sales@angenesci.com
Login | Register
logo
Structures Search
Home Other Building Blocks Tetrahydrofolic acid

Tetrahydrofolic acid

CAS No.:
135-16-0
Catalog Number:
AG009BK3
Molecular Formula:
C19H23N7O6
Molecular Weight:
445.4292
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
67+%
1 week
United States
$194
- +
Product Description
Catalog Number:
AG009BK3
Chemical Name:
Tetrahydrofolic acid
CAS Number:
135-16-0
Molecular Formula:
C19H23N7O6
Molecular Weight:
445.4292
MDL Number:
MFCD00135583
IUPAC Name:
(2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
InChI:
InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1
InChI Key:
MSTNYGQPCMXVAQ-KIYNQFGBSA-N
SMILES:
OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NCC1CNc2c(N1)c(=O)[nH]c(n2)N
EC Number:
205-181-1
Properties
Complexity:
834  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
445.171g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Isotope Atom Count:
0
Molecular Weight:
445.436g/mol
Monoisotopic Mass:
445.171g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
207A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.6  
Literature
Title Journal
Tetrahydrofolate recognition by the mitochondrial folate transporter. The Journal of biological chemistry 20110909
Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. Chemico-biological interactions 20110530
A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. The American journal of clinical nutrition 20070401
Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. Journal of cellular biochemistry 20060901
Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. Endocrine-related cancer 20060601
Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization. American journal of physiology. Renal physiology 20040301
Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase. The Journal of biological chemistry 20020809
Molecular cloning of the human placental folate transporter. Biochemical and biophysical research communications 19950117
Thymidylate synthetase activity in the Novikoff hepatoma. Cancer research 19761201
The toxicity of tetrahydrohomofolic acid in normal and malaria-infected monkeys. The Journal of pharmacology and experimental therapeutics 19680201
Properties