6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b]
| Title | Journal |
|---|---|
| Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. | Journal of medicinal chemistry 20140508 |
| Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. | Journal of medicinal chemistry 20131024 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Rational design of highly selective spleen tyrosine kinase inhibitors. | Journal of medicinal chemistry 20121213 |
| Discovery and development of spleen tyrosine kinase (SYK) inhibitors. | Journal of medicinal chemistry 20120426 |
| Comprehensive analysis of kinase inhibitor selectivity. | Nature biotechnology 20111030 |
| Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. | Protein science : a publication of the Protein Society 20110201 |
| Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. | Chemistry & biology 20101124 |
| Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. | Chemical biology & drug design 20090401 |
| Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. | Bioorganic & medicinal chemistry letters 20090401 |
| Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. | Birth defects research. Part A, Clinical and molecular teratology 20090201 |
| R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. | The Journal of pharmacology and experimental therapeutics 20061201 |