Tuning hemoglobin-poly(acrylic acid) interactions by controlled chemical modification with triethylenetetramine.

The journal of physical chemistry. B 20121025

Comparative evaluation of small-molecule chemosensitizers in reversal of cisplatin resistance in ovarian cancer cells.

Anticancer research 20120901

Role of the cellular prion protein in the neuron adaptation strategy to copper deficiency.

Cellular and molecular neurobiology 20120801

A theoretical study on the molecular structure and vibrational (FT-IR and Raman) spectra of cyano-bridged heteronuclear polymeric complex of triethylenetetramine.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120801

Overcoming platinum resistance through the use of a copper-lowering agent.

Molecular cancer therapeutics 20120601

Cellular responses to the metal-binding properties of metformin.

Diabetes 20120601

Liver structures of a patient with idiopathic copper toxicosis.

Medical molecular morphology 20120601

Sacrificial templating synthesis of hematite nanochains from [Fe18S25](TETAH)14 nanoribbons: their magnetic, electrochemical, and photocatalytic properties.

Chemistry (Weinheim an der Bergstrasse, Germany) 20120416

Functional properties and biodistribution of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)- poly(ethylene glycol) mixtures formed with nucleic acid.

Journal of controlled release : official journal of the Controlled Release Society 20120410

[Diagnosis and care of Wilson disease with neurological revelation].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20120301

Wilson's disease--treatment of psychiatric manifestations in pregnancy.

Psychosomatics 20120101

A copper for your thoughts.

Journal of insurance medicine (New York, N.Y.) 20120101

Complex N-acetylation of triethylenetetramine.

Drug metabolism and disposition: the biological fate of chemicals 20111201

Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy.

Pathology international 20111101

Prognostic significance of neurologic examination findings in Wilson disease.

Parkinsonism & related disorders 20110801

Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease.

Drugs 20110709

Copper depletion increases the mitochondrial-associated SOD1 in neuronal cells.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20110401

Optimization of poly(amido amine)s as vectors for siRNA delivery.

Journal of controlled release : official journal of the Controlled Release Society 20110310

Excess copper chelating therapy for Wilson disease induces anemia and liver dysfunction.

Internal medicine (Tokyo, Japan) 20110101

Triethylenetetramine pharmacology and its clinical applications.

Molecular cancer therapeutics 20100901

Pharmacological properties of orally available, amphipathic polyaminocarboxylic acid chelators for actinide decorporation.

Health physics 20100901

Oral complications associated with D-penicillamine treatment for Wilson disease: a clinicopathologic report.

Journal of periodontology 20100801

Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper.

Colloids and surfaces. B, Biointerfaces 20100701

Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial.

Journal of clinical pharmacology 20100601

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.

Diabetologia 20100601

Teaching NeuroImages: MRI reversal in Wilson disease with trientine treatment.

Neurology 20100427

Effect of modifying agents on the preparation and properties of the new adsorbents from wheat straw.

Bioresource technology 20100301

Evaluation of Cuprimine and Syprine for decorporation of (60)Co and (210)Po.

Health physics 20100301

Poly(methyl methacrylate)-graft-oligoamines as low cytotoxic and efficient nonviral gene vectors.

Molecular bioSystems 20100101

Influence of cyclic polyamines on silica formation during the Stöber process.

Physical chemistry chemical physics : PCCP 20091121

Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells by activation of the p38 MAPK pathway.

The Journal of veterinary medical science 20091101

Adsorption of Cu(II), Cd(II) and Pb(II) from aqueous single metal solutions by succinylated twice-mercerized sugarcane bagasse functionalized with triethylenetetramine.

Water research 20091001

Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.

Proteomics 20090901

Determination of ammonium, calcium, magnesium, potassium and sodium in drinking waters by capillary zone electrophoresis on a column-coupling chip.

Journal of chromatography. A 20090821

Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine.

Translational research : the journal of laboratory and clinical medicine 20090801

Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults.

