Home Other Building Blocks (E)-3-(4-hydroxyphenyl)-1-phenyl-prop-2-en-1-one

(E)-3-(4-hydroxyphenyl)-1-phenyl-prop-2-en-1-one

CAS No.:
38239-55-3
Catalog Number:
AG00CT7H
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00CT7H
Chemical Name:
(E)-3-(4-hydroxyphenyl)-1-phenyl-prop-2-en-1-one
CAS Number:
38239-55-3
MDL Number:
MFCD00016488
IUPAC Name:
(E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
InChI:
InChI=1S/C15H12O2/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11,16H/b11-8+
InChI Key:
PWWCDTYUYPOAIU-DHZHZOJOSA-N
UNII:
JO97Q47VBU
NSC Number:
170282
Properties
Complexity:
269  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
224.084g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
224.259g/mol
Monoisotopic Mass:
224.084g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
37.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology 20150201
Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. Chemical research in toxicology 20121119
Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. European journal of pharmacology 20120915
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. Bioorganic & medicinal chemistry letters 20120715
Synthesis of chalcone derivatives as potential anti-diabetic agents. Bioorganic & medicinal chemistry letters 20120615
Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). Journal of enzyme inhibition and medicinal chemistry 20111001
Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies. Bioorganic & medicinal chemistry letters 20110101
Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. Journal of medicinal chemistry 20091126
Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I. Journal of enzyme inhibition and medicinal chemistry 20090601
Antifungal activity of chalcones: a mechanistic study using various yeast strains. European journal of medicinal chemistry 20081001
Sulfonate chalcone as new class voltage-dependent K+ channel blocker. Bioorganic & medicinal chemistry letters 20080101
Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans. European journal of medicinal chemistry 20070101
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. Journal of molecular graphics & modelling 20061101
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Journal of medicinal chemistry 20050908
Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites. Drug metabolism and disposition: the biological fate of chemicals 20050801
