Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.

Chemical research in toxicology 20140421

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.

Toxicology letters 20140113

Combination of electrochemistry and nuclear magnetic resonance spectroscopy for metabolism studies.

Analytical chemistry 20121016

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.

The Journal of pharmacology and experimental therapeutics 20120801

An investigation of the bioactivation potential and metabolism profile of Zebrafish versus human.

Journal of biomolecular screening 20120801

Predictive toxicology using systemic biology and liver microfluidic 'on chip' approaches: application to acetaminophen injury.

Toxicology and applied pharmacology 20120315

Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice.

Evidence-based complementary and alternative medicine : eCAM 20120101

Gene expression in rat hearts following oral administration of a single hepatotoxic dose of acetaminophen.

Yonsei medical journal 20120101

Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.

Pharmacognosy research 20120101

Comparative mitochondrial proteomics: perspective in human diseases.

Journal of hematology & oncology 20120101

Rodent animal models for surrogate analysis of cell therapy in acute liver failure.

Frontiers in physiology 20120101

TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse.

Scientific reports 20120101

Simple reversed-phase HPLC method with spectrophotometric detection for measuring acetaminophen-protein adducts in rat liver samples.

TheScientificWorldJournal 20120101

Acetaminophen induced cytotoxicity and altered gene expression in cultured cardiomyocytes of h(9)c(2) cells.

Environmental health and toxicology 20120101

The impact of Caesarean delivery on paracetamol and ketorolac pharmacokinetics: a paired analysis.

Journal of biomedicine & biotechnology 20120101

Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice.

The Journal of toxicological sciences 20120101

Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity.

Medicina (Kaunas, Lithuania) 20120101

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.

Nature communications 20111122

Plasmid DNA linearization in the antibacterial action of a new fluorescent Ag nanoparticle-paracetamol dimer composite.

Nanoscale 20111005

Microsomal oxidative damage promoted by acetaminophen metabolism.

Toxicology in vitro : an international journal published in association with BIBRA 20111001

Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity.

Hepatology (Baltimore, Md.) 20111001

Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.

Chemical research in toxicology 20110815

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.

EMBO reports 20110801

A reliable method of liquid chromatography for the quantification of acetaminophen and identification of its toxic metabolite N-acetyl-p-benzoquinoneimine for application in pediatric studies.

Biomedical chromatography : BMC 20110701

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system.

Pharmacology & therapeutics 20110701

Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis.

Cell death & disease 20110701

Repeated preexposure or coexposure to arsenic differentially alters acetaminophen-induced oxidative stress in rat kidney.

Environmental toxicology 20110601

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage.

Cell death & disease 20110601

In-source formation of N-acetyl-p-benzoquinone imine (NAPQI), the putatively toxic acetaminophen (paracetamol) metabolite, after derivatization with pentafluorobenzyl bromide and GC-ECNICI-MS analysis.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110515

Discrimination of haptens from prohaptens using the metabolically deficient Cpr(low/low) mouse.

Toxicology and applied pharmacology 20110501

Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral counting.

Chemical research in toxicology 20110418

Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase.

The Journal of pharmacology and experimental therapeutics 20110401

Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.

Toxicological sciences : an official journal of the Society of Toxicology 20110301

A novel approach for the determination of paracetamol based on the reduction of N-acetyl-p-benzoquinoneimine formed on the electrochemically treated pencil graphite electrode.

Analytica chimica acta 20110124

Hepatoprotective activity of dried- and fermented-processed virgin coconut oil.

Evidence-based complementary and alternative medicine : eCAM 20110101

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.

BMC gastroenterology 20110101

Monocrotophos induced apoptosis in PC12 cells: role of xenobiotic metabolizing cytochrome P450s.

PloS one 20110101

A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.

Drug metabolism and pharmacokinetics 20110101

Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity.

International journal of nanomedicine 20110101

Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series.

BMC gastroenterology 20110101

Age-related changes in the hepatic pharmacology and toxicology of paracetamol.

Current gerontology and geriatrics research 20110101

Frequent use of paracetamol and risk of allergic disease among women in an Ethiopian population.

PloS one 20110101

Comparison of the effect of vanadium and deferoxamine on acetaminophen toxicity in rats.

Indian journal of pharmacology 20110101

Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip.

PloS one 20110101

Activation of TRPA1 by membrane permeable local anesthetics.

Molecular pain 20110101

Ameliorative Potential of Quercetin Against Paracetamol-induced Oxidative Stress in Mice Blood.

Toxicology international 20110101

Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats.

Lipids in health and disease 20110101

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.

PloS one 20110101

Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity.

BMC gastroenterology 20110101

Acetaminophen: beyond pain and Fever-relieving.

Frontiers in pharmacology 20110101

Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.