Journal of clinical pharmacology 20090801

Lanthanide complexes of triethylenetetramine tetra-, penta-, and hexaacetamide ligands as paramagnetic chemical exchange-dependent saturation transfer contrast agents for magnetic resonance imaging: nona- versus decadentate coordination.

Inorganic chemistry 20090720

Inflammation induced by photocoagulation laser is minimized by copper chelators.

Lasers in medical science 20090701

Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery.

Journal of controlled release : official journal of the Controlled Release Society 20090701

A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study.

Diabetologia 20090401

Education and imaging. Hepatobiliary and pancreatic: hypersensitivity pneumonitis induced by penicillamine.

Journal of gastroenterology and hepatology 20090401

Targeting superoxide dismutase 1 to overcome cisplatin resistance in human ovarian cancer.

Cancer chemotherapy and pharmacology 20090301

Selective complexation of 3d metal(II) ions with multidentate and chiral isomers derived from condensation of 2-pyridinecarboxaldehyde with triethylenetetramine.

Dalton transactions (Cambridge, England : 2003) 20090107

The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat.

Experimental diabetes research 20090101

Polycarboxylates enhance beetle antifreeze protein activity.

Biochimica et biophysica acta 20081201

The risks of free copper in the body and the development of useful anticopper drugs.

Current opinion in clinical nutrition and metabolic care 20081101

[Wilson's disease in paediatric age: diagnosis and treatment. Recent advances].

Recenti progressi in medicina 20081101

Characterization and antitumor activity of triethylene tetramine, a novel telomerase inhibitor.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080901

A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.

Diabetologia 20080901

Triethylenetetramine penta- and hexa-acetamide ligands and their ytterbium complexes as paraCEST contrast agents for MRI.

Dalton transactions (Cambridge, England : 2003) 20080821

A chemically modified glass surface that facilitates transglutaminase-mediated protein immobilization.

Biotechnology letters 20080601

Effect of trientine on manganese intoxication in a patient with acquired hepatocerebral degeneration.

Movement disorders : official journal of the Movement Disorder Society 20080415

Cold comfort pharm.

Practical neurology 20080201

Once daily trientine for maintenance therapy of Wilson disease.

The American journal of gastroenterology 20080201

Triethylene tetramine, a novel ligand of G-quadruplex, induces senescence of MCF-7 cells.

Biotechnology letters 20080101

Evaluation of the Unified Wilson's Disease Rating Scale (UWDRS) in German patients with treated Wilson's disease.

Movement disorders : official journal of the Movement Disorder Society 20080101

Therapeutic effects of an oral chelator targeting skeletal tissue damage in experimental postmenopausal osteoporosis in rats.

Hemoglobin 20080101

Development and validation of a rapid HPLC method for the simultaneous determination of triethylenetetramine and its two main metabolites in human serum.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

Synthesis of novel size exclusion chromatography support by surface initiated aqueous atom transfer radical polymerization.

Langmuir : the ACS journal of surfaces and colloids 20071106

Determination of triethylenetetramine (TETA) and its metabolites in human plasma and urine by liquid chromatography-mass spectrometry (LC-MS).

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101

Combined effects of treatment with trientine, a copper-chelating agent, and x-irradiation on tumor growth in transplantation model of a murine fibrosarcoma.

The Journal of veterinary medical science 20071001

Synthesis and characteristics of macroporous epoxy resin-triethylenetetramine polymer modified by sodium chloroacetate for copper chelation in aqueous solution.

Annali di chimica 20071001

Wilson disease--a practical approach to diagnosis, treatment and follow-up.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070701

Validated, stability-indicated quantitative purity test for triethylenetetramine tetrachlorhydrate by automated multiple development.

Journal of chromatographic science 20070701

Effects of triethylene tetraamine on the G-quadruplex structure in the human c-myc promoter.

Journal of biochemistry 20070501

Wilson disease in children: serum aminotransferases and urinary copper on triethylene tetramine dihydrochloride (trientine) treatment.

Journal of pediatric gastroenterology and nutrition 20070501

Wilson's disease.

Lancet (London, England) 20070317

Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal.

Journal of controlled release : official journal of the Controlled Release Society 20070312

Wilson's disease.

