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Home Aminos (S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide

(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide

CAS No.:
133865-88-0
Catalog Number:
AG009DNR
Molecular Formula:
C17H19FN2O2
Molecular Weight:
302.3434
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Product Description
Catalog Number:
AG009DNR
Chemical Name:
(S)-2-((4-((2-Fluorobenzyl)oxy)benzyl)amino)propanamide
CAS Number:
133865-88-0
Molecular Formula:
C17H19FN2O2
Molecular Weight:
302.3434
MDL Number:
MFCD08272558
IUPAC Name:
(2S)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide
InChI:
InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-6-8-15(9-7-13)22-11-14-4-2-3-5-16(14)18/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
InChI Key:
BHJIBOFHEFDSAU-LBPRGKRZSA-N
SMILES:
NC(=O)[C@@H](NCc1ccc(cc1)OCc1ccccc1F)C
EC Number:
603-771-7
UNII:
3LPF0S0GVV
Properties
Complexity:
346  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
302.143g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
302.349g/mol
Monoisotopic Mass:
302.143g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
64.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes. Frontiers in pharmacology 20110101
Disposition and metabolism of ralfinamide, a novel Na-channel blocker, in healthy male volunteers. Pharmacology 20100101
Functional and pharmacological properties of human and rat NaV1.8 channels. Neuropharmacology 20090401
Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain 20081015
Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats. Experimental neurology 20071101
Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells. European journal of pharmacology 20051228
The anti-nociceptive agent ralfinamide inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive Na+ currents in dorsal root ganglion neurons. European journal of pharmacology 20050314
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20050301
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20050101
Ralfinamide. Newron Pharmaceuticals. IDrugs : the investigational drugs journal 20041001
Properties