3,5-dihydroxy-3-methyl-Pentanoic acid
| Title | Journal |
|---|---|
| Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway. | Oncotarget 20160301 |
| Prevention of Simvastatin-Induced Inhibition of Tendon Cell Proliferation and Cell Cycle Progression by Geranylgeranyl Pyrophosphate. | Toxicological sciences : an official journal of the Society of Toxicology 20160201 |
| Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity. | Toxicology 20150302 |
| Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. | The FEBS journal 20140801 |
| Evidence of a novel mevalonate pathway in archaea. | Biochemistry 20140701 |
| (R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. | The Journal of biological chemistry 20140606 |
| Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. | The Journal of clinical endocrinology and metabolism 20130301 |
| Differentially expressed transcripts from leaf and root tissue of Chlorophytum borivilianum: a plant with high medicinal value. | Gene 20121210 |
| Alcohol depletes coenzyme-Q(10) associated with increased TNF-alpha secretion to induce cytotoxicity in HepG2 cells. | Toxicology 20121208 |
| Restoration of alveolar type II cell function contributes to simvastatin-induced attenuation of lung ischemia-reperfusion injury. | International journal of molecular medicine 20121201 |
| Heritable disorders in the metabolism of the dolichols: A bridge from sterol biosynthesis to molecular glycosylation. | American journal of medical genetics. Part C, Seminars in medical genetics 20121115 |
| Clinical and biochemical landmarks in systemic autoinflammatory diseases. | Annals of medicine 20121101 |
| Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content. | Molecular membrane biology 20121101 |
| Construction and analysis of EST libraries of the trans-polyisoprene producing plant, Eucommia ulmoides Oliver. | Planta 20121101 |
| Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation. | Thrombosis and haemostasis 20121101 |
| Biologic drugs in autoinflammatory syndromes. | Autoimmunity reviews 20121101 |
| Effects of glucans and eicosapentaenoic acid on differential regulation of phenylpropanoid and mevalonic pathways during potato response to Phytophthora infestans. | Plant physiology and biochemistry : PPB 20121101 |
| Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. | Blood 20121018 |
| Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes. | The Biochemical journal 20121015 |
| Molecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase. | Biochemistry 20121009 |
| Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. | European journal of pharmacology 20121005 |
| Incidence and clinical features of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) and spectrum of mevalonate kinase (MVK) mutations in German children. | Rheumatology international 20121001 |
| Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. | Neurobiology of aging 20121001 |
| PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots. | Physiologia plantarum 20121001 |
| Atorvastatin and pitavastatin enhance lipoprotein lipase production in L6 skeletal muscle cells through activation of adenosine monophosphate-activated protein kinase. | Metabolism: clinical and experimental 20121001 |
| Hereditary autoinflammatory syndromes: a Brazilian multicenter study. | Journal of clinical immunology 20121001 |
| Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal). | Plant cell reports 20121001 |
| Efficacy of interleukin-1-targeting drugs in mevalonate kinase deficiency. | Rheumatology (Oxford, England) 20121001 |
| Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20121001 |
| Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis. | Nature genetics 20121001 |
| Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human γδ T cells. | Journal of immunotherapy (Hagerstown, Md. : 1997) 20121001 |
| Effects of simvastatin on the expression of heme oxygenase-1 in human RPE cells. | Investigative ophthalmology & visual science 20120921 |
| Structure of the GcpE (IspG)-MEcPP complex from Thermus thermophilus. | FEBS letters 20120921 |
| Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. | Blood 20120913 |
| Ox-LDL-induced TGF-β1 production in human alveolar epithelial cells: involvement of the Ras/ERK/PLTP pathway. | Journal of cellular physiology 20120901 |
| Statin-dependent activation of protein kinase Cδ in acute promyelocytic leukemia cells and induction of leukemic cell differentiation. | Leukemia & lymphoma 20120901 |
| No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. | Journal of inherited metabolic disease 20120901 |
| Methylenebisphosphonate and triphosphate derivatives of the mevalonate pathway are substrates of yeast UTP:glucose-1-phosphate uridylyltransferase. | Biochimie 20120901 |
| The multifunctionality of human Vγ9Vδ2 γδ T cells: clonal plasticity or distinct subsets? | Scandinavian journal of immunology 20120901 |
| Gene expression profile of early in vitro biofilms of Streptococcus pneumoniae. | Microbiology and immunology 20120901 |
| Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. | Oncology reports 20120901 |
| An ultrasensitive enzymatic method for measuring mevalonic acid in serum. | Journal of lipid research 20120901 |
| Bioinformatics study of the 3-hydroxy-3-methylglotaryl-coenzyme A reductase (HMGR) gene in Gramineae. | Molecular biology reports 20120901 |
| Engineering triterpene metabolism in tobacco. | Planta 20120901 |
| Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. | The American journal of pathology 20120901 |
| Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism. | Biochemical pharmacology 20120815 |
| Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE-/- mice. | Clinical science (London, England : 1979) 20120801 |
| CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. | The American journal of pathology 20120801 |
| Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. | Molecular neurobiology 20120801 |
| Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death. | Arteriosclerosis, thrombosis, and vascular biology 20120801 |
| Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway. | Endocrinology 20120801 |
| Multieffector-functional immune responses of HMBPP-specific Vγ2Vδ2 T cells in nonhuman primates inoculated with Listeria monocytogenes ΔactA prfA*. | Journal of immunology (Baltimore, Md. : 1950) 20120801 |
| ATP-citrate lyase: a key player in cancer metabolism. | Cancer research 20120801 |
| Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. | Biochemistry 20120717 |
| Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1α in vascular smooth muscle cells. | Cardiovascular research 20120715 |
| p53 and cancer stem cells: the mevalonate connexion. | Cell cycle (Georgetown, Tex.) 20120715 |
| Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. | Applied biochemistry and biotechnology 20120701 |
| The bisphosphonate incadronate inhibits intraperitoneal dissemination in an in vivo pancreatic cancer model. | Oncology reports 20120701 |
| Simvastatin decreases invasiveness of human endometrial stromal cells. | Biology of reproduction 20120701 |
| HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. | Microbiology (Reading, England) 20120701 |
| Novel aspects of mevalonate pathway inhibitors as antitumor agents. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120701 |
| The isoprenoid-precursor dependence of Plasmodium spp. | Natural product reports 20120701 |
| Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. | Stem cells (Dayton, Ohio) 20120701 |
| Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. | Hypertension (Dallas, Tex. : 1979) 20120701 |
| Changes in the expression of hepatic genes involved in cholesterol homeostasis in dairy cows in the transition period and at different stages of lactation. | Journal of dairy science 20120701 |
| Novel mutations causing hyperimmunoglobulin D and periodic fever syndrome. | Indian pediatrics 20120701 |
| [Roles of periostin in proliferation and migration of vascular smooth muscle cells and the effect of atorvastatin on them]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120701 |
| Structure, function and regulation of gonadotropin receptors - a perspective. | Molecular and cellular endocrinology 20120605 |
| Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20120601 |
| New role for an established drug? Bisphosphonates as potential anticancer agents. | Prostate cancer and prostatic diseases 20120601 |
| To cardiovascular disease and beyond: new therapeutic perspectives of statins in autoimmune diseases and cancer. | Current drug targets 20120601 |
| Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. | Reproductive sciences (Thousand Oaks, Calif.) 20120601 |
| 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. | Journal of cellular biochemistry 20120601 |
| Nociceptive and pro-inflammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. | British journal of pharmacology 20120601 |
| Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development. | The Plant journal : for cell and molecular biology 20120601 |
| Atorvastatin attenuates TNF-α-induced increase of glucose oxidation through PGC-1α upregulation in cardiomyocytes. | Journal of cardiovascular pharmacology 20120601 |
| Liver transplantation followed by allogeneic hematopoietic stem cell transplantation for atypical mevalonic aciduria. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120601 |
| Isoprenoid biosynthesis in bacterial pathogens. | Microbiology (Reading, England) 20120601 |
| Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. | Atherosclerosis 20120601 |
| Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. | Cell death & disease 20120601 |
| Cycloheximide as a tool to investigate protein import in peroxisomes: a case study of the subcellular localization of isoprenoid biosynthetic enzymes. | Journal of plant physiology 20120515 |
| The differential effects of statins on the metastatic behaviour of prostate cancer. | British journal of cancer 20120508 |
| IcmF family protein TssM exhibits ATPase activity and energizes type VI secretion. | The Journal of biological chemistry 20120504 |
| Optimization of the mated fermentation process for the production of lycopene by Blakeslea trispora NRRL 2895 (+) and NRRL 2896 (-). | Bioprocess and biosystems engineering 20120501 |
| 2',7'-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. | Journal of hepatology 20120501 |
| Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. 'When the wine goes in, strange things come out' - S.T. Coleridge, The Piccolomini. | Journal of inherited metabolic disease 20120501 |
| Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors. | Biotechnology letters 20120501 |
| Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. | The Plant journal : for cell and molecular biology 20120501 |
| The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases. | Glycobiology 20120501 |
| Different clinical presentation of the hyperimmunoglobulin D syndrome (HIDS) (four cases from Turkey). | Clinical rheumatology 20120501 |
| Involvement of the mevalonate pathway in the antiproliferative effect of zoledronate on ACHN renal cell carcinoma cells. | Oncology reports 20120501 |
| Statins and protein prenylation in cancer cell biology and therapy. | Anti-cancer agents in medicinal chemistry 20120501 |
| Cellular interactions of synovial fluid γδ T cells in juvenile idiopathic arthritis. | Journal of immunology (Baltimore, Md. : 1950) 20120501 |
| Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. | Clinical and experimental immunology 20120501 |
| Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. | PLoS genetics 20120501 |
| Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation. | Toxicology and applied pharmacology 20120415 |
| Simvastatin inhibits glucose-stimulated vascular smooth muscle cell migration involving increased expression of RhoB and a block of Ras/Akt signal. | Cardiovascular therapeutics 20120401 |
| RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo. | Gene therapy 20120401 |
| Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | Molecular biology reports 20120401 |
| Fluvastatin inhibits angiotensin II-induced nuclear factor kappa B activation in renal tubular epithelial cells through the p38 MAPK pathway. | Molecular biology reports 20120401 |
| Transcriptome analysis of an oil-rich race B strain of Botryococcus braunii (BOT-22) by de novo assembly of pyrosequencing cDNA reads. | Bioresource technology 20120401 |
| Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. | Cancer immunology, immunotherapy : CII 20120401 |
| Bisphosphonates as antimyeloma drugs. | Leukemia 20120401 |
| Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression. | International journal of oncology 20120401 |
| Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. | The Biochemical journal 20120401 |
| A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis? | Progress in lipid research 20120401 |
| Lipid metabolic pathways as lung cancer therapeutic targets: a computational study. | International journal of molecular medicine 20120401 |
| Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. | Journal of experimental botany 20120401 |
| Isoprenoid biosynthesis in eukaryotic phototrophs: a spotlight on algae. | Plant science : an international journal of experimental plant biology 20120401 |
| Statins and vein graft failure in coronary bypass surgery. | Current opinion in pharmacology 20120401 |
| Current advances in detection and treatment of babesiosis. | Current medicinal chemistry 20120401 |
| Autoinflammatory syndromes. | Pediatric clinics of North America 20120401 |
| NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | Gut and liver 20120401 |
| Application of targeted proteomics to metabolically engineered Escherichia coli. | Proteomics 20120401 |
| Ambivalent effects of atorvastatin on angiogenesis, epidermal cell proliferation and tumorgenesis in animal models. | Iranian biomedical journal 20120401 |
| Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability. | Toxicology 20120329 |
| Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel. | Journal of controlled release : official journal of the Controlled Release Society 20120328 |
| Medical management of metabolic dysfunction in PCOS. | Steroids 20120310 |
| Molecular cloning, tissue expression and protein structure prediction of the porcine 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) gene. | Gene 20120310 |
| Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20120309 |
| The fresco of autoinflammatory diseases from the pediatric perspective. | Autoimmunity reviews 20120301 |
| A cholesterol and actinide dependent shadow biosphere of archaea and viroids in autoimmune diseases. | Immunobiology 20120301 |
| Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis latex. | Journal of experimental botany 20120301 |
| Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). | Journal of experimental botany 20120301 |
| Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells. | Bone 20120301 |
| Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum. | Plant physiology 20120301 |
| Clarification of the pleiotropic effects of statins on mevalonate pathway and the feedback regulation of isoprenoids requires more comprehensive investigation. | Cell biochemistry and function 20120301 |
| Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene α-santalene in a fed-batch mode. | Metabolic engineering 20120301 |
| Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori. | PLoS genetics 20120301 |
| The silkworm coming of age--early. | PLoS genetics 20120301 |
| Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D. | Science China. Life sciences 20120301 |
| Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells. | Experimental & molecular medicine 20120227 |
| Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. | Nature communications 20120221 |
| Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. | Journal of the American Chemical Society 20120215 |
| Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. | International journal of cancer 20120201 |
| Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. | Cancer 20120201 |
| The chemistry of bisphosphonates: from antiscaling agents to clinical therapeutics. | Anti-cancer agents in medicinal chemistry 20120201 |
| Enhanced production of β-carotene by recombinant industrial wine yeast using grape juice as substrate. | Current microbiology 20120201 |
| Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway. | Cardiovascular drugs and therapy 20120201 |
| A review of the rationale for additional therapeutic interventions to attain lower LDL-C when statin therapy is not enough. | Current atherosclerosis reports 20120201 |
| Explication of interactions between HMGCR isoform 2 and various statins through In silico modeling and docking. | Computers in biology and medicine 20120201 |
| Clinical, genetic, and therapeutic diversity in 2 patients with severe mevalonate kinase deficiency. | Pediatrics 20120201 |
| Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098. | Acta crystallographica. Section D, Biological crystallography 20120201 |
| Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke. | Inflammation & allergy drug targets 20120201 |
| Genome-wide transcriptional profiling of appressorium development by the rice blast fungus Magnaporthe oryzae. | PLoS pathogens 20120201 |
| The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase. | Biochemistry 20120131 |
| Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. | Neuroscience 20120127 |
| Suppression of Gαs synthesis by simvastatin treatment of vascular endothelial cells. | The Journal of biological chemistry 20120120 |
| Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. | Cell 20120120 |
| Etanercept and anakinra can prolong febrile episodes in patients with hyperimmunoglobulin D and periodic fever syndrome. | Rheumatology international 20120101 |
| The 3-methylglutaconic acidurias: what's new? | Journal of inherited metabolic disease 20120101 |
| Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS). | Journal of inherited metabolic disease 20120101 |
| The analytical determination of isoprenoid intermediates from the mevalonate pathway. | Analytical and bioanalytical chemistry 20120101 |
| Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells. | Clinical science (London, England : 1979) 20120101 |
| Inhibition of AMPK-dependent autophagy enhances in vitro antiglioma effect of simvastatin. | Pharmacological research 20120101 |
| Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. | Biology of reproduction 20120101 |
| Communication in fungi. | International journal of microbiology 20120101 |
| Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis. | Glia 20120101 |
| The Medical Research Council Myeloma IX trial: the impact on treatment paradigms. | European journal of haematology 20120101 |
| Plastid structure and carotenogenic gene expression in red- and white-fleshed loquat (Eriobotrya japonica) fruits. | Journal of experimental botany 20120101 |
| Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway. | The Journal of antimicrobial chemotherapy 20120101 |
| Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases. | Current opinion in rheumatology 20120101 |
| Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells. | Prostate cancer 20120101 |
| Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. | Metabolic engineering 20120101 |
| Non-alcoholic Fatty liver disease: the bile Acid-activated farnesoid x receptor as an emerging treatment target. | Journal of lipids 20120101 |
| Mechanism of the relaxant effect of rosuvastatin lactone on rat aortic rings. | Frontiers in bioscience (Elite edition) 20120101 |
| Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model. | Malaria journal 20120101 |
| Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. | PLoS pathogens 20120101 |
| β-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats. | Lipids in health and disease 20120101 |
| Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. | Plant methods 20120101 |
| Trypanosoma cruzi gene expression in response to gamma radiation. | PloS one 20120101 |
| Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer. | Cell death & disease 20120101 |
| Risedronate's Role in Reducing Hip Fracture in Postmenopausal Women with Established Osteoporosis. | Clinical medicine insights. Arthritis and musculoskeletal disorders 20120101 |
| Cell walls of Saccharomyces cerevisiae differentially modulated innate immunity and glucose metabolism during late systemic inflammation. | PloS one 20120101 |
| Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors. | PloS one 20120101 |
| Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): a review of the synthesis and biological evaluation of recent inhibitors. | Current topics in medicinal chemistry 20120101 |
| In vitro assembly of multiple DNA fragments using successive hybridization. | PloS one 20120101 |
| Metabolic profiles and cDNA-AFLP analysis of Salvia miltiorrhiza and Salvia castanea Diel f. tomentosa Stib. | PloS one 20120101 |
| Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. | BMC genomics 20120101 |
| Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. | Frontiers in pharmacology 20120101 |
| Iron - A Key Nexus in the Virulence of Aspergillus fumigatus. | Frontiers in microbiology 20120101 |
| Exploitation of lipid components by viral and host proteins for hepatitis C virus infection. | Frontiers in microbiology 20120101 |
| Pravastatin inhibits cell proliferation and increased MAT1A expression in hepatocarcinoma cells and in vivo models. | Cancer cell international 20120101 |
| Defective expression and function of the leukocyte associated Ig-like receptor 1 in B lymphocytes from systemic lupus erythematosus patients. | PloS one 20120101 |
| Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. | PloS one 20120101 |
| A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. | PloS one 20120101 |
| Site specific effects of zoledronic acid during tibial and mandibular fracture repair. | PloS one 20120101 |
| Delivery of iron-sulfur clusters to the hydrogen-oxidizing [NiFe]-hydrogenases in Escherichia coli requires the A-type carrier proteins ErpA and IscA. | PloS one 20120101 |
| Current approaches toward production of secondary plant metabolites. | Journal of pharmacy & bioallied sciences 20120101 |
| Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. | PloS one 20120101 |
| Effect of simvastatin on transforming growth factor beta-1-induced myofibroblast differentiation and collagen production in nasal polyp-derived fibroblasts. | American journal of rhinology & allergy 20120101 |
| Functional expression of an orchid fragrance gene in Lactococcus lactis. | International journal of molecular sciences 20120101 |
| Gibberellin biosynthetic inhibitors make human malaria parasite Plasmodium falciparum cells swell and rupture to death. | PloS one 20120101 |
| Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases. | Frontiers in pharmacology 20120101 |
| Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA reductase. | Substance abuse treatment, prevention, and policy 20120101 |
| Effect of local zoledronate on implant osseointegration in a rat model. | BMC musculoskeletal disorders 20120101 |
| RhoA: a therapeutic target for chronic myeloid leukemia. | Molecular cancer 20120101 |
| Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial). | PloS one 20120101 |
| From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. | Journal of biomedical science 20120101 |
| RNA-Seq analysis uncovers transcriptomic variations between morphologically similar in vivo- and in vitro-derived bovine blastocysts. | BMC genomics 20120101 |
| Effect of PGC-1α on proliferation, migration, and transdifferentiation of rat vascular smooth muscle cells induced by high glucose. | Journal of biomedicine & biotechnology 20120101 |
| Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion. | PloS one 20120101 |
| Conservation of gene order and content in the circular chromosomes of 'Candidatus Liberibacter asiaticus' and other Rhizobiales. | PloS one 20120101 |
| Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans. | PloS one 20120101 |
| Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice. | Journal of pharmacological sciences 20120101 |
| Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model. | Pharmacognosy research 20120101 |
| Nonsterol Triterpenoids as Major Constituents of Olea europaea. | Journal of lipids 20120101 |
| Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| De novo transcriptomic analysis of an oleaginous microalga: pathway description and gene discovery for production of next-generation biofuels. | PloS one 20120101 |
| The effect of rosuvastatin in a murine model of influenza A infection. | PloS one 20120101 |
| Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. | PloS one 20120101 |
| Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | PloS one 20120101 |
| IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening. | PloS one 20120101 |
| Phytol-derived novel isoprenoid immunostimulants. | Frontiers in immunology 20120101 |
| The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]. | PloS one 20120101 |
| Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. | Experimental diabetes research 20120101 |
| Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Pathways of carotenoid biosynthesis in bacteria and microalgae. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Novel approach in the biosynthesis of functional carotenoids in Escherichia coli. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| NMR-based isotopologue profiling of microbial carotenoids. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Oxidative stress and heart failure in altered thyroid States. | TheScientificWorldJournal 20120101 |
| The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations. | Journal of transplantation 20120101 |
| LDL-apheresis: technical and clinical aspects. | TheScientificWorldJournal 20120101 |
| Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells. | PloS one 20120101 |
| Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. | PloS one 20120101 |
| Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains. | Genetics, selection, evolution : GSE 20120101 |
| Antimicrobial Activity of Essential Oils against Streptococcus mutans and their Antiproliferative Effects. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. | PloS one 20120101 |
| Recent progress in synthetic biology for microbial production of C3-C10 alcohols. | Frontiers in microbiology 20120101 |
| Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments. | International journal of hepatology 20120101 |
| Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease. | PloS one 20120101 |
| Type 2 IDI performs better than type 1 for improving lycopene production in metabolically engineered E. coli strains. | World journal of microbiology & biotechnology 20120101 |
| [Effect of bisphosphonates on anticancer activity in prostate cancer cells]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101 |
| Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells. | PloS one 20120101 |
| Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. | European journal of pharmacology 20111230 |
| Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. | Journal of natural products 20111227 |
| Patient with neonatal-onset chronic hepatitis presenting with mevalonate kinase deficiency with a novel MVK gene mutation. | Modern rheumatology 20111201 |
| Biochemistry of the non-mevalonate isoprenoid pathway. | Cellular and molecular life sciences : CMLS 20111201 |
| On-demand anakinra treatment is effective in mevalonate kinase deficiency. | Annals of the rheumatic diseases 20111201 |
| Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol. | Journal of neurochemistry 20111201 |
| Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. | Biochemical pharmacology 20111201 |
| Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. | Apoptosis : an international journal on programmed cell death 20111201 |
| Familial hypercholesterolemia: present and future management. | Current cardiology reports 20111201 |
| Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. | Plant signaling & behavior 20111201 |
| Bisphosphonates and osteonecrosis of the jaw. | Journal of the American Geriatrics Society 20111201 |
| Preventive effects of zoledronic acid on bone metastasis in mice injected with human breast cancer cells. | Journal of Korean medical science 20111201 |
| Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. | PLoS pathogens 20111201 |
| Metabolic variation during development in culture of Leishmania donovani promastigotes. | PLoS neglected tropical diseases 20111201 |
| Five questions about non-mevalonate isoprenoid biosynthesis. | PLoS pathogens 20111201 |
| Adjuvant Effect of IV Clodronate on the Delay of Bone Metastasis in High-Risk Prostate Cancer Patients: A Prospective Study. | Cancer research and treatment : official journal of Korean Cancer Association 20111201 |
| Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. | Chembiochem : a European journal of chemical biology 20111125 |
| 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. | Blood 20111117 |
| Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. | Journal of immunology (Baltimore, Md. : 1950) 20111115 |
| Chance and serendipity in science: two examples from my own career. | The Journal of biological chemistry 20111104 |
| Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. | The Journal of organic chemistry 20111104 |
| HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients. | Rheumatology international 20111101 |
| Protective effect of dietary tocotrienols against infection and inflammation-induced hyperlipidemia: an in vivo and in silico study. | Phytotherapy research : PTR 20111101 |
| Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. | Planta 20111101 |
| Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. | Clinical science (London, England : 1979) 20111101 |
| Divergent DNA methylation patterns associated with abiotic stress in Hevea brasiliensis. | Molecular plant 20111101 |
| Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production. | Journal of cellular biochemistry 20111101 |
| Atorvastatin modulates anti-proliferative and pro-proliferative signals in Her2/neu-positive mammary cancer. | Biochemical pharmacology 20111101 |
| RNA-seq discovery, functional characterization, and comparison of sesquiterpene synthases from Solanum lycopersicum and Solanum habrochaites trichomes. | Plant molecular biology 20111101 |
| Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. | Journal of experimental botany 20111101 |
| A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. | Journal of lipid research 20111101 |
| Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures. | Epilepsia 20111101 |
| Resveratrol inhibits the mevalonate pathway and potentiates the antiproliferative effects of simvastatin in rat theca-interstitial cells. | Fertility and sterility 20111101 |
| Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. | Journal of experimental botany 20111101 |
| Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis. | Natural product reports 20111101 |
| Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10). | Metabolic engineering 20111101 |
| The effects of statin and niacin on plaque stability, plaque regression, inflammation and oxidative stress in patients with mild to moderate coronary artery stenosis. | Korean circulation journal 20111101 |
| Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. | FEBS letters 20111020 |
| Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. | Cancer biology & therapy 20111015 |
| Lycopene regulation of cholesterol synthesis and efflux in human macrophages. | The Journal of nutritional biochemistry 20111001 |
| An anti-juvenile hormone agent, ethyl 4-(2-benzylhexyloxy)benzoate, inhibits juvenile hormone synthesis through the suppression of the transcription of juvenile hormone biosynthetic enzymes in the corpora allata in Bombyx mori. | Insect biochemistry and molecular biology 20111001 |
| Physiology of the aging bone and mechanisms of action of bisphosphonates. | Biogerontology 20111001 |
| Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma. | Annals of hematology 20111001 |
| Synthesis and anti-hypercholesterolemic evaluations of calcium salts of 4-substituted quinoline-based mevalonic acid. | Chemical biology & drug design 20111001 |
| The cytostatic effects of lovastatin on ACC-MESO-1 cells. | The Journal of surgical research 20111001 |
| Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. | European journal of medicinal chemistry 20111001 |
| Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria. | Bioorganic & medicinal chemistry 20111001 |
| Hyperimmunoglobulinemia d syndrome variant--seek and you shall find. | The Journal of rheumatology 20111001 |
| A semi-quantitative, synteny-based method to improve functional predictions for hypothetical and poorly annotated bacterial and archaeal genes. | PLoS computational biology 20111001 |
| Inhibition of geranylgeranyl transferase-I decreases cell viability of HTLV-1-transformed cells. | Viruses 20111001 |
| Identification and microbial production of a terpene-based advanced biofuel. | Nature communications 20110927 |
| Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. | The Journal of biological chemistry 20110916 |
| Genomic analysis of the phenylacetyl-CoA pathway in Burkholderia xenovorans LB400. | Archives of microbiology 20110901 |
| β-Carotene production by Saccharomyces cerevisiae with regard to plasmid stability and culture media. | Applied microbiology and biotechnology 20110901 |
| Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management. | Expert opinion on drug delivery 20110901 |
| Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes. | Apoptosis : an international journal on programmed cell death 20110901 |
| Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010). | Expert opinion on therapeutic patents 20110901 |
| Hyper-IgD syndrome or mevalonate kinase deficiency. | Current opinion in rheumatology 20110901 |
| The volatile metabolome of grapevine roots: first insights into the metabolic response upon phylloxera attack. | Plant physiology and biochemistry : PPB 20110901 |
| Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases. | Metabolic engineering 20110901 |
| Current world literature. | Current opinion in rheumatology 20110901 |
| Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3. | Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20110901 |
| The effect of antiviral therapy on serum cholesterol levels in chronic hepatitis C. | Gut and liver 20110901 |
| Overexpression of the Trichoderma brevicompactum tri5 gene: effect on the expression of the trichodermin biosynthetic genes and on tomato seedlings. | Toxins 20110901 |
| Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. | The Biochemical journal 20110815 |
| Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts. | Toxicology and applied pharmacology 20110815 |
| Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vγ9Vδ2 T cells, αβ CD8+ T cells, regulatory T cells, and dendritic cells. | Journal of immunology (Baltimore, Md. : 1950) 20110815 |
| Corpus cavernosal smooth muscle relaxation effect of a novel AMPK activator, beta-lapachone. | The journal of sexual medicine 20110801 |
| Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110801 |
| Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures. | Molecular pharmaceutics 20110801 |
| Monogenic autoinflammatory syndromes at a dermatological level. | Archives of dermatological research 20110801 |
| Renal amyloidosis in children. | Pediatric nephrology (Berlin, Germany) 20110801 |
| From glycosylation disorders to dolichol biosynthesis defects: a new class of metabolic diseases. | Journal of inherited metabolic disease 20110801 |
| Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. | Plant, cell & environment 20110801 |
| Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. | Endocrinology 20110801 |
| Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. | Journal of thrombosis and haemostasis : JTH 20110801 |
| Modulation of plant HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism. | Plant signaling & behavior 20110801 |
| Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. | Cell biochemistry and function 20110801 |
| Effect of farnesol on mevalonate pathway of Staphylococcus aureus. | The Journal of antibiotics 20110801 |
| Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. | Cell death & disease 20110801 |
| What do human parasites do with a chloroplast anyway? | PLoS biology 20110801 |
| Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. | PLoS biology 20110801 |
| Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling. | Circulation 20110719 |
| Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. | The Journal of biological chemistry 20110708 |
| A riddle for paediatricians: two siblings with recurrent urticaria and fever. | Journal of paediatrics and child health 20110701 |
