Home Sulfos 3-Chloro-2-methyl-n-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide

3-Chloro-2-methyl-n-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide

CAS No.:
376640-41-4
Catalog Number:
AG00C6IP
Molecular Formula:
C17H21ClN4O3S2
Molecular Weight:
428.9566
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$158
- +
10mg
99%
1 week
United States
$240
- +
25mg
≥98%
1 week
United States
$514
- +
50mg
99%
1 week
United States
$723
- +
100mg
99%
1 week
United States
$1140
- +
Product Description
Catalog Number:
AG00C6IP
Chemical Name:
3-Chloro-2-methyl-n-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide
CAS Number:
376640-41-4
Molecular Formula:
C17H21ClN4O3S2
Molecular Weight:
428.9566
MDL Number:
MFCD13152134
IUPAC Name:
3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide
InChI:
InChI=1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20)
InChI Key:
YDPRNGAPPNPYQQ-UHFFFAOYSA-N
SMILES:
CN1CCN(CC1)C(=O)Cc1csc(n1)NS(=O)(=O)c1cccc(c1C)Cl
UNII:
2EGD70329U
Properties
Complexity:
622  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
428.074g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
428.95g/mol
Monoisotopic Mass:
428.074g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
119A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2  
Literature
Title Journal
BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PloS one 20120101
Adipose tissue-targeted 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity. Endocrine journal 20110101
[Mechanism of BVT.2733 and pioglitazone in the improvement of insulin resistance]. Zhonghua nei ke za zhi 20081101
Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes. Journal of medicinal chemistry 20080828
Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorganic & medicinal chemistry letters 20061215
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice. Diabetologia 20060601
Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 20031101
Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 20021101
Properties