Pharmacognosy research 20110101

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101201

Therapeutic misadventure with paracetamol in children.

Indian journal of pharmacology 20101201

Successful drug development despite adverse preclinical findings part 2: examples.

Journal of toxicologic pathology 20101201

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.

Archives of toxicology 20101101

Protective effect of Livactine against CCl(4) and paracetamol induced hepatotoxicity in adult Wistar rats.

North American journal of medical sciences 20101001

Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos.

Toxicology 20100910

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.

Biochemical pharmacology 20100801

Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes.

Chemical research in toxicology 20100719

Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans.

Clinical pharmacology and therapeutics 20100701

Enzyme immobilized magnetic nanoparticles for in-line capillary electrophoresis and drug biotransformation studies: application to paracetamol.

Combinatorial chemistry & high throughput screening 20100701

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.

Toxicology and applied pharmacology 20100701

Genetic analysis of cytoprotective functions supported by graded expression of Keap1.

Molecular and cellular biology 20100601

Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice.

Biochemical pharmacology 20100501

Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1.

Free radical research 20100301

Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N-acetylcysteine.

Chemical communications (Cambridge, England) 20100121

Mechanism of protection by metallothionein against acetaminophen hepatotoxicity.

Toxicology and applied pharmacology 20100115

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.

Hepatology (Baltimore, Md.) 20100101

Fluorescence-based liver microsomal assay for screening of pharmaceutical reactive metabolites using a glutathione conjugated 96-well plate.

Bioconjugate chemistry 20100101

Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70.

Journal of clinical biochemistry and nutrition 20100101

The effect of acetaminophen nanoparticles on liver toxicity in a rat model.

International journal of nanomedicine 20100101

Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.

BMC pharmacology 20100101

Acetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats.

Toxicology international 20100101

Acetaminophen induces apoptosis in rat cortical neurons.

PloS one 20100101

The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats.

Journal of veterinary pharmacology and therapeutics 20091201

[Dosing time based on molecular mechanism of biological clock of hepatic drug metabolic enzyme].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091101

Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury.

The American journal of pathology 20090901

Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.

Drug metabolism and disposition: the biological fate of chemicals 20090801

Current concepts of mechanisms in drug-induced hepatotoxicity.

Current medicinal chemistry 20090801

Reduced exposure of imatinib after coadministration with acetaminophen in mice.

Indian journal of pharmacology 20090801

The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion.

Pakistan journal of biological sciences : PJBS 20090515

Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.

Toxicological sciences : an official journal of the Society of Toxicology 20090501

Metabolism of acetaminophen (paracetamol) in plants--two independent pathways result in the formation of a glutathione and a glucose conjugate.

Environmental science and pollution research international 20090301

Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.

Biochemistry 20090113

Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.

Laboratory investigation; a journal of technical methods and pathology 20090101

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.

Xenobiotica; the fate of foreign compounds in biological systems 20090101

Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity.

Critical care (London, England) 20090101

Management of the critically poisoned patient.

Scandinavian journal of trauma, resuscitation and emergency medicine 20090101

Life-threatening hyponatremia due to intravenous n-acetylcysteine treatment in an infant: a case report.

Cases journal 20090101

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.

Hepatology (Baltimore, Md.) 20081001

Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.

Toxicology letters 20080828

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.

Toxicology in vitro : an international journal published in association with BIBRA 20080601

Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.

Toxicology letters 20080401

Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080301

Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites.

Proteomics 20080101

Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

Toxicological sciences : an official journal of the Society of Toxicology 20071001

Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.

International journal of clinical pharmacology and therapeutics 20070901

Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.

Drug metabolism and disposition: the biological fate of chemicals 20070801

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

Drug metabolism and disposition: the biological fate of chemicals 20070701

Protein targets of reactive electrophiles in human liver microsomes.

Chemical research in toxicology 20070601

Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.

Chemical research in toxicology 20070501

Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.

Toxicology 20070212

Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.

Biological & pharmaceutical bulletin 20070101

Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretion.

ALTEX 20070101

The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.

BMC medicine 20070101

Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study.

BMC urology 20070101

Are we getting enough sulfur in our diet?

Nutrition & metabolism 20070101

Abstracts of papers presented at the 2007 pittsburgh conference.

Journal of automated methods & management in chemistry 20070101

Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.

The Biochemical journal 20061101

Multicommuted flow system employing pinch solenoid valves and micro-pumps. Spectrophotometric determination of paracetamol in pharmaceutical formulations.

Journal of pharmaceutical and biomedical analysis 20061011

An experimental design for the controlled modulation of intracellular GSH levels in cultured hepatocytes.

Free radical biology & medicine 20060815

Role of innate immunity in acetaminophen-induced hepatotoxicity.

Expert opinion on drug metabolism & toxicology 20060801

Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.