Lancet (London, England) 20070203

Triethylenetetramine and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type 2 diabetic patients.

Drug metabolism and disposition: the biological fate of chemicals 20070201

Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease.

Journal of clinical pharmacy and therapeutics 20070201

Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells in vivo and in vitro.

The Journal of veterinary medical science 20070201

Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study.

Gut 20070101

Studies on DNA binding to metal complexes of Sal2trien.

Biochemistry. Biokhimiia 20070101

[Wilson's disease: forms of presentation in childhood].

Gastroenterologia y hepatologia 20061101

[Wilson disease: an update].

The Korean journal of hepatology 20060901

Age-associated iron accumulation in bone: implications for postmenopausal osteoporosis and a new target for prevention and treatment by chelation.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20060601

Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease.

Archives of neurology 20060401

Efficacy of orally administered amphipathic polyaminocarboxylic acid chelators for the removal of plutonium and americium: comparison with injected Zn-DTPA in the rat.

Radiation protection dosimetry 20060101

The bane of a silent illness: when Wilson's disease takes its course.

International journal of psychiatry in medicine 20060101

A case study: identifying a new case of Wilson's disease.

Journal of the American Academy of Nurse Practitioners 20051201

The passivation of pyrrhotite by surface coating.

Chemosphere 20051101

Two male patients with Wilson's disease treated using trientine and iron reduction therapy.

Journal of gastroenterology and hepatology 20051001

Combination treatment with penicillamine and trientine in a patient with Wilson's disease.

Pediatrics international : official journal of the Japan Pediatric Society 20051001

Pharmacological studies on mechanisms of aminophylline-induced seizures in rats.

Indian journal of experimental biology 20051001

Inhibitory effects of trientine, a copper-chelating agent, on induction of DNA strand breaks in kidney cells of Long-Evans Cinnamon (LEC) rats.

Experimental animals 20051001

[Acute liver failure and hemolysis in a 16-year-old woman. First manifestation of Wilson's disease].

Medizinische Klinik (Munich, Germany : 1983) 20050915

Anticopper therapy against cancer and diseases of inflammation and fibrosis.

Drug discovery today 20050815

Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice.

Oncology reports 20050701

Improvement of cardiovascular autonomic dysfunction following anti-copper therapy in Wilson's disease.

Journal of neurology 20050401

Wilson's disease with depression and parkinsonism.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050401

Hydroxyl stereochemistry and amine number within poly(glycoamidoamine)s affect intracellular DNA delivery.

Journal of the American Chemical Society 20050309

Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.

CNS drugs 20050101

[DNA repair and antioxidant defence in the repair-deficient human cells (Marfan's syndrome) after gamma-irradiation].

Radiatsionnaia biologiia, radioecologiia 20050101

A copper chelating agent suppresses carbonyl stress in diabetic rat lenses.

Journal of diabetes and its complications 20050101

Inhibitory effects of trientine, a copper-chelating agent, on induction of DNA strand breaks in hepatic cells of Long-Evans Cinnamon rats.

Biochimica et biophysica acta 20041101

Regeneration of the heart in diabetes by selective copper chelation.

Diabetes 20040901

Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.

Neurology 20040824

Metal contents of liver parenchyma after percutaneous ethanol injection or radiofrequency ablation in patients with hepatocellular carcinoma before and after trientine hydrochloride therapy.

The Journal of laboratory and clinical medicine 20040601

[Wilson's disease with severe neurological manifestations: response to trientine plus zinc therapy].

Gastroenterologia y hepatologia 20040501

Accelerated Koenigs-Knorr glucuronidation of a deactivated nitrophenol: unveiling the role of polyamine additive 1,1,4,7,10,10-hexamethyltriethylenetetramine through design of experiments.

The Journal of organic chemistry 20040220

[Wilson disease].

Nihon rinsho. Japanese journal of clinical medicine 20040101

Effects of triethylene tetraamine on telomerase activity and proliferation in HeLa cells.

Cell biology international 20040101

[Wilson disease in 2003].

