Home Other Building Blocks COBINAMIDE DICYANIDE

COBINAMIDE DICYANIDE

CAS No.:
27792-36-5
Catalog Number:
AG00C46E
Molecular Formula:
Molecular Weight:
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Purity
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Product Description
Catalog Number:
AG00C46E
Chemical Name:
COBINAMIDE DICYANIDE
CAS Number:
27792-36-5
MDL Number:
MFCD00239454
IUPAC Name:
cobalt;3-[(1R,2S,3S,5Z,7S,8S,10Z,13S,15Z,17R,18R)-2,7,18-tris(2-amino-2-oxoethyl)-3,13-bis(3-amino-3-oxopropyl)-17-[3-(2-hydroxypropylamino)-3-oxopropyl]-1,2,5,7,12,12,15,17-octamethyl-8,13,18,19-tetrahydro-3H-corrin-24-id-8-yl]propanamide;dicyanide
InChI:
InChI=1S/C48H73N11O8.2CN.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;2*1-2;/h19,23,26-29,43,60H,10-18,20-22H2,1-9H3,(H14,49,50,51,52,53,54,55,56,57,58,59,61,62,63,64,65,66,67);;;/q;2*-1;/p-1/t23?,26-,27-,28-,29+,43?,45-,46+,47+,48+;;;/m1.../s1
InChI Key:
NWXVHVXSDZHCFS-TWXWJCICSA-M
Properties
Complexity:
2440  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
4  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
3  
Exact Mass:
1041.496g/mol
Formal Charge:
-3  
Heavy Atom Count:
72  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
8  
Isotope Atom Count:
0
Molecular Weight:
1042.142g/mol
Monoisotopic Mass:
1041.496g/mol
Rotatable Bond Count:
20  
Topological Polar Surface Area:
394A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Gene cloning and function analysis of complement B factor-2 of Apostichopus japonicus. Fish & shellfish immunology 20120901
Eculizumab for dense deposit disease and C3 glomerulonephritis. Clinical journal of the American Society of Nephrology : CJASN 20120501
Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. Experimental eye research 20120301
Alternative complement pathway and factor B activities in rats with altered blood levels of thyroid hormone. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120301
Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. Investigative ophthalmology & visual science 20120216
Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells. Cellular immunology 20120101
Microbe-specific C3b deposition in the horseshoe crab complement system in a C2/factor B-dependent or -independent manner. PloS one 20120101
The association between macular pigment optical density and CFH, ARMS2, C2/BF, and C3 genotype. Experimental eye research 20111101
Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Investigative ophthalmology & visual science 20111011
Circulating glucagon is associated with inflammatory mediators in metabolically compromised subjects. European journal of endocrinology 20111001
Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD. Investigative ophthalmology & visual science 20110701
Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population. Ophthalmic epidemiology 20110601
Specificity of EIA immunoassay for complement factor Bb testing. Clinical laboratory 20110101
Complement factor B polymorphism 32W protects against age-related macular degeneration. Molecular vision 20110101
Increased complement consumption in MuSK-antibody-positive myasthenia gravis patients. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101
Complement factor B expression profile in a spontaneous uveitis model. Immunobiology 20101201
Efficient osteoclast differentiation requires local complement activation. Blood 20101125
The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 20101109
Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. European journal of immunology 20101001
Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. Ophthalmology 20100801
C3, C5, and factor B bind to chitosan without complement activation. Journal of biomedical materials research. Part A 20100615
A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndrome. Pediatric nephrology (Berlin, Germany) 20100501
Screening biomaterials for functional complement activation in serum. Journal of biomedical materials research. Part A 20100101
Complement factor H is expressed in adipose tissue in association with insulin resistance. Diabetes 20100101
Bisretinoids of RPE lipofuscin: trigger for complement activation in age-related macular degeneration. Advances in experimental medicine and biology 20100101
Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study. Eye (London, England) 20091201
Structure-activity relationships for substrate-based inhibitors of human complement factor B. Journal of medicinal chemistry 20091008
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Human molecular genetics 20090915
Multilocus analysis of age-related macular degeneration. European journal of human genetics : EJHG 20090901
Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. The EMBO journal 20090819
Cloning and molecular characterization of two complement Bf/C2 genes in large yellow croaker (Pseudosciaena crocea). Fish & shellfish immunology 20090801
Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age-related macular degeneration. Journal of cellular physiology 20090701
Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies. Investigative ophthalmology & visual science 20090201
Alternative complement activity in the egg cytosol of amphioxus Branchiostoma belcheri: evidence for the defense role of maternal complement components. PloS one 20090101
Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population. Chinese medical journal 20081220
Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina. Experimental eye research 20081201
Surviving mousepox infection requires the complement system. PLoS pathogens 20081201
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Investigative ophthalmology & visual science 20080601
Molecular and immunochemical demonstration of a novel member of Bf/C2 homolog in amphioxus Branchiostoma belcheri: implications for involvement of hepatic cecum in acute phase response. Fish & shellfish immunology 20080601
Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Investigative ophthalmology & visual science 20080601
