Home Other Building Blocks 5,8,11,14-Eicosatetraenoicacid, 20-hydroxy-, (5Z,8Z,11Z,14Z)-

5,8,11,14-Eicosatetraenoicacid, 20-hydroxy-, (5Z,8Z,11Z,14Z)-

CAS No.:
79551-86-3
Catalog Number:
AG0051DN
Molecular Formula:
C20H32O3
Molecular Weight:
320.4663
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Purity
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Product Description
Catalog Number:
AG0051DN
Chemical Name:
5,8,11,14-Eicosatetraenoicacid, 20-hydroxy-, (5Z,8Z,11Z,14Z)-
CAS Number:
79551-86-3
Molecular Formula:
C20H32O3
Molecular Weight:
320.4663
MDL Number:
MFCD00171542
IUPAC Name:
(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid
InChI:
InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
InChI Key:
NNDIXBJHNLFJJP-DTLRTWKJSA-N
SMILES:
OCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
Properties
Complexity:
378  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
4  
Exact Mass:
320.235g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
320.473g/mol
Monoisotopic Mass:
320.235g/mol
Rotatable Bond Count:
15  
Topological Polar Surface Area:
57.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.7  
Literature
Title Journal
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Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicology and applied pharmacology 20131001
Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. Experimental cell research 20121001
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. Toxicology and applied pharmacology 20121001
Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice. Gene 20120901
Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120901
Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. Biochemical pharmacology 20120815
20-HETE in neovascularization. Prostaglandins & other lipid mediators 20120801
Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction. Arteriosclerosis, thrombosis, and vascular biology 20120801
Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. European journal of pharmacology 20120705
The circadian clock modulates renal sodium handling. Journal of the American Society of Nephrology : JASN 20120601
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Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on adriamycin-induced toxicity of human renal tubular epithelial cell (HK-2). European journal of pharmacology 20120515
Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. American journal of physiology. Regulatory, integrative and comparative physiology 20120515
20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel. The Journal of biological chemistry 20120420
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. Journal of neurochemistry 20120401
Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. American journal of physiology. Heart and circulatory physiology 20120315
Evaluation of CMV and KAP promoters for driving the expression of human CYP4F2 in transgenic mice. International journal of molecular medicine 20120101
Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats. Molecular and cellular biochemistry 20120101
Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. Current opinion in nephrology and hypertension 20120101
Arachidonic acid inhibits Na⁺-K⁺-ATPase via cytochrome P-450, lipoxygenase and protein kinase C-dependent pathways in sheep pulmonary artery. Vascular pharmacology 20120101
20-HETE-producing enzymes are up-regulated in human cancers. Cancer genomics & proteomics 20120101
A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. Anti-inflammatory & anti-allergy agents in medicinal chemistry 20120101
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11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension. Prostaglandins & other lipid mediators 20111101
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Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide. Basic & clinical pharmacology & toxicology 20110901
The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood. The Journal of pharmacology and experimental therapeutics 20110801
Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. American journal of physiology. Heart and circulatory physiology 20110801
20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina 20110801
Cerebrospinal fluid 20-HETE is associated with delayed cerebral ischemia and poor outcomes after aneurysmal subarachnoid hemorrhage. Stroke 20110701
Inhibition of 20-HETE attenuates diabetes-induced decreases in retinal hemodynamics. Experimental eye research 20110701
20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells. British journal of pharmacology 20110601
Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. American journal of physiology. Regulatory, integrative and comparative physiology 20110601
Postmenopausal hypertension: role of 20-HETE. American journal of physiology. Regulatory, integrative and comparative physiology 20110601
Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow. American journal of physiology. Heart and circulatory physiology 20110501
Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. Drug metabolism and disposition: the biological fate of chemicals 20110501
Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction. Clinical and experimental pharmacology & physiology 20110501
Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen. Canadian journal of physiology and pharmacology 20110501
Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution. Environmental toxicology and pharmacology 20110501
Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake. Acta physiologica (Oxford, England) 20110401
20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. American journal of physiology. Heart and circulatory physiology 20110401
Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. Hypertension (Dallas, Tex. : 1979) 20110401
Peripheral and central augmentation indexes in relation to the CYP4F2 polymorphisms in Chinese. Journal of hypertension 20110301
20-Hydroxyeicosatetraenoic acid induces apoptosis in neonatal rat cardiomyocytes through mitochondrial-dependent pathways. Journal of cardiovascular pharmacology 20110301
Cytochrome P450 eicosanoids and cerebral vascular function. Expert reviews in molecular medicine 20110301
Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. Kidney international 20110101
20-HETE in acute kidney injury. Kidney international 20110101
Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade. PloS one 20110101
Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101201
2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1. American journal of physiology. Heart and circulatory physiology 20101201
The effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function in overweight subjects. Antioxidants & redox signaling 20101115
The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. British journal of pharmacology 20101101
20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension. Hypertension (Dallas, Tex. : 1979) 20101101
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. Hypertension (Dallas, Tex. : 1979) 20101101
Renal function and vasomotor activity in mice lacking the Cyp4a14 gene. Experimental biology and medicine (Maywood, N.J.) 20101101
20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca2+ channel via a PKC-dependent mechanism in cardiomyocytes. American journal of physiology. Heart and circulatory physiology 20101001
20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension. Journal of cardiovascular pharmacology 20101001
Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats. Microcirculation (New York, N.Y. : 1994) 20101001
Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation. Diabetes 20100801
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Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome p-450 arachidonic acid metabolites. Bosnian journal of basic medical sciences 20100801
A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats. Basic & clinical pharmacology & toxicology 20100501
Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation. Pharmacological research 20100501
20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. American journal of physiology. Lung cellular and molecular physiology 20100401
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clinical science (London, England : 1979) 20100223
Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicology and applied pharmacology 20100101
20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. The Journal of pharmacology and experimental therapeutics 20100101
20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PloS one 20100101
Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. Pharmacological reports : PR 20100101
Role of 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of vascular function in a model of hypertension and endothelial dysfunction. Pharmacology 20100101
CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension. Microvascular research 20091201
Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive. Hypertension (Dallas, Tex. : 1979) 20091201
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CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb. Kidney international 20091001
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. American journal of physiology. Renal physiology 20091001
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney international 20091001
Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. Anticancer research 20091001
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. American journal of physiology. Renal physiology 20090901
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20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells. American journal of physiology. Heart and circulatory physiology 20090801
Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. Circulation research 20090619
Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure. Kidney international 20090601
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Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report. Transplant international : official journal of the European Society for Organ Transplantation 20090501
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Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes care 20090501
Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. American journal of physiology. Regulatory, integrative and comparative physiology 20090501
Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1. British journal of pharmacology 20090401
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High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. American journal of physiology. Regulatory, integrative and comparative physiology 20090301
Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. American journal of physiology. Renal physiology 20090301
Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy. American journal of physiology. Renal physiology 20090301
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. American journal of physiology. Heart and circulatory physiology 20090301
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Cytochrome P-450 metabolites in renal circulation and excretion--interaction with the nitric oxide (NO) system. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201
Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation. Drug metabolism and disposition: the biological fate of chemicals 20081101
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Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers. Biochimica et biophysica acta 20081001
CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. Journal of lipid research 20081001
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. The Journal of pharmacology and experimental therapeutics 20081001
20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. Journal of the American Society of Nephrology : JASN 20081001
Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. Kidney international 20081001
A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock (Augusta, Ga.) 20080901
Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. American journal of physiology. Heart and circulatory physiology 20080801
The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure. Hypertension (Dallas, Tex. : 1979) 20080801
Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension 20080701
20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. European journal of pharmacology 20080624
20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents. The Journal of physiology 20080515
Arachidonic acid metabolism in glucocorticoid-induced hypertension. Clinical and experimental pharmacology & physiology 20080501
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. American journal of physiology. Lung cellular and molecular physiology 20080501
Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress. American journal of physiology. Heart and circulatory physiology 20080501
Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease. Hypertension (Dallas, Tex. : 1979) 20080501
A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension (Dallas, Tex. : 1979) 20080501
Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. Journal of the American Society of Nephrology : JASN 20080401
Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject. Endocrine 20080401
20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. American journal of physiology. Renal physiology 20080301
Effects of omega-hydroxylase product on distal human pulmonary arteries. American journal of physiology. Heart and circulatory physiology 20080301
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Hypertension (Dallas, Tex. : 1979) 20080301
Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries. Journal of cardiovascular pharmacology 20080301
Endothelial dysfunction and improvement of the angiotensin II-reactivity in hypercholesterolemic rabbits: role of cyclooxygenase metabolites. European journal of pharmacology 20080202
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. American journal of physiology. Heart and circulatory physiology 20080201
Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. American journal of physiology. Heart and circulatory physiology 20080101
20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-beta. Journal of lipid research 20080101
20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells. The Journal of pharmacology and experimental therapeutics 20080101
Cerebral blood flow changes in acute subarachnoid hemorrhage. Frontiers in bioscience : a journal and virtual library 20080101
Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Pharmacological reports : PR 20080101
Continuous inhibition of 20-HETE synthesis by TS-011 improves neurological and functional outcomes after transient focal cerebral ischemia in rats. Neuroscience research 20071201
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug metabolism and disposition: the biological fate of chemicals 20071101
Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation. American journal of physiology. Lung cellular and molecular physiology 20071001
Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Current opinion in nephrology and hypertension 20070901
Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. American journal of physiology. Renal physiology 20070801
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug metabolism and disposition: the biological fate of chemicals 20070701
Does 20-hydroxyeicosatetraenoic acid contribute to sex differences in cardiovascular risk by increasing oxidative stress? Hypertension (Dallas, Tex. : 1979) 20070701
Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension (Dallas, Tex. : 1979) 20070701
Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiological genomics 20070619
Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. American journal of physiology. Regulatory, integrative and comparative physiology 20070601
A reduction in alcohol consumption is associated with reduced plasma F2-isoprostanes and urinary 20-HETE excretion in men. Free radical biology & medicine 20070601
Role of 20-HETE in D1/D2 dopamine receptor synergism resulting in the inhibition of Na+-K+-ATPase activity in the proximal tubule. American journal of physiology. Renal physiology 20070501
Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. The Journal of pharmacology and experimental therapeutics 20070501
Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. The Journal of pharmacology and experimental therapeutics 20070401
[Roles of 20-HETE on physiologic and pathologic regulation in organism]. Sheng li ke xue jin zhan [Progress in physiology] 20070401
High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. American journal of physiology. Heart and circulatory physiology 20070301
Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis. Hypertension (Dallas, Tex. : 1979) 20070301
20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. Prostaglandins & other lipid mediators 20070101
20-Hydroxyeicosatetraenoic acid (20-HETE) stimulates migration of vascular smooth muscle cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats. Vascular pharmacology 20070101
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats. Kidney & blood pressure research 20070101
Role of cytochrome P450 metabolites of arachidonic acid in regulation of corporal smooth muscle tone in diabetic and older rats. Vascular pharmacology 20070101
Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20061201
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans. Diabetes research and clinical practice 20061101
20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase. American journal of physiology. Heart and circulatory physiology 20061101
Inability to upregulate cytochrome P450 4A and 2C causes salt sensitivity in young Sprague-Dawley rats. American journal of hypertension 20061101
20-HETE and salt-sensitivity of blood pressure a novel emerging concept. American journal of hypertension 20061101
Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE. American journal of physiology. Regulatory, integrative and comparative physiology 20061001
Editorial: experimental subarachnoid hemorrhage second issue: cerebral vasospasm. Neurological research 20061001
Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm. Neurological research 20061001
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. American journal of physiology. Lung cellular and molecular physiology 20060901
VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. American journal of physiology. Lung cellular and molecular physiology 20060901
Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins, leukotrienes, and essential fatty acids 20060901
Nitric oxide/cytochrome P450 interactions in cyclosporin A-induced effects in the rat. Journal of hypertension 20060901
Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. American journal of physiology. Heart and circulatory physiology 20060801
Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. American journal of physiology. Renal physiology 20060601
Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. Stroke 20060501
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circulation research 20060414
Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circulation research 20060414
Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. The Journal of pharmacology and experimental therapeutics 20060401
Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315
Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics. Clinical and experimental pharmacology & physiology 20060301
Expression of cytochrome P-450 4 enzymes in the kidney and liver: regulation by PPAR and species-difference between rat and human. Molecular and cellular biochemistry 20060301
Elevated 12- and 20-hydroxyeicosatetraenoic acid in urine of patients with prostatic diseases. Cancer letters 20060227
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. American journal of physiology. Heart and circulatory physiology 20060201
Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH. American journal of physiology. Regulatory, integrative and comparative physiology 20060101
Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin. Journal of applied physiology (Bethesda, Md. : 1985) 20060101
Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR. American journal of neuroradiology 20060101
Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. American journal of physiology. Renal physiology 20051201
Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. American journal of physiology. Lung cellular and molecular physiology 20051201
Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE. American journal of physiology. Heart and circulatory physiology 20051101
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. American journal of physiology. Renal physiology 20051101
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. The Journal of pharmacology and experimental therapeutics 20051101
Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance. Hypertension (Dallas, Tex. : 1979) 20051101
Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. Cardiovascular research 20051001
Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. The Journal of biological chemistry 20050930
Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery. Pharmacological research 20050901
Contribution of 20-HETE to augmented myogenic constriction in coronary arteries of endothelial NO synthase knockout mice. Hypertension (Dallas, Tex. : 1979) 20050901
Cytochrome P450 4A isoform inhibitory profile of N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a selective inhibitor of 20-HETE synthesis. Biological & pharmaceutical bulletin 20050901
Taking the 20-HETE out of the cardiovascular system: the potential of 20-HETE synthesis inhibitors. Current opinion in investigational drugs (London, England : 2000) 20050901
Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase. Cell research 20050901
Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids. American journal of physiology. Renal physiology 20050801
Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation. American journal of physiology. Lung cellular and molecular physiology 20050801
Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20050801
Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. Life sciences 20050715
Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. The Journal of pharmacology and experimental therapeutics 20050701
Endothelial dysfunction: its role in hypertensive coronary disease. Current opinion in cardiology 20050701
Identification and quantification of the hydroxyeicosatetraenoic acids, 20-HETE and 12-HETE, in the cerebrospinal fluid after subarachnoid hemorrhage. Journal of neuroscience methods 20050615
Differential effects of 20-hydroxyeicosatetraenoic acid on intrarenal blood flow in the rat. The Journal of pharmacology and experimental therapeutics 20050601
Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cells. Pediatric nephrology (Berlin, Germany) 20050601
Contribution of arachidonic acid metabolites derived via cytochrome P4504A to angiotensin II-induced neointimal growth. Hypertension (Dallas, Tex. : 1979) 20050601
Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects. Free radical biology & medicine 20050415
Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries. American journal of physiology. Heart and circulatory physiology 20050401
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension (Dallas, Tex. : 1979) 20050401
Fenofibrate prevents the development of angiotensin II-dependent hypertension in mice. Hypertension (Dallas, Tex. : 1979) 20050401
Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979) 20050401
20-HETE-mediated vasoconstriction by hemoglobin-O2 carrier in Sprague-Dawley but not Wistar rats. Journal of applied physiology (Bethesda, Md. : 1985) 20050301
Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology 20050301
The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation. Cardiovascular research 20050201
P450 in the angiogenesis affair: the unusual suspect. The American journal of pathology 20050201
Inhibitors of cytochrome P450 4A suppress angiogenic responses. The American journal of pathology 20050201
Pathophysiological role of 20-HETE a cytochrome P450 metabolite of arachidonic acid. Journal of pharmacological sciences 20050201
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation 20050104
Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension. Circulation 20050104
Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20050101
Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on glomerular protein permeability barrier. Kidney international 20050101
Increased excretion of urinary 20-HETE in rats with cyclosporine-induced nephrotoxicity. Journal of pharmacological sciences 20050101
Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. Annual review of pharmacology and toxicology 20050101
Transfection and functional expression of CYP4A1 and CYP4A2 using bicistronic vectors in vascular cells and tissues. The Journal of pharmacology and experimental therapeutics 20041201
P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid. The Journal of pharmacology and experimental therapeutics 20041201
Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. Bioorganic & medicinal chemistry 20041201
Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. Journal of molecular and cellular cardiology 20041201
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circulation research 20041112
Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb. American journal of physiology. Renal physiology 20041101
Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors. Bioorganic & medicinal chemistry letters 20041101
Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. Circulation research 20041015
Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases. Clinical and experimental pharmacology & physiology 20041001
[Role of androgens in the renal production of 20-hydroxyeicosatetraenoic acid in spontaneously hypertensive rats]. Nihon Jinzo Gakkai shi 20041001
Neurobiology: feeding the brain. Nature 20040909
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature 20040909
Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli. American journal of physiology. Heart and circulatory physiology 20040901
Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases. Journal of lipid research 20040901
20-hydroxyeicosatetraenoic acid is a vasoconstrictor in the newborn piglet pulmonary microcirculation. American journal of physiology. Lung cellular and molecular physiology 20040801
Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction. Hypertension (Dallas, Tex. : 1979) 20040801
Activation of Na+-independent Mg2+ efflux by 20-hydroxyeicosatetraenoic acid in rat renal epithelial cells. The Japanese journal of physiology 20040801
Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation 20040727
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis. American journal of physiology. Regulatory, integrative and comparative physiology 20040701
20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis? American journal of physiology. Regulatory, integrative and comparative physiology 20040701
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. Drug metabolism and disposition: the biological fate of chemicals 20040701
Cytochrome P-450 metabolites in endothelin-stimulated cardiac hormone secretion. American journal of physiology. Regulatory, integrative and comparative physiology 20040501
Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys. Hypertension (Dallas, Tex. : 1979) 20040401
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. The Journal of pharmacology and experimental therapeutics 20040301
Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension. Current opinion in nephrology and hypertension 20040301
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. European journal of pharmacology 20040223
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. The Journal of biological chemistry 20040220
Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels. Circulation research 20040206
20-HETE and circulating insulin in essential hypertension with obesity. Hypertension (Dallas, Tex. : 1979) 20040201
20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. The Journal of biological chemistry 20040123
Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorganic & medicinal chemistry letters 20040119
Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry. Clinical chemistry 20040101
Renal COX-2, cytokines and 20-HETE: tubular and vascular mechanisms. Current pharmaceutical design 20040101
Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation. Methods in enzymology 20040101
Regulation of cytochrome P-450 4A activity by peroxisome proliferator-activated receptors in the rat kidney. Hypertension research : official journal of the Japanese Society of Hypertension 20031101
Asian Federation of Medicinal Chemistry (AFMC) - Fifth International Medicinal Chemistry Symposium. 14-17 October 2003, Kyoto, Japan. IDrugs : the investigational drugs journal 20031101
Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. Biochemistry 20031014
Inhibitors of 20-HETE formation promote salt-sensitive hypertension in rats. Hypertension (Dallas, Tex. : 1979) 20031001
Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney. Hypertension (Dallas, Tex. : 1979) 20031001
Inhibitors of 20-hydroxyeicosatetraenoic acid reduce renal vasoconstrictor responsiveness. The Journal of pharmacology and experimental therapeutics 20031001
Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905
20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology 20030901
20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. The Journal of biological chemistry 20030822
Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. American journal of physiology. Renal physiology 20030801
Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action. European journal of pharmacology 20030725
20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction. Bioorganic & medicinal chemistry 20030703
CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. American journal of physiology. Heart and circulatory physiology 20030501
Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Stroke 20030501
Functional expression of human heme oxygenase-1 gene in renal structure of spontaneously hypertensive rats. Experimental biology and medicine (Maywood, N.J.) 20030501
Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. American journal of physiology. Regulatory, integrative and comparative physiology 20030401
Cyclooxygenase and cytochrome P-450 pathways induced by fetal calf serum regulate wound closure in 3T6 fibroblast cultures through the effect of prostaglandin E2 and 12 and 20 hydroxyeicosatetraenoic acids. Journal of cellular physiology 20030401
Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation. American journal of physiology. Regulatory, integrative and comparative physiology 20030401
Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase. American journal of physiology. Renal physiology 20030301
Contributions of 20-HETE to the antihypertensive effects of Tempol in Dahl salt-sensitive rats. Hypertension (Dallas, Tex. : 1979) 20030301
20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension (Dallas, Tex. : 1979) 20030301
20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension (Dallas, Tex. : 1979) 20030301
Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone. Kidney international 20030301
Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. Circulation 20030204
Quantification of 20-hydroxyeicosatetraenoic acid by colorimetric competitive enzyme linked immunosorbent assay. Journal of biosciences 20030201
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. American journal of physiology. Renal physiology 20030101
Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Archives of biochemistry and biophysics 20030101