| Biochemical and molecular mechanisms of action of bisphosphonates. | Bone 20110701 |
| The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. | Bone 20110701 |
| The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency. | Pediatric research 20110701 |
| Prevention of transplant coronary artery disease by prenylation inhibitors. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110701 |
| Antitumor effects of the combination of cholesterol reducing drugs. | Oncology reports 20110701 |
| The relationship between the chemistry and biological activity of the bisphosphonates. | Bone 20110701 |
| Bisphosphonates inhibit expression of p63 by oral keratinocytes. | Journal of dental research 20110701 |
| Screening for mevalonate biosynthetic pathway inhibitors using sensitized bacterial strains. | Journal of biomolecular screening 20110701 |
| High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. | Cancer research 20110701 |
| [Autoinflammatory diseases as cause of wound healing defects]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20110701 |
| Mevalonate kinase deficiency: a survey of 50 patients. | Pediatrics 20110701 |
| Index of suspicion: case 1: leg cramps, hand spasms, diarrhea, and substantial weight loss in a 12 year old: case 2: hypothermia, hypoglycemia, and hyperbilirubinemia in a neonate: case 3: recurrent fevers, abdominal pain, and cervical lymphadenopathy in a 7 year old. | Pediatrics in review 20110701 |
| Polished rice as natural sources of cancer-preventing geranylgeranoic acid. | Journal of clinical biochemistry and nutrition 20110701 |
| [Plasmacytoid dendritic cells as therapeutic targets in novel therapeutics for autoimmune diseases]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20110701 |
| [Biosynthesis of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli through introducing mevalonate pathway]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20110701 |
| Lovastatin inhibits thrombospondin-1-induced smooth muscle cell chemotaxis. | The Journal of surgical research 20110601 |
| Potential metabolic consequences of statins in sepsis. | Critical care medicine 20110601 |
| Bisphosphonates induce senescence in normal human oral keratinocytes. | Journal of dental research 20110601 |
| Significant liver disease in a patient with Y116H mutation in the MVK gene. | American journal of medical genetics. Part A 20110601 |
| Differences in citation frequency of clinical and basic science papers in cardiovascular research. | Medical & biological engineering & computing 20110601 |
| Letter to the editor: acute effects of intravenous administration of pamidronate in patients with osteoporosis. | Journal of Korean medical science 20110601 |
| SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. | Aging 20110601 |
| Effects of D-003 (10 mg/day) on bone mineral density of the lumbar spine and femoral neck in postmenopausal women: a randomized, double-blinded study. | The Korean journal of internal medicine 20110601 |
| Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs. | PLoS genetics 20110601 |
| Impact of High-Dose Statin Pretreatment in Patients with Stable Angina during Off-Pump Coronary Artery Bypass. | The Korean journal of thoracic and cardiovascular surgery 20110601 |
| Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. | Chemico-biological interactions 20110530 |
| Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization. | The Journal of biological chemistry 20110513 |
| A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. | Biochemistry 20110503 |
| Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. | Journal of hepatology 20110501 |
| Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. | The Journal of veterinary medical science 20110501 |
| Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501 |
| No effect of rosuvastatin in the zoledronate-induced acute-phase response. | Calcified tissue international 20110501 |
| Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20110501 |
| Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. | Pain 20110501 |
| Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. | Annals of clinical biochemistry 20110501 |
| Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. | Cancer letters 20110501 |
| The role of atorvastatin in regulating the immune response leading to vascular damage in a model of Kawasaki disease. | Clinical and experimental immunology 20110501 |
| Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. | The Journal of investigative dermatology 20110501 |
| The methyl ester of rosuvastatin elicited an endothelium-independent and 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent relaxant effect in rat aorta. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110501 |
| Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. | Experimental biology and medicine (Maywood, N.J.) 20110501 |
| Structural and functional studies of mycobacterial IspD enzymes. | Acta crystallographica. Section D, Biological crystallography 20110501 |
| Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. | PLoS pathogens 20110501 |
| A bacterial platform for fermentative production of plant alkaloids. | Nature communications 20110501 |
| Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | The Journal of biological chemistry 20110429 |
| Polyisoprenoids - Secondary metabolites or physiologically important superlipids? | Biochemical and biophysical research communications 20110422 |
| Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. | Biochemical and biophysical research communications 20110422 |
| Establishment of transgenic mice carrying the gene for farnesyl pyrophosphate synthase. | Biotechnology letters 20110401 |
| Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. | The Journal of biological chemistry 20110401 |
| Long-term clinical profile of children with the low-penetrance R92Q mutation of the TNFRSF1A gene. | Arthritis and rheumatism 20110401 |
| Efficient functional analysis system for cyanobacterial or plant cytochromes P450 involved in sesquiterpene biosynthesis. | Applied microbiology and biotechnology 20110401 |
| Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. | Biochimica et biophysica acta 20110401 |
| Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. | Applied microbiology and biotechnology 20110401 |
| Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. | Cytokine 20110401 |
| Statins are logical candidates for overcoming limitations of targeting therapies on malignancy: their potential application to gastrointestinal cancers. | Cancer chemotherapy and pharmacology 20110401 |
| Platinum-bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis. | Journal of inorganic biochemistry 20110401 |
| Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function. | Environmental health perspectives 20110401 |
| The Eurofever Project: towards better care for autoinflammatory diseases. | European journal of pediatrics 20110401 |
| Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A. | The Plant cell 20110401 |
| Gerosuppressant metformin: less is more. | Aging 20110401 |
| Association between atherosclerosis and osteoporosis, the role of vitamin D. | Archives of medical science : AMS 20110401 |
| [Hereditary periodical fever syndromes]. | Ugeskrift for laeger 20110328 |
| Use of bisphosphonates and reduced risk of colorectal cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320 |
| MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase. | Cancer research 20110315 |
| Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. | Development (Cambridge, England) 20110315 |
| Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. | British journal of cancer 20110315 |
| Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. | Journal of agricultural and food chemistry 20110309 |
| The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells. | Journal of cellular and molecular medicine 20110301 |
| The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle. | American journal of respiratory cell and molecular biology 20110301 |
| Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. | Cellular and molecular life sciences : CMLS 20110301 |
| The validation of a simple LC/MS/MS method for determining the level of mevalonic acid in human plasma. | Biomedical chromatography : BMC 20110301 |
| Astaxanthin biosynthesis is enhanced by high carotenogenic gene expression and decrease of fatty acids and ergosterol in a Phaffia rhodozyma mutant strain. | FEMS yeast research 20110301 |
| Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK. | International journal of oncology 20110301 |
| Targeted proteomics for metabolic pathway optimization: application to terpene production. | Metabolic engineering 20110301 |
| Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. | American journal of physiology. Endocrinology and metabolism 20110301 |
| Geranylgeraniol - a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw. | Oral oncology 20110301 |
| Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110301 |
| The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042. | Microbial biotechnology 20110301 |
| Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. | PLoS biology 20110301 |
| Zoledronic acid for adjuvant use in patients with breast cancer. | Expert review of anticancer therapy 20110301 |
| Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. | The Journal of biological chemistry 20110204 |
| Structure of the E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) from Thermus thermophilus. | FEBS letters 20110204 |
| [Bisphosphonate treatment of osteoporosis and other skeletal diseases]. | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110204 |
| Osteonecrosis of the jaw and the role of macrophages. | Journal of the National Cancer Institute 20110202 |
| Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase. | Bone 20110201 |
| Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. | Journal of cardiovascular pharmacology 20110201 |
| A preliminary score for the assessment of disease activity in hereditary recurrent fevers: results from the AIDAI (Auto-Inflammatory Diseases Activity Index) Consensus Conference. | Annals of the rheumatic diseases 20110201 |
| The anti-ischemic and anti-anginal properties of statins. | Current atherosclerosis reports 20110201 |
| Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions. | Thrombosis and haemostasis 20110201 |
| Statins in heart failure-where do we stand? | Cardiovascular drugs and therapy 20110201 |
| Luteinizing hormone receptor mRNA down-regulation is mediated through ERK-dependent induction of RNA binding protein. | Molecular endocrinology (Baltimore, Md.) 20110201 |
| Educational paper: Primary immunodeficiencies in children: a diagnostic challenge. | European journal of pediatrics 20110201 |
| Effect of temperature on postillumination isoprene emission in oak and poplar. | Plant physiology 20110201 |
| Recurrent Fever, arthritis, lymphadenopathy, and hepatosplenomegaly. | The Pediatric infectious disease journal 20110201 |
| Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments. | Drug metabolism reviews 20110201 |
| Design and application of a mevalonate-responsive regulatory protein. | Angewandte Chemie (International ed. in English) 20110201 |
| PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. | British journal of cancer 20110118 |
| Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza involved in diterpenoid tanshinone accumulation. | Journal of plant physiology 20110115 |
| Enzymes of the mevalonate pathway of isoprenoid biosynthesis. | Archives of biochemistry and biophysics 20110115 |
| Rosuvastatin-induced neuroprotection in cortical neurons exposed to OGD/reoxygenation is due to nitric oxide inhibition and ERK1/2 pathway activation. | International journal of physiology, pathophysiology and pharmacology 20110110 |
| Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. | Acta oncologica (Stockholm, Sweden) 20110101 |
| Origins and early evolution of the mevalonate pathway of isoprenoid biosynthesis in the three domains of life. | Molecular biology and evolution 20110101 |
| Hyperimmunoglobulinemia D and periodic fever syndrome in children. Review on therapy with biological drugs and case report. | Acta paediatrica (Oslo, Norway : 1992) 20110101 |
| Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol. | Applied microbiology and biotechnology 20110101 |
| Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. | Haematologica 20110101 |
| Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. | Anti-cancer drugs 20110101 |
| Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. | Drug metabolism and disposition: the biological fate of chemicals 20110101 |
| Atorvastatin neutralises the thrombin-induced tissue factor expresion in endothelial cells via geranylgeranyl pyrophosphate. | Cytotechnology 20110101 |
| Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes. | Endocrinology 20110101 |
| Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase. | Current medicinal chemistry 20110101 |
| Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. | Drug metabolism letters 20110101 |
| Expression, identification and purification of Dictyostelium acetoacetyl-coa thiolase expressed in Escherichia coli. | International journal of biological sciences 20110101 |
| Periodic Fever syndromes. | Pediatric annals 20110101 |
| [Anti-atherosclerotic and anti-inflammatory effects of statin on cardiovascular disease and their mechanisms]. | Nihon rinsho. Japanese journal of clinical medicine 20110101 |
| Enzymatic total synthesis of gibberellin A₄ from acetate. | Bioscience, biotechnology, and biochemistry 20110101 |
| Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line. | Lipids in health and disease 20110101 |
| Differential effect of corn oil-based low trans structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated trans fat. | Lipids in health and disease 20110101 |
| γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection. | Clinical & developmental immunology 20110101 |
| An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea. | BMC evolutionary biology 20110101 |
| Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis. | Annals of clinical microbiology and antimicrobials 20110101 |
| Effects of the histone deacetylase inhibitor ITF2357 in autoinflammatory syndromes. | Molecular medicine (Cambridge, Mass.) 20110101 |
| Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. | Microbial cell factories 20110101 |
| Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen. | Breast cancer research : BCR 20110101 |
| Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency. | In vivo (Athens, Greece) 20110101 |
| Computational design of auxotrophy-dependent microbial biosensors for combinatorial metabolic engineering experiments. | PloS one 20110101 |
| Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers. | Journal of carcinogenesis 20110101 |
| Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. | PloS one 20110101 |
| Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. | Clinical and experimental rheumatology 20110101 |
| Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents. | Lipids in health and disease 20110101 |
| Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage. | Malaria journal 20110101 |
| δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens. | Lipids in health and disease 20110101 |
| The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon. | Biology direct 20110101 |
| A synthetic library of RNA control modules for predictable tuning of gene expression in yeast. | Molecular systems biology 20110101 |
| An effective assessment of simvastatin-induced toxicity with NMR-based metabonomics approach. | PloS one 20110101 |
| Biogenic volatile organic compound and respiratory CO2 emissions after 13C-labeling: online tracing of C translocation dynamics in poplar plants. | PloS one 20110101 |
| Differences in candidate gene association between European ancestry and African American asthmatic children. | PloS one 20110101 |
| Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. | BMC plant biology 20110101 |
| A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial. | Trials 20110101 |
| Residual beta cell function in newly diagnosed type 1 diabetes after treatment with atorvastatin: the Randomized DIATOR Trial. | PloS one 20110101 |
| Perinatal onset mevalonate kinase deficiency. | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 20110101 |
| Therapeutics formulated to target cancer stem cells: Is it in our future? | Cancer cell international 20110101 |
| Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. | PloS one 20110101 |
| Statins: cardiovascular risk reduction in percutaneous coronary intervention-basic and clinical evidence of hyperacute use of statins. | International journal of hypertension 20110101 |
| Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats. | Circulation journal : official journal of the Japanese Circulation Society 20110101 |
| Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly. | Clinical interventions in aging 20110101 |
| Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial. | BMC pulmonary medicine 20110101 |
| NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells. | PloS one 20110101 |
| Zoledronic acid enhances Vδ2 T-lymphocyte antitumor response to human glioma cell lines. | International journal of immunopathology and pharmacology 20110101 |
| A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells. | Lipids in health and disease 20110101 |
| Mevalonate pathway is a novel target for hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20110101 |
| Gene expression profile analysis of tobacco leaf trichomes. | BMC plant biology 20110101 |
| Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. | PloS one 20110101 |
| Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A. | BMC microbiology 20110101 |
| Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. | PloS one 20110101 |
| Therapeutic targets for bone metastases in breast cancer. | Breast cancer research : BCR 20110101 |
| Role of zoledronic acid in the prevention and treatment of osteoporosis. | Clinical interventions in aging 20110101 |
| A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana. | BMC systems biology 20110101 |
| [Autoinflammatory syndromes]. | Medicina clinica 20110101 |
| [Syndrome CINCA/NOMID]. | Medicina clinica 20110101 |
| Zoledronic acid preserves bone structure and increases survival but does not limit tumour incidence in a prostate cancer bone metastasis model. | PloS one 20110101 |
| Emerging strategies and therapies for treatment of Paget's disease of bone. | Drug design, development and therapy 20110101 |
| Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites. | Current topics in medicinal chemistry 20110101 |
| Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus. | Drug design, development and therapy 20110101 |
| A woman with recurrent 'infections' since birth--a new mevalonate kinase mutation. | Acta clinica Belgica 20110101 |
| Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription. | International journal of biological sciences 20110101 |
| Comparative gamma delta T cell immunology: a focus on mycobacterial disease in cattle. | Veterinary medicine international 20110101 |
| Malignancy-associated dyslipidemia. | The open cardiovascular medicine journal 20110101 |
| Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. | BMC microbiology 20110101 |
| Deoxyuridines from the marine sponge associated actinomycete Streptomyces microflavus. | Marine drugs 20110101 |
| Carotenoid β-ring hydroxylase and ketolase from marine bacteria-promiscuous enzymes for synthesizing functional xanthophylls. | Marine drugs 20110101 |
| In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase. | Journal of parasitology research 20110101 |
| Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats. | Lipids in health and disease 20110101 |
| Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. | PloS one 20110101 |
| The role of fatty aldehyde dehydrogenase in epidermal structure and function. | Dermato-endocrinology 20110101 |
| OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62. | PloS one 20110101 |
| Antiviral drugs against hepatitis C virus. | Genetic vaccines and therapy 20110101 |
| An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis. | BMC genomics 20110101 |
| Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. | Marine drugs 20110101 |
| The biosynthesis of isoprenoids and the mechanisms regulating it in plants. | Bioscience, biotechnology, and biochemistry 20110101 |
| Carotenoids in algae: distributions, biosyntheses and functions. | Marine drugs 20110101 |
| Gene discovery using next-generation pyrosequencing to develop ESTs for Phalaenopsis orchids. | BMC genomics 20110101 |
| Alendronate (ALN) combined with osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats. | Journal of orthopaedic surgery and research 20110101 |
| Fluorescent analysis of the cell-selective Alzheimer's disease aβ Peptide surface membrane binding: influence of membrane components. | International journal of Alzheimer's disease 20110101 |
| [The laboratory approach in the diagnosis of systemic autoinflammatory diseases]. | Reumatismo 20110101 |
| Treating statin-intolerant patients. | Diabetes, metabolic syndrome and obesity : targets and therapy 20110101 |
| [Hereditary systemic autoinflammatory diseases]. | Reumatologia clinica 20110101 |
| Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system. | Microbial cell factories 20110101 |
| Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. | PloS one 20110101 |
| Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. | PloS one 20110101 |
| Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. | Critical care (London, England) 20110101 |
| Early evolution of the biotin-dependent carboxylase family. | BMC evolutionary biology 20110101 |
| Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. | Journal of experimental & clinical cancer research : CR 20110101 |
| Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis. | Frontiers in pharmacology 20110101 |
| Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway. | PloS one 20110101 |
| 'Glucose and ethanol-dependent transcriptional regulation of the astaxanthin biosynthesis pathway in Xanthophyllomyces dendrorhous'. | BMC microbiology 20110101 |
| Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts. | Respiratory research 20110101 |
| Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis. | BMC cancer 20110101 |
| Emerging therapies for severe asthma. | BMC medicine 20110101 |
| Studies on the antibacterial effects of statins--in vitro and in vivo. | PloS one 20110101 |
| HMGB1 and cord blood: its role as immuno-adjuvant factor in innate immunity. | PloS one 20110101 |
| No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis. | Journal of biomedicine & biotechnology 20110101 |
| Expansion of human peripheral blood γδ T cells using zoledronate. | Journal of visualized experiments : JoVE 20110101 |
| In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells. | International journal of nanomedicine 20110101 |
| The hedgehog receptor patched is involved in cholesterol transport. | PloS one 20110101 |
| BglBrick vectors and datasheets: A synthetic biology platform for gene expression. | Journal of biological engineering 20110101 |
| Ameliorative effects of herbal combinations in hyperlipidemia. | Oxidative medicine and cellular longevity 20110101 |
| Imaging of zebrafish in vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin. | PloS one 20110101 |
| Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. | American journal of cancer research 20110101 |
| Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview. | Journal of translational medicine 20110101 |
| Impact of bile acids on the growth of human cholangiocarcinoma via FXR. | Journal of hematology & oncology 20110101 |
| Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. | Respiratory research 20110101 |
| Tumour macrophages as potential targets of bisphosphonates. | Journal of translational medicine 20110101 |
| Anti-α-enolase Antibodies in Serum from Pediatric Patients Affected by Inflammatory Diseases: Diagnostic and Pathogenetic Insights. | International journal of rheumatology 20110101 |
| Mechanism of resistance to dietary cholesterol. | Journal of lipids 20110101 |
| Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids. | Lipids in health and disease 20110101 |
| Expression and localization of microRNAs in perinatal rat pancreas: role of miR-21 in regulation of cholesterol metabolism. | PloS one 20110101 |
| Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors. | PloS one 20110101 |
| [Hyperimmunoglobulinemia D and periodic fever syndrome]. | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20110101 |
| Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause. | Chinese medicine 20110101 |
| Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins. | BMC genomics 20110101 |
| Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. | PloS one 20110101 |
| An essential farnesylated kinesin in Trypanosoma brucei. | PloS one 20110101 |
| Recognition of morphometric vertebral fractures by artificial neural networks: analysis from GISMO Lombardia Database. | PloS one 20110101 |
| Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro. | BMC neuroscience 20110101 |
| Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates. | Drug design, development and therapy 20110101 |
| Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB. | PloS one 20110101 |
| Adaptation to statins restricts human tumour growth in Nude mice. | BMC cancer 20110101 |
| Development and Validation of a Reversed-phase HPLC Method for Simultaneous Determination of Aspirin, Atorvastatin Calcium and Clopidogrel Bisulphate in Capsules. | Indian journal of pharmaceutical sciences 20110101 |
| Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis. | Journal of signal transduction 20110101 |
| Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study. | Acta biochimica Polonica 20110101 |
| Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma. | Sarcoma 20110101 |
| De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | BMC genomics 20110101 |
| ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer. | Journal of translational medicine 20110101 |
| Combining antihypertensive and antihyperlipidemic agents - optimizing cardiovascular risk factor management. | Integrated blood pressure control 20110101 |
| What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS). | Fibrogenesis & tissue repair 20110101 |
| Genome characterization of the oleaginous fungus Mortierella alpina. | PloS one 20110101 |
| [Statins and thrombogenesis]. | Duodecim; laaketieteellinen aikakauskirja 20110101 |
| Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. | PloS one 20110101 |
| The mevalonate pathway in C. elegans. | Lipids in health and disease 20110101 |
| The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. | PloS one 20110101 |
| Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. | BMC medical genomics 20110101 |
| Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites. | PloS one 20110101 |
| Litsea deccanensis ameliorates myocardial infarction in wistar rats: evidence from biochemical and histological studies. | Journal of young pharmacists : JYP 20110101 |
| Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective. | Pharmacognosy reviews 20110101 |
| Novel effects of statins in enhancing efficacy of chemotherapy in vitro in nasopharyngeal carcinoma. | International forum of allergy & rhinology 20110101 |
| Senescence (ageing) @ 2011. | Indian journal of dermatology 20110101 |
| Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum. | Scientific reports 20110101 |
| Genome-wide essential gene identification in Streptococcus sanguinis. | Scientific reports 20110101 |
| Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. | BMC genomics 20110101 |
| Triterpenoid biosynthesis and engineering in plants. | Frontiers in plant science 20110101 |
| Flux-balance modeling of plant metabolism. | Frontiers in plant science 20110101 |
| Effects of D-003 on Lipopolysaccharides-induced Osteonecrosis in Rabbits. | Indian journal of pharmaceutical sciences 20110101 |
| Statins inhibited erythropoietin-induced proliferation of rat vascular smooth muscle cells. | European journal of pharmacology 20101215 |
| Laminar shear stress prevents simvastatin-induced adhesion molecule expression in cytokine activated endothelial cells. | European journal of pharmacology 20101215 |
| Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process. | Cancer research 20101215 |
| Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. | International journal of cancer 20101215 |
| Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. | Chemico-biological interactions 20101205 |
| Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. | Journal of cellular and molecular medicine 20101201 |
| Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. | Annals of the rheumatic diseases 20101201 |
| Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP. | Molecular and cellular biochemistry 20101201 |
| The addition of pravastatin to chemotherapy in advanced gastric carcinoma: a randomised phase II trial. | European journal of cancer (Oxford, England : 1990) 20101201 |
| Chronic inhibition of farnesyl pyrophosphate synthase improves endothelial function in spontaneously hypertensive rats. | Biochemical pharmacology 20101201 |
| Current progress in the study on biosynthesis and regulation of ganoderic acids. | Applied microbiology and biotechnology 20101201 |
| Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? | Translational research : the journal of laboratory and clinical medicine 20101201 |
| Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). | Aging 20101201 |
| Usual dose of simvastatin does not inhibit plaque progression and lumen loss at the peri-stent reference segments after bare-metal stent implantation: a serial intravascular ultrasound analysis. | The Korean journal of internal medicine 20101201 |
| d-δ-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells. | Anticancer research 20101201 |
| Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism. | Molecular and cellular endocrinology 20101125 |
| Mast cell death induced by 24(S),25-epoxycholesterol. | Experimental cell research 20101115 |
| Atorvastatin induces apoptosis in vitro and slows growth of tumor xenografts but not polyp formation in MIN mice. | Digestive diseases and sciences 20101101 |
| Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. | Annals of hematology 20101101 |
| Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. | Glia 20101101 |
| Coenzyme Q(10) and statin myalgia: what is the evidence? | Current atherosclerosis reports 20101101 |
| Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases. | The oncologist 20101101 |
| Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review. | Current genomics 20101101 |
| Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. | Biotechnology and bioengineering 20101015 |
| The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. | The Biochemical journal 20101015 |
| On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme. | Journal of agricultural and food chemistry 20101013 |
| Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits tumor metastasis in mouse melanoma through suppression of the Rho/ROCK pathway. | Clinical & experimental metastasis 20101001 |
| Transcriptome analysis of Hpa1Xoo transformed cotton revealed constitutive expression of genes in multiple signalling pathways related to disease resistance. | Journal of experimental botany 20101001 |
| Transcriptional-metabolic networks in beta-carotene-enriched potato tubers: the long and winding road to the Golden phenotype. | Plant physiology 20101001 |
| Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. | Endocrinology 20101001 |
| Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. | Carcinogenesis 20101001 |
| Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua. | Plant physiology 20101001 |
| Pheromone production in bark beetles. | Insect biochemistry and molecular biology 20101001 |
| A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS. | Analytical and bioanalytical chemistry 20101001 |
| The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae. | The Journal of antibiotics 20101001 |
| Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency. | Journal of inherited metabolic disease 20101001 |
| Fevers and the rheumatologist. | Indian journal of pediatrics 20101001 |
| Evaluation of anti-diabetic potential of leaves and stem of Flacourtia jangomas in streptozotocin-induced diabetic rats. | Indian journal of pharmacology 20101001 |
| Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | Toxins 20101001 |
| Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. | Circulation 20100914 |
| The 'other' vasculitis syndromes and kidney involvement. | Pediatric nephrology (Berlin, Germany) 20100901 |
| High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment. | Journal of bone and mineral metabolism 20100901 |
| Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells. | European journal of pharmacology 20100901 |
| Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha. | Diabetes 20100901 |
| The isogene 1-deoxy-D-xylulose 5-phosphate synthase 2 controls isoprenoid profiles, precursor pathway allocation, and density of tomato trichomes. | Molecular plant 20100901 |
| Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae. | Phytochemistry 20100901 |
| Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. | Hypertension (Dallas, Tex. : 1979) 20100901 |
| [Periodic fever with increased IgD]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100901 |
| Subgroup 4 R2R3-MYBs in conifer trees: gene family expansion and contribution to the isoprenoid- and flavonoid-oriented responses. | Journal of experimental botany 20100901 |
| Identification of biologically relevant compounds in aboveground and belowground induced volatile blends. | Journal of chemical ecology 20100901 |
| Acute effects of intravenous administration of pamidronate in patients with osteoporosis. | Journal of Korean medical science 20100901 |
| Chemistry and biotechnology of carotenoids. | Critical reviews in food science and nutrition 20100901 |
| 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases. | Archives of neurology 20100901 |
| Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. | PLoS pathogens 20100901 |
| [Effect of acetyl-CoA synthase gene overexpression on physiological function of Saccharomyces cerevisiae]. | Wei sheng wu xue bao = Acta microbiologica Sinica 20100901 |
| Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma. | British journal of cancer 20100824 |
| Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway. | Chemical communications (Cambridge, England) 20100807 |
| Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update. | Seminars in arthritis and rheumatism 20100801 |
| Ichthyosis in Sjögren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion. | Archives of dermatological research 20100801 |
| Isoprenoids, small GTPases and Alzheimer's disease. | Biochimica et biophysica acta 20100801 |
| Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction. | Immunology 20100801 |
| Rapid reverse phase-HPLC assay of HMG-CoA reductase activity. | Journal of lipid research 20100801 |
| Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. | Cell biology international 20100801 |
| Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43. | Journal of applied physiology (Bethesda, Md. : 1985) 20100801 |
| Atorvastatin affects TLR4 clustering via lipid raft modulation. | International immunopharmacology 20100801 |
| Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP. | Journal of neurochemistry 20100801 |
| Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways. | The Biochemical journal 20100801 |
| A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis. | The Plant journal : for cell and molecular biology 20100801 |
| Biosynthesis of andrographolide in Andrographis paniculata. | Phytochemistry 20100801 |
| High throughput screening of mutants of oat that are defective in triterpene synthesis. | Phytochemistry 20100801 |
| Do structural differences in statins correlate with clinical efficacy? | Current opinion in lipidology 20100801 |
| Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx. | British journal of pharmacology 20100801 |
| Prostate specific antigen reduction following statin therapy: Mechanism of action and review of the literature. | IUBMB life 20100801 |
| Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions. | Brain research 20100730 |
| Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress. | Life sciences 20100717 |
| Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. | Cardiovascular research 20100715 |
| Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. | The Journal of biological chemistry 20100702 |
| Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells. | Cellular and molecular neurobiology 20100701 |