Orvosi hetilap 20031214

Treatment of Wilson's disease with zinc. XVIII. Initial treatment of the hepatic decompensation presentation with trientine and zinc.

The Journal of laboratory and clinical medicine 20031201

Triethylene tetraamine: a novel telomerase inhibitor.

Bioorganic & medicinal chemistry letters 20031117

[Electrophysiological impairment profile of patients with Wilson's disease].

Der Nervenarzt 20031001

Influence of electrolyte composition on the electroosmotic flow and electrophoretic mobility of proteins and peptides.

Journal of chromatography. A 20030926

Wilson disease.

Mayo Clinic proceedings 20030901

Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells.

Cellular and molecular life sciences : CMLS 20030801

[Peripheral haemosiderosis of the central nervous system].

Revue neurologique 20030701

Antiangiogenic therapy through copper chelation.

Expert opinion on therapeutic targets 20030601

Regulation of copper absorption by copper availability in the Caco-2 cell intestinal model.

American journal of physiology. Gastrointestinal and liver physiology 20030501

The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice.

Experimental neurology 20030201

[Wilson's disease: physiopathological, clinical and therapeutic considerations].

Gastroenterologia y hepatologia 20030101

The copper-chelating agent, trientine, attenuates liver enzyme-altered preneoplastic lesions in rats by angiogenesis suppression.

Oncology reports 20030101

[Pathogenesis and treatment of Wilson's disease].

Acta pharmaceutica Hungarica 20030101

The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production.

International journal of cancer 20021210

[Superficial siderosis of the central nervous system: a case report].

Journal de radiologie 20021201

Re-patch testing patients with long-term contact dermatitis.

Contact dermatitis 20021001

Effects of trientine, a metal chelator, on defective endothelium-dependent relaxation in the mesenteric vasculature of diabetic rats.

Free radical research 20021001

Wilson's disease.

Indian journal of pediatrics 20020901

Liquid chromatographic determination of triethylenetetramine in human and rabbit sera based on intramolecular excimer-forming fluorescence derivatization.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020715

Diagnosis and treatment of Wilson's disease.

Current neurology and neuroscience reports 20020701

Dense Kayser-Fleischer ring in asymptomatic Wilson's disease (hepatolenticular degeneration).

The British journal of ophthalmology 20020101

Transition metals and polyol pathway in the development of diabetic neuropathy in rats.

Diabetes/metabolism research and reviews 20020101

[The role of copper in tumor angiogenesis--clinical implications].

Postepy higieny i medycyny doswiadczalnej 20020101

The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells.

International journal of cancer 20011215

Chronic and cyclical neuronal loss in hippocampal slice cultures following transient inhibition of the type 1 isoform of superoxide dismutase.

Brain research 20010921

Personality traits in treated Wilson's disease determined by means of the Karolinska Scales of Personality (KSP).

European psychiatry : the journal of the Association of European Psychiatrists 20010901

Haemolytic onset of Wilson disease in a patient with homozygous truncation of ATP7B at Arg1319.

British journal of haematology 20010701

Wilson's disease: from the liver to the brain.

Nursing times 20010701

Increased susceptibility of copper-deficient neuroblastoma cells to oxidative stress-mediated apoptosis.

Free radical biology & medicine 20010515

Iatrogenic copper deficiency associated with long-term copper chelation for treatment of copper storage disease in a Bedlington Terrier.

Journal of the American Veterinary Medical Association 20010515

Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

Experimental neurology 20010401

Ultrastructural identification of iron and copper accumulation in the liver of a male patient with Wilson disease.

Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan 20010301

Treatment of Wilson's disease: what are the relative roles of penicillamine, trientine, and zinc supplementation?

Current gastroenterology reports 20010201

Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.

Journal of structural biology 20000601

Early onset of nephrotic syndrome after treatment with D-penicillamine in a patient with Wilson's disease.

The American journal of gastroenterology 19981201

[Wilson's disease: physiopathology, therapeutic approach and case report].

Minerva gastroenterologica e dietologica 19941201

Triethylene tetramine dihydrochloride toxicity in primary biliary cirrhosis.

Gastroenterology 19800601