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Home Other Building Blocks Syk Inhibitor IV, BAY 61-3606

Syk Inhibitor IV, BAY 61-3606

CAS No.:
732983-37-8
Catalog Number:
AG005P6Y
Molecular Formula:
C20H19ClN6O3
Molecular Weight:
426.8563
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Product Description
Catalog Number:
AG005P6Y
Chemical Name:
Syk Inhibitor IV, BAY 61-3606
CAS Number:
732983-37-8
Molecular Formula:
C20H19ClN6O3
Molecular Weight:
426.8563
MDL Number:
MFCD18641826
IUPAC Name:
2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
InChI:
InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
InChI Key:
JWQOJVOKBAAAAR-UHFFFAOYSA-N
SMILES:
COc1cc(ccc1OC)c1nc(Nc2ncccc2C(=O)N)n2c(c1)ncc2.Cl
UNII:
61G8S0H9KX
Properties
Complexity:
566  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
390.144g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
390.403g/mol
Monoisotopic Mass:
390.144g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
117A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3  
Literature
Title Journal
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells. PloS one 20160101
Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120919
Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells. Experimental cell research 20120910
ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways. Journal of thrombosis and haemostasis : JTH 20120601
Discovery and development of spleen tyrosine kinase (SYK) inhibitors. Journal of medicinal chemistry 20120426
Spleen tyrosine kinase mediates BEAS-2B cell migration and proliferation and human rhinovirus-induced expression of vascular endothelial growth factor and interleukin-8. The Journal of pharmacology and experimental therapeutics 20120201
Osteosarcoma Phenotype Is Inhibited by 3,4-Methylenedioxy-β-nitrostyrene. Sarcoma 20120101
BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PloS one 20120101
Central nervous system mast cells in peripheral inflammatory nociception. Molecular pain 20110101
Treatment of allergic asthma: modulation of Th2 cells and their responses. Respiratory research 20110101
A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. British journal of cancer 20100727
Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcepsilonRI-activated RBL-2H3 basophilic cells. Cellular immunology 20100101
Kinase inhibitors for the treatment of inflammatory and autoimmune disorders. Purinergic signalling 20090301
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. The Journal of pharmacology and experimental therapeutics 20030901
Properties