| Reduced LDL-cholesterol levels in patients with coronary artery disease are paralleled by improved endothelial function: An observational study in patients from 2003 and 2007. | Atherosclerosis 20100701 |
| Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and low-density lipoprotein on proliferation and migration of keratinocytes. | The British journal of dermatology 20100701 |
| The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. | European journal of human genetics : EJHG 20100701 |
| Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100701 |
| Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. | Molecular & cellular proteomics : MCP 20100701 |
| Statins and inflammation: an update. | Current opinion in cardiology 20100701 |
| Inflammasome and IL-1beta-mediated disorders. | Current allergy and asthma reports 20100701 |
| Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. | The Journal of clinical endocrinology and metabolism 20100701 |
| Studies of a biochemical factory: tomato trichome deep expressed sequence tag sequencing and proteomics. | Plant physiology 20100701 |
| Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. | Plant physiology 20100701 |
| Therapeutic modulation of k-ras signaling in colorectal cancer. | Drug discovery today 20100701 |
| Statin post-treatment provides protection against simulated ischemia in bovine pulmonary arterial endothelial cells. | European journal of pharmacology 20100625 |
| Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. | ACS chemical biology 20100618 |
| Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. | The Journal of biological chemistry 20100618 |
| Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. | The Journal of biological chemistry 20100618 |
| A novel statin-mediated 'prenylation block-and-release' assay provides insight into the membrane targeting mechanisms of small GTPases. | Biochemical and biophysical research communications 20100618 |
| Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. | Blood 20100610 |
| Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling. | Regulatory peptides 20100608 |
| Elevation of night-time temperature increases terpenoid emissions from Betula pendula and Populus tremula. | Journal of experimental botany 20100601 |
| Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601 |
| Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches. | Pharmacological research 20100601 |
| Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale. | Planta 20100601 |
| Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes. | International immunopharmacology 20100601 |
| Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway. | International immunopharmacology 20100601 |
| Stress and developmental responses of terpenoid biosynthetic genes in Cistus creticus subsp. creticus. | Plant cell reports 20100601 |
| Synthetic biology approaches in drug discovery and pharmaceutical biotechnology. | Applied microbiology and biotechnology 20100601 |
| Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis. | Cell research 20100601 |
| Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. | Molecular neurobiology 20100601 |
| Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa. | Journal of experimental botany 20100601 |
| The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains. | Plant & cell physiology 20100601 |
| The orthopaedic implications of diphosphonate therapy. | The Journal of the American Academy of Orthopaedic Surgeons 20100601 |
| Characterization of growth and metabolism of the haloalkaliphile Natronomonas pharaonis. | PLoS computational biology 20100601 |
| The molecular basis of bisphosphonate activity: a preclinical perspective. | Seminars in oncology 20100601 |
| [Immunoglobulin D]. | Nihon rinsho. Japanese journal of clinical medicine 20100601 |
| X-ray structures of isopentenyl phosphate kinase. | ACS chemical biology 20100521 |
| Coenzyme Q--biosynthesis and functions. | Biochemical and biophysical research communications 20100521 |
| Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK. | Human molecular genetics 20100515 |
| Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design. | Journal of molecular biology 20100514 |
| A historical perspective on the discovery of statins. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511 |
| Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. | Journal of cellular and molecular medicine 20100501 |
| Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. | Cardiovascular research 20100501 |
| The impact of HMG-CoA reductase therapy on serum PSA. | The Prostate 20100501 |
| Atorvastatin inhibits homocysteine-induced oxidative stress and apoptosis in endothelial progenitor cells involving Nox4 and p38MAPK. | Atherosclerosis 20100501 |
| Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. | Biotechnology and bioengineering 20100501 |
| Antiangiogenic mechanisms of simvastatin in retinal endothelial cells. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20100501 |
| Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. | Biochimica et biophysica acta 20100501 |
| Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100501 |
| Genetic variation in jasmonic acid- and spider mite-induced plant volatile emission of cucumber accessions and attraction of the predator Phytoseiulus persimilis. | Journal of chemical ecology 20100501 |
| Lipid metabolism and HCV infection. | Viruses 20100501 |
| Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. | The Journal of biological chemistry 20100430 |
| Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. | Neuroscience letters 20100426 |
| Increased anti-tumour effects of doxorubicin and zoledronic acid in prostate cancer cells in vitro: supporting the benefits of combination therapy. | Cancer chemotherapy and pharmacology 20100401 |
| Zoledronic acid decreases mRNA six-transmembrane epithelial antigen of prostate protein expression in prostate cancer cells. | Journal of endocrinological investigation 20100401 |
| Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. | Molecular and biochemical parasitology 20100401 |
| Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. | Biochimica et biophysica acta 20100401 |
| Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. | Diabetes 20100401 |
| 3-Methyl-1-butanol production in Escherichia coli: random mutagenesis and two-phase fermentation. | Applied microbiology and biotechnology 20100401 |
| A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic anemia. | Pediatrics 20100401 |
| Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis. | Bioorganic & medicinal chemistry 20100401 |
| Hyperimmunoglobulin D syndrome in childhood. | Current rheumatology reports 20100401 |
| Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. | Anticancer research 20100401 |
| The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. | British journal of cancer 20100330 |
| Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction. | British journal of cancer 20100316 |
| The evolution, metabolism and functions of the apicoplast. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20100312 |
| Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk. | British journal of cancer 20100302 |
| Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD). | Journal of molecular modeling 20100301 |
| Targeting the mevalonate pathway in multiple myeloma. | Leukemia research 20100301 |
| Statins inhibit matrix metalloproteinase release from human lung fibroblasts. | The European respiratory journal 20100301 |
| Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. | Biochemical pharmacology 20100301 |
| 2-methoxyestradiol inhibits atorvastatin-induced rounding of human vascular smooth muscle cells. | Journal of cellular physiology 20100301 |
| A genomics resource for investigating regulation of essential oil production in Lavandula angustifolia. | Planta 20100301 |
| Effect of statins on the viability of macrophages and smooth muscle cells. | Journal of cardiovascular pharmacology 20100301 |
| Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria. | FEMS microbiology letters 20100301 |
| Reconstruction of metabolic pathways, protein expression, and homeostasis machineries across maize bundle sheath and mesophyll chloroplasts: large-scale quantitative proteomics using the first maize genome assembly. | Plant physiology 20100301 |
| Statins suppress interleukin-6-induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells. | British journal of pharmacology 20100301 |
| The effect of zoledronate during bone healing. | Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20100301 |
| The effects of rosuvastatin on the serum cortisol, serum lipid, and serum mevalonic acid levels in the healthy Indian male population. | AAPS PharmSciTech 20100301 |
| Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. | Nutrition research (New York, N.Y.) 20100301 |
| Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100301 |
| A new view of alcohol metabolism and alcoholism--role of the high-Km Class III alcohol dehydrogenase (ADH3). | International journal of environmental research and public health 20100301 |
| Sponge-derived Streptomyces producing isoprenoids via the mevalonate pathway. | Journal of natural products 20100226 |
| NMR dynamics investigation of ligand-induced changes of main and side-chain arginine N-H's in human phosphomevalonate kinase. | Journal of the American Chemical Society 20100224 |
| Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. | International journal of cancer 20100215 |
| Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells. | Biochemical pharmacology 20100215 |
| Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. | Toxicology and applied pharmacology 20100215 |
| Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells. | European journal of pharmacology 20100210 |
| Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. | Applied microbiology and biotechnology 20100201 |
| Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats. | Biochemical pharmacology 20100201 |
| A novel Y331X nonsense mutation in TNFRSF1A gene in two unrelated Turkish families with periodic fever syndrome. | International journal of immunogenetics 20100201 |
| Overcoming multidrug-resistance in cancer: statins offer a logical candidate. | Medical hypotheses 20100201 |
| The PPR protein encoded by the LOVASTATIN INSENSITIVE 1 gene is involved in RNA editing at three sites in mitochondria of Arabidopsis thaliana. | The Plant journal : for cell and molecular biology 20100201 |
| AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. | The Biochemical journal 20100201 |
| The mitochondrial PPR protein LOVASTATIN INSENSITIVE 1 plays regulatory roles in cytosolic and plastidial isoprenoid biosynthesis through RNA editing. | The Plant journal : for cell and molecular biology 20100201 |
| Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. | Neurochemistry international 20100201 |
| Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. | Phytochemistry 20100201 |
| Ezetimibe effect on bone mineral density and markers of bone formation and resorption. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20100201 |
| Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. | Bioorganic & medicinal chemistry 20100201 |
| [Tgammadelta lymphocytes in oncology: unconventional killer lymphocytes]. | Medecine sciences : M/S 20100201 |
| Molecular mechanisms involved in farnesol-induced apoptosis. | Cancer letters 20100128 |
| Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. | Biochemical and biophysical research communications 20100122 |
| A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion. | British journal of cancer 20100119 |
| Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. | The Journal of biological chemistry 20100115 |
| Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells. | The Biochemical journal 20100115 |
| Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. | The Journal of biological chemistry 20100115 |
| Characterization of thermophilic archaeal isopentenyl phosphate kinases. | Biochemistry 20100112 |
| Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+. | The Journal of biological chemistry 20100108 |
| Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate. | Atherosclerosis 20100101 |
| Protective effect of atorvastatin in cultured osteoarthritic chondrocytes. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100101 |
| Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells. | Atherosclerosis 20100101 |
| Pentanol isomer synthesis in engineered microorganisms. | Applied microbiology and biotechnology 20100101 |
| Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence. | Plant physiology 20100101 |
| Effect of simvastatin on endothelial cell apoptosis mediated by Fas and TNF-alpha. | Cytokine 20100101 |
| Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis? | Calcified tissue international 20100101 |
| Pleiotropic regulatory locus 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis. | Molecular plant 20100101 |
| Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial. | International journal of endocrinology 20100101 |
| Association of statins and diabetes mellitus. | American journal of therapeutics 20100101 |
| Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. | Medical science monitor : international medical journal of experimental and clinical research 20100101 |
| Toward engineering synthetic microbial metabolism. | Journal of biomedicine & biotechnology 20100101 |
| The path to next generation biofuels: successes and challenges in the era of synthetic biology. | Microbial cell factories 20100101 |
| Polysaccharide from fuzi (FPS) prevents hypercholesterolemia in rats. | Lipids in health and disease 20100101 |
| Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. | Biology direct 20100101 |
| The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum. | Bioscience, biotechnology, and biochemistry 20100101 |
| Melanoma cells treated with GGTI and IFN-gamma allow murine vaccination and enhance cytotoxic response against human melanoma cells. | PloS one 20100101 |
| Simulation of a Petri net-based model of the terpenoid biosynthesis pathway. | BMC bioinformatics 20100101 |
| Synthetic biology: tools to design, build, and optimize cellular processes. | Journal of biomedicine & biotechnology 20100101 |
| Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression. | Endocrine journal 20100101 |
| Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz. | BMC biochemistry 20100101 |
| Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids. | Cancer cell international 20100101 |
| Chlamydia trachomatis growth inhibition and restoration of LDL-receptor level in HepG2 cells treated with mevastatin. | Comparative hepatology 20100101 |
| Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. | Breast cancer research : BCR 20100101 |
| Current status and future directions in lipid management: emphasizing low-density lipoproteins, high-density lipoproteins, and triglycerides as targets for therapy. | Vascular health and risk management 20100101 |
| Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. | BMC cancer 20100101 |
| Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function. | PloS one 20100101 |
| Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. | Lipids in health and disease 20100101 |
| A novel mutation in TNFRSF1A associated with overlapping features of tumor necrosis factor receptor-associated periodic syndrome and hyper-IgD syndrome. | Clinical and experimental rheumatology 20100101 |
| Functional genomics of mountain pine beetle (Dendroctonus ponderosae) midguts and fat bodies. | BMC genomics 20100101 |
| Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer. | BMC cancer 20100101 |
| Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. | Pharmacological reports : PR 20100101 |
| Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells. | Clinical & developmental immunology 20100101 |
| Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression. | Lipids in health and disease 20100101 |
| Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae). | BMC plant biology 20100101 |
| Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology. | Journal of biomedicine & biotechnology 20100101 |
| Socio-environmental and endocrine influences on developmental and caste-regulatory gene expression in the eusocial termite Reticulitermes flavipes. | BMC molecular biology 20100101 |
| De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. | BMC genomics 20100101 |
| Statins for acutely hospitalized patients: randomized controlled trials are long overdue. | Critical care (London, England) 20100101 |
| High-content, image-based screening for drug targets in yeast. | PloS one 20100101 |
| EST analysis reveals putative genes involved in glycyrrhizin biosynthesis. | BMC genomics 20100101 |
| Identifying essential genes in bacterial metabolic networks with machine learning methods. | BMC systems biology 20100101 |
| Cardiovascular dementia - a different perspective. | The open biochemistry journal 20100101 |
| Age-Related Hypercholesterolemia and HMG-CoA Reductase Dysregulation: Sex Does Matter (A Gender Perspective). | Current gerontology and geriatrics research 20100101 |
| A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. | Cellular immunology 20100101 |
| Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. | Nutrition & metabolism 20100101 |
| Pharmacokinetic/pharmacodynamic modeling and simulation of rosuvastatin using an extension of the indirect response model by incorporating a circadian rhythm. | Biological & pharmaceutical bulletin 20100101 |
| Niemann-Pick disease type C. | Orphanet journal of rare diseases 20100101 |
| Efficacy and safety of zoledronic acid in the treatment of glucocorticoid-induced osteoporosis. | Therapeutics and clinical risk management 20100101 |
| Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication. | Molecular systems biology 20100101 |
| The Waddlia genome: a window into chlamydial biology. | PloS one 20100101 |
| [Controversies regarding the use of statins in the acute coronary syndrome]. | Medicina intensiva 20100101 |
| Response of the mosquito protein interaction network to dengue infection. | BMC genomics 20100101 |
| Microarray analysis of relative gene expression stability for selection of internal reference genes in the rhesus macaque brain. | BMC molecular biology 20100101 |
| Identification of novel genes potentially involved in somatic embryogenesis in chicory (Cichorium intybus L.). | BMC plant biology 20100101 |
| Proteomics of plant pathogenic fungi. | Journal of biomedicine & biotechnology 20100101 |
| Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism. | PPAR research 20100101 |
| Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients. | Head & face medicine 20100101 |
| Microarray-based transcriptional profiling of Eimeria bovis-infected bovine endothelial host cells. | Veterinary research 20100101 |
| Identification and characterization of genes associated with tapping panel dryness from Hevea brasiliensis latex using suppression subtractive hybridization. | BMC plant biology 20100101 |
| The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro. | Head & face medicine 20100101 |
| Osteogenic activity of locally applied small molecule drugs in a rat femur defect model. | Journal of biomedicine & biotechnology 20100101 |
| Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy. | Journal of ophthalmology 20100101 |
| ROCK as a Therapeutic Target of Diabetic Retinopathy. | Journal of ophthalmology 20100101 |
| Contribution of mevalonate and methylerythritol phosphate pathways to polyisoprenoid biosynthesis in the rubber-producing plant Eucommia ulmoides oliver. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101 |
| Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis. | Therapeutics and clinical risk management 20100101 |
| Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii. | Archaea (Vancouver, B.C.) 20100101 |
| Radiation-induced DNA damage and repair in human gammadelta and alphabeta T-lymphocytes analysed by the alkaline comet assay. | Genome integrity 20100101 |
| Therapeutic effect of oral bisphosphonates on choroidal neovascularization in the human eye. | Journal of ophthalmology 20100101 |
| The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease. | PPAR research 20100101 |
| Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. | Marine drugs 20100101 |
| Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition. | Current pharmaceutical design 20100101 |
| Structural comparison of human mammalian ste20-like kinases. | PloS one 20100101 |
| Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism. | Cardiovascular diabetology 20100101 |
| The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation. | Arthritis research & therapy 20100101 |
| Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone. | BMC cancer 20100101 |
| Competing activities of heterotrimeric G proteins in Drosophila wing maturation. | PloS one 20100101 |
| Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. | PloS one 20100101 |
| AMPK-Dependent Metabolic Regulation by PPAR Agonists. | PPAR research 20100101 |
| Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. | BMC pediatrics 20100101 |
| HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. | Molecular systems biology 20100101 |
| Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. | PloS one 20100101 |
| Synthetic biology guides biofuel production. | Journal of biomedicine & biotechnology 20100101 |
| Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination. | Cancer cell international 20100101 |
| Analyzing the regulation of metabolic pathways in human breast cancer. | BMC medical genomics 20100101 |
| Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. | PloS one 20100101 |
| Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway. | Journal of experimental & clinical cancer research : CR 20100101 |
| Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. | BMC plant biology 20100101 |
| Cloning and characterization of a putative farnesoic acid O-methyltransferase gene from the brown planthopper, Nilaparvata lugens. | Journal of insect science (Online) 20100101 |
| Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. | PloS one 20100101 |
| Statins and clinical outcome of acute ischemic stroke: a systematic review. | International archives of medicine 20100101 |
| Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body. | BMC genomics 20100101 |
| Pediatric hereditary autoinflammatory syndromes. | Jornal de pediatria 20100101 |
| Human γδ T lymphocytes for immunotherapeutic strategies against cancer. | F1000 medicine reports 20100101 |
| Perioperative protective effects of statins. | F1000 medicine reports 20100101 |
| Periodic fever syndrome and autoinflammatory diseases. | F1000 medicine reports 20100101 |
| Deciphering the intracellular metabolism of Listeria monocytogenes by mutant screening and modelling. | BMC genomics 20100101 |
| Benefits of statin therapy and compliance in high risk cardiovascular patients. | Vascular health and risk management 20100101 |
| Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. | BMC plant biology 20100101 |
| Gene discovery from Jatropha curcas by sequencing of ESTs from normalized and full-length enriched cDNA library from developing seeds. | BMC genomics 20100101 |
| Superparamagnetic bifunctional bisphosphonates nanoparticles: a potential MRI contrast agent for osteoporosis therapy and diagnostic. | Journal of osteoporosis 20100101 |
| Survey of artemisinin production by diverse Artemisia species in northern Pakistan. | Malaria journal 20100101 |
| Biology by design: from top to bottom and back. | Journal of biomedicine & biotechnology 20100101 |
| Distribution and biosynthesis of 20-hydroxyecdysone in plants of Achyranthes japonica Nakai. | Bioscience, biotechnology, and biochemistry 20100101 |
| Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. | BMC molecular biology 20100101 |
| Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells. | Lipids in health and disease 20100101 |
| Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis. | Molecular systems biology 20100101 |
| Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. | Journal of clinical lipidology 20100101 |
| Combined mutation and rearrangement screening by quantitative PCR high-resolution melting: is it relevant for hereditary recurrent Fever genes? | PloS one 20100101 |
| Mechanism of statin-induced contractile dysfunction in rat cultured skeletal myofibers. | Journal of pharmacological sciences 20100101 |
| Combination therapy of statin and ezetimibe for the treatment of familial hypercholesterolemia. | Vascular health and risk management 20100101 |
| Zoledronic acid infusion for prevention and treatment of osteoporosis. | International journal of women's health 20100101 |
| Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. | PloS one 20100101 |
| Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol. | PloS one 20100101 |
| Nicotiana benthamiana as a production platform for artemisinin precursors. | PloS one 20100101 |
| Metabolic and transcriptomic responses of weaned pigs induced by different dietary amylose and amylopectin ratio. | PloS one 20100101 |
| Simvastatin impairs murine melanoma growth. | Lipids in health and disease 20100101 |
| Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice. | Lipids in health and disease 20100101 |
| Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications. | BMC genomics 20100101 |
| Anti-tumour activity of bisphosphonates in preclinical models of breast cancer. | Breast cancer research : BCR 20100101 |
| Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats. | Journal of pharmacy & bioallied sciences 20100101 |
| Improving the iMM904 S. cerevisiae metabolic model using essentiality and synthetic lethality data. | BMC systems biology 20100101 |
| Optimal management of familial hypercholesterolemia: treatment and management strategies. | Vascular health and risk management 20100101 |
| Elevated immunoglobulin D levels in children with PFAPA syndrome. | Neuro endocrinology letters 20100101 |
| A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity. | PloS one 20100101 |
| T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade. | PloS one 20100101 |
| Simultaneous effects of light intensity and phosphorus supply on the sterol content of phytoplankton. | PloS one 20100101 |
| The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. | PloS one 20100101 |
| Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis. | BMC genomics 20100101 |
| Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. | Drug design, development and therapy 20100101 |
| Bridging the gap between fluxomics and industrial biotechnology. | Journal of biomedicine & biotechnology 20100101 |
| Structural and functional characterization of HMG-COA reductase from Artemisia annua. | Bioinformation 20100101 |
| Deciphering the nuclear bile acid receptor FXR paradigm. | Nuclear receptor signaling 20100101 |
| Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells. | Mediators of inflammation 20100101 |
| Controversial data on simvastatin in asthma: What about the rat model? | Journal of asthma and allergy 20100101 |
| Pleiotropic effects of rosuvastatin on microvascular function in type 2 diabetes. | Diabetes, metabolic syndrome and obesity : targets and therapy 20100101 |
| Pitavastatin: evidence for its place in treatment of hypercholesterolemia. | Core evidence 20100101 |
| Accumulation of VEGFR2 in zoledronic acid-treated endothelial cells. | Molecular medicine reports 20100101 |
| Down-regulation of the global regulator SATB1 by statins in COLO205 colon cancer cells. | Molecular medicine reports 20100101 |
| Intravenous bisphosphonates for postmenopausal osteoporosis. | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20100101 |
| Rosuvastatin counteracts vessel arterialisation and sinusoid capillarisation, reduces tumour growth, and prolongs survival in murine hepatocellular carcinoma. | Gastroenterology research and practice 20100101 |
| Management of glucocorticoid-induced osteoporosis: prevalence, and emerging treatment options. | Drug, healthcare and patient safety 20100101 |
| Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management. | Drug, healthcare and patient safety 20100101 |
| Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. | Pharmacognosy reviews 20100101 |
| Various types and management of breast cancer: an overview. | Journal of advanced pharmaceutical technology & research 20100101 |
| Pharmacological management of metabolic syndrome and its lipid complications. | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101 |
| The use of statins in hematopoietic stem cell transplantation. | Current stem cell research & therapy 20091201 |
| Abnormal IgD and IgA1 O-glycosylation in hyperimmunoglobulinaemia D and periodic fever syndrome. | Clinical and experimental medicine 20091201 |
| Operons. | Cellular and molecular life sciences : CMLS 20091201 |
| Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091201 |
| Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201 |
| The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. | Bone 20091201 |
| Simvastatin inhibits Candida albicans biofilm in vitro. | Pediatric research 20091201 |
| Social and ethical checkpoints for bottom-up synthetic biology, or protocells. | Systems and synthetic biology 20091201 |
| Synthetic biology: ethical ramifications 2009. | Systems and synthetic biology 20091201 |
| Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones. | Bioorganic & medicinal chemistry 20091201 |
| Towards commercial production of sponge medicines. | Marine drugs 20091201 |
| Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae. | Toxins 20091201 |
| Simvastatin as a potential therapeutic for acute respiratory distress syndrome. | American journal of respiratory and critical care medicine 20091115 |
| Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. | Virology 20091110 |
| Stimulation of artemisinin synthesis by combined cerebroside and nitric oxide elicitation in Artemisia annua hairy roots. | Applied microbiology and biotechnology 20091101 |
| Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. | Biology of reproduction 20091101 |
| Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. | Journal of molecular and cellular cardiology 20091101 |
| Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation. | Biochimica et biophysica acta 20091101 |
| Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells. | Apoptosis : an international journal on programmed cell death 20091101 |
| Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. | Journal of immunology (Baltimore, Md. : 1950) 20091101 |
| [Autoinflammatory diseases in childhood]. | Zeitschrift fur Rheumatologie 20091101 |
| The 423Q polymorphism of the X-linked inhibitor of apoptosis gene influences monocyte function and is associated with periodic fever. | Arthritis and rheumatism 20091101 |
| Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. | International journal of environmental research and public health 20091101 |
| Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. | Biochemical and biophysical research communications 20091030 |
| Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. | American journal of respiratory and critical care medicine 20091015 |
| Green and black tea extracts inhibit HMG-CoA reductase and activate AMP kinase to decrease cholesterol synthesis in hepatoma cells. | The Journal of nutritional biochemistry 20091001 |
| Mevalonate pathway modulation is associated with hepatitis C virus RNA presence in peripheral blood mononuclear cells. | Virus research 20091001 |
| Low LDL cholesterol, albuminuria, and statins for the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry. | Diabetes care 20091001 |
| Molecular characterization of the Oncidium orchid HDR gene encoding 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, the last step of the methylerythritol phosphate pathway. | Plant cell reports 20091001 |
| Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001 |
| Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli. | Applied microbiology and biotechnology 20091001 |
| Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase. | Insect biochemistry and molecular biology 20091001 |
| Targeting the airway smooth muscle for asthma treatment. | Translational research : the journal of laboratory and clinical medicine 20091001 |
| Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | Lipids 20091001 |
| Differentiating PFAPA syndrome from monogenic periodic fevers. | Pediatrics 20091001 |
| Statin therapy and risk of developing type 2 diabetes: a meta-analysis. | Diabetes care 20091001 |
| Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials. | The Lancet. Oncology 20090909 |
| Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090909 |
| Identified biosynthetic pathway of aspergiolide A and a novel strategy to increase its production in a marine-derived fungus Aspergillus glaucus by feeding of biosynthetic precursors and inhibitors simultaneously. | Bioresource technology 20090901 |
| Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090901 |
| Spatial expression of the mevalonate enzymes involved in juvenile hormone biosynthesis in the corpora allata in Bombyx mori. | Journal of insect physiology 20090901 |
| Functional analysis and subcellular localization of two geranylgeranyl diphosphate synthases from Penicillium paxilli. | Molecular genetics and genomics : MGG 20090901 |
| Adverse effects of statins - mechanisms and consequences. | Current drug safety 20090901 |
| REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. | PLoS biology 20090901 |
| [Pharmacological profile and clinical efficacy of minodronic acid hydrate as a new therapeutic agent for osteoporosis]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20090901 |
| Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation. | European cytokine network 20090901 |
| Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. | European cytokine network 20090901 |
| Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages. | Bulletin of experimental biology and medicine 20090901 |
| Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. | Biochemical pharmacology 20090815 |
| Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants, and comparison with galactose-1-phosphate kinase. | The Journal of biological chemistry 20090807 |
| Synthetic biology and biomass conversion: a match made in heaven? | Journal of the Royal Society, Interface 20090806 |
| Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells. | Biology of reproduction 20090801 |
| Inhibition of the mevalonate pathway rescues the dexamethasone-induced suppression of the mineralization in osteoblasts via enhancing bone morphogenetic protein-2 signal. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090801 |
| Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. | Neurobiology of disease 20090801 |
| Coenzyme Q(10) is decreased in fibroblasts of patients with methylmalonic aciduria but not in mevalonic aciduria. | Journal of inherited metabolic disease 20090801 |
| Targeting the mevalonate pathway for improved anticancer therapy. | Current cancer drug targets 20090801 |
| A clinical criterion to exclude the hyperimmunoglobulin D syndrome (mild mevalonate kinase deficiency) in patients with recurrent fever. | The Journal of rheumatology 20090801 |
| OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. | Journal of molecular medicine (Berlin, Germany) 20090801 |
| Autoinflammatory syndromes behind the scenes of recurrent fevers in children. | Medical science monitor : international medical journal of experimental and clinical research 20090801 |
| Synthetic protein scaffolds provide modular control over metabolic flux. | Nature biotechnology 20090801 |
| A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. | PLoS genetics 20090801 |
| Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. | International journal of molecular sciences 20090801 |
| Revisiting the IspH catalytic system in the deoxyxylulose phosphate pathway: achieving high activity. | Journal of the American Chemical Society 20090729 |
| Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle. | The Journal of biological chemistry 20090724 |
| Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica. | The Journal of biological chemistry 20090724 |
| Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family. | Biochemistry 20090714 |
| B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome. | European journal of pediatrics 20090701 |
| Additive interaction between the renin-angiotensin system and lipid metabolism for cancer in type 2 diabetes. | Diabetes 20090701 |
| Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids. | Archives of biochemistry and biophysics 20090701 |
| Two terpene synthases are responsible for the major sesquiterpenes emitted from the flowers of kiwifruit (Actinidia deliciosa). | Journal of experimental botany 20090701 |
