7-Methyl-2-(morpholin-4-yl)-9-[1-(phenylamino)ethyl]pyrido[1,2-a]pyrimidin-4-one
| Title | Journal |
|---|---|
| Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers. | Journal of medicinal chemistry 20140213 |
| Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation. | Bioorganic & medicinal chemistry letters 20121101 |
| Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases. | American journal of respiratory cell and molecular biology 20121001 |
| PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. | Molecular endocrinology (Baltimore, Md.) 20120801 |
| Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. | Journal of medicinal chemistry 20120524 |
| Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. | Cancer discovery 20120501 |
| A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. | Nature chemical biology 20120429 |
| Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation. | PloS one 20120101 |
| Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes. | Journal of biomedical science 20120101 |
| Discovery of new aminopyrimidine-based phosphoinositide 3-kinase beta (PI3Kβ) inhibitors with selectivity over PI3Kα. | Bioorganic & medicinal chemistry letters 20111201 |
| Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice. | Thrombosis research 20110601 |
| Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. | The Journal of pharmacology and experimental therapeutics 20110501 |
| Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. | BMC cancer 20110101 |
| Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways. | The Biochemical journal 20100715 |
| Advantages of a selective beta-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat. | European journal of pharmacology 20080610 |
| Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation. | Thrombosis and haemostasis 20080301 |
| PI 3-kinase p110beta: a new target for antithrombotic therapy. | Nature medicine 20050501 |