Regulation of renal microvascular 20-hydroxyeicosatetraenoic acid (20-HETE) levels. Advances in experimental medicine and biology 20030101
Cytochrome P450 arachidonic acid metabolites modulate renal tubular function. Advances in experimental medicine and biology 20030101
Candida bombicola cells immobilized on patterned lipid films as enzyme sources for the transformation of arachidonic acid to 20-HETE. Biotechnology progress 20030101
20-Hydroxyeicosatetraenoic acid potentiates contractile activation of canine basilar artery in response to stretch via protein kinase Calpha-mediated inhibition of calcium-activated potassium channel. Advances in experimental medicine and biology 20030101
20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel. British journal of pharmacology 20021201
Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR. Cellular and molecular biology (Noisy-le-Grand, France) 20021201
Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. Journal of applied physiology (Bethesda, Md. : 1985) 20021001
Arachidonic acid inhibits K channels in basolateral membrane of the thick ascending limb. American journal of physiology. Renal physiology 20020901
Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity. American journal of physiology. Regulatory, integrative and comparative physiology 20020901
20-HETE pathway antagonists inhibit rat small mesenteric artery tone. Microvascular research 20020901
Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries. American journal of physiology. Regulatory, integrative and comparative physiology 20020801
Renal cytochrome p450 oxygenases and preglomerular vascular response to arachidonic acid and endothelin-1 following ischemia/reperfusion. The Journal of pharmacology and experimental therapeutics 20020801
Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. American journal of physiology. Renal physiology 20020701
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. American journal of physiology. Regulatory, integrative and comparative physiology 20020701
CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. Journal of applied physiology (Bethesda, Md. : 1985) 20020701
Cytochrome P450 pathways of arachidonic acid metabolism. Current opinion in lipidology 20020601
Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure. Acta pharmacologica Sinica 20020601
The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020601
Parenchymal tissue cytochrome P450 4A enzymes contribute to oxygen-induced alterations in skeletal muscle arteriolar tone. Microvascular research 20020501
Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells. American journal of physiology. Heart and circulatory physiology 20020401
20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. American journal of physiology. Heart and circulatory physiology 20020401
Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy. American journal of physiology. Regulatory, integrative and comparative physiology 20020201
Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney. Hypertension (Dallas, Tex. : 1979) 20020201
Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. American journal of physiology. Renal physiology 20020101
P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiological reviews 20020101
Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detection. Rapid communications in mass spectrometry : RCM 20020101
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorganic & medicinal chemistry letters 20011203
Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension (Dallas, Tex. : 1979) 20011201
The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. American journal of physiology. Heart and circulatory physiology 20011101
Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries. Microvascular research 20011101
Cytochrome p450 and vascular homeostasis. Circulation research 20011026
Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K(+) channels in the TAL. American journal of physiology. Cell physiology 20011001
Involvement of cytochrome P450 metabolites in the vascular action of angiotensin II on the afferent arterioles. Hypertension research : official journal of the Japanese Society of Hypertension 20010901
Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine. The Journal of biological chemistry 20010511
Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia. The Journal of pharmacology and experimental therapeutics 20010501
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. Analytical biochemistry 20010501
Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells. American journal of physiology. Heart and circulatory physiology 20010401
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. Microcirculation (New York, N.Y. : 1994) 20010401
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid. American journal of physiology. Regulatory, integrative and comparative physiology 20010301
20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats. American journal of physiology. Heart and circulatory physiology 20010301
20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure. Current opinion in nephrology and hypertension 20010301
Role of 20-HETE in mediating the effect of dietary K intake on the apical K channels in the mTAL. American journal of physiology. Renal physiology 20010201
20-Hydroxyeicosatetraenoic acid mediates angiotensin ii-induced phospholipase d activation in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979) 20010201
20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats. Microcirculation (New York, N.Y. : 1994) 20010201
Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. Biochemistry 20010130
CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. American journal of physiology. Regulatory, integrative and comparative physiology 20010101
Regulation of preglomerular microvascular 20-hydroxyeicosatetraenoic acid levels by salt depletion. Medical science monitor : international medical journal of experimental and clinical research 20010101
Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. Journal of vascular research 20010101
Synergistic induction of acyl-CoA oxidase activity, an indicator of peroxisome proliferation, by arachidonic acid and retinoic acid in Morris hepatoma 7800C1 cells. Biochimica et biophysica acta 19951005
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. Molecular endocrinology (Baltimore, Md.)
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