| The effects of arbuscular mycorrhizal fungi on direct and indirect defense metabolites of Plantago lanceolata L. | Journal of chemical ecology 20090701 |
| Insect-induced gene expression at the core of volatile terpene release in Medicago truncatula. | Plant signaling & behavior 20090701 |
| Thiopyrophosphoantigens: solid-phase synthesis and in vitro characterization of a new class of Vgamma9 Vdelta2 T cells activators. | Journal of medicinal chemistry 20090625 |
| Cholesterol biosynthesis modulation regulates dengue viral replication. | Virology 20090620 |
| Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. | Journal of immunology (Baltimore, Md. : 1950) 20090615 |
| Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats. | Evidence-based complementary and alternative medicine : eCAM 20090601 |
| High-dose lovastatin decreased basal prostacyclin production in cultured endothelial cells. | Prostaglandins & other lipid mediators 20090601 |
| Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin. | Investigative ophthalmology & visual science 20090601 |
| Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. | Journal of biochemistry 20090601 |
| Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20090601 |
| Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. | International immunology 20090601 |
| Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation. | European journal of immunology 20090601 |
| Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast. | Genes to cells : devoted to molecular & cellular mechanisms 20090601 |
| Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants. | PLoS neglected tropical diseases 20090601 |
| Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts. | The Journal of pharmacy and pharmacology 20090601 |
| The intermediate enzymes of isoprenoid metabolism as anticancer targets. | Anti-cancer agents in medicinal chemistry 20090601 |
| Alendronate inhibits growth of high-grade chondrosarcoma cells. | Anticancer research 20090601 |
| Established and newly proposed mechanisms of chronic cyclosporine nephropathy. | The Korean journal of internal medicine 20090601 |
| Two regulatory mechanisms of monoterpenoid pheromone production in Ips spp. of bark beetles. | Journal of chemical ecology 20090601 |
| Expression, purification, characteristics and homology modeling of the HMGS from Streptococcus pneumoniae. | Biomedical and environmental sciences : BES 20090601 |
| Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats. | Experimental lung research 20090601 |
| Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. | The Journal of biological chemistry 20090529 |
| Human caspase 7 is positively controlled by SREBP-1 and SREBP-2. | The Biochemical journal 20090527 |
| Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells. | Life sciences 20090522 |
| Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. | The Journal of biological chemistry 20090522 |
| Regulation of different inflammatory diseases by impacting the mevalonate pathway. | Immunology 20090501 |
| A novel third generation bisphosphonate, minodronate (YM529), prevented proliferation and migration of hepatocellular carcinoma cells through inhibition of mevalonate pathway. | Hepatology research : the official journal of the Japan Society of Hepatology 20090501 |
| Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. | Diabetes care 20090501 |
| Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. | Drug metabolism and disposition: the biological fate of chemicals 20090501 |
| d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells. | Pancreas 20090501 |
| Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action. | International journal of molecular medicine 20090501 |
| Complete blockage of the mevalonate pathway results in male gametophyte lethality. | Journal of experimental botany 20090501 |
| Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. | Molecular bioSystems 20090501 |
| DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells. | European journal of immunology 20090501 |
| Periodic fever syndromes. | Pediatrics in review 20090501 |
| The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae. | FEMS yeast research 20090501 |
| Iron-sulfur (Fe/S) protein biogenesis: phylogenomic and genetic studies of A-type carriers. | PLoS genetics 20090501 |
| Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. | Metabolic engineering 20090501 |
| gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. | Radiation research 20090501 |
| Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study. | Yonsei medical journal 20090430 |
| A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy. | Journal of medicinal chemistry 20090423 |
| Statins, stem cells, and cancer. | Journal of cellular biochemistry 20090415 |
| Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. | Journal of immunology (Baltimore, Md. : 1950) 20090415 |
| Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism. | Proteins 20090401 |
| Overexpression of the gene encoding HMG-CoA reductase in Saccharomyces cerevisiae for production of prenyl alcohols. | Applied microbiology and biotechnology 20090401 |
| Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells. | Melanoma research 20090401 |
| Measurement of human serum IgD levels. | Current protocols in immunology 20090401 |
| Indirect antitumor effects of bisphosphonates on prostatic LNCaP cells co-cultured with bone cells. | Anticancer research 20090401 |
| [The effects of simvastatin on cardiac hypertrophy and association on calcium channel modulation in rats with myocardial hypertrophy induced by abdominal aortic constriction]. | Zhonghua xin xue guan bing za zhi 20090401 |
| Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli. | Journal of biotechnology 20090325 |
| N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. | International journal of cancer 20090315 |
| Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. | The Journal of biological chemistry 20090313 |
| Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. | The Journal of biological chemistry 20090313 |
| Potential immunologic effects of statins in cancer following transplantation. | Cancer immunology, immunotherapy : CII 20090301 |
| High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. | The international journal of biochemistry & cell biology 20090301 |
| Birth prevalence of homocystinuria in Central Europe: frequency and pathogenicity of mutation c.1105C>T (p.R369C) in the cystathionine beta-synthase gene. | The Journal of pediatrics 20090301 |
| Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20090301 |
| Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes. | Rheumatology (Oxford, England) 20090301 |
| Rosuvastatin positively changes nerve electrophysiology in diabetic rats. | Diabetes/metabolism research and reviews 20090301 |
| Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. | Nature genetics 20090301 |
| Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway. | PLoS pathogens 20090301 |
| Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. | Journal of cell communication and signaling 20090301 |
| The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico. | Marine drugs 20090301 |
| Simvastatin treatment induces morphology alterations and apoptosis in murine cochlear neuronal cells. | Acta oto-laryngologica 20090201 |
| Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei. | International journal for parasitology 20090201 |
| Atorvastatin decreases stearoyl-CoA desaturase gene expression in THP-1 macrophages incubated with oxidized LDL. | Lipids 20090201 |
| Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. | Arteriosclerosis, thrombosis, and vascular biology 20090201 |
| Recurrent arthritis as a unique manifestation of hyperimmunoglobulinaemia D. | Rheumatology (Oxford, England) 20090201 |
| Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation. | Journal of neurochemistry 20090201 |
| A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. | PLoS pathogens 20090201 |
| Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level. | European journal of pharmacology 20090114 |
| Pleiotropic effects and cholesterol-lowering therapy. | Cardiology 20090101 |
| Inhibition of the mevalonate pathway potentiates the effects of lenalidomide in myeloma. | Leukemia research 20090101 |
| Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. | Metabolic engineering 20090101 |
| Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. | Applied microbiology and biotechnology 20090101 |
| Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination. | Experimental neurology 20090101 |
| Hyper-IgD syndrome with novel mutation in a Japanese girl. | Modern rheumatology 20090101 |
| Osteonecrosis of the jaw: who gets it, and why? | Bone 20090101 |
| Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. | American journal of physiology. Cell physiology 20090101 |
| Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression. | American journal of physiology. Endocrinology and metabolism 20090101 |
| Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. | British journal of haematology 20090101 |
| Engineering prokaryotic gene circuits. | FEMS microbiology reviews 20090101 |
| Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways. | Phytochemistry 20090101 |
| Regulation by transcription factors in bacteria: beyond description. | FEMS microbiology reviews 20090101 |
| Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. | BMC plant biology 20090101 |
| Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study. | Lipids in health and disease 20090101 |
| Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. | PLoS genetics 20090101 |
| The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells. | The Plant cell 20090101 |
| Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports. | Journal of experimental & clinical cancer research : CR 20090101 |
| Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. | BMC chemical biology 20090101 |
| The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. | PloS one 20090101 |
| Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. | BMC cancer 20090101 |
| The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. | PloS one 20090101 |
| An account of cloned genes of Methyl-erythritol-4-phosphate pathway of isoprenoid biosynthesis in plants. | Current issues in molecular biology 20090101 |
| Multivariate explanatory model for sporadic carcinoma of the colon in Dukes' stages I and IIa. | International journal of medical sciences 20090101 |
| A comparative genomics study of genetic products potentially encoding ladderane lipid biosynthesis. | Biology direct 20090101 |
| High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. | PloS one 20090101 |
| Developments in the scientific and clinical understanding of autoinflammatory disorders. | Arthritis research & therapy 20090101 |
| Statin pleiotropy against renal injury. | Journal of the cardiometabolic syndrome 20090101 |
| Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes. | Genome biology 20090101 |
| Effects of statins on the secretion of human serum albumin in cultured HepG2 cells. | Journal of biomedical science 20090101 |
| RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation. | Journal of translational medicine 20090101 |
| Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). | Annual review of immunology 20090101 |
| Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model. | Immunity & ageing : I & A 20090101 |
| Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics. | PloS one 20090101 |
| Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. | PloS one 20090101 |
| Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. | PloS one 20090101 |
| Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats. | Respiratory research 20090101 |
| Prevention of atherosclerosis in patients living with HIV. | Vascular health and risk management 20090101 |
| Potential antitumor effects of nitrogen-containing bisphosphonate in hormone receptor negative breast cancer patients with bone metastases. | BMC cancer 20090101 |
| Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-alpha in macrophages. | Journal of biomedical science 20090101 |
| Efficacy, effectiveness and real life goal attainment of statins in managing cardiovascular risk. | Vascular health and risk management 20090101 |
| Fixed combination of amlodipine and atorvastatin in cardiovascular risk management: patient perspectives. | Vascular health and risk management 20090101 |
| Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer. | PloS one 20090101 |
| Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells. | PloS one 20090101 |
| Once-yearly zoledronic acid in hip fracture prevention. | Clinical interventions in aging 20090101 |
| Efficacy and safety of risedronate 150 mg once a month in the treatment of postmenopausal osteoporosis. | Clinical interventions in aging 20090101 |
| Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells. | PloS one 20090101 |
| The biosynthesis and accumulation of beta-carotene in Dunaliella salina proceed via the glyceraldehyde 3-phosphate/pyruvate pathway. | Natural product research 20090101 |
| The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. | BMC medical genetics 20090101 |
| Automated genome mining for natural products. | BMC bioinformatics 20090101 |
| A functional gammadeltaTCR/CD3 complex distinct from gammadeltaT cells is expressed by human eosinophils. | PloS one 20090101 |
| Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH). | BMC genomics 20090101 |
| Children's toxicology from bench to bed--Liver Injury (4): Mitochondrial respiratory chain disorder and liver disease in children. | The Journal of toxicological sciences 20090101 |
| Lipoproteins, cholesterol homeostasis and cardiac health. | International journal of biological sciences 20090101 |
| Simvastatin reduces OX40 and OX40 ligand expression in human peripheral blood mononuclear cells and in patients with atherosclerotic cerebral infarction. | The Journal of international medical research 20090101 |
| Bacillus subtilis as potential producer for polyhydroxyalkanoates. | Microbial cell factories 20090101 |
| Nummular keratopathy in a patient with Hyper-IgD Syndrome. | Pediatric rheumatology online journal 20090101 |
| Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: extending MapMan ontology for grapevine. | BMC plant biology 20090101 |
| Are all n-3 polyunsaturated fatty acids created equal? | Lipids in health and disease 20090101 |
| Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | Interdisciplinary perspectives on infectious diseases 20090101 |
| Quantification of dolichol in the human lens with different types of cataracts. | Molecular vision 20090101 |
| The innate immune and systemic response in honey bees to a bacterial pathogen, Paenibacillus larvae. | BMC genomics 20090101 |
| RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension. | Vascular health and risk management 20090101 |
| Comparative 454 pyrosequencing of transcripts from two olive genotypes during fruit development. | BMC genomics 20090101 |
| Statins, fracture risk, and bone remodeling. | Journal of endocrinological investigation 20090101 |
| Comparative analyses of genotype dependent expressed sequence tags and stress-responsive transcriptome of chickpea wilt illustrate predicted and unexpected genes and novel regulators of plant immunity. | BMC genomics 20090101 |
| Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection. | Genome biology 20090101 |
| The inherited autoinflammatory syndrome: a decade of discovery. | Transactions of the American Clinical and Climatological Association 20090101 |
| Comparative SNP diversity among four Eucalyptus species for genes from secondary metabolite biosynthetic pathways. | BMC genomics 20090101 |
| Perspectives on using physcomitrella patens as an alternative production platform for thapsigargin and other terpenoid drug candidates. | Perspectives in medicinal chemistry 20090101 |
| Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. | BMC genomics 20090101 |
| Prenylation of aromatic compounds, a key diversification of plant secondary metabolites. | Phytochemistry 20090101 |
| Alendronate inhibits VEGF expression in growth plate chondrocytes by acting on the mevalonate pathway. | The open orthopaedics journal 20090101 |
| Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion. | Mediators of inflammation 20090101 |
| Gastrointestinal tolerability with ibandronate after previous weekly bisphosphonate treatment. | Clinical interventions in aging 20090101 |
| Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. | BMC medical genetics 20090101 |
| [Utility of denaturing high performance liquid chromatography (DHPLC) for the diagnosis of mevalonate kinase deficiency in periodic disease]. | Reumatismo 20090101 |
| Pleiotropic vasoprotective effects of statins: the chicken or the egg? | Drug design, development and therapy 20090101 |
| Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans. | PloS one 20090101 |
| The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway. | PloS one 20090101 |
| A genome-wide survey for host response of silkworm, Bombyx mori during pathogen Bacillus bombyseptieus infection. | PloS one 20090101 |
| A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival. | BMC medical genomics 20090101 |
| Cloning, expression and purification of an acetoacetyl CoA thiolase from sunflower cotyledon. | International journal of biological sciences 20090101 |
| Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). | PloS one 20090101 |
| Conjugated hyperbilirubinaemia as the first manifestation of mevalonic aciduria in a term newborn. | Neuro endocrinology letters 20090101 |
| Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | PloS one 20090101 |
| Transgenic fat-1 mouse as a model to study the pathophysiology of cardiovascular, neurological and psychiatric disorders. | Lipids in health and disease 20090101 |
| The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences. | Vascular health and risk management 20090101 |
| Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature. | Genome biology and evolution 20090101 |
| Intravenous zoledronic acid for the treatment of osteoporosis: The evidence of its therapeutic effect. | Core evidence 20090101 |
| Frontiers in the pathogenesis of Alzheimer's disease. | Indian journal of psychiatry 20090101 |
| Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. | Journal of the American Chemical Society 20081224 |
| Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation. | Biochemical and biophysical research communications 20081212 |
| Reconstruction of a bacterial isoprenoid biosynthetic pathway in Saccharomyces cerevisiae. | FEBS letters 20081210 |
| Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation. | Life sciences 20081205 |
| Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | Journal of lipid research 20081201 |
| The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. | Endocrine-related cancer 20081201 |
| Detection of nonsterol isoprenoids by HPLC-MS/MS. | Analytical biochemistry 20081201 |
| Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. | Archives of biochemistry and biophysics 20081201 |
| From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway. | Lipids 20081201 |
| A patient with hyper-IgD syndrome responding to simvastatin treatment. | European journal of internal medicine 20081201 |
| Biosynthetic evidence supporting the generation of terpene chemodiversity in marine mollusks of the genus Doriopsilla. | Journal of natural products 20081201 |
| Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression. | Journal of medicinal food 20081201 |
| Genetic changes that correlate with the pine-oil disinfectant-reduced susceptibility mechanism of Staphylococcus aureus. | Journal of applied microbiology 20081201 |
| A theoretical model for template-free synthesis of long DNA sequence. | Systems and synthetic biology 20081201 |
| Methyl 5,7-dihydr-oxy-2,2,9-trimethyl-6,11-dioxo-6,11-dihydro-2H-anthra[2,3-b]pyran-8-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20081201 |
| Lipid rafts and T-lymphocyte function: implications for autoimmunity. | FEBS letters 20081112 |
| Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | The Journal of biological chemistry 20081107 |
| Modulation of osteoclastogenesis by fatty acids. | Endocrinology 20081101 |
| HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. | Blood 20081101 |
| Simvastatin activates Keap1/Nrf2 signaling in rat liver. | Journal of molecular medicine (Berlin, Germany) 20081101 |
| Dehydroepiandrosterone induces growth arrest of hepatoma cells via alteration of mitochondrial gene expression and function. | International journal of oncology 20081101 |
| Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. | Plant physiology 20081101 |
| Biosynthesis of aurachins A-L in Stigmatella aurantiaca: a feeding study. | Journal of natural products 20081101 |
| Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis. | Bioscience, biotechnology, and biochemistry 20081101 |
| Molecular analysis of post-harvest withering in grape by AFLP transcriptional profiling. | Journal of experimental botany 20081101 |
| Long-term follow-up, clinical features, and quality of life in a series of 103 patients with hyperimmunoglobulinemia D syndrome. | Medicine 20081101 |
| Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. | International journal of molecular sciences 20081101 |
| Regulation of oxidative stress and cardioprotection in diabetes mellitus. | Current cardiology reviews 20081101 |
| Hyperimmunoglobulinemia D and periodic fever syndrome; treatment with etanercept and follow-up. | Clinical rheumatology 20081001 |
| HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression. | Cardiovascular research 20081001 |
| Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin. | Molecular and cellular biochemistry 20081001 |
| Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. | The Journal of pharmacology and experimental therapeutics 20081001 |
| Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins. | Diabetes 20081001 |
| Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation. | Journal of leukocyte biology 20081001 |
| Isoprenoid quantitation in human brain tissue: a validated HPLC-fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP). | Analytical and bioanalytical chemistry 20081001 |
| Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments. | Biochemical pharmacology 20081001 |
| Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae. | Biochimica et biophysica acta 20081001 |
| Do bisphosphonates and statins have a role in spondyloarthritis management? | Current rheumatology reports 20081001 |
| Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation. | European journal of immunology 20081001 |
| Autoinflammatory diseases. | Best practice & research. Clinical rheumatology 20081001 |
| Targeting multiple dyslipidemias with fixed combinations--focus on extended release niacin and simvastatin. | Vascular health and risk management 20081001 |
| [Ibandronate in the treatment of postmenopausal osteoporosis]. | Lege artis medicinae : uj magyar orvosi hirmondo 20081001 |
| Miscellaneous. | Indian journal of pharmacology 20081001 |
| HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway. | Biochemical and biophysical research communications 20080919 |
| Lovastatin inhibits TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. | Investigative ophthalmology & visual science 20080901 |
| Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. | Kidney international 20080901 |
| Effects of HMG-CoA reductase inhibitors (statins) on progression of kidney disease. | Kidney international 20080901 |
| The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia. | British journal of haematology 20080901 |
| Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20080901 |
| Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis. | Current medical research and opinion 20080901 |
| Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system. | Journal of natural products 20080901 |
| Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent. | Thrombosis and haemostasis 20080901 |
| Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids. | Journal of biotechnology 20080831 |
| [The anticancer properties of statins]. | Postepy higieny i medycyny doswiadczalnej (Online) 20080807 |
| Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. | Pediatric research 20080801 |
| Increase of serum cholesterol levels by heat-moisture-treated high-amylose cornstarch in rats fed a high-cholesterol diet. | Lipids 20080801 |
| Rerouting of pyruvate metabolism during acid adaptation in Lactobacillus bulgaricus. | Proteomics 20080801 |
| Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. | European journal of immunology 20080801 |
| Synchronization of the cell cycle using lovastatin. | Cell cycle (Georgetown, Tex.) 20080801 |
| Cloning and characterization of mevalonate pathway genes in a natural rubber producing plant, Hevea brasiliensis. | Bioscience, biotechnology, and biochemistry 20080801 |
| The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke. | International journal of stroke : official journal of the International Stroke Society 20080801 |
| Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. | Archivum immunologiae et therapiae experimentalis 20080801 |
| Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. | Biochemical and biophysical research communications 20080725 |
| Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plants. | The Journal of biological chemistry 20080725 |
| Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins. | FEBS letters 20080723 |
| Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway. | Spine 20080715 |
| Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. | The Journal of nutritional biochemistry 20080701 |
| Autoinflammatory diseases: an update of clinical and genetic aspects. | Rheumatology (Oxford, England) 20080701 |
| Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression. | Molecular pharmacology 20080701 |
| Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanism. | The Journal of pharmacology and experimental therapeutics 20080701 |
| Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase--role of the catalytic center in mRNA recognition. | The FEBS journal 20080701 |
| High-content assay to study protein prenylation. | Journal of biomolecular screening 20080701 |
| Statins and prostate cancer prevention: where we are now, and future directions. | Nature clinical practice. Urology 20080701 |
| Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | Thrombosis and haemostasis 20080701 |
| Pravastatin increases the expression of the tissue inhibitor of matrix metalloproteinase-1 and the oncogene Bax in human aortic abdominal aneurysms. | Canadian journal of physiology and pharmacology 20080701 |
| Risks and benefits of bisphosphonates. | British journal of cancer 20080603 |
| The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. | European journal of pediatrics 20080601 |
| Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080601 |
| Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety. | Toxicology in vitro : an international journal published in association with BIBRA 20080601 |
| LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. | Atherosclerosis 20080601 |
| Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes. | Diabetes research and clinical practice 20080601 |
| Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery. | The FEBS journal 20080601 |
| Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. | Cell research 20080601 |
| A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children. | Arthritis and rheumatism 20080601 |
| [Muscle and bone health as a risk factor of fall among the elderly. Prevention of fracture and bisphosphonate]. | Clinical calcium 20080601 |
| Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. | The AAPS journal 20080601 |
| Emerging lipid-lowering drugs: squalene synthase inhibitors. | Expert opinion on emerging drugs 20080601 |
| Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin. | Archives of neurology 20080601 |
| 7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. | Journal of atherosclerosis and thrombosis 20080601 |
| Bisphosphonates in the management of postmenopausal osteoporosis--optimizing efficacy in clinical practice. | Clinical interventions in aging 20080601 |
| The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. | Therapeutics and clinical risk management 20080601 |
| Cholesterol-induced stimulation of postinflammatory liver fibrosis. | Bulletin of experimental biology and medicine 20080601 |
| Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. | The Journal of biological chemistry 20080530 |
| Polyisoprenoid epoxides stimulate the biosynthesis of coenzyme Q and inhibit cholesterol synthesis. | The Journal of biological chemistry 20080523 |
| Carotenoid accumulation in bacteria with enhanced supply of isoprenoid precursors by upregulation of exogenous or endogenous pathways. | Journal of biotechnology 20080520 |
| Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. | Journal of immunology (Baltimore, Md. : 1950) 20080515 |
| Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. | Molecular pharmacology 20080501 |
| A systems biology investigation of the MEP/terpenoid and shikimate/phenylpropanoid pathways points to multiple levels of metabolic control in sweet basil glandular trichomes. | The Plant journal : for cell and molecular biology 20080501 |
| Molecular cloning and functional characterization of alpha-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith). | Planta 20080501 |
| Lovastatin inhibits formation of AA amyloid. | Journal of leukocyte biology 20080501 |
| Diagnosis and management of autoinflammatory diseases in childhood. | Journal of clinical immunology 20080501 |
| Coenzyme Q10: is there a clinical role and a case for measurement? | The Clinical biochemist. Reviews 20080501 |
| Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. | Journal of biochemical and biophysical methods 20080424 |
| Vgamma9Vdelta2 T cell-mediated recognition of human solid tumors. Potential for immunotherapy of hepatocellular and colorectal carcinomas. | Cancer immunology, immunotherapy : CII 20080401 |
| Effect of estrogen on the expression of luteinizing hormone-human chorionic gonadotropin receptor messenger ribonucleic acid in cultured rat granulosa cells. | Endocrinology 20080401 |
| Chloroplast localization of methylerythritol 4-phosphate pathway enzymes and regulation of mitochondrial genes in ispD and ispE albino mutants in Arabidopsis. | Plant molecular biology 20080401 |
| Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1. | Molecular immunology 20080401 |
| European guidance for the diagnosis and management of osteoporosis in postmenopausal women. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080401 |
| Multiplex PCR assay to identify methicillin-resistant Staphylococcus haemolyticus. | FEMS immunology and medical microbiology 20080401 |
| Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. | Plant & cell physiology 20080401 |
| Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. | The FEBS journal 20080401 |
| Atorvastatin induces apoptosis by a caspase-9-dependent pathway: an in vitro study on activated rat hepatic stellate cells. | Liver international : official journal of the International Association for the Study of the Liver 20080401 |
| Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. | The American journal of gastroenterology 20080401 |
| Biphasic effects of atorvastatin on inflammation. | Pakistan journal of pharmaceutical sciences 20080401 |
| Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. | Current protein & peptide science 20080401 |
| Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway. | Journal of cardiovascular pharmacology 20080401 |
| Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth. | Anti-cancer drugs 20080401 |
| Combination therapy in cholesterol reduction: focus on ezetimibe and statins. | Vascular health and risk management 20080401 |
| Use of ibandronate in the prevention of skeletal events in metastatic breast cancer. | Therapeutics and clinical risk management 20080401 |
| Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. | Biochemistry 20080325 |
| Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells. | Biochemical and biophysical research communications 20080307 |
| Isolation and functional characterization of a beta-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. | FEBS letters 20080305 |
| Dual mode of HMG-CoA reductase inhibition on dendritic cell invasion. | Atherosclerosis 20080301 |
| Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons. | The Journal of pharmacology and experimental therapeutics 20080301 |
| Physiological function of IspE, a plastid MEP pathway gene for isoprenoid biosynthesis, in organelle biogenesis and cell morphogenesis in Nicotiana benthamiana. | Plant molecular biology 20080301 |
| Abnormal prenatal ultrasound findings in mevalonic aciduria. | Prenatal diagnosis 20080301 |
| Metabolism of halophilic archaea. | Extremophiles : life under extreme conditions 20080301 |
| Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway. | The Journal of endocrinology 20080301 |
| The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. | The Plant cell 20080301 |
| Autoinflammatory diseases: clinical and genetic advances. | Archives of dermatology 20080301 |
| Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. | Journal of cardiovascular pharmacology 20080301 |
| Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. | PLoS medicine 20080301 |
| The potential effect of statins on rituximab immunotherapy. | PLoS medicine 20080301 |
| Comparison of effects of alendronate and raloxifene on lumbar bone mineral density, bone turnover, and lipid metabolism in elderly women with osteoporosis. | Yonsei medical journal 20080227 |
| Statins enhance toll-like receptor 4-mediated cytokine gene expression in astrocytes: implication of Rho proteins in negative feedback regulation. | Journal of neuroscience research 20080215 |
| The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells. | European journal of pharmacology 20080202 |
| Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord. | Pain 20080201 |
| Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis. | Journal of neuro-oncology 20080201 |
| Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. | Nitric oxide : biology and chemistry 20080201 |
| Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours. | Leukemia & lymphoma 20080201 |
| Modeling cancer progression via pathway dependencies. | PLoS computational biology 20080201 |
| Rosuvastatin: characterization of induced myopathy in the rat. | Toxicologic pathology 20080201 |
| Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. | Archives of pharmacal research 20080201 |
| Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis. | The Journal of biological chemistry 20080111 |
| Hydroxymethylglutaryl--CoA reductase inhibitor inhibits induction of nitric oxide synthase in 3T3--L1 preadipocytes. | Life sciences 20080102 |
| Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. | Breast cancer research and treatment 20080101 |
| 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (IDS) is encoded by multicopy genes in gymnosperms Ginkgo biloba and Pinus taeda. | Planta 20080101 |
| Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of jasmonate, ethylene and calcium signaling. | Planta 20080101 |
| Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. | ChemMedChem 20080101 |
| In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent. | Lung 20080101 |
| The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria. | Medical hypotheses 20080101 |
| Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products. | Cardiology 20080101 |
| Lovastatin inhibits oxidized low-density lipoprotein-induced plasminogen activator inhibitor and transforming growth factor-beta1 expression via a decrease in Ras/extracellular signal-regulated kinase activity in mesangial cells. | Translational research : the journal of laboratory and clinical medicine 20080101 |
| Implication of HMGR in homeostasis of sequestered and de novo produced precursors of the iridoid biosynthesis in leaf beetle larvae. | Insect biochemistry and molecular biology 20080101 |
| Bisphosphonates may increase peritoneal fibrinolytic activity by inhibiting the mevalonate pathway. | Annals of surgery 20080101 |
| Atorvastatin accelerates extracellular nucleotide degradation in human endothelial cells. | Molecular and cellular biochemistry 20080101 |
| Statins in the treatment of polycystic ovary syndrome. | Seminars in reproductive medicine 20080101 |
| Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. | Breast cancer research : BCR 20080101 |
| The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose. | Journal of diabetes and its complications 20080101 |
| The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. | BMC cancer 20080101 |