Toxicological sciences : an official journal of the Society of Toxicology 20060701

Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.

World journal of gastroenterology 20060628

[Drug-induced liver injury].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601

Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity.

Experimental biology and medicine (Maywood, N.J.) 20060501

Thermodynamically based profiling of drug metabolism and drug-drug metabolic interactions: a case study of acetaminophen and ethanol toxic interaction.

Biophysical chemistry 20060320

Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice.

Hepatology (Baltimore, Md.) 20060201

Transformation of acetaminophen by chlorination produces the toxicants 1,4-benzoquinone and N-acetyl-p-benzoquinone imine.

Environmental science & technology 20060115

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.

Drug metabolism and disposition: the biological fate of chemicals 20051201

Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice.

Mutation research 20051111

An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children.

Current opinion in pediatrics 20050401

Ebselen and diphenyl diselenide change biochemical hepatic responses to overdosage with paracetamol.

Environmental toxicology and pharmacology 20050201

Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity II. Possible involvement of the gamma-glutamyl cycle.

Toxicology and applied pharmacology 20050115

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.

Journal of hepatology 20050101

Drug interactions with paracetamol.

American journal of therapeutics 20050101

The therapeutic use of acetaminophen in patients with liver disease.

American journal of therapeutics 20050101

A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure.

Clinical toxicology (Philadelphia, Pa.) 20050101

Enhanced acetaminophen toxicity by activation of the pregnane X receptor.

Toxicological sciences : an official journal of the Society of Toxicology 20041201

Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice.

The Journal of pharmacology and experimental therapeutics 20041101

Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle.

Thrombosis and haemostasis 20041001

Enhancement of acetaminophen cytotoxicity in selenium-binding protein-overexpressed COS-1 cells.

Drug metabolism and pharmacokinetics 20040801

Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol.

British journal of cancer 20040504

Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates.

European journal of clinical pharmacology 20040501

N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.

Biochemistry 20040330

Cytoprotection following endoplasmic reticulum stress protein induction in continuous cell lines.

Basic & clinical pharmacology & toxicology 20040301

NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer.

Neoplasma 20040101

Acetaminophen-induced hepatotoxicity.

Drug metabolism and disposition: the biological fate of chemicals 20031201

Mangafodipir prevents liver injury induced by acetaminophen in the mouse.

Journal of hepatology 20031101

Cellular events preceding acetaminophen cataractogenesis studied by confocal fluorescence microscopy.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031001

Autoprotection against acetaminophen toxicity in cultured rat hepatocytes: the effect of pretreatment and growth factors.

Pharmacology & toxicology 20030901

Transiently altered acetaminophen metabolism after liver transplantation.

Clinical pharmacology and therapeutics 20030601

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice.

Journal of hepatology 20030201

[Paracetamol: therapeutic action, pathogenesis and treatment of acute poisonings complicated by severe liver damage].

Przeglad lekarski 20030101

Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics.

Drug metabolism and disposition: the biological fate of chemicals 20021201

Toxicology. Protecting liver from painkiller's lethal dose.

Science (New York, N.Y.) 20021011

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.

Science (New York, N.Y.) 20021011

Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.

Hepatology (Baltimore, Md.) 20020801

Synergetic signaling for apoptosis in vitro by ethanol and acetaminophen.

Alcohol (Fayetteville, N.Y.) 20020601

Reduction of toxic metabolite formation of acetaminophen.

Biochemical and biophysical research communications 20020308

Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).

Biochimica et biophysica acta 20020131

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver.

Toxicological sciences : an official journal of the Society of Toxicology 20020101

Acetaminophen poisoning: an update for the intensivist.

Critical care (London, England) 20020101

Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case for.

Drug safety 20020101

Chronoamperometric determination of paracetamol using an avocado tissue (Persea americana) biosensor.

Talanta 20011031

[Effect of bicyclol on acetaminophen-induced hepatotoxicity: energetic metabolism and mitochondrial injury in acetaminophen-intoxicated mice].

Yao xue xue bao = Acta pharmaceutica Sinica 20011001

Research strategies for design and development of NSAIDs: clue to balance potency and toxicity of acetanilide compounds.

Journal of biomolecular structure & dynamics 20010801

Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010801

Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse.

Hepatology (Baltimore, Md.) 20010501

[About paracetamol again].

Orvosi hetilap 20010218

Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.

Toxicology and applied pharmacology 20010201

Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.

Toxicology and applied pharmacology 20001015

Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2.

Pharmacology & toxicology 19960401

Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis.

Journal of toxicology and environmental health 19951001

Dysmorphogenesis elicited by microinjected acetaminophen analogs and metabolites in rat embryos cultured in vitro.

The Journal of pharmacology and experimental therapeutics 19901001