901

Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.

Circulation journal : official journal of the Japanese Circulation Society 20020901

Activation-recovery interval as a parameter to assess the intracardiac ventricular repolarization in patients with congenital long QT syndrome.

The American journal of cardiology 20020815

Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers.

Journal of the American Veterinary Medical Association 20020815

Pharmacological rescue of mutant ion channels.

Cardiovascular research 20020801

A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.

Cardiovascular research 20020801

Sodium channel-blocking agents are not of benefit to rats with kaolin-induced hydrocephalus.

Neurosurgery 20020801

Effects of analgesics on delayed postherpetic pain in mice.

Anesthesiology 20020501

Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.

Clinical pharmacology and therapeutics 20020501

Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.

Brain research 20020405

Cardioprotective effect of mexiletine in acute myocardial ischemia tudies in the rabbit closed chest ischemia mode.

Circulation journal : official journal of the Japanese Circulation Society 20020401

Mexiletine related chronic defibrillation threshold elevation: case report and review of the literature.

Pacing and clinical electrophysiology : PACE 20020401

Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol.

Journal of the Formosan Medical Association = Taiwan yi zhi 20020401

Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients.

Journal of clinical pharmacology 20020301

Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects.

Journal of neurophysiology 20020301

Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel.

FEBS letters 20020227

Electrical storms in an ICD-recipient with 429 delivered appropriate shocks: therapeutic management with antiarrhythmic drug combination.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20020201

Evaluation of mexiletine clearance in a Japanese population.

The Annals of pharmacotherapy 20020201

Alteration of ischemic reperfusion injury in the rat neocortex by a potent antioxidant mexiletine.

Acta neurochirurgica 20020201

Rehabilitation of peripheral nerve injuries.

Physical medicine and rehabilitation clinics of North America 20020201

[Lipomatosis dolorosa--a frequently overlooked disease picture].

Der Nervenarzt 20020201

Mexiletine is effective on segmental hyperhidrosis: report of two cases.

Journal of neurology, neurosurgery, and psychiatry 20020101

[Possibility of gene-specific treatment for hereditary arrhythmic diseases].

Nihon rinsho. Japanese journal of clinical medicine 20020101

The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine.

Current medicinal chemistry 20020101

Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.

Circulation journal : official journal of the Japanese Circulation Society 20020101

Schwartz-Jampel syndrome: report of one case.

Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi 20020101

Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel.

The Journal of physiology 20011215

Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats.

British journal of pharmacology 20011201

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.

Neurology 20011127

Scavenger effect of experimental and clinically used cardiovascular drugs.

Journal of cardiovascular pharmacology 20011101

Mexiletine inhibits pharmacological actions of salbutamol through blockade of beta2-adrenoceptors in bovine tracheal smooth muscle.

Naunyn-Schmiedeberg's archives of pharmacology 20011101

Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.

Anesthesiology 20010901

Lidocaine potentiates atrial natriuretic peptide-induced relaxation of bovine tracheal smooth muscle.

European journal of pharmacology 20010810

Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.

British journal of clinical pharmacology 20010701

In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.

British journal of pharmacology 20010701

Mild alkalinization and acidification differentially modify the effects of lidocaine or mexiletine on vasorelaxation mediated by ATP-sensitive K+ channels.

Anesthesiology 20010701

Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.

Japanese journal of pharmacology 20010701

Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.

Japanese journal of pharmacology 20010501

DDPH inhibited L-type calcium current and sodium current in single ventricular myocyte of guinea pig.

Acta pharmacologica Sinica 20010501

The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury.

Brain research 20010420

Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20010401

Suppressive effects of oxcarbazepine on tooth pulp-evoked potentials recorded at the trigeminal spinal tract nucleus in cats.

Clinical and experimental pharmacology & physiology 20010301

Effect of fluvoxamine on the pharmacokinetics of mexiletine in healthy Japanese men.

Clinical pharmacology and therapeutics 20010301

[Enantioseparation of twelve pharmaceutical racemates with high performance capillary electrophoresis using L-leucine as chiral selector].