| Statin induces apoptosis and cell growth arrest in prostate cancer cells. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080101 |
| Small molecules for the activation of human gammadelta T cell responses against infection. | Recent patents on anti-infective drug discovery 20080101 |
| Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation. | BMC biology 20080101 |
| Polyisoprenoid alcohols--recent results of structural studies. | Chemical record (New York, N.Y.) 20080101 |
| OptCircuit: an optimization based method for computational design of genetic circuits. | BMC systems biology 20080101 |
| Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice. | BMC cancer 20080101 |
| Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation. | Chinese medicine 20080101 |
| [Effect of simvastatin on endothelin-1 expression in endothelial cell cultured hypoxically]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080101 |
| Comparative transcriptome analysis of Arabidopsis thaliana infested by diamond back moth (Plutella xylostella) larvae reveals signatures of stress response, secondary metabolism, and signalling. | BMC genomics 20080101 |
| Changes in cholesterol kinetics following sugar cane policosanol supplementation: a randomized control trial. | Lipids in health and disease 20080101 |
| The plastid-like organelle of apicomplexan parasites as drug target. | Current pharmaceutical design 20080101 |
| Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas. | Molecular cancer 20080101 |
| Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake. | BMC microbiology 20080101 |
| Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae. | Genome biology 20080101 |
| HMG-CoA reductase inhibitor simvastatin inhibits proinflammatory cytokine production from murine mast cells. | International archives of allergy and immunology 20080101 |
| Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. | American journal of nephrology 20080101 |
| Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar). | BMC genomics 20080101 |
| Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains. | BMC microbiology 20080101 |
| The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies. | PloS one 20080101 |
| Incorporation of enzyme concentrations into FBA and identification of optimal metabolic pathways. | BMC systems biology 20080101 |
| Analysis of expressed sequence tags from Actinidia: applications of a cross species EST database for gene discovery in the areas of flavor, health, color and ripening. | BMC genomics 20080101 |
| Modelling neurofibromatosis type 1 tibial dysplasia and its treatment with lovastatin. | BMC medicine 20080101 |
| [Interrelation between the pathways of isoprenoid biosynthesis and carbon source catabolism in anaerobic and facultatively anaerobic bacteria]. | Mikrobiologiia 20080101 |
| Yeast cell factories for fine chemical and API production. | Microbial cell factories 20080101 |
| Zoledronic acid increases docetaxel cytotoxicity through pMEK and Mcl-1 inhibition in a hormone-sensitive prostate carcinoma cell line. | Journal of translational medicine 20080101 |
| Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats. | BMC pharmacology 20080101 |
| [Cholesterol lowering properties of a complex compound simvastatin with glycyrrhizic acid (simvaglyzin) in experimental models]. | Biomeditsinskaia khimiia 20080101 |
| Catalogue of epidermal genes: genes expressed in the epidermis during larval molt of the silkworm Bombyx mori. | BMC genomics 20080101 |
| Neuropeptide receptor transcriptome reveals unidentified neuroendocrine pathways. | PloS one 20080101 |
| Fevers, genes, and innate immunity. | Current topics in microbiology and immunology 20080101 |
| Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and modulatory effect of statins. | PloS one 20080101 |
| Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. | BMC biology 20080101 |
| The evolving transcriptome of head and neck squamous cell carcinoma: a systematic review. | PloS one 20080101 |
| Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. | Journal of muscle research and cell motility 20080101 |
| Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer. | Breast cancer research : BCR 20080101 |
| Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. | Breast cancer research : BCR 20080101 |
| Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. | Lipids in health and disease 20080101 |
| The prince and the pauper. A tale of anticancer targeted agents. | Molecular cancer 20080101 |
| Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | BMC genomics 20080101 |
| Towards the understanding of the cocoa transcriptome: Production and analysis of an exhaustive dataset of ESTs of Theobroma cacao L. generated from various tissues and under various conditions. | BMC genomics 20080101 |
| Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. | BMC biotechnology 20080101 |
| The transcriptomic signature of fasting murine liver. | BMC genomics 20080101 |
| A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. | Genome biology 20080101 |
| Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. | BMC genomics 20080101 |
| [Differences among bisfosfonates--specificity of risedronate (Actonel)]. | Reumatizam 20080101 |
| Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. | BMC systems biology 20080101 |
| The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles. | BMC systems biology 20080101 |
| MFS transportome of the human pathogenic yeast Candida albicans. | BMC genomics 20080101 |
| Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. | Microbial cell factories 20080101 |
| Selective androgen receptor modulators in preclinical and clinical development. | Nuclear receptor signaling 20080101 |
| Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context. | Molecular cancer 20080101 |
| Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation. | BMC genomics 20080101 |
| Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation. | PloS one 20080101 |
| Predicted mouse peroxisome-targeted proteins and their actual subcellular locations. | BMC bioinformatics 20080101 |
| Stimulation of coenzyme Q synthesis. | BioFactors (Oxford, England) 20080101 |
| Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse. | BMC developmental biology 20080101 |
| HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi. | Studies in mycology 20080101 |
| Long Term Cyclic Pamidronate Reduces Bone Growth by Inhibiting Osteoclast Mediated Cartilage-to-Bone Turnover in the Mouse. | The open orthopaedics journal 20080101 |
| Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. | Analytical chemistry insights 20080101 |
| Liver x receptor: a novel therapeutic target. | Indian journal of pharmaceutical sciences 20080101 |
| Antifungals: need to search for a new molecular target. | Indian journal of pharmaceutical sciences 20080101 |
| Microbial production and biomedical applications of lovastatin. | Indian journal of pharmaceutical sciences 20080101 |
| Stability Indicating RP-HPLC Estimation of Atorvastatin Calcium and Amlodipine Besylate in Pharmaceutical Formulations. | Indian journal of pharmaceutical sciences 20080101 |
| Hypolipidemia: a word of caution. | The Libyan journal of medicine 20080101 |
| Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. | Blood 20071215 |
| Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function. | Journal of cellular physiology 20071201 |
| Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. | Atherosclerosis 20071201 |
| Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. | Plant cell reports 20071201 |
| Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. | Journal of thrombosis and haemostasis : JTH 20071201 |
| Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. | Journal of neurochemistry 20071201 |
| Effect of a disulfide bond on mevalonate kinase. | Biochimica et biophysica acta 20071201 |
| Mevalonate kinase deficiency syndrome with structural damage responsive to anakinra. | Rheumatology (Oxford, England) 20071201 |
| Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin. | Cytokine 20071201 |
| Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. | Journal of pharmacological sciences 20071201 |
| The antitumour activities of statins. | Current oncology (Toronto, Ont.) 20071201 |
| Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells. | Neoplasia (New York, N.Y.) 20071201 |
| Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma. | Molecular cancer therapeutics 20071201 |
| 3-hydroxy-3-methylglutaryl coenzyme a reductase 1 interacts with NORK and is crucial for nodulation in Medicago truncatula. | The Plant cell 20071201 |
| Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model. | Evidence-based complementary and alternative medicine : eCAM 20071201 |
| Linköping University Medical Dissertation No. 1033. Following the mevalonate pathway to bone heal alley. | Acta orthopaedica. Supplementum 20071201 |
| Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. | Journal of medicinal chemistry 20071129 |
| [Influence on atherosclerosis of improvement of bone mineral density after medication for osteoporosis]. | Nihon rinsho. Japanese journal of clinical medicine 20071128 |
| Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. | Bioorganic & medicinal chemistry letters 20071115 |
| Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety. | Carbohydrate research 20071105 |
| Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. | Plant biotechnology journal 20071101 |
| Lovastatin induces the expression of bradykinin type 2 receptors in cultured human coronary artery endothelial cells. | Journal of molecular and cellular cardiology 20071101 |
| Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. | Oncology reports 20071101 |
| Mevalonate kinase deficiency and autoinflammation. | The New England journal of medicine 20071101 |
| Statin myopathy: incidence, risk factors, and pathophysiology. | Current atherosclerosis reports 20071101 |
| Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. | Journal of inherited metabolic disease 20071101 |
| Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro. | Molecular cancer therapeutics 20071101 |
| Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. | Annals of the New York Academy of Sciences 20071101 |
| [Simvastatin downregulates CD40L induced vascular cell adhesion molecule-1 expression and adhesive function in human umbilical vein endothelial cells]. | Zhonghua xin xue guan bing za zhi 20071101 |
| Biosynthesis of monoterpenes and norisoprenoids in raspberry fruits (Rubus idaeus L.): the role of cytosolic mevalonate and plastidial methylerythritol phosphate pathway. | Journal of agricultural and food chemistry 20071031 |
| Functional evaluation of conserved basic residues in human phosphomevalonate kinase. | Biochemistry 20071023 |
| Activation of the integrated stress response regulates lovastatin-induced apoptosis. | The Journal of biological chemistry 20071012 |
| A patient with hyper-IgD syndrome responding to anti-TNF treatment. | Clinical rheumatology 20071001 |
| Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. | Cell biology international 20071001 |
| Expression of the gene for sterol-biosynthesis enzyme squalene epoxidase in parenchyma cells of the oil plant, Euphorbia tirucalli. | Planta 20071001 |
| Mevalonic aciduria: report of two cases. | Journal of inherited metabolic disease 20071001 |
| Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. | Blood 20071001 |
| Diagnostic value of serum immunoglobulinaemia D level in patients with a clinical suspicion of hyper IgD syndrome. | Rheumatology (Oxford, England) 20071001 |
| D-003 does not possess oestrogenic potential in-vivo: findings of the uterotrophic assay. | The Journal of pharmacy and pharmacology 20071001 |
| Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. | Chemical & pharmaceutical bulletin 20071001 |
| [Pharmacological and clinical profile of once weekly alendronate for the treatment of osteoporosis (Fosamac 35 mg/Bonalon 35 mg)]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20071001 |
| [Biosynthesis of a hybrid terpenoid polyketide-derived natural product and production of useful prenylated compounds by using prenyltransferase]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20071001 |
| The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation. | Vascular health and risk management 20071001 |
| Are pleiotropic effects of statins real? | Vascular health and risk management 20071001 |
| Can combining different risk interventions into a single formulation contribute to improved cardiovascular disease risk reduction? The single pill of amlodipine/atorvastatin. | Vascular health and risk management 20071001 |
| Use of zoledronic acid in the treatment of Paget's disease. | Therapeutics and clinical risk management 20071001 |
| Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. | The Journal of biological chemistry 20070928 |
| Mevalonic aciduria cured by bone marrow transplantation. | The New England journal of medicine 20070927 |
| Statins reduce amyloid-beta production through inhibition of protein isoprenylation. | The Journal of biological chemistry 20070914 |
| Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. | European journal of pharmacology 20070910 |
| Zoledronic acid-induced IPP/ApppI production in vivo. | Life sciences 20070908 |
| Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolism. | Molecular endocrinology (Baltimore, Md.) 20070901 |
| Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. | Diabetes 20070901 |
| Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells. | Archives of biochemistry and biophysics 20070901 |
| Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? | Toxicology and applied pharmacology 20070901 |
| Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. | Free radical research 20070901 |
| Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901 |
| Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. | Biochemical pharmacology 20070815 |
| Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. | Toxicology and applied pharmacology 20070815 |
| Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. | Journal of molecular biology 20070810 |
| Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. | Cancer letters 20070808 |
| Atorvastatin partially prevents an inflammatory barrier breakdown of cultured human brain endothelial cells at a pharmacologically relevant concentration. | Journal of neurochemistry 20070801 |
| Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues. | The Biochemical journal 20070801 |
| A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro. | Journal of neurochemistry 20070801 |
| Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha. | Journal of leukocyte biology 20070801 |
| Evidence for a gram-positive, eubacterial root of the tree of life. | Molecular biology and evolution 20070801 |
| Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin. | American journal of physiology. Lung cellular and molecular physiology 20070801 |
| Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). | Phytochemistry 20070801 |
| HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways. | Hypertension (Dallas, Tex. : 1979) 20070801 |
| Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis. | Oncology reports 20070801 |
| Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. | Insect biochemistry and molecular biology 20070801 |
| Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. | Cancer research 20070801 |
| Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. | PLoS pathogens 20070801 |
| [Effects of pravastatin on the expression of endothelin induced by aldosterone in rat cardiac fibroblasts]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801 |
| [Abnormalities of the enzymes involved in lipid metabolism]. | Nihon rinsho. Japanese journal of clinical medicine 20070728 |
| The non-mevalonate pathway of isoprenoid precursor biosynthesis. | The Journal of biological chemistry 20070727 |
| Osmoadaptation-dependent activity of microsomal HMG-CoA reductase in the extremely halotolerant black yeast Hortaea werneckii is regulated by ubiquitination. | FEBS letters 20070724 |
| Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. | The Journal of biological chemistry 20070706 |
| Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | The Journal of pharmacology and experimental therapeutics 20070701 |
| Isoprenoid biosynthesis authenticates the classification of the green alga Mesostigma viride as an ancient streptophyte. | Gene 20070701 |
| Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis. | Applied microbiology and biotechnology 20070701 |
| Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. | Stem cells (Dayton, Ohio) 20070701 |
| Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. | European journal of cell biology 20070701 |
| Effect of two-hour daily hemodialysis and sham dialysis on breath isoprene exhalation. | The International journal of artificial organs 20070701 |
| Mevalonate kinase deficiency and autoinflammatory disorders. | The New England journal of medicine 20070628 |
| Allogeneic bone marrow transplantation in mevalonic aciduria. | The New England journal of medicine 20070628 |
| Autoinflammatory gene mutations in Behçet's disease. | Annals of the rheumatic diseases 20070601 |
| Modulation of COX-2 expression by statins in human monocytic cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070601 |
| Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. | American journal of respiratory cell and molecular biology 20070601 |
| Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. | ChemMedChem 20070601 |
| Biomass in the manufacture of industrial products--the use of proteins and amino acids. | Applied microbiology and biotechnology 20070601 |
| Effects of statins on bone mineral density: a meta-analysis of clinical studies. | Bone 20070601 |
| Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. | Cancer science 20070601 |
| Coenzyme Q10 in phenylketonuria and mevalonic aciduria. | Mitochondrion 20070601 |
| Mevalonate pathway: a review of clinical and therapeutical implications. | Clinical biochemistry 20070601 |
| Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction. | Clinical immunology (Orlando, Fla.) 20070601 |
| The antioxidant role of coenzyme Q. | Mitochondrion 20070601 |
| Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. | Molecular cancer therapeutics 20070601 |
| Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. | Journal of cardiovascular pharmacology 20070601 |
| Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion. | International journal of clinical pharmacology and therapeutics 20070601 |
| Time-of-intake (morning versus evening) of extended-release fluvastatin in hyperlipemic patients is without influence on the pharmacodynamics (mevalonic acid excretion) and pharmacokinetics. | International journal of clinical pharmacology and therapeutics 20070601 |
| Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. | Circulation research 20070525 |
| Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042. | The Journal of organic chemistry 20070525 |
| R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. | Journal of cellular physiology 20070501 |
| Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. | Journal of lipid research 20070501 |
| Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. | Arteriosclerosis, thrombosis, and vascular biology 20070501 |
| Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate. | Protein science : a publication of the Protein Society 20070501 |
| Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity. | Heart rhythm 20070501 |
| 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. | Molecular cancer therapeutics 20070501 |
| Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland. | Current eye research 20070501 |
| Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. | Journal of clinical biochemistry and nutrition 20070501 |
| Pleiotropic effects of statins and related pharmacological experimental approaches. | Timely topics in medicine. Cardiovascular diseases 20070418 |
| Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. | International journal of cancer 20070415 |
| Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism. | Biochemical and biophysical research communications 20070406 |
| Human coenzyme Q10 deficiency. | Neurochemical research 20070401 |
| Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages. | American journal of physiology. Heart and circulatory physiology 20070401 |
| Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. | Human reproduction (Oxford, England) 20070401 |
| C-terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosomal sorting to lysosomes. | Traffic (Copenhagen, Denmark) 20070401 |
| Defect in fatty acid esterification of dolichol in Niemann-Pick type C1 mouse livers in vivo. | Biochimica et biophysica acta 20070401 |
| Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo. | Experimental biology and medicine (Maywood, N.J.) 20070401 |
| Towards complete sets of farnesylated and geranylgeranylated proteins. | PLoS computational biology 20070401 |
| The hereditary autoinflammatory syndromes. | The Pediatric infectious disease journal 20070401 |
| [MVK gene abnormality and new approach to treatment of hyper IgD syndrome and periodic fever syndrome]. | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20070401 |
| Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface. | Biochemical and biophysical research communications 20070309 |
| Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma. | Leukemia research 20070301 |
| Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. | Histochemistry and cell biology 20070301 |
| Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids. | Metabolic engineering 20070301 |
| Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. | Metabolic engineering 20070301 |
| Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus. | The Journal of antimicrobial chemotherapy 20070301 |
| Lovastatin attenuates nerve injury in an animal model of Guillain-Barré syndrome. | Journal of neurochemistry 20070301 |
| Bisphosphonates: mode of action and pharmacology. | Pediatrics 20070301 |
| Synthetic biology: caught between property rights, the public domain, and the commons. | PLoS biology 20070301 |
| Posttranscriptional expression regulation: what determines translation rates? | PLoS computational biology 20070301 |
| The differential effects of bisphosphonates, SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone remodeling in osteoporosis. | Clinical interventions in aging 20070301 |
| Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. | Journal of immunology (Baltimore, Md. : 1950) 20070215 |
| Atorvastatin reduces tissue factor expression in adipose tissue of atherosclerotic rabbits. | International journal of cardiology 20070207 |
| A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation. | Current biology : CB 20070206 |
| Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1. | Circulation research 20070202 |
| Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. | Applied microbiology and biotechnology 20070201 |
| Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells. | International immunopharmacology 20070201 |
| Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. | International immunology 20070201 |
| Lovastatin insensitive 1, a Novel pentatricopeptide repeat protein, is a potential regulatory factor of isoprenoid biosynthesis in Arabidopsis. | Plant & cell physiology 20070201 |
| Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | British journal of pharmacology 20070201 |
| Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway. | British journal of haematology 20070201 |
| Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. | Annals of surgery 20070201 |
| c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis. | Biochimica et biophysica acta 20070201 |
| Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways. | Investigative ophthalmology & visual science 20070201 |
| Diagnostics and therapeutic insights in a severe case of mevalonate kinase deficiency. | Pediatrics 20070201 |
| [Introduction to bisphosphonates. History and functional mechanisms]. | Der Orthopade 20070201 |
| The mevalonate pathway as a therapeutic target in the Ph-negative chronic myeloproliferative disorders. | Current drug targets 20070201 |
| Simvastatin reduces insulin-like growth factor-1 signaling in differentiating C2C12 mouse myoblast cells in an HMG-CoA reductase inhibition-independent manner. | The Journal of toxicological sciences 20070201 |
| Molecular genetics of plant sterol backbone synthesis. | Lipids 20070201 |
| Formation of triterpenoids throughout Olea europaea fruit ontogeny. | Lipids 20070201 |
| Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. | The Journal of biological chemistry 20070126 |
| Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. | The Journal of biological chemistry 20070105 |
| Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. | Molecular and cellular endocrinology 20070102 |
| Cerivastatin reduces cytokine-induced surface expression of ICAM-1 via increased shedding in human endothelial cells. | Atherosclerosis 20070101 |
| Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts. | The Biochemical journal 20070101 |
| HMG-CoA reductase is regulated by salinity at the level of transcription in Haloferax volcanii. | Extremophiles : life under extreme conditions 20070101 |
| Statins induce differentiation and cell death in neurons and astroglia. | Glia 20070101 |
| Microbial sensors for small molecules: development of a mevalonate biosensor. | Metabolic engineering 20070101 |
| Statins decrease TNF-alpha-induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro. | Biochemical pharmacology 20070101 |
| Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. | Arteriosclerosis, thrombosis, and vascular biology 20070101 |
| Antennally mediated negative feedback regulation of pheromone production in the pine engraver beetle, Ips pini. | Die Naturwissenschaften 20070101 |
| Biosynthesis and engineering of isoprenoid small molecules. | Applied microbiology and biotechnology 20070101 |
| Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are targeted either to peroxisomes or cytosol but not to mitochondria. | Plant molecular biology 20070101 |
| Multilevel modulation of the mevalonate and protein-prenylation circuitries as a novel strategy for anticancer therapy. | Trends in pharmacological sciences 20070101 |
| Structure-based rational quest for potential novel inhibitors of human HMG-CoA reductase by combining CoMFA 3D QSAR modeling and virtual screening. | Journal of combinatorial chemistry 20070101 |
| Squalene synthase inhibitors : clinical pharmacology and cholesterol-lowering potential. | Drugs 20070101 |
| Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines. | BMC cancer 20070101 |
| Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | Journal of neuroinflammation 20070101 |
| Different migration of vascular smooth muscle cells from human coronary artery bypass vessels. Role of Rho/ROCK pathway. | Journal of vascular research 20070101 |
| Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. | PloS one 20070101 |
| Statins ameliorate glomerular permeability changes in streptozotocin-induced diabetic rats. | American journal of therapeutics 20070101 |
| Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. | Molecular cancer 20070101 |
| The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | Immunity & ageing : I & A 20070101 |
| Genetic determinants of statin intolerance. | Lipids in health and disease 20070101 |
| Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. | BMC structural biology 20070101 |
| Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | Lipids in health and disease 20070101 |
| Developments in the synovial biology field 2006. | Arthritis research & therapy 20070101 |
| Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. | Anticancer research 20070101 |
| Zoledronate inhibits alphavbeta3 and alphavbeta5 integrin cell surface expression in endothelial cells. | Endothelium : journal of endothelial cell research 20070101 |
| Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. | Biotechnology progress 20070101 |
| Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria. | Malaria journal 20070101 |
| Leptin stimulates endogenous cholesterol synthesis in human monocytes: New role of an old player in atherosclerotic plaque formation. Leptin-induced increase in cholesterol synthesis. | The international journal of biochemistry & cell biology 20070101 |
| The in vitro anti-tumour activity of zoledronic acid and docetaxel at clinically achievable concentrations in prostate cancer. | Acta oncologica (Stockholm, Sweden) 20070101 |
| Tissue-specific mRNA expression profiling in grape berry tissues. | BMC genomics 20070101 |
| Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. | Journal of musculoskeletal & neuronal interactions 20070101 |
| Inhibition of Plasmodium falciparum ispH (lytB) gene expression by hammerhead ribozyme. | Oligonucleotides 20070101 |
| Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. | BMC infectious diseases 20070101 |
| Falling into TRAPS--receptor misfolding in the TNF receptor 1-associated periodic fever syndrome. | Arthritis research & therapy 20070101 |
| Zoledronic acid - a multiplicity of anti-cancer action. | Current medicinal chemistry 20070101 |
| Establishment of Croton stellatopilosus suspension culture for geranylgeraniol production and diterpenoid biosynthesis. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101 |
| Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. | Mediators of inflammation 20070101 |
| Role of the cholesterol biosynthetic pathway in osteoblastic differentiation. | Journal of endocrinological investigation 20070101 |
| Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension. | Physiological research 20070101 |
| The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data. | Genome biology 20070101 |
| Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells. | Endothelium : journal of endothelial cell research 20070101 |
| The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. | BMC structural biology 20070101 |
| Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. | Theoretical biology & medical modelling 20070101 |
| Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions. | BMC genomics 20070101 |
| Age-related subproteomic analysis of mouse liver and kidney peroxisomes. | Proteome science 20070101 |
| Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. | BMC cell biology 20070101 |
| Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. | BMC cancer 20070101 |
| Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. | Clinical and experimental rheumatology 20070101 |
| Synthetic biology: promises and challenges. | Molecular systems biology 20070101 |
| The effects of Rhizoma Curculiginis and Rhizoma Drynariae extracts on bones. | Chinese medicine 20070101 |
| A high quality draft consensus sequence of the genome of a heterozygous grapevine variety. | PloS one 20070101 |
| Photosensitivity in Smith-Lemli-Opitz syndrome: a flux balance analysis of altered metabolism. | Bioinformation 20070101 |
| Atherosclerosis, cholesterol, nutrition, and statins--a critical review. | German medical science : GMS e-journal 20070101 |
| Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders. | Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20070101 |
| Simvastatin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiomyocytes: The role of reactive oxygen species. | Biochemical and biophysical research communications 20061229 |
| Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | European journal of pharmacology 20061215 |
| Immunomodulatory effects of statins and autoimmune rheumatic diseases: novel intracellular mechanism involved. | International immunopharmacology 20061205 |
| Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity. | Biochemistry 20061205 |
| Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. | American journal of respiratory cell and molecular biology 20061201 |
| Increased nonsterol isoprenoids, dolichol and ubiquinone, in the Smith-Lemli-Opitz syndrome: effects of dietary cholesterol. | Journal of lipid research 20061201 |
| Relationships among the biosyntheses of ubiquinone, carotene, sterols, and triacylglycerols in Zygomycetes. | Archives of microbiology 20061201 |
| Cytochrome P450 subfamily CYP710A genes encode sterol C-22 desaturase in plants. | Biochemical Society transactions 20061201 |
| Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. | Oncology reports 20061201 |
| The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2. | PLoS biology 20061201 |
| Hyperimmunoglobulinaemia D syndrome in India: report of two siblings with a novel mutation. | Annals of the rheumatic diseases 20061201 |
| Comparative effects of antiresorptive agents on bone mineral density and bone turnover in postmenopausal women. | Clinical interventions in aging 20061201 |
| A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. | British journal of cancer 20061120 |
| RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. | Cell death and differentiation 20061101 |
| Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics. | Journal of molecular graphics & modelling 20061101 |
| HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced 'inside-out' signaling to extracellular matrix by preventing RhoA activation. | American journal of physiology. Renal physiology 20061101 |
| Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome. | Rheumatology international 20061101 |
| Effect of naringin on bone cells. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20061101 |
| Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome. | The Journal of clinical endocrinology and metabolism 20061101 |
| Up-regulation of 1-deoxy-D-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender. | Plant physiology 20061101 |
| Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases. | European journal of immunology 20061101 |
| Potential benefit of statins for vascular disease in systemic sclerosis. | Current opinion in rheumatology 20061101 |
| [Periodic fever syndromes]. | Zeitschrift fur Rheumatologie 20061101 |
| A role for geranylgeranylation in interleukin-1beta secretion. | Arthritis and rheumatism 20061101 |
| RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin. | Arthritis and rheumatism 20061101 |
| Pleiotropic effects of statins and related pharmacological experimental approaches. | Methods and findings in experimental and clinical pharmacology 20061101 |
| Last generation of amino-bisphosphonates (N-BPs) and cancer angio-genesis: a new role for these drugs? | Recent patents on anti-cancer drug discovery 20061101 |
| Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells. | European journal of pharmacology 20061024 |
| Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms. | The Biochemical journal 20061015 |
| Pig liver phosphomevalonate kinase: kinetic mechanism. | Archives of biochemistry and biophysics 20061015 |
| Molecular mechanisms of action of bisphosphonates: current status. | Clinical cancer research : an official journal of the American Association for Cancer Research 20061015 |
| Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei. | FEBS letters 20061009 |
| Statins in the treatment of polycythaemia vera and allied disorders: an antithrombotic and cytoreductive potential? | Leukemia research 20061001 |
| Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension. | American journal of physiology. Lung cellular and molecular physiology 20061001 |
| Regulation of ABCA1 expression in human keratinocytes and murine epidermis. | Journal of lipid research 20061001 |
| Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. | Journal of neuroimmunology 20061001 |
| Simvastatin improves diabetes-induced coronary endothelial dysfunction. | The Journal of pharmacology and experimental therapeutics 20061001 |
| Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect. | Journal of lipid research 20061001 |
| Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. | Fertility and sterility 20061001 |
| Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. | Neuropeptides 20061001 |
| A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20061001 |
| Escherichia coli type I isopentenyl diphosphate isomerase: structural and catalytic roles for divalent metals. | Journal of the American Chemical Society 20060906 |
| Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. | Atherosclerosis 20060901 |
| Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. | Bone 20060901 |
| Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver. | Journal of lipid research 20060901 |
| Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. | Metabolic engineering 20060901 |
| The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. | Science (New York, N.Y.) 20060901 |
| Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains. | Neuropharmacology 20060901 |
