6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
| Title | Journal |
|---|---|
| On dihydroorotate dehydrogenases and their inhibitors and uses. | Journal of medicinal chemistry 20130425 |
| New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. | European journal of medicinal chemistry 20120301 |
| Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. | International journal of antimicrobial agents 20111101 |
| Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. | Bioorganic & medicinal chemistry letters 20100315 |
| The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites. | Biochemistry 20080826 |
| Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans. | The FEBS journal 20060701 |
| Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. | Bioorganic & medicinal chemistry letters 20060315 |
| Dual binding mode of a novel series of DHODH inhibitors. | Journal of medicinal chemistry 20060223 |
| Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors. | Bioorganic & medicinal chemistry letters 20060115 |
| Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase. | Bioorganic & medicinal chemistry 20050315 |
| Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. | Protein science : a publication of the Protein Society 20040401 |
| Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. | The Journal of biological chemistry 20021101 |
| In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. | Scandinavian journal of immunology 20020701 |
| Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation. | Transplantation proceedings 20010501 |
| Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase. | Biochemistry 20010220 |
| Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010101 |
| Immunosuppressive drugs: the first 50 years and a glance forward. | Immunopharmacology 20000501 |
| Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. | Chemico-biological interactions 20000103 |
| Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. | Biochemical pharmacology 19981101 |
| Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria. | Biochemical pharmacology 19981015 |
| 2',3'-Didehydro-3'-deoxythymidine: regulation of its metabolic activation by modulators of thymidine-5'-triphosphate biosynthesis. | Molecular pharmacology 19960701 |
| Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390). | Cancer research 19890815 |
| The role of the tail in temperature regulation of the cotton rat, Sigmodon hispidus. | Comparative biochemistry and physiology. A, Comparative physiology 19751201 |