Se pu = Chinese journal of chromatography 20010301

Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.

Anesthesiology 20010101

Regional block and mexiletine: the effect on pain after cancer breast surgery.

Regional anesthesia and pain medicine 20010101

Acute exanthematous pustular drug eruption induced by mexiletine.

European journal of dermatology : EJD 20010101

[Paramyotonia congenita].

Ryoikibetsu shokogun shirizu 20010101

[Na channel myotonia].

Ryoikibetsu shokogun shirizu 20010101

Effects of mexiletine on the canine cardiovascular system complicating cisapride overdose: potential utility of mexiletine for the treatment of drug-induced long QT syndrome.

Japanese journal of pharmacology 20000801

Efficacy of oral mexiletine for neuropathic pain with allodynia: a double-blind, placebo-controlled, crossover study.

Regional anesthesia and pain medicine 20000101

Effect of oral mexiletine on capsaicin-induced allodynia and hyperalgesia: a double-blind, placebo-controlled, crossover study.

Regional anesthesia and pain medicine 20000101

Lack of stereoselectivity for the antiallodynic effect of mexiletine in spinally injured rats.

European journal of pain (London, England) 20000101

Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice.

Methods and findings in experimental and clinical pharmacology 19990101

Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction.

Pain 19971001

Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed.

American heart journal 19940401

Neurotoxicity of lidocaine combined with mexiletine.

Anesthesia and analgesia 19931201

Mexiletine's antifibrillatory actions are limited by the occurrence of convulsions in conscious animals.

European journal of pharmacology 19920121

Mexiletine-associated left ventricular dysfunction: a case study.

Maryland medical journal (Baltimore, Md. : 1985) 19910601

Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia.

The American journal of cardiology 19901115

Combined application of class I antiarrhythmic drugs causes 'additive', 'reductive', or 'synergistic' sodium channel block in cardiac muscles.

Cardiovascular research 19901101

Changes in cardiac output determined by continuous-wave Doppler echocardiography during propafenone or mexiletine drug testing.

The American journal of cardiology 19900215

Congestive heart failure induced by six of the newer antiarrhythmic drugs.

Journal of the American College of Cardiology 19891101

General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.

Arzneimittel-Forschung 19881001

Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias.

The American journal of cardiology 19871201

[2 cases of lidocaine-resistant ventricular tachycardia treated with i.v. mexiletine during complicated acute myocardial infarct].

La Clinica terapeutica 19871130

Pharmacological investigation of a new anti-arrhythmic agent, GYKI-23 107.

Drugs under experimental and clinical research 19870101

[Anti-arrhythmic efficacy of the amiodarone-mexiletine combination in the treatment of resistant complex ventricular arrhythmias].

Giornale italiano di cardiologia 19860501

Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes.

Southern medical journal 19850201

Inhibition of sympathetic nervous system by mexiletine, an antiarrhythmic agent, and its antagonism against ouabain.

Arzneimittel-Forschung 19850101

International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. Impact Research Group.

Journal of the American College of Cardiology 19841201

Mexiletine for recurring ventricular arrhythmias: assessment by long-term electrocardiographic recordings and sequential electrophysiologic studies.

American heart journal 19840901

Hemodynamic effects of mexiletine.

American heart journal 19840501

Mexiletine in refractory ventricular arrhythmias.

Clinical pharmacology and therapeutics 19831201

Quantitative analysis of the antiarrhythmic effect of drugs on canine ventricular arrhythmias by the determination of minimum effective plasma concentrations.

Japanese circulation journal 19830101

[Sulfinpyrazone-associated renal failure (author's transl)].

Deutsche medizinische Wochenschrift (1946) 19820709

[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results].

Giornale italiano di cardiologia 19820101

New drugs for treating cardiac arrhythmias.

Postgraduate medicine 19810101

Torsades de pointes as a manifestation of mexiletine toxicity.

American heart journal 19801201

Mexiletine in the treatment of ventricular arrhythmias.

Acta cardiologica. Supplementum 19800101