| Growth inhibition of Candida species and Aspergillus fumigatus by statins. | FEMS microbiology letters 20060901 |
| Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. | PLoS biology 20060901 |
| Simvastatin promotes neurite outgrowth in the presence of inhibitory molecules found in central nervous system injury. | Journal of neurotrauma 20060901 |
| Management of age-related osteoporosis and prevention of associated fractures. | Therapeutics and clinical risk management 20060901 |
| HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1. | Life sciences 20060829 |
| Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells. | Biochemical and biophysical research communications 20060825 |
| Proteomic analysis of Caco-2 cells treated with monacolin K. | Journal of agricultural and food chemistry 20060823 |
| Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. | Biotechnology and bioengineering 20060820 |
| Herbicidal effects of statin pharmaceuticals in Lemna gibba. | Environmental science & technology 20060815 |
| Roles of endogenously synthesized sterols in the endocytic pathway. | The Journal of biological chemistry 20060811 |
| The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. | The Journal of biological chemistry 20060804 |
| Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits. | Clinica chimica acta; international journal of clinical chemistry 20060801 |
| Dynamic pathway allocation in early terpenoid biosynthesis of stress-induced lima bean leaves. | Phytochemistry 20060801 |
| 25-Hydroxycholesterol has a dual effect on the proliferation of cultured rat astrocytes. | Neuropharmacology 20060801 |
| Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control. | Diabetologia 20060801 |
| Hypothesis: the antitumor activities of statins may be mediated by IL-18. | Journal of leukocyte biology 20060801 |
| Hypertrophic cardiomyopathy, cataract, developmental delay, lactic acidosis: a novel subtype of 3-methylglutaconic aciduria. | Journal of inherited metabolic disease 20060801 |
| Proteomic examination of Ralstonia eutropha in cellular responses to formic acid. | Proteomics 20060801 |
| Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. | Stroke 20060801 |
| Mutational spectrum and genotype-phenotype correlations in mevalonate kinase deficiency. | Human mutation 20060801 |
| Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. | Nature biotechnology 20060801 |
| The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin. | Journal of thrombosis and haemostasis : JTH 20060801 |
| Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. | PLoS biology 20060801 |
| Statin therapy for native and peri-interventional coronary heart disease. | Current molecular medicine 20060801 |
| Statins in the treatment of chronic heart failure: a systematic review. | PLoS medicine 20060801 |
| Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060715 |
| Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. | International journal of cancer 20060701 |
| Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. | Biology of reproduction 20060701 |
| AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer. | The Journal of physiology 20060701 |
| Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. | Biochimica et biophysica acta 20060701 |
| Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701 |
| The nonlipid effects of statins on endothelial function. | Trends in cardiovascular medicine 20060701 |
| The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target. | Acta crystallographica. Section D, Biological crystallography 20060701 |
| Different anti-HCV profiles of statins and their potential for combination therapy with interferon. | Hepatology (Baltimore, Md.) 20060701 |
| Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. | Arthritis and rheumatism 20060701 |
| Further support for the statins as antiinflammatory and immunomodulatory agents: comment on the review by Abeles and Pillinger and the editorial by Arnaud and Mach. | Arthritis and rheumatism 20060701 |
| Synergistic antimyeloma effects of zoledronate and simvastatin. | Anti-cancer drugs 20060701 |
| Incadronate inhibits aminopeptidase N expression in prostatic PC-3 cells. | Cancer letters 20060618 |
| Synthesis and biological activity of isoprenoid bisphosphonates. | Bioorganic & medicinal chemistry 20060615 |
| Overexpression of the Saccharomyces cerevisiae RER2 gene in Trichoderma reesei affects dolichol dependent enzymes and protein glycosylation. | Fungal genetics and biology : FG & B 20060601 |
| Anticancer effects of zoledronic acid against human osteosarcoma cells. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601 |
| Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway. | British journal of pharmacology 20060601 |
| Recent advances in understanding the mechanism of action of bisphosphonates. | Current opinion in pharmacology 20060601 |
| Simvastatin decreases IL-6 and IL-8 production in epithelial cells. | Journal of dental research 20060601 |
| The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. | Journal of neurochemistry 20060501 |
| Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | Journal of bacteriology 20060501 |
| Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. | Journal of immunology (Baltimore, Md. : 1950) 20060501 |
| Bisphosphonates inhibit the growth of mesothelioma cells in vitro and in vivo. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060501 |
| Biosynthesis of sespendole. | The Journal of antibiotics 20060501 |
| Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro. | Biochemical pharmacology 20060428 |
| Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library. | Archives of biochemistry and biophysics 20060415 |
| Production of the antimalarial drug precursor artemisinic acid in engineered yeast. | Nature 20060413 |
| Statins prevent NF-kappaB transactivation independently of the IKK-pathway in human endothelial cells. | Atherosclerosis 20060401 |
| Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP. | The Journal of pharmacology and experimental therapeutics 20060401 |
| Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060401 |
| Statins and renal diseases: from primary prevention to renal replacement therapy. | Journal of the American Society of Nephrology : JASN 20060401 |
| Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition. | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20060401 |
| Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. | Arthritis and rheumatism 20060401 |
| Effect of monoterpenes on the formation and activation of osteoclasts in vitro. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060401 |
| Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060401 |
| Isolation, endocrine regulation and mRNA distribution of the 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMG-S) gene from the pine engraver, Ips pini (Coleoptera: Scolytidae). | Insect molecular biology 20060401 |
| Effects of juvenile hormone on gene expression in the pheromone-producing midgut of the pine engraver beetle, Ips pini. | Insect molecular biology 20060401 |
| [Auto-inflammatory disease with hyperimmunoglobulinemia D of late onset]. | Annales de dermatologie et de venereologie 20060401 |
| Molecular cloning of a HMG-CoA reductase gene from Eucommia ulmoides Oliver. | Bioscience reports 20060401 |
| Bisphosphonates: from bench to bedside. | Annals of the New York Academy of Sciences 20060401 |
| Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. | Organic letters 20060316 |
| Phosphomevalonate kinase: functional investigation of the recombinant human enzyme. | Biochemistry 20060314 |
| Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis. | Planta 20060301 |
| Natural and directed biosynthesis of communesin alkaloids. | Phytochemistry 20060301 |
| HMG-CoA reductase inhibitors induce apoptosis in pericytes. | Microvascular research 20060301 |
| Reduction of background interference in the spectrophotometric assay of mevalonate kinase. | Analytical and bioanalytical chemistry 20060301 |
| Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors. | Pharmacotherapy 20060301 |
| N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301 |
| Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | The Journal of rheumatology 20060301 |
| Caterpillar herbivory and salivary enzymes decrease transcript levels of Medicago truncatula genes encoding early enzymes in terpenoid biosynthesis. | Plant molecular biology 20060301 |
| Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes. | Molecular and cellular biochemistry 20060301 |
| Minodronate suppresses prostaglandin F2alpha-induced vascular endothelial growth factor synthesis in osteoblasts. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060301 |
| Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase. | Plant biotechnology journal 20060301 |
| Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa. | Vascular health and risk management 20060301 |
| Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis. | Therapeutics and clinical risk management 20060301 |
| Differences between the bisphosphonates for the prevention and treatment of osteoporosis. | Therapeutics and clinical risk management 20060301 |
| Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. | Journal of agricultural and food chemistry 20060222 |
| Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. | Bone 20060201 |
| Kinetic characterization of Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase mutants. | Biochimica et biophysica acta 20060201 |
| Mevalonate kinase activity during different stages of plant regeneration from nodular callus cultures in white pine (Pinus strobus). | Tree physiology 20060201 |
| Isoprenylated proteins. | Cellular and molecular life sciences : CMLS 20060201 |
| Rho/ROCK pathway as a target of tumor therapy. | Journal of neuroscience research 20060201 |
| A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. | British journal of pharmacology 20060201 |
| Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | Immunology and cell biology 20060201 |
| Simvastatin protection against acute immune-mediated glomerulonephritis in mice. | Kidney international 20060201 |
| Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. | Arthritis and rheumatism 20060201 |
| Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201 |
| Anti-cancer therapy: targeting the mevalonate pathway. | Current cancer drug targets 20060201 |
| [Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201 |
| Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | Bulletin of experimental biology and medicine 20060201 |
| Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells. | Biochemical and biophysical research communications 20060120 |
| Simvastatin induces caspase-independent apoptosis in LPS-activated RAW264.7 macrophage cells. | Biochemical and biophysical research communications 20060120 |
| The emerging role of statins in the treatment of heart failure. | Journal of the American College of Cardiology 20060117 |
| Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. | Blood 20060115 |
| Complex histories of genes encoding 3-hydroxy-3-methylglutaryl-CoenzymeA reductase. | Molecular biology and evolution 20060101 |
| Erythropoietin receptor signal transduction requires protein geranylgeranylation. | The Journal of pharmacology and experimental therapeutics 20060101 |
| Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. | Proteins 20060101 |
| Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma. | Journal of hepatology 20060101 |
| Cleavage of focal adhesion proteins and PKCdelta during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts. | The FEBS journal 20060101 |
| Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum. | Fungal genetics and biology : FG & B 20060101 |
| Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines. | Breast cancer research : BCR 20060101 |
| Simvastatin reduces serum level of vascular endothelial growth factor in hypercholesterolemic patients. | Journal of cardiovascular pharmacology 20060101 |
| Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. | Journal of cardiovascular pharmacology 20060101 |
| New treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway. | Current pharmaceutical design 20060101 |
| Autoinflammatory syndromes. | Clinical and experimental rheumatology 20060101 |
| EST analysis of the scaly green flagellate Mesostigma viride (Streptophyta): implications for the evolution of green plants (Viridiplantae). | BMC plant biology 20060101 |
| Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo. | BMC biochemistry 20060101 |
| Thiazolidinediones inhibit albumin uptake by proximal tubular cells through a mechanism independent of peroxisome proliferator activated receptor gamma. | American journal of nephrology 20060101 |
| The effect of bisphosphonates on gene expression: GAPDH as a housekeeping or a new target gene? | BMC cancer 20060101 |
| Attacking pathogens through their hosts. | Genome biology 20060101 |
| Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells. | BMC cancer 20060101 |
| Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20060101 |
| Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | Microbial cell factories 20060101 |
| Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. | Orphanet journal of rare diseases 20060101 |
| Synthetic biology: new engineering rules for an emerging discipline. | Molecular systems biology 20060101 |
| Regulation of inducible nitric oxide synthase gene in glial cells. | Antioxidants & redox signaling 20060101 |
| Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts. | Arthritis research & therapy 20060101 |
| Statin use and cancer risk: an epidemiologic review. | Cancer investigation 20060101 |
| Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice. | Skin pharmacology and physiology 20060101 |
| Is there a role of statins in the prevention of aortic biological prostheses degeneration. | Cardiovascular ultrasound 20060101 |
| Comparison of transcripts in Phalaenopsis bellina and Phalaenopsis equestris (Orchidaceae) flowers to deduce monoterpene biosynthesis pathway. | BMC plant biology 20060101 |
| Statins may decrease skeletal-related events in breast cancer patients with bone metastases. | Medical hypotheses 20060101 |
| Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. | Arthritis research & therapy 20060101 |
| Simvastatin inhibits interferon-gamma-induced MHC class II up-regulation in cultured astrocytes. | Journal of neuroinflammation 20060101 |
| Cholesterol, statins and tau. | Acta neurologica Scandinavica. Supplementum 20060101 |
| The role of pleiotropic effects of statins in dementia. | Acta neurologica Scandinavica. Supplementum 20060101 |
| Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. | Drug safety 20060101 |
| Inhibitory effect of statins on renal epithelial-to-mesenchymal transition. | American journal of nephrology 20060101 |
| Systemic zoledronate treatment both prevents resorption of allograft bone and increases the retention of new formed bone during revascularization and remodelling. A bone chamber study in rats. | BMC musculoskeletal disorders 20060101 |
| 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'. | Cancer cell international 20060101 |
| Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. | Genome biology 20060101 |
| In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells. | Breast cancer research : BCR 20060101 |
| ApoE polymorphism is associated with C-reactive protein in low-HDL family members and in normolipidemic subjects. | Mediators of inflammation 20060101 |
| Investigation of de novo cholesterol synthetic capacity in the gonads of goldfish (Carassius auratus) exposed to the phytosterol beta-sitosterol. | Reproductive biology and endocrinology : RB&E 20060101 |
| A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. | PloS one 20060101 |
| Autoinflammatory diseases. | Acta clinica Belgica 20060101 |
| Effect of atorvastatin withdrawal on circulating coenzyme Q10 concentration in patients with hypercholesterolemia. | BioFactors (Oxford, England) 20060101 |
| Effects of exogenous mevalonic acid on sterol lipid classes in Larix kaempferi callus. | Journal of oleo science 20060101 |
| Juvenile hormone titer versus juvenile hormone synthesis in female nymphs and adults of the German cockroach, Blattella germanica. | Journal of insect science (Online) 20060101 |
| Comparison of effect of treatment with etidronate and alendronate on lumbar bone mineral density in elderly women with osteoporosis. | Yonsei medical journal 20051231 |
| Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary. | The Journal of biological chemistry 20051230 |
| Regulation of fatty acid synthesis by farnesyl pyrophosphate. | The Journal of biological chemistry 20051223 |
| Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts. | Journal of cellular biochemistry 20051215 |
| Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate. | Journal of the American Chemical Society 20051214 |
| Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. | The Journal of biological chemistry 20051202 |
| Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway. | Cardiovascular research 20051201 |
| Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis. | Circulation journal : official journal of the Japanese Circulation Society 20051201 |
| Effect of incadronate on proliferation of mesenchymal tumor cells with or without activated Ras mutation. | Journal of experimental & clinical cancer research : CR 20051201 |
| Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum. | FEBS letters 20051121 |
| Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli. | The Journal of organic chemistry 20051111 |
| Neonatal mortality from in utero exposure to perfluorooctanesulfonate (PFOS) in Sprague-Dawley rats: dose-response, and biochemical and pharamacokinetic parameters. | Toxicology 20051105 |
| Blockade of geranylgeranylation by rosuvastatin upregulates eNOS expression in human venous endothelial cells. | Biochemical and biophysical research communications 20051104 |
| Statins in nephrotic syndrome: a new weapon against tissue injury. | Medicinal research reviews 20051101 |
| HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101 |
| Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment. | Toxicology and applied pharmacology 20051101 |
| X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA. | Biochemistry 20051101 |
| Pseudodominant inheritance of the hyperimmunoglobulinemia D with periodic fever syndrome in a mother and her two monozygotic twins. | Arthritis and rheumatism 20051101 |
| HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster. | Developmental cell 20051101 |
| Muscle coenzyme Q10 level in statin-related myopathy. | Archives of neurology 20051101 |
| In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. | Journal of immunology (Baltimore, Md. : 1950) 20051015 |
| Simvastatin has deleterious effects on human first trimester placental explants. | Human reproduction (Oxford, England) 20051001 |
| Statins ameliorate endothelial barrier permeability changes in the cerebral tissue of streptozotocin-induced diabetic rats. | Diabetes 20051001 |
| [Fluvastatin affects HLA class I expression on endothelial cells]. | Nephrologie & therapeutique 20051001 |
| Zoledronate induces apoptosis in cells from fibro-cellular membrane of unicameral bone cyst (UBC). | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20050901 |
| Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. | Clinical immunology (Orlando, Fla.) 20050901 |
| Lovastatin inhibits the growth and survival pathway of phosphoinositide 3-kinase/protein kinase B in immortalized rat brain neuroblasts. | Journal of neurochemistry 20050901 |
| Effect of rosuvastatin on insulin sensitivity in patients with familial combined hyperlipidaemia. | European journal of clinical investigation 20050901 |
| Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling. | Endocrine-related cancer 20050901 |
| MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. | Cancer research 20050815 |
| Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. | British journal of cancer 20050808 |
| Brassica juncea HMG-CoA synthase: localization of mRNA and protein. | Planta 20050801 |
| Down-regulation of Na+/Ca2+ exchanger by fluvastatin in rat cardiomyoblast H9c2 cells: involvement of RhoB in Na+/Ca2+ exchanger mRNA stability. | Molecular pharmacology 20050801 |
| Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. | Cardiovascular research 20050801 |
| Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. | Journal of immunology (Baltimore, Md. : 1950) 20050801 |
| Suppression of Wolffia arrhiza growth by brassinazole, an inhibitor of brassinosteroid biosynthesis and its restoration by endogenous 24-epibrassinolide. | Phytochemistry 20050801 |
| Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2' of bacterioruberin in Halobacterium halobium. | The Biochemical journal 20050801 |
| Statins and cancer development. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050801 |
| Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. | The Journal of biological chemistry 20050722 |
| fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. | FEBS letters 20050704 |
| Induction of macrophage elastase (MMP-12) gene expression by statins. | Journal of cellular physiology 20050701 |
| Effect of pravastatin on development of left ventricular hypertrophy in spontaneously hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20050701 |
| Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. | Journal of the American Society of Nephrology : JASN 20050701 |
| Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes. | Arteriosclerosis, thrombosis, and vascular biology 20050701 |
| Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin. | Pharmacology 20050701 |
| Pleiotropic effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: candidate mechanisms for anti-lipid deposition in blood vessels. | Current medicinal chemistry. Cardiovascular and hematological agents 20050701 |
| In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis. | European journal of endocrinology 20050701 |
| Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity. | Archiv der Pharmazie 20050701 |
| Polyisoprenoids: structure, biosynthesis and function. | Progress in lipid research 20050701 |
| JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050701 |
| Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. | Cancer letters 20050628 |
| A novel type of geosmin biosynthesis in myxobacteria. | The Journal of organic chemistry 20050624 |
| Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. | The Journal of biological chemistry 20050610 |
| Statins downregulate myeloperoxidase gene expression in macrophages. | Biochemical and biophysical research communications 20050603 |
| Tendonitis in variant hyperimmunoglobulinaemia D and periodic fever syndrome--a rare disease with a new symptom. | European journal of pediatrics 20050601 |
| Chemical-based translational induction of luciferase expression: an efficient tool for in vivo screening of protein farnesylation inhibitors. | Molecular pharmacology 20050601 |
| Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. | Arteriosclerosis, thrombosis, and vascular biology 20050601 |
| The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. | Plant physiology 20050601 |
| Periodic fever in children with hyperimmunoglobulinemia D and mevalonate kinase mutations. | The Pediatric infectious disease journal 20050601 |
| The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. | Journal of Korean medical science 20050601 |
| 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | Journal of chemical ecology 20050601 |
| A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei. | Acta crystallographica. Section F, Structural biology and crystallization communications 20050601 |
| Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1. | The Journal of biological chemistry 20050527 |
| Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism. | The Journal of biological chemistry 20050513 |
| Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. | Molecular cell 20050513 |
| Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. | Circulation 20050510 |
| HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma. | British journal of cancer 20050509 |
| Molecular clues into the pathogenesis of statin-mediated muscle toxicity. | Muscle & nerve 20050501 |
| Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501 |
| Enterococcus faecalis phosphomevalonate kinase. | Protein science : a publication of the Protein Society 20050501 |
| Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses. | Radiation research 20050501 |
| Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications. | Current drug targets 20050501 |
| [Bisphosphonates: the molecular targets and mechanisms of action]. | Clinical calcium 20050501 |
| [Simvastatin induces eosinophil apoptosis in vitro]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20050501 |
| Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells. | British journal of cancer 20050425 |
| Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells. | Biochimica et biophysica acta 20050415 |
| Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. | The Journal of biological chemistry 20050408 |
| Induction of apoptosis in breast cancer cells by apomine is mediated by caspase and p38 mitogen activated protein kinase activation. | Biochemical and biophysical research communications 20050408 |
| [Statins for treatment of CNS diseases. Status report from research and clinical practice]. | Der Nervenarzt 20050401 |
| Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae. | Applied microbiology and biotechnology 20050401 |
| Identification of a novel mevalonate kinase gene mutation in combination with the common MVK V377I substitution and the low-penetrance TNFRSF1A R92Q mutation. | European journal of human genetics : EJHG 20050401 |
| Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401 |
| [Effects of fosmidomycin and lovastatin treatment on taxol biosynthesis in suspension culture cells of Taxus chinensis]. | Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology 20050401 |
| Statins and thrombin. | Current drug targets. Cardiovascular & haematological disorders 20050401 |
| Cholesterol-independent effects of statins in inflammation, immunomodulation and atherosclerosis. | Current drug targets. Cardiovascular & haematological disorders 20050401 |
| Three's company: regulation of cell fate by statins. | Current drug targets. Cardiovascular & haematological disorders 20050401 |
| Presence and titer of methyl palmitate in the Medfly (Ceratitis capitata) during reproductive maturation. | Journal of insect physiology 20050401 |
| Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes. | The Journal of antibiotics 20050401 |
| Statin-associated neuromyotoxicity. | Drugs of today (Barcelona, Spain : 1998) 20050401 |
| HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. | Circulation 20050322 |
| Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050315 |
| Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2. | Biochemical and biophysical research communications 20050304 |
| Effect of simvastatin on left ventricular mass in hypercholesterolemic rabbits. | American journal of physiology. Heart and circulatory physiology 20050301 |
| MVK mutations and associated clinical features in Italian patients affected with autoinflammatory disorders and recurrent fever. | European journal of human genetics : EJHG 20050301 |
| Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. | Journal of leukocyte biology 20050301 |
| Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease. | Arteriosclerosis, thrombosis, and vascular biology 20050301 |
| Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. | Journal of neurochemistry 20050301 |
| Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana. | Bioscience, biotechnology, and biochemistry 20050301 |
| Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview. | Wiener klinische Wochenschrift 20050301 |
| Ongoing clinical trials of the pleiotropic effects of statins. | Vascular health and risk management 20050301 |
| Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings. | Life sciences 20050225 |
| Invasive characteristics of human prostatic epithelial cells: understanding the metastatic process. | British journal of cancer 20050214 |
| Statin-inhibited endothelial permeability could be associated with its effect on PECAM-1 in endothelial cells. | FEBS letters 20050214 |
| Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery. | Arteriosclerosis, thrombosis, and vascular biology 20050201 |
| Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. | Molecular nutrition & food research 20050201 |
| A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway. | Chembiochem : a European journal of chemical biology 20050201 |
| Hyperimmunoglobulinemia D syndrome in an Arab child. | Clinical rheumatology 20050201 |
| Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways. | Phytochemistry 20050201 |
| Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. | Metabolism: clinical and experimental 20050201 |
| Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies. | Thrombosis and haemostasis 20050201 |
| [Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes]. | The Japanese journal of antibiotics 20050201 |
| Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. | Journal of periodontology 20050201 |
| Therapy insight: Potential of statins for cancer chemoprevention and therapy. | Nature clinical practice. Oncology 20050201 |
| Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. | International journal of cancer 20050120 |
| A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase. | Journal of the American Chemical Society 20050119 |
| Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. | Archives of biochemistry and biophysics 20050115 |
| Alendronate inhibits intraperitoneal dissemination in in vivo ovarian cancer model. | Cancer research 20050115 |
| 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112 |
| The mevalonate pathway and the synthesis of juvenile hormone in insects. | Annual review of entomology 20050101 |
| Regulation of luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid expression in the rat ovary: relationship to cholesterol metabolism. | Endocrinology 20050101 |
| Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion. | American journal of physiology. Endocrinology and metabolism 20050101 |
| Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). | Biochemical pharmacology 20050101 |
| The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. | Clinical and experimental immunology 20050101 |
| Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | Plant physiology 20050101 |
| Aspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol. | FEMS microbiology letters 20050101 |
| Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK. | PLoS medicine 20050101 |
| Lipid oxidative stress and the anti-inflammatory properties of statins and ACE inhibitors. | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20050101 |
| Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress, ionising or ultraviolet radiation. | BMC genomics 20050101 |
| Transport of isoprenoid intermediates across chloroplast envelope membranes. | Plant biology (Stuttgart, Germany) 20050101 |
| HMG-CoA reductase inhibitors and coenzyme Q10. | Cardiology in review 20050101 |
| Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases? | Arthritis research & therapy 20050101 |
| A comprehensive update of the sequence and structure classification of kinases. | BMC structural biology 20050101 |
| Henoch-Schönlein purpura in a child with hyperimmunoglobulinemia D and periodic fever syndrome. | Pediatric dermatology 20050101 |
| New lipid-lowering agents acting on LDL receptors. | Current topics in medicinal chemistry 20050101 |
| [Prevalence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis among bacteria of different systematic groups]. | Mikrobiologiia 20050101 |
| Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. | Journal of atherosclerosis and thrombosis 20050101 |
| Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes. | Journal of atherosclerosis and thrombosis 20050101 |
| Biochemical changes of mevalonate pathway in human colorectal cancer. | Anticancer research 20050101 |
| [Isoprenoid pigments in representatives of the family Microbacteriaceae]. | Mikrobiologiia 20050101 |
| Organic acid toxicity, tolerance, and production in Escherichia coli biorefining applications. | Microbial cell factories 20050101 |
| JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs. | BMC cardiovascular disorders 20050101 |
| Lipid-modified proteins as biomarkers for cardiovascular disease: a review. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20050101 |
| Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli. | Biotechnology progress 20050101 |
| Bisphosphonates and atherosclerosis: why? | Lupus 20050101 |
| [Arginine and statins: relationship between the nitric oxide pathway and the atherosclerosis development]. | Annales de biologie clinique 20050101 |
| Treatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease. | Lipids in health and disease 20050101 |
| Plant cells: secondary metabolite heterogeneity and its manipulation. | Advances in biochemical engineering/biotechnology 20050101 |
| Hypercholesterolemia and apolipoprotein B expression: regulation by selenium status. | Lipids in health and disease 20050101 |
| Hereditary periodic fever syndromes. | Hematology. American Society of Hematology. Education Program 20050101 |
| The effect of D-003 (10 mg/day) on biochemical parameters of bone remodelling in postmenopausal women: a randomized, double-blind study. | International journal of clinical pharmacology research 20050101 |
| Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. | Genome biology 20050101 |
| Comparison of the effects of D-003, a mixture of high-molecular-weight aliphatic acids from sugarcane wax, and pravastatin on bones and osteoclast apoptosis of ovariectomized rats. | Drugs under experimental and clinical research 20050101 |
| First-trimester enzymatic and molecular prenatal diagnosis of mevalonic aciduria. | Journal of inherited metabolic disease 20050101 |
| Retinitis pigmentosa in mevalonate kinase deficiency. | Journal of inherited metabolic disease 20050101 |
| Effects of D-003 (5-200 mg/kg), a mixture of high molecular weight aliphatic acids from sugarcane wax, on bones and bone cell apoptosis in ovariectomized rats. | International journal of tissue reactions 20050101 |
| Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. | Breast cancer research : BCR 20050101 |
| Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato. | Plant biotechnology journal 20050101 |
| A 'block and rescue' pharmacogenetic approach to dissecting a biochemical pathway controlling germ cell migration. | Zebrafish 20050101 |
| Statins and modulation of oxidative stress. | Toxicology mechanisms and methods 20050101 |
| Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. | Biochemistry 20041228 |
| Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1. | Biochemical and biophysical research communications 20041217 |
| Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition. | The Biochemical journal 20041215 |
| The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. | Free radical biology & medicine 20041215 |
| HMG-CoA reductase inhibitors induce COX-2 gene expression in murine macrophages: role of MAPK cascades and promoter elements for CREB and C/EBPbeta. | Experimental cell research 20041210 |
| From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates. | Calcified tissue international 20041201 |
| Regulation and degradation of HMGCo-A reductase. | Applied microbiology and biotechnology 20041201 |
| The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study). | European heart journal 20041201 |
| [Anabolic effects of statin and beta-blocker on bone metabolism]. | Clinical calcium 20041201 |
| Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta. | Bioscience, biotechnology, and biochemistry 20041201 |
| Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuroblastoma SH-SY5Y cells exposed to A beta. | Neuroscience letters 20041123 |
| Molecular functions of conserved aspects of the GHMP kinase family. | Biochemistry 20041123 |
| Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. | Journal of cellular biochemistry 20041115 |
| Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. | The Journal of biological chemistry 20041112 |
| Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell. | Biochemical and biophysical research communications 20041112 |
| Brassica juncea 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase 1: expression and characterization of recombinant wild-type and mutant enzymes. | The Biochemical journal 20041101 |
| Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. | Arteriosclerosis, thrombosis, and vascular biology 20041101 |
| Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. | Biochemical pharmacology 20041101 |
| Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells. | British journal of cancer 20041101 |
| HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. | Cardiovascular research 20041101 |
| Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. | Circulation journal : official journal of the Japanese Circulation Society 20041101 |
| Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinone. | Toxicology and applied pharmacology 20041101 |
| Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer. | Cancer treatment reviews 20041101 |
| Presence of copalyl diphosphate synthase gene in an actinomycete possessing the mevalonate pathway. | The Journal of antibiotics 20041101 |
| Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism. | The Journal of biological chemistry 20041022 |
| Beta4 integrin is involved in statin-induced endothelial cell death. | Biochemical and biophysical research communications 20041022 |
| Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis. | Journal of immunology (Baltimore, Md. : 1950) 20041015 |
| Genoprotective pathways. II. Attenuation of oxidative DNA damage by isopentenyl diphosphate. | Mutation research 20041004 |
| Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. | Bioorganic chemistry 20041001 |
| Comparison of mechanism and functional effects of magnesium and statin pharmaceuticals. | Journal of the American College of Nutrition 20041001 |
| The fellowship of natural abundance 2H-isotopomers of monoterpenes. | Phytochemistry 20041001 |
| Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway. | Trends in cardiovascular medicine 20041001 |
| Production of mevalonate by a metabolically-engineered Escherichia coli. | Biotechnology letters 20041001 |
| The metabolic imbalance underlying lesion formation in Arabidopsis thaliana overexpressing farnesyl diphosphate synthase (isoform 1S) leads to oxidative stress and is triggered by the developmental decline of endogenous HMGR activity. | Planta 20041001 |
| Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. | The Journal of biological chemistry 20040910 |
| Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans. | Journal of lipid research 20040901 |
| HMG-CoA reductase inhibitors and the risk of vertebral fracture. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040901 |
| Effect of inflammatory attacks in the classical type hyper-IgD syndrome on immunoglobulin D, cholesterol and parameters of the acute phase response. | Journal of internal medicine 20040901 |
| Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. | Journal of thrombosis and haemostasis : JTH 20040901 |
| Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells. | Journal of the American Society of Nephrology : JASN 20040901 |
| Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cells. | Journal of the American Society of Nephrology : JASN 20040901 |
| Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase synthesis. | Molecular carcinogenesis 20040901 |
| Are iridoids in leaf beetle larvae synthesized de novo or derived from plant precursors? A methodological approach. | Isotopes in environmental and health studies 20040901 |
| First report of systemic reactive (AA) amyloidosis in a patient with the hyperimmunoglobulinemia D with periodic fever syndrome. | Arthritis and rheumatism 20040901 |
| Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level. | Journal of biochemistry 20040901 |
| Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. | Biochemical and biophysical research communications 20040827 |
| Multienzyme mevalonate pathway bioreactor. | Biotechnology and bioengineering 20040820 |
| Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins. | Circulation 20040817 |
| Update on statins: 2003. | Circulation 20040817 |
| Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells. | British journal of cancer 20040816 |
| Statins inhibit HIV-1 infection by down-regulating Rho activity. | The Journal of experimental medicine 20040816 |
| Mevalonate promotes the growth of tumors derived from human cancer cells in vivo and stimulates proliferation in vitro with enhanced cyclin-dependent kinase-2 activity. | The Journal of biological chemistry 20040806 |
| Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells. | Biochimica et biophysica acta 20040804 |
| Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. | American journal of physiology. Heart and circulatory physiology 20040801 |
| Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | Arteriosclerosis, thrombosis, and vascular biology 20040801 |
| [Hereditary periodic fever]. | Der Internist 20040801 |
| Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. | Atherosclerosis 20040801 |
| Autoinflammatory diseases: the hereditary periodic fever syndromes. | Acta bio-medica : Atenei Parmensis 20040801 |
| MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMG-CoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway. | Life sciences 20040730 |
| A new definition for the consensus sequence of the peroxisome targeting signal type 2. | Journal of molecular biology 20040730 |
| Lipid rafts mediate the synaptic localization of alpha-synuclein. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728 |
| Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes. | Biochimica et biophysica acta 20040705 |
| Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase. | The Journal of biological chemistry 20040702 |
| Identification of active site residues in mevalonate diphosphate decarboxylase: implications for a family of phosphotransferases. | Protein science : a publication of the Protein Society 20040701 |
| Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. | European journal of biochemistry 20040701 |
| Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27. | Journal of the American Society of Nephrology : JASN 20040701 |
| Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. | Experimental biology and medicine (Maywood, N.J.) 20040701 |
| Coordinated gene expression for pheromone biosynthesis in the pine engraver beetle, Ips pini (Coleoptera: Scolytidae). | Die Naturwissenschaften 20040701 |
| [Cloning and analysis of cDNA encoding key enzyme gene (dxr) of the non-MVA pathway in Taxus chinensis cells]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040701 |
| Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors. | Biochemical pharmacology 20040615 |
| Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. | Journal of immunology (Baltimore, Md. : 1950) 20040615 |
| Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. | Chembiochem : a European journal of chemical biology 20040607 |
| Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells. | American journal of physiology. Heart and circulatory physiology 20040601 |
| Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. | Analytical biochemistry 20040601 |
| Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii. | Protein science : a publication of the Protein Society 20040601 |
| Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells. | Journal of cellular biochemistry 20040601 |
| Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. | Biochimica et biophysica acta 20040601 |
| Multisite inhibition by phenylacetate of PC-3 cell growth. | Anti-cancer drugs 20040601 |
| Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, blocks vascular smooth muscle cell populated-collagen lattice contraction. | Journal of cardiovascular pharmacology 20040601 |
| Statins as immunomodulatory agents. | Circulation 20040601 |
| Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa. | Arthritis and rheumatism 20040601 |
| Biosynthesis of isoprenoids via the non-mevalonate pathway. | Cellular and molecular life sciences : CMLS 20040601 |
| The methylerythritol phosphate pathway contributes to carotenoid but not phytol biosynthesis in Euglena gracilis. | Journal of natural products 20040601 |
| [In vitro effects of mevastatin on the proliferation and apoptosis in human multiple myeloma cell line U266]. | Zhongguo shi yan xue ye xue za zhi 20040601 |
| Statins as potential therapeutic agents in multiple sclerosis. | Current neurology and neuroscience reports 20040501 |
| Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | Molecular pharmacology 20040501 |
| Simvastatin treatment for inflammatory attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. | Clinical pharmacology and therapeutics 20040501 |
| Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501 |
| Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages. | DNA and cell biology 20040501 |
| Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1. | Oncogene 20040415 |
| Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62:6015-20. | Cancer research 20040415 |
| Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovary. | The Journal of biological chemistry 20040409 |
| Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. | The Journal of biological chemistry 20040409 |
| Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: normalization by atorvastatin. | Journal of the American College of Cardiology 20040407 |
| Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. | The Journal of biological chemistry 20040402 |
| A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis. | Endocrinology 20040401 |
| HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. | Journal of neurochemistry 20040401 |
| A patient with hyper-IgD syndrome in Antalya, Turkey. | Clinical rheumatology 20040401 |
| Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. | The Plant journal : for cell and molecular biology 20040401 |
| Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing. | Plant physiology 20040401 |
| Origins and evolution of isoprenoid lipid biosynthesis in archaea. | Molecular microbiology 20040401 |
| Defects in the N-linked oligosaccharide biosynthetic pathway in a Trypanosoma brucei glycosylation mutant. | Eukaryotic cell 20040401 |
| Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes? | Journal of Alzheimer's disease : JAD 20040401 |
| Biosynthesis of unusual monocyclic alkenes by the diatom Rhizosolenia setigera (Brightwell). | Phytochemistry 20040401 |
| Heterologous mevalonate production in Streptomyces lividans TK23. | Bioscience, biotechnology, and biochemistry 20040401 |
| Mevalonate kinase deficiency: Evidence for a phenotypic continuum. | Neurology 20040323 |
| Regulation of geranylgeranyl pyrophosphate synthase in the proliferation of rat FRTL-5 cells: involvement of both cAMP-PKA and PI3-AKT pathways. | Biochemical and biophysical research communications 20040319 |
| Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. | Biochemical and biophysical research communications 20040312 |
| The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. | FEBS letters 20040312 |
| Farnesol-DMPC phase behaviour: a (2)H-NMR study. | Biochimica et biophysica acta 20040309 |
| Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris. | Planta 20040301 |
| Enterococcus faecalis mevalonate kinase. | Protein science : a publication of the Protein Society 20040301 |
| Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. | The Plant journal : for cell and molecular biology 20040301 |
| Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. | Cardiovascular research 20040301 |
| Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae. | European journal of biochemistry 20040301 |
| The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301 |
| Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries. | Journal of cardiovascular pharmacology 20040301 |
| Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity. | The Journal of biological chemistry 20040220 |
| Statin use and cancer risk in the General Practice Research Database. | British journal of cancer 20040209 |
| Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency. | The Journal of biological chemistry 20040206 |
| Hydroxymethyl-glutaryl coenzyme a reductase inhibition limits cytomegalovirus infection in human endothelial cells. | Circulation 20040203 |
| Mevalonate kinase is a cytosolic enzyme in humans. | Journal of cell science 20040201 |
| Carbon and hydrogen isotopic fractionation during lipid biosynthesis in a higher plant (Cryptomeria japonica). | Phytochemistry 20040201 |
| Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. | Developmental cell 20040201 |
| Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040201 |
| Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes. | Atherosclerosis 20040201 |
| [The role of mevalonate pathway in osteogenic cells]. | Nihon rinsho. Japanese journal of clinical medicine 20040201 |
| Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs. | Current opinion in investigational drugs (London, England : 2000) 20040201 |
| [Statins as possible therapeutic tools for osteoporosis]. | Clinical calcium 20040201 |
| Metabolism and function of coenzyme Q. | Biochimica et biophysica acta 20040128 |
| Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. | Biochemical and biophysical research communications 20040123 |
| Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. | Biochemical pharmacology 20040115 |
| Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. | Neuroscience letters 20040109 |
| Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose. | Plant physiology 20040101 |
| Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. | The Plant cell 20040101 |
| HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis. | Atherosclerosis 20040101 |
| Novel genotype of mevalonic aciduria with fatalities in premature siblings. | Archives of disease in childhood. Fetal and neonatal edition 20040101 |
| Down-regulating effect of nicotine on connexin43 gap junctions in human umbilical vein endothelial cells is attenuated by statins. | European journal of cell biology 20040101 |
| Rising statin use and effect on ischemic stroke outcome. | BMC medicine 20040101 |
| Investigation of regulatory mechanisms in coenzyme Q metabolism. | Methods in enzymology 20040101 |
| NFY interacts with the promoter region of two genes involved in the rat peroxisomal fatty acid beta-oxidation: the multifunctional protein type 1 and the 3-ketoacyl-CoA B thiolase. | Lipids in health and disease 20040101 |
| Identifying mutations in autoinflammatory diseases: towards novel genetic tests and therapies? | American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20040101 |
| Pathogenesis of peroxisomal deficiency disorders (Zellweger syndrome) may be mediated by misregulation of the GABAergic system via the diazepam binding inhibitor. | BMC pediatrics 20040101 |
| Effect of Lovastatin on lipid peroxidation and total antioxidant concentrations in hemodialysis patients. | Lipids in health and disease 20040101 |
| The influence of statins on the free intracellular calcium concentration in human umbilical vein endothelial cells. | BMC cardiovascular disorders 20040101 |
| Detection of evolutionarily stable fragments of cellular pathways by hierarchical clustering of phyletic patterns. | Genome biology 20040101 |
| Effects of D-003, a mixture of high molecular weight aliphatic acids from sugar cane wax, on bones from ovariectomized rats. | Drugs under experimental and clinical research 20040101 |
| Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo. | Lipids in health and disease 20040101 |
| Bone metabolism, mineral homeostasis and its pharmacological modulation. | Clinical laboratory 20040101 |
| Role of isoprenoids in cytoskeleton integrity and albumin endocytosis by opossum kidney cells. | Nephron. Experimental nephrology 20040101 |
| Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis. | Nephron. Experimental nephrology 20040101 |
| Effect of D-003, a mixture of very high molecular weight aliphatic acids, on prednisolone-induced osteoporosis in Sprague-Dawley rats. | Drugs in R&D 20040101 |
| Policosanol prevents bone loss in ovariectomized rats. | Drugs under experimental and clinical research 20040101 |
| Delivery of mevalonate to murine extrahepatic tissues via mini-osmotic pumps. | Journal of pharmacological and toxicological methods 20040101 |
| Bisphosphonates: preclinical review. | The oncologist 20040101 |
| [Hyper-IgD syndrome and other hereditary periodic fever syndromes]. | Reumatismo 20040101 |
| The pivotal role of cholesterol absorption inhibitors in the management of dyslipidemia. | Lipids in health and disease 20040101 |
| Bisphosphonates and cancer. | Journal of veterinary internal medicine 20040101 |
| Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana. | Genome biology 20040101 |
| The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. | Genome biology 20040101 |
| Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq. | BMC plant biology 20040101 |
| Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2. | Cell biology international 20040101 |
| [Statins]. | Clinical calcium 20040101 |
| Lipid metabolism in zebrafish. | Methods in cell biology 20040101 |
| [Mevastatin induced apoptosis in U266 human myeloma cell line]. | Magyar onkologia 20040101 |
| [Periodic fever: the first Portuguese case-report of hyper-IgD syndrome (HIDS)]. | Acta medica portuguesa 20040101 |
| Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. | The Journal of biological chemistry 20031226 |
| Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors. | Toxicology and applied pharmacology 20031215 |
| Statins induce suppressor of cytokine signaling-3 in macrophages. | FEBS letters 20031204 |
| Studies on the biosynthesis of asperparaline A: origin of the spirosuccinimde ring system. | Journal of the American Chemical Society 20031203 |
| 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031203 |
| Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes. | Biochemical pharmacology 20031201 |
| Statin therapy and angiogenesis. | Current opinion in lipidology 20031201 |
| Effects of pravastatin on cardiomyocyte hypertrophy and ventricular vulnerability in normolipidemic rats after myocardial infarction. | Journal of molecular and cellular cardiology 20031201 |
| Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20031201 |
| Direct vascular effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. | Clinical and experimental pharmacology & physiology 20031201 |
| Dietary dehydroepiandrosterone inhibits bone marrow and leukemia cell transplants: role of food restriction. | Experimental biology and medicine (Maywood, N.J.) 20031201 |
| Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Th2 development. | Circulation research 20031114 |
| Molecular mechanisms of amyloidosis. | The New England journal of medicine 20031106 |
| Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. | Blood 20031101 |
| Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. | Journal of lipid research 20031101 |
| Epidermal growth factor receptor-targeted therapy potentiates lovastatin-induced apoptosis in head and neck squamous cell carcinoma cells. | Journal of cancer research and clinical oncology 20031101 |
| Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. | Arteriosclerosis, thrombosis, and vascular biology 20031101 |
| HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9. | Basic research in cardiology 20031101 |
| Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. | Free radical biology & medicine 20031101 |
| Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates. | Bone 20031101 |
| The potential therapeutic role of statins in central nervous system autoimmune disorders. | Cellular and molecular life sciences : CMLS 20031101 |
| Effects of statins on adhesion molecule expression in endothelial cells. | Journal of thrombosis and haemostasis : JTH 20031101 |
| Cell-cycle gene expression in lovastatin-induced medulloblastoma apoptosis. | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20031101 |
| Expression, purification, and characterization of His20 mutants of rat mevalonate kinase. | Protein expression and purification 20031101 |
| Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts. | Molecular genetics and metabolism 20031101 |
| A relationship between the mevalonate pathway and isoprenoid production in actinomycetes. | The Journal of antibiotics 20031101 |
| Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. | The Journal of biological chemistry 20031031 |
| Sites for interaction between Gal80p and Gal1p in Kluyveromyces lactis: structural model of galactokinase based on homology to the GHMP protein family. | Journal of molecular biology 20031024 |
| Comparison of gene representation in midguts from two phytophagous insects, Bombyx mori and Ips pini, using expressed sequence tags. | Gene 20031016 |
| Methodology for synthesis and isolation of 5-phosphomevalonic acid. | Analytical biochemistry 20031015 |
| Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. | Journal of cellular biochemistry 20031015 |
| Withdrawal of cerivastatin induces monocyte chemoattractant protein 1 and tissue factor expression in cultured vascular smooth muscle cells. | Arteriosclerosis, thrombosis, and vascular biology 20031001 |
| Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. | International journal of oncology 20031001 |
| Cloning, purification, crystallization and preliminary crystallographic analysis of galactokinase from Pyrococcus furiosus. | Acta crystallographica. Section D, Biological crystallography 20031001 |
| Statins as novel immunomodulators: from cell to potential clinical benefit. | Thrombosis and haemostasis 20031001 |
| How do statins control neuroinflammation? | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031001 |
| The mevalonate synthesis pathway as a therapeutic target in cancer. | Clinical orthopaedics and related research 20031001 |
| All hydrophobic HMG-CoA reductase inhibitors induce apoptotic death in rat pulmonary vein endothelial cells. | Atherosclerosis 20031001 |
| 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes. | Circulation 20030923 |
| Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. | Virology 20030915 |
| Statins and their role in vascular protection. | Clinical science (London, England : 1979) 20030901 |
| Isoprenoid metabolism and the pleiotropic effects of statins. | Current atherosclerosis reports 20030901 |
| Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. | Journal of immunology (Baltimore, Md. : 1950) 20030901 |
| Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. | Endocrinology 20030901 |
| Effects of rosuvastatin on nitric oxide-dependent function in aorta and corpus cavernosum of diabetic mice: relationship to cholesterol biosynthesis pathway inhibition and lipid lowering. | Diabetes 20030901 |
| Role of cholesterol-enriched diet and the mevalonate pathway in cardiac nitric oxide synthesis. | Basic research in cardiology 20030901 |
| The HMG-CoA reductase inhibitor cerivastatin enhances the nitric oxide bioavailability of the endothelium. | Journal of cardiovascular pharmacology 20030901 |
| Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery. | Pharmacology & toxicology 20030901 |
| Favorable preliminary experience with etanercept in two patients with the hyperimmunoglobulinemia D and periodic fever syndrome. | Arthritis and rheumatism 20030901 |
| Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells. | Cardiovascular research 20030901 |
| An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants. | Journal of biosciences 20030901 |
| Statins differ in their ability to block NF-kappaB activation in human blood monocytes. | International journal of clinical pharmacology and therapeutics 20030901 |
| The use of zoledronic acid in the management of metastatic bone disease and hypercalcaemia. | Palliative medicine 20030901 |
| Inhibition of lovastatin on proliferation and expression of proinflammatory cytokines in cultured human glomerular mesangial cells. | Chinese medical journal 20030901 |
| Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. | Pharmacopsychiatry 20030901 |
| Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. | Hypertension research : official journal of the Japanese Society of Hypertension 20030901 |
| Computational analysis of the evolution of the structure and function of 1-deoxy-D-xylulose-5-phosphate synthase, a key regulator of the mevalonate-independent pathway in plants. | Gene 20030814 |
| Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. | The Journal of biological chemistry 20030808 |
| Atorvastatin limits the pro-inflammatory response of rat aortic smooth muscle cells to thrombin. | European journal of pharmacology 20030808 |
| Frontalin: De novo biosynthesis of an aggregation pheromone component by Dendroctonus spp. bark beetles (Coleoptera: Scolytidae). | Insect biochemistry and molecular biology 20030801 |
| Expression and purification of Arg196 and Lys272 mutants of mevalonate kinase from Methanococcus jannaschii. | Protein expression and purification 20030801 |
| Circadian rhythms in Neurospora crassa: farnesol or geraniol allow expression of rhythmicity in the otherwise arrhythmic strains frq10, wc-1, and wc-2. | Journal of biological rhythms 20030801 |
| HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030801 |
| Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. | Journal of biochemistry 20030801 |
| Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis. | Bone 20030801 |
| The methylerythritol phosphate pathway and its significance as a novel drug target. | Current pharmaceutical biotechnology 20030801 |
| Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis in THP-1 cells. | Lipids 20030801 |
| Zinc is an essential cofactor for type I isopentenyl diphosphate:dimethylallyl diphosphate isomerase. | Journal of the American Chemical Society 20030730 |
| Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation. | Circulation 20030722 |
| Cross-talk between the cytosolic mevalonate and the plastidial methylerythritol phosphate pathways in tobacco bright yellow-2 cells. | The Journal of biological chemistry 20030718 |
| Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane. | Archives of biochemistry and biophysics 20030715 |
| Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity. | Bioorganic & medicinal chemistry letters 20030707 |
| Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survival. | British journal of cancer 20030707 |
| Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. | Cellular signalling 20030701 |
| Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. | Nature biotechnology 20030701 |
| Bcl-xL overexpression protects from apoptosis induced by HMG-CoA reductase inhibitors in murine tubular cells. | Kidney international 20030701 |
| Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells. | International journal of oncology 20030701 |
| Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells. | The Journal of urology 20030701 |
| Looking to the future: diabetic neuropathy and effects of rosuvastatin on neurovascular function in diabetes models. | Diabetes research and clinical practice 20030701 |
| Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701 |
| Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) in a child with normal serum IgD, but increased serum IgA concentration. | The Journal of pediatrics 20030701 |
| Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. | British journal of cancer 20030616 |
| Monoterpene regulation of Ras and Ras-related protein expression. | Journal of lipid research 20030601 |
| HMG CoA reductase inhibitors and the skeleton: a comprehensive review. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030601 |
| Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. | Kidney international 20030601 |
| Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis. | Biochemical Society transactions 20030601 |
| HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering? | Journal of cardiovascular risk 20030601 |
| Biosynthetic maturation of the corpus allatum of the female adult medfly, Ceratitis capitata, and its putative control. | Journal of insect physiology 20030601 |
| Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. | Biological & pharmaceutical bulletin 20030601 |
| Production of rubber-like polymers by microorganisms. | Current opinion in microbiology 20030601 |
| Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. | Cellular and molecular life sciences : CMLS 20030601 |
| Fosmidomycin for the treatment of malaria. | Parasitology research 20030601 |
| New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects. | British journal of cancer 20030519 |
| Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. | The Journal of biological chemistry 20030516 |
| Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. | Blood 20030501 |
| Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. | Arteriosclerosis, thrombosis, and vascular biology 20030501 |
| Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. | Journal of hepatology 20030501 |
| Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen. | Cellular immunology 20030501 |
| Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production. | Cellular immunology 20030501 |
| Isoprenoid pyrophosphate analogues regulate expression of Ras-related proteins. | Biochemistry 20030422 |
| XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. | Genes & development 20030415 |
| Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins. | Molecular pharmacology 20030401 |
| Statin rebound effect? | The Journal of laboratory and clinical medicine 20030401 |
| Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. | The Journal of laboratory and clinical medicine 20030401 |
| Diversity of the biosynthesis of the isoprene units. | Natural product reports 20030401 |
| Contribution of increased HMG-CoA reductase gene expression to hypercholesterolemia in experimental chronic renal failure. | Molecular and cellular biochemistry 20030401 |
| Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans. | Circulation 20030325 |
| Terpene biosynthesis in the nudibranch Doriopsilla areolata. | The Journal of organic chemistry 20030321 |
| Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata. | Journal of biotechnology 20030306 |
| Effects of cerivastatin on human arterial smooth muscle cell growth and extracellular matrix expression at varying glucose and low-density lipoprotein levels. | Journal of cardiovascular pharmacology 20030301 |
| Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family. | Arteriosclerosis, thrombosis, and vascular biology 20030301 |
| Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. | Arteriosclerosis, thrombosis, and vascular biology 20030301 |
| Beyond lipid-lowering: effects of statins on endothelial nitric oxide. | European journal of clinical pharmacology 20030301 |
| Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation. | British journal of pharmacology 20030301 |
| Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. | Trends in molecular medicine 20030301 |
| Effects of statin on plaque stability and thrombogenicity in hypercholesterolemic patients with coronary artery disease. | International journal of cardiology 20030301 |
| Biosynthesis of chloroplastidic and extrachloroplastidic terpenoids in liverwort cultured cells: 13C serine as a probe of terpene biosynthesis via mevalonate and non-mevalonate pathways. | Journal of natural products 20030301 |
| Statins: maid-of-all-work in cardiovascular diseases! | Archives des maladies du coeur et des vaisseaux 20030301 |
| Regulation of osteoclast differentiation by statins. | Journal of musculoskeletal & neuronal interactions 20030301 |
| Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients. | The Journal of biological chemistry 20030221 |
| Involvement of retinoid X receptor alpha in coenzyme Q metabolism. | Journal of molecular biology 20030221 |
| Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. | European journal of pharmacology 20030221 |
| Molecular characterization of three 3-hydroxy-3-methylglutaryl-CoA reductase genes including pathogen-induced Hmg2 from pepper (Capsicum annuum). | Biochimica et biophysica acta 20030220 |
| The kinetic mechanism of phosphomevalonate kinase. | The Journal of biological chemistry 20030214 |
| Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro. | Calcified tissue international 20030201 |
| Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression. | Leukemia research 20030201 |
| HMG-CoA reductase inhibitor enhances inducible nitric oxide synthase expression in rat vascular smooth muscle cells; involvement of the Rho/Rho kinase pathway. | Atherosclerosis 20030201 |
| Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. | Endocrinology 20030201 |
| Effect of atorvastatin on adhesive phenotype of human endothelial cells activated by tumor necrosis factor alpha. | Journal of cardiovascular pharmacology 20030201 |
| Mevalonate kinase deficiency: enlarging the clinical and biochemical spectrum. | Pediatrics 20030201 |
| Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei. | Biotechnology and applied biochemistry 20030201 |
| Bisphosphonate mechanism of action. | Current rheumatology reports 20030201 |
| Statins can inhibit proliferation of human breast cancer cells in vitro. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201 |
| Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. | Phytochemistry 20030201 |
| Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and periodic fever syndrome, in the Netherlands. | European journal of human genetics : EJHG 20030201 |
| Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. | The Journal of nutritional biochemistry 20030201 |
| [Evidences and the taking measurements against G-I tract adverse events in amino bisphosphonate]. | Clinical calcium 20030201 |
| Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols. | Journal of agricultural and food chemistry 20030115 |
| HMGCoA reductase inhibition partially mediates tumor necrosis factor alpha-induced apoptosis in human U-937 and HL-60 cells. | Biochemical and biophysical research communications 20030110 |
| Cholesterol cell content modulates GTPase activity of G proteins in GH4C1 cell membranes. | Cellular signalling 20030101 |
| Biochemistry and molecular biology of de novo isoprenoid pheromone production in the Scolytidae. | Annual review of entomology 20030101 |
| Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. | Kidney international 20030101 |
| Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected]. | European journal of clinical investigation 20030101 |
| Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. | Acta crystallographica. Section D, Biological crystallography 20030101 |
| Statins regulate alpha2beta1-integrin expression and collagen I-dependent functions in human vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20030101 |
| HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells. | Cardiovascular research 20030101 |
| Cloning, expression, and purification of His-tagged rat mevalonate kinase. | Protein expression and purification 20030101 |
| The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030101 |
| Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase. | Journal of lipid research 20030101 |
| Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. | Plant physiology 20030101 |
| Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. | Molecular cell 20030101 |
| Implications of growth factor alterations in the treatment of pancreatic cancer. | Molecular cancer 20030101 |
| The statins as anticancer agents. | Clinical cancer research : an official journal of the American Association for Cancer Research 20030101 |
| Changes in serum HDL and LDL cholesterol in patients with Paget's bone disease treated with pamidronate. | Bone 20030101 |
| Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2. | Journal of atherosclerosis and thrombosis 20030101 |
| Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells. | Lipids in health and disease 20030101 |
| Drugs in development: bisphosphonates and metalloproteinase inhibitors. | Arthritis research & therapy 20030101 |
| Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat. | BMC neuroscience 20030101 |
| Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. | Biotechnology progress 20030101 |
| [The statins: new properties]]. | Therapie 20030101 |
| Put your heart into the joint benefits of statins! | Arthritis research & therapy 20030101 |
| HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. | Journal of biomedical science 20030101 |
| HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. | BMC cardiovascular disorders 20030101 |
| Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard. | Rapid communications in mass spectrometry : RCM 20030101 |
| Immunomodulatory effects of HMG-CoA reductase inhibitors. | Archivum immunologiae et therapiae experimentalis 20030101 |
| Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. | Chemical record (New York, N.Y.) 20030101 |
| Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes. | Drugs 20030101 |
| The role of osteoprotegerin in arthritis. | Arthritis research & therapy 20030101 |
| New insights into the molecular mechanisms of action of bisphosphonates. | Current pharmaceutical design 20030101 |
| Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20030101 |
| Potential role of statins in inflammation and atherosclerosis. | Journal of atherosclerosis and thrombosis 20030101 |
| Cerivastatin ameliorates high insulin-enhanced neutrophil-endothelial cell adhesion and endothelial intercellular adhesion molecule-1 expression by inhibiting mitogen-activated protein kinase activation. | Journal of diabetes and its complications 20030101 |
| Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor. | Clinical & experimental metastasis 20030101 |
| Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. | Journal of vascular research 20030101 |
| Statin cardiomyopathy? A potential role for Co-Enzyme Q10 therapy for statin-induced changes in diastolic LV performance: description of a clinical protocol. | BioFactors (Oxford, England) 20030101 |
| TEXTAL system: artificial intelligence techniques for automated protein model building. | Methods in enzymology 20030101 |
| Age-related changes of isoprenoid biosynthesis in rat liver and brain. | Biogerontology 20030101 |
| Evaluation of simvastatin antioxidant effects. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101 |
| Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. | The Journal of biological chemistry 20021220 |
| Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. | Brain research 20021220 |
| Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. | FEBS letters 20021218 |
| Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. | Circulation 20021203 |
| Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndrome. | Human molecular genetics 20021201 |
| Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. | Planta 20021201 |
| Fluvastatin induces apoptosis in rat neonatal cardiac myocytes: a possible mechanism of statin-attenuated cardiac hypertrophy. | Journal of cardiovascular pharmacology 20021201 |
| Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept. | Clinical and experimental immunology 20021201 |
| A second gene for peroxisomal HMG-CoA reductase? A genomic reassessment. | Journal of lipid research 20021201 |
| Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity. | Japanese journal of pharmacology 20021201 |
| Biosynthesis of the lipophilic side chain in the cyclic hexadepsipeptide antibiotic IC101. | Journal of natural products 20021201 |
| Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201 |
| Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | Plant & cell physiology 20021201 |
| Amyloplast formation in cultured tobacco BY-2 cells requires a high cytokinin content. | Plant & cell physiology 20021201 |
| [Pharmacological and clinical properties of alendronate sodium hydrate]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021201 |
| Mechanisms of bisphosphonate effects on osteoclasts, tumor cell growth, and metastasis. | American journal of clinical oncology 20021201 |
| Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. | The Journal of biological chemistry 20021122 |
| Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines. | FEBS letters 20021120 |
| Isoprenoids influence expression of Ras and Ras-related proteins. | Biochemistry 20021119 |
| The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. | Nature 20021107 |
| Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells. | Atherosclerosis 20021101 |
| The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia. | Atherosclerosis 20021101 |
| Simvastatin increases fibrinolytic activity in human peritoneal mesothelial cells independent of cholesterol lowering. | Kidney international 20021101 |
| Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. | The Journal of pharmacology and experimental therapeutics 20021101 |
| Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor. | Molecular pharmacology 20021101 |
| Pamidronate causes apoptosis of plasma cells in vivo in patients with multiple myeloma. | British journal of haematology 20021101 |
| Bisphosphonates in cancer therapy. | Current opinion in oncology 20021101 |
| Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101 |
| Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho. | Cancer research 20021101 |
| 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent inhibition of CD40 expression by atorvastatin in human endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20021101 |
| Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. | Plant physiology 20021101 |
| Male jeffrey pine beetle, Dendroctonus jeffreyi, synthesizes the pheromone component frontalin in anterior midgut tissue. | Insect biochemistry and molecular biology 20021101 |
| Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin. | European journal of pharmacology 20021025 |
| Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. | Circulation research 20021018 |
| Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion. | Journal of lipid research 20021001 |
| Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. | Arthritis and rheumatism 20021001 |
| Detection of the mevalonate pathway in Streptomyces species using the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. | The Journal of antibiotics 20021001 |
| Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion. | Journal of nutritional science and vitaminology 20021001 |
| Lipid modification of proteins in Archaea: attachment of a mevalonic acid-based lipid moiety to the surface-layer glycoprotein of Haloferax volcanii follows protein translocation. | The Biochemical journal 20020915 |
| A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria. | The Journal of biological chemistry 20020906 |
| Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. | Gene 20020904 |
| Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes. | Molecular pharmacology 20020901 |
| The succinate mechanism of insulin release. | Diabetes 20020901 |
| Effects of pravastatin sodium on mevalonate metabolism in common marmosets. | Journal of biochemistry 20020901 |
| Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. | Plant physiology 20020901 |
| [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)]. | Comptes rendus biologies 20020901 |
| Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin. | Clinical and experimental pharmacology & physiology 20020801 |
| Mechanisms of inhibitory effects of cerivastatin on rat vascular smooth muscle cell growth. | Journal of cardiovascular pharmacology 20020801 |
| Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. | Diabetes 20020801 |
| Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin. | Biochemical pharmacology 20020801 |
| The mevalonate pathway during acute tubular injury: selected determinants and consequences. | The American journal of pathology 20020801 |
| HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells. | Clinical science (London, England : 1979) 20020801 |
| Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. | Bioscience, biotechnology, and biochemistry 20020801 |
| Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. | FEMS yeast research 20020801 |
| The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. | British journal of cancer 20020729 |
| Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. | Neoplasia (New York, N.Y.) 20020701 |
| The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells. | Leukemia 20020701 |
| Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. | Journal of vascular surgery 20020701 |
| Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone. | The Journal of endocrinology 20020701 |
| Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. | Arteriosclerosis, thrombosis, and vascular biology 20020701 |
| Overt and occult rheumatic diseases: the child with chronic fever. | Best practice & research. Clinical rheumatology 20020701 |
| Validation and application of an assay for the determination of mevalonic acid in human plasma by liquid chromatography tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020625 |
| Disparity between angiographic regression and clinical event rates with hydrophobic statins. | Lancet (London, England) 20020622 |
| Biosynthesis of nodulisporic acid A: precursor studies. | Journal of the American Chemical Society 20020619 |
| Increased transforming growth factor-beta(1) circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase inhibition with pravastatin. | Journal of the American College of Cardiology 20020605 |
| Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. | Planta 20020601 |
| Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells. | Cardiovascular research 20020601 |
| Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. | Plant physiology 20020601 |
| Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | Journal of neuroscience research 20020601 |
| Inherited disorders of cholesterol biosynthesis. | Clinical genetics 20020601 |
| The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. | The Journal of biological chemistry 20020517 |
| The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells. | British journal of cancer 20020506 |
| Hereditary periodic fever. | The New England journal of medicine 20020502 |
| Atorvastatin inhibition of cytokine-inducible nitric oxide synthase expression in native endothelial cells in situ. | British journal of pharmacology 20020501 |
| Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | Cancer research 20020501 |
| High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production. | Lipids 20020501 |
| [Bisphosphonates and adhesion molecules]. | Clinical calcium 20020501 |
| [The role of the mevalonate pathway in osteogenic cells]. | Clinical calcium 20020501 |
| Age-related changes of cholesterol and dolichol biosynthesis in rat liver. | Mechanisms of ageing and development 20020430 |
| The genetics and molecular genetics of terpene and sterol origami. | Current opinion in plant biology 20020401 |
| CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. | Blood 20020401 |
| Effects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach. | Archives of insect biochemistry and physiology 20020401 |
| Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. | Applied microbiology and biotechnology 20020401 |
| HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. | Leukemia 20020401 |
| Statins and osteoporosis: can these lipid-lowering drugs also bolster bones? | Cleveland Clinic journal of medicine 20020401 |
| Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. | The Plant journal : for cell and molecular biology 20020401 |
| The biosynthesis of C5-C25 terpenoid compounds. | Natural product reports 20020401 |
| Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. | Bioscience, biotechnology, and biochemistry 20020401 |
| Regulatory aspects of coenzyme Q metabolism. | Free radical research 20020401 |
| Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. | The Journal of biological chemistry 20020322 |
| Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily. | The Journal of biological chemistry 20020315 |
| Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. | The Journal of biological chemistry 20020308 |
| Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases. | Circulation research 20020308 |
| 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. | Atherosclerosis 20020301 |
| Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. | Carcinogenesis 20020301 |
| [Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action]. | Nihon rinsho. Japanese journal of clinical medicine 20020301 |
| HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells. | Cardiovascular drugs and therapy 20020301 |
| HMG-CoA reductase inhibitors - a review of the recent patent literature. | IDrugs : the investigational drugs journal 20020301 |
| Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. | Circulation 20020226 |
| HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. | Circulation 20020226 |
| Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. | Journal of molecular biology 20020208 |
| Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study. | The Journal of organic chemistry 20020208 |
| Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | American journal of physiology. Heart and circulatory physiology 20020201 |
| Fluvastatin enhances apoptosis in cytokine-stimulated vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20020201 |
| 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. | Gastroenterology 20020201 |
| Cellular antioxidant effects of atorvastatin in vitro and in vivo. | Arteriosclerosis, thrombosis, and vascular biology 20020201 |
| Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. | American heart journal 20020201 |
| Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. | Leukemia 20020201 |
| Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue. | Breast cancer research and treatment 20020201 |
| Midgut tissue of male pine engraver, Ips pini, synthesizes monoterpenoid pheromone component ipsdienol de novo. | Die Naturwissenschaften 20020201 |
| [Inhibitory effects of lovastatin on the proliferation and cell cycle phase of cultured human glomerular mesangial cells in vitro]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020201 |
| Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. | Biochemical and biophysical research communications 20020118 |
| Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase. | FEBS letters 20020116 |
| Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. | Biochemical and biophysical research communications 20020111 |
| HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro: a comparative study using different statins. | British journal of pharmacology 20020101 |
| Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors. | Bone 20020101 |
| Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. | Journal of lipid research 20020101 |
| Genes for mevalonate biosynthesis in Phycomyces. | Molecular genetics and genomics : MGG 20020101 |
| Statin drugs and dietary isoprenoids downregulate protein prenylation in signal transduction and are antithrombotic and prothrombolytic agents. | Biochemistry. Biokhimiia 20020101 |
| Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled, dose-ranging trial [ISRCTN85429598]. | BMC musculoskeletal disorders 20020101 |
| Direct effects of bisphosphonates on breast cancer cells. | Breast cancer research : BCR 20020101 |
| Development of bisphosphonates. | Breast cancer research : BCR 20020101 |
| Actions of bisphosphonates in animal models of breast cancer. | Breast cancer research : BCR 20020101 |
| Alendronate disturbs vesicular trafficking in osteoclasts. | Calcified tissue international 20020101 |
| Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase. | Journal of neuro-oncology 20020101 |
| Statins as modulators of bone formation. | Arthritis research 20020101 |
| Improved paclitaxel and baccatin III production in suspension cultures of Taxus media. | Biotechnology progress 20020101 |
| Iridoid patterns in Galium L. and some phylogenetic considerations. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101 |
| Studies on the biosynthesis of striatal-type diterpenoids and the biological activity of herical. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101 |
| The role of statins as potential targets for bone formation. | Arthritis research 20020101 |
| An intestinal obstruction in an eight-month-old child suffering from mevalonic aciduria. | Acta paediatrica (Oslo, Norway : 1992) 20020101 |
| Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | Journal of atherosclerosis and thrombosis 20020101 |
| Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells. | Physiological chemistry and physics and medical NMR 20020101 |
| Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells. | Clinical & experimental metastasis 20020101 |
| Chromosomal localization of genes involved in biosynthesis, metabolism or transport of cholesterol in the rat. | Cytogenetic and genome research 20020101 |
| Brassinosteroids. Plant counterparts to animal steroid hormones? | Vitamins and hormones 20020101 |
| [Organic acid disorders: cerebral organic acidemia]. | Ryoikibetsu shokogun shirizu 20020101 |
| Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism. | BMC pediatrics 20020101 |
| The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3-hydroxy-3-methylglutaryl-coenzyme A reductase on Vero cells. | The American journal of Chinese medicine 20020101 |
| Abstracts of the Fourth International Symposium on Molecular Insect Science. May 28-June 2, 2002. Tucson, Arizona, USA. | Journal of insect science (Online) 20020101 |
| Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. | The Journal of biological chemistry 20011228 |
| Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. | Biochemical pharmacology 20011215 |
| Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. | The Journal of biological chemistry 20011214 |
| Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. | The Biochemical journal 20011201 |
| Statins and their potential for osteoporosis. | Bone 20011201 |
| Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. | European journal of biochemistry 20011201 |
| Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. | Arteriosclerosis, thrombosis, and vascular biology 20011201 |
| Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype. | Arthritis and rheumatism 20011201 |
| Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. | Molecular and cellular biochemistry 20011201 |
| Synergistic interaction of lovastatin and paclitaxel in human cancer cells. | Molecular cancer therapeutics 20011201 |
| Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. | The Journal of clinical investigation 20011115 |
| More on pamidronate in Langerhans'-cell histiocytosis. | The New England journal of medicine 20011115 |
| Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. | European journal of pharmacology 20011109 |
| Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. | Biochemical and biophysical research communications 20011102 |
| Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. | FEBS letters 20011102 |
| Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells. | Chinese medical journal 20011101 |
| Bisphosphonates: an overview with special reference to alendronate. | Annals of clinical biochemistry 20011101 |
| Regulation of lipid metabolism and gene expression by fenofibrate in hamsters. | Biochimica et biophysica acta 20011031 |
| Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. | Journal of bacteriology 20011001 |
| The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates. | Current opinion in chemical biology 20011001 |
| Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. | Bone 20011001 |
| Biosynthetic pathway of insect juvenile hormone III in cell suspension cultures of the sedge Cyperus iria. | Plant physiology 20011001 |
| Bisphosphonates in the treatment of metastatic breast cancer. | Journal of mammary gland biology and neoplasia 20011001 |
| Ubiquinone biosynthesis in microorganisms. | FEMS microbiology letters 20010925 |
| Molecular analysis of the mevalonate kinase gene in a cohort of patients with the hyper-igd and periodic fever syndrome: its application as a diagnostic tool. | Annals of internal medicine 20010904 |
| Summaries for patients. Can genetics help diagnose the hyper-IgD and periodic fever syndrome. | Annals of internal medicine 20010904 |
| Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. | Leukemia 20010901 |
| Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. | Plant physiology 20010901 |
| Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression. | Japanese journal of cancer research : Gann 20010901 |
| Hereditary periodic fever syndromes. | The Netherlands journal of medicine 20010901 |
| Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. | Methods and findings in experimental and clinical pharmacology 20010901 |
| Determination of mevalonic acid in human urine as mevalonic acid lactone by gas chromatography-mass spectrometry. | Journal of chromatography. B, Biomedical sciences and applications 20010825 |
| Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. | Biochemical and biophysical research communications 20010810 |
| Increased urinary leukotriene E(4) during febrile attacks in the hyperimmunoglobulinaemia D and periodic fever syndrome. | Archives of disease in childhood 20010801 |
| Action of an HMG CoA reductase inhibitor, lovastatin, on apoptosis of untransformed and ts-SV40 transformed human smooth muscle cells derived from saphenous vein. | Journal of cardiovascular pharmacology 20010801 |
| Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). | British journal of pharmacology 20010801 |
| In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products. | Arteriosclerosis, thrombosis, and vascular biology 20010801 |
| Peroxisomes in the apocrine sweat glands of the human axilla and their putative role in pheromone production. | Cellular and molecular life sciences : CMLS 20010801 |
| Statins and bone: myth or reality? | Calcified tissue international 20010801 |
| HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. | Carcinogenesis 20010701 |
| Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. | Nature structural biology 20010701 |
| Lipophilic statins augment inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes. | Journal of cardiovascular pharmacology 20010701 |
| Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010701 |
| Genetic basis of mitochondrial HMG-CoA synthase deficiency. | Human genetics 20010701 |
| Effects of fluvastatin and its major metabolites on low-density lipoprotein oxidation and cholesterol esterification in macrophages. | Japanese journal of pharmacology 20010701 |
| Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. | Bioscience, biotechnology, and biochemistry 20010701 |
| The in vitro inhibitory effect of flavonoid astilbin on 3-hydroxy-3-methylglutaryl coenzyme A reductase on Vero cells. | Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 20010701 |
| [Inhibition of bone resorption by bisphosphonates, heterogeneous group of drugs with different intracellular model of action]. | Polskie Archiwum Medycyny Wewnetrznej 20010701 |
| Molecular characterization of Hmg2 gene encoding a 3-hydroxy-methylglutaryl-CoA reductase in rice. | Molecules and cells 20010630 |
| Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. | The Journal of biological chemistry 20010629 |
| Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives. | Biochimica et biophysica acta 20010629 |
| Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. | Cancer research 20010615 |
| LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. | FEBS letters 20010615 |
| Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. | The Journal of biological chemistry 20010601 |
| A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. | British journal of pharmacology 20010601 |
| Isolation of NPC1-deficient Chinese hamster ovary cell mutants by gene trap mutagenesis. | Journal of biochemistry 20010601 |
| Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I. | The Journal of clinical investigation 20010601 |
| Effect of atorvastatin on plasminogen activator inhibitor type-1 synthesis in human monocytes/macrophages. | Journal of cardiovascular pharmacology 20010601 |
| Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. | Atherosclerosis 20010601 |
| The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro. | Anti-cancer drugs 20010601 |
| HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. | Arteriosclerosis, thrombosis, and vascular biology 20010601 |
| Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. | Journal of leukocyte biology 20010601 |
| Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor. | Bioorganic & medicinal chemistry 20010601 |
| The pathway of biosynthesis of abscisic acid in vascular plants: a review of the present state of knowledge of ABA biosynthesis. | Journal of experimental botany 20010601 |
| Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. | Planta 20010601 |
| Mevalonate kinase deficiency in a child with periodic fever and without hyperimmunoglobulinaemia D. | Journal of inherited metabolic disease 20010601 |
| Mevalonic aciduria and hyper-IgD syndrome: two sides of the same coin? | Journal of inherited metabolic disease 20010601 |
| Inherited disorders of cholesterol biosynthesis. | Neuropediatrics 20010601 |
| Pleiotropic effects of statins on the vascular tissue. | Current drug targets. Cardiovascular & haematological disorders 20010601 |
| Colocalization prostacyclin (PGI2) synthase--caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis. | Experimental cell research 20010515 |
| Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors. | Transplantation 20010515 |
| NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. | British journal of pharmacology 20010501 |
| 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: balance between transcriptional and posttranscriptional regulation. | Arteriosclerosis, thrombosis, and vascular biology 20010501 |
| Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. | Arteriosclerosis, thrombosis, and vascular biology 20010501 |
| The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells. | Pharmacology 20010501 |
| Clinical and molecular variability in childhood periodic fever with hyperimmunoglobulinaemia D. | Rheumatology (Oxford, England) 20010501 |
| High IgD could be a nonpathogenetic diagnostic marker of the hyper-IgD and periodic fever syndrome. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010501 |
| Statins and bone formation. | Current pharmaceutical design 20010501 |
| American cockroach (Periplaneta americana) synthesizes carotenoids from the precursor. | Biochemistry. Biokhimiia 20010501 |
| Incadronate and etidronate accelerate phosphate-primed mineralization of MC4 cells via ERK1/2-Cbfa1 signaling pathway in a Ras-independent manner: further involvement of mevalonate-pathway blockade for incadronate. | Japanese journal of pharmacology 20010501 |
| Labeling patterns of chloroplastidic isoprenoids in cultured cells of liverwort Ptychanthus striatus. | Bioscience, biotechnology, and biochemistry 20010501 |
| Catabolic and anabolic signals in bone: therapeutic implications. | Current opinion in clinical nutrition and metabolic care 20010501 |
| Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1. | Breast cancer research and treatment 20010501 |
| Metabolic labeling of prenyl and carboxyl-methyl groups. | Current protocols in cell biology 20010501 |
| Analysis of protein prenylation and carboxyl-methylation. | Current protocols in protein science 20010501 |
| Characterization of mevalonate kinase V377I, a mutant implicated in defective isoprenoid biosynthesis and HIDS/periodic fever syndrome. | Biochimica et biophysica acta 20010430 |
| Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. | Journal of chromatography. B, Biomedical sciences and applications 20010425 |
| Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease. | The Journal of biological chemistry 20010420 |
| Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells. | Biochemical pharmacology 20010415 |
| Concise synthesis of (+)-2-C-methyl-D-erythritol-4-phosphate. | The Journal of organic chemistry 20010406 |
| Synthetic applications of epoxide hydrolases. | Current opinion in chemical biology 20010401 |
| Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. | Journal of lipid research 20010401 |
| The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. | British journal of cancer 20010401 |
| Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome. | European journal of human genetics : EJHG 20010401 |
| Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome. | European journal of human genetics : EJHG 20010401 |
| Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis. | The Journal of steroid biochemistry and molecular biology 20010401 |
| [Recent topics on therapeutics for osteoporosis in patients complicated with vascular diseases]. | Clinical calcium 20010401 |
| The effect of HMG-CoA reductase inhibitors on chronic allograft rejection. | Expert opinion on emerging drugs 20010401 |
| An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast. | The Journal of biological chemistry 20010323 |
| 3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene. | Insect biochemistry and molecular biology 20010315 |
| Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. | Molecular pharmacology 20010301 |
| Cerivastatin prevents tumor necrosis factor-alpha-induced downregulation of endothelial nitric oxide synthase: role of endothelial cytosolic proteins. | Atherosclerosis 20010301 |
| Nonorthologous gene displacement of phosphomevalonate kinase. | Molecular genetics and metabolism 20010301 |
| Retrobiosynthetic nuclear magnetic resonance analysis of amino acid biosynthesis and intermediary metabolism. Metabolic flux in developing maize kernels. | Plant physiology 20010301 |
| Effect of simvastatin on vascular smooth muscle responsiveness: involvement of Ca(2+) homeostasis. | European journal of pharmacology 20010301 |
| Biosynthesis of the bicycloalternarenes, mixed terpenoids of Alternaria alternata. | Phytochemistry 20010301 |
| Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. | European journal of cell biology 20010301 |
| Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in melon (Cucumis melo L. reticulatus). | Molecular genetics and genomics : MGG 20010301 |
| Role of inhibitors of isoprenylation in proliferation, phenotype and apoptosis of human retinal pigment epithelium. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010301 |
| Butyrate-induced differentiation of Caco-2 cells occurs independently from p27. | Biochemical and biophysical research communications 20010223 |
| Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. | The Journal of pharmacology and experimental therapeutics 20010201 |
| Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. | Molecular pharmacology 20010201 |
| Deoxyxylulose phosphate pathway to terpenoids. | Trends in plant science 20010201 |
| Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. | Molecular and cellular neurosciences 20010201 |
| Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids. | Planta 20010201 |
| Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. | Medical hypotheses 20010201 |
| [Inhibition of proliferation and induction of apoptosis by simvastatin in K562 leukemic cell line]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010201 |
| The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells. | Swiss medical weekly 20010127 |
| Simvastatin and Ca(2+) signaling in endothelial cells: involvement of rho protein. | Biochemical and biophysical research communications 20010119 |
| Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). | Gene 20010110 |
| Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. | Circulation 20010102 |
| Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. | The Biochemical journal 20010101 |
| Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation. | Medical hypotheses 20010101 |
| Hyper-immunoglobulin A in the hyperimmunoglobulinemia D syndrome. | Clinical and diagnostic laboratory immunology 20010101 |
| Tracer studies on the incorporation of [2-14C]-DL-mevalonate into chlorophylls a and b, alpha-chaconine, and alpha-solanine of potato sprouts. | Journal of agricultural and food chemistry 20010101 |
| Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010101 |
| Investigation of avenacin-deficient mutants of Avena strigosa. | Phytochemistry 20010101 |
| Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma. | Investigational new drugs 20010101 |
| In vivo prenylation analysis of Ras and Rho proteins. | Methods in enzymology 20010101 |
| Carotenoid biosynthesis and biotechnological application. | Archives of biochemistry and biophysics 20010101 |
| Lovastatin controls signal transduction in vascular smooth muscle cells by modulating phosphorylation levels of mevalonate-independent pathways. | Basic research in cardiology 20010101 |
| Genetic disorders of cholesterol biosynthesis in mice and humans. | Molecular genetics and metabolism 20010101 |
| Inborn errors of sterol biosynthesis. | Annual review of genomics and human genetics 20010101 |
| Identification of a gene cluster for the mevalonate pathway in Lactobacillus helveticus. | DNA sequence : the journal of DNA sequencing and mapping 20010101 |
| Isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway. | Acta biochimica Polonica 20010101 |
| Identification of genes in the oligodendrocyte lineage through the analysis of conditionally immortalized cell lines. | Developmental neuroscience 20010101 |
| Statins: mechanism of action and effects. | Journal of cellular and molecular medicine 20010101 |
| Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone. | The Journal of eukaryotic microbiology 20010101 |
| Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells. | Circulation research 20000929 |
| Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. | Journal of immunology (Baltimore, Md. : 1950) 20000901 |
| Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture. | Atherosclerosis 20000601 |
| Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. | Biochemical and biophysical research communications 20000519 |
| Biosynthesis of avenacins and phytosterols in roots of Avena sativa cv. Image. | Phytochemistry 20000501 |
| The mevalonate/isoprenoid pathway inhibitor apomine (SR-45023A) is antiproliferative and induces apoptosis similar to farnesol. | Biochemical and biophysical research communications 20000402 |
| Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. | Journal of molecular biology 20000331 |
| Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. | Archives of biochemistry and biophysics 20000101 |
| Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. | Science (New York, N.Y.) 19990903 |
| Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 19990801 |
| Effect of lipid-lowering strategies on tubular cell biology. | Kidney international. Supplement 19990701 |
| The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | Cancer research 19981201 |
| Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. | The Journal of clinical investigation 19980615 |
| Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401 |
| Hepatic cholesterol metabolism in experimental nephrotic syndrome. | Lipids 19980201 |
| Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. | Journal of lipid research 19971101 |
| Identification of catalytic residues in human mevalonate kinase. | The Journal of biological chemistry 19971010 |
| Identification and functional characterization of an active-site lysine in mevalonate kinase. | The Journal of biological chemistry 19970227 |
| Human multidrug-resistant (MRP,p190) myeloid leukemia HL-60/ADR cells in vitro: resistance to the mevalonate pathway inhibitor lovastatin. | Neoplasma 19970101 |
| Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. | Journal of medicinal chemistry 19960719 |
| Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells. | Biochimica et biophysica acta 19960412 |
| Phenoxypropylamines: a new series of squalene synthase inhibitors. | Journal of medicinal chemistry 19951013 |
| In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. | Cancer research 19950201 |
| ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase. | The Journal of biological chemistry 19941216 |
| Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells. | Kidney international 19930901 |
| Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. | The Biochemical journal 19930115 |
| Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia. | The Quarterly journal of medicine 19920901 |
| Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. | Biochimica et biophysica acta 19920709 |
| Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19920106 |
| Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase. | The Journal of biological chemistry 19901215 |
| The gamma subunit of transducin is farnesylated. | Proceedings of the National Academy of Sciences of the United States of America 19901001 |
| [Lipid metabolism in daunomycin-induced nephrotic rats (5)]. | Nihon Jinzo Gakkai shi 19900901 |
| Purification and regulation of mevalonate kinase from rat liver. | The Journal of biological chemistry 19900205 |
| Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles. | Journal of medicinal chemistry 19900101 |
| Plasma mevalonate response in lovastatin-related myopathy. | Lancet (London, England) 19891104 |
| Lipid and lipoprotein metabolism in Hep G2 cells. | Biochimica et biophysica acta 19880812 |
| The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat. | Journal of lipid research 19861001 |
| Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. | Antimicrobial agents and chemotherapy 19840401 |
| Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. | The Biochemical journal 19790701 |
| Effect in vitro of 3-hydroxy-3-methylglutaric acid on the synthesis of mevalonate and its precursors. | Archives internationales de physiologie et de biochimie 19770201 |
| The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid. | The Biochemical journal 19660401 |