Bimosiamose
| Title | Journal |
|---|---|
| Inhaled pan-selectin antagonist Bimosiamose attenuates airway inflammation in COPD. | Pulmonary pharmacology & therapeutics 20130401 |
| Efficacy of the pan-selectin antagonist Bimosiamose on ozone-induced airway inflammation in healthy subjects--a double blind, randomized, placebo-controlled, cross-over clinical trial. | Pulmonary pharmacology & therapeutics 20111001 |
| Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. | Journal of medicinal chemistry 20100826 |
| The engagement of selectins and their ligands in colorectal cancer liver metastases. | Journal of cellular and molecular medicine 20100101 |
| Small molecule selectin inhibitor in global cerebral ischemia and controlled hemorrhagic shock. | The Journal of trauma 20080901 |
| Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. | Shock (Augusta, Ga.) 20080401 |
| The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers. | Biopharmaceutics & drug disposition 20071201 |
| Tolerability and pharmacokinetics of inhaled bimosiamose disodium in healthy males. | British journal of clinical pharmacology 20070401 |
| Rational design of novel, potent small molecule pan-selectin antagonists. | Journal of medicinal chemistry 20070322 |
| Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. | Journal of medicinal chemistry 20070111 |
| Selectin inhibitors and their proposed role in ischemia and reperfusion. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20070101 |
| Pan-selectin antagonism improves psoriasis manifestation in mice and man. | Archives of dermatological research 20060201 |
| Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial. | Pulmonary pharmacology & therapeutics 20060101 |
| Physiochemical properties, safety and pharmacokinetics of bimosiamose disodium after intravenous administration. | International journal of clinical pharmacology and therapeutics 20051001 |
| The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. | Journal of leukocyte biology 20050101 |
| Selectin antagonists : therapeutic potential in asthma and COPD. | Treatments in respiratory medicine 20050101 |
| Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines. | Journal of the American Society of Nephrology : JASN 20041101 |
| Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD. | Pulmonary pharmacology & therapeutics 20040101 |
| Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20040101 |
| Blockade of cell adhesion by a small molecule selectin antagonist attenuates myocardial ischemia/reperfusion injury. | European journal of pharmacology 20031128 |
| Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure. | Kidney international 20011201 |
| Targeting selectins for the treatment of respiratory diseases. | Current opinion in investigational drugs (London, England : 2000) 20010701 |
| Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269). | Journal of medicinal chemistry 19980326 |