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MURISTERONE A

CAS No.:
38778-30-2
Catalog Number:
AG00BYDG
Molecular Formula:
C27H44O8
Molecular Weight:
496.6335
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
1 week
United States
$213
- +
5mg
1 week
United States
$696
- +
25mg
1 week
United States
$2450
- +
Product Description
Catalog Number:
AG00BYDG
Chemical Name:
MURISTERONE A
CAS Number:
38778-30-2
Molecular Formula:
C27H44O8
Molecular Weight:
496.6335
MDL Number:
MFCD00056450
IUPAC Name:
(2S,3R,5S,9R,10R,11R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,5,11,14-pentahydroxy-10,13-dimethyl-1,2,3,4,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-6-one
InChI:
InChI=1S/C27H44O8/c1-14(2)6-7-20(31)25(5,33)19-8-9-26(34)15-10-21(32)27(35)13-17(29)16(28)11-24(27,4)22(15)18(30)12-23(19,26)3/h10,14,16-20,22,28-31,33-35H,6-9,11-13H2,1-5H3/t16-,17+,18+,19-,20+,22+,23+,24+,25+,26+,27+/m0/s1
InChI Key:
LRJUYAVTHIEHAI-LHBNDURVSA-N
SMILES:
CC(CC[C@H]([C@@]([C@H]1CC[C@@]2([C@]1(C)C[C@@H](O)[C@H]1C2=CC(=O)[C@]2([C@]1(C)C[C@H](O)[C@@H](C2)O)O)O)(O)C)O)C
Properties
Complexity:
904  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Defined Bond Stereocenter Count:
0
Exact Mass:
496.304g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0
Molecular Weight:
496.641g/mol
Monoisotopic Mass:
496.304g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
159A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.1  
Literature
Title Journal
Alternative sumoylation sites in the Drosophila nuclear receptor Usp. The Journal of steroid biochemistry and molecular biology 20121101
Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. Journal of medicinal chemistry 20120614
Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling. Pest management science 20111101
Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties. General and comparative endocrinology 20110901
Comparative pharmacology of the human NMDA-receptor subtypes R1-2A, R1-2B, R1-2C and R1-2D using an inducible expression system. European journal of pharmacology 20100710
HPLC and TLC characterisation of ecdysteroid alkyl ethers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001
A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum. Experimental cell research 20090415
A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types. Toxicology in vitro : an international journal published in association with BIBRA 20080201
Influence of hormone on intracellular localization of the Drosophila melanogaster ecdysteroid receptor (EcR). Cellular signalling 20071201
DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation. Biochemical and biophysical research communications 20070831
Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer research 20061201
Analysis of transcriptional activity mediated by Drosophila melanogaster ecdysone receptor isoforms in a heterologous cell culture system. Insect molecular biology 20061201
Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell death and differentiation 20060201
Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. FEBS letters 20050718
Development of an inducible suicide gene system based on human caspase 8. Cancer gene therapy 20050701
Inducible expression and pharmacological characterization of recombinant rat NR1a/NR2A NMDA receptors. Neurochemistry international 20050401
Microflow NMR: concepts and capabilities. Analytical chemistry 20040515
Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system. Insect biochemistry and molecular biology 20031201
Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms. The Biochemical journal 20030615
Regulation of cell morphology and adhesion by the tuberous sclerosis complex (TSC1/2) gene products in human kidney epithelial cells through increased E-cadherin/beta-catenin activity. Molecular carcinogenesis 20030601
p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media. Biotechnology and bioengineering 20020920
Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle. European journal of biochemistry 20020701
Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance. Carcinogenesis 20020601
Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells. Oncogene 20011206
Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Tissue engineering 20010601
Plasma hyaluronidase (Hyal-1) promotes tumor cell cycling. Cancer letters 20010210
Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line. Cell death and differentiation 20010101
The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells. European cytokine network 20010101
Titrating the expression of a Gi protein-coupled receptor using an ecdysone-inducible system in CHO-K1 cells. Receptors & channels 20010101
Phenotypic changes associated with exogenous expression of p16INK4a in human glioma cells. Brain tumor pathology 20010101
Interaction of PAHs and PCBs with ecdysone-dependent gene expression and cell proliferation. Toxicology and applied pharmacology 19991001
Properties