[Update on the genetics of age-related macular degeneration]. Journal francais d'ophtalmologie 20080601
Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. The Journal of biological chemistry 20080404
Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice. American journal of physiology. Endocrinology and metabolism 20080301
Resistance of the Echinococcus granulosus cyst wall to complement activation: analysis of the role of InsP6 deposits. Parasite immunology 20080101
C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. PloS one 20080101
Interaction between the coagulation and complement system. Advances in experimental medicine and biology 20080101
Profiling the enzymatic properties and inhibition of human complement factor B. The Journal of biological chemistry 20071130
Progress in defining the molecular biology of age related macular degeneration. Human genetics 20071101
Effect of the extract of the tamarind (Tamarindus indica) fruit on the complement system: studies in vitro and in hamsters submitted to a cholesterol-enriched diet. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070801
The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy. American journal of physiology. Renal physiology 20070801
Factor B structure provides insights into activation of the central protease of the complement system. Nature structural & molecular biology 20070301
An update on the genetics of age-related macular degeneration. Molecular vision 20070101
Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. Journal of neuroinflammation 20070101
Molecular cloning, structural analysis and expression of complement component Bf/C2 genes in the nurse shark, Ginglymostoma cirratum. Developmental and comparative immunology 20070101
Reversible self-association of recombinant bovine factor B. Biochimica et biophysica acta 20061101
A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression. Xenotransplantation 20060901
Bovine factor B: cloning, expression, and characterization. Archives of biochemistry and biophysics 20060701
Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury. Journal of the American Society of Nephrology : JASN 20060301
Assessment of anti-estrogenic activity of tamoxifen in transgenic mice expressing an enhanced green fluorescent protein gene regulated by estrogen response element. Biochimica et biophysica acta 20060201
Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC neuroscience 20060101
[The effect of retinoic acid on C3 and factor B secretion of human alveolar type II epithelial cells induced with cytokines]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20050701
[Immunologic tests: Factor B, factor D]. Nihon rinsho. Japanese journal of clinical medicine 20050701
Response of the alternative complement pathway to an oral fat load in first-degree relatives of subjects with type II diabetes. International journal of obesity (2005) 20050401
Structure and the evolutionary implication of the triplicated complement factor B genes of a urochordate ascidian, Ciona intestinalis. Immunogenetics 20050301
Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease. Disease markers 20050101
Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice. Arteriosclerosis, thrombosis, and vascular biology 20040601
Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects. Clinical and experimental immunology 20040501
Acylation-stimulating protein precursor proteins in adipose tissue in human obesity. Metabolism: clinical and experimental 20031001
Molecular cloning of C4 gene and identification of the class III complement region in the shark MHC. Journal of immunology (Baltimore, Md. : 1950) 20030901
High expression of complement components in omental adipose tissue in obese men. Obesity research 20030601
Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. Journal of immunology (Baltimore, Md. : 1950) 20030201
Critical review of acylation-stimulating protein physiology in humans and rodents. Biochimica et biophysica acta 20030131
Factor B is essential for ATP synthesis by mitochondria. Archives of biochemistry and biophysics 20021015
Calnexin is associated with and induced by overexpressed human complement protein C2. The Anatomical record 20020501
Ovarian steroid-regulated synthesis and secretion of complement C3 and factor B in mouse endometrium during the natural estrous cycle and pregnancy period. Biology of reproduction 20020201
Complement activation in factor D-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 20011204
Characterization of IFN-gamma regulation of the complement factor B gene in macrophages. European journal of immunology 20011201
Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region. Frontiers in bioscience : a journal and virtual library 20010801
Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice. Journal of immunology (Baltimore, Md. : 1950) 20010601
Occurrence of structural specialization of the serine protease domain of complement factor B at the emergence of jawed vertebrates and adaptive immunity. Immunogenetics 20010401
Structural biology of the alternative pathway convertase. Immunological reviews 20010401
The ancestral complement system in sea urchins. Immunological reviews 20010401
Complement C3b interactions studied with surface plasmon resonance technique. International immunopharmacology 20010301
Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA. Biochemical and biophysical research communications 19980519
Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. Journal of immunology (Baltimore, Md. : 1950) 19960715
Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates. The Journal of biological chemistry 19870315
An improved fluorogenic substrate for the alternative complement pathway C3/5 converting enzyme CVFBb. Biochimica et biophysica acta 19830518
Structural evidence that complement factor B constitutes a novel class of serine protease. The Journal of biological chemistry 19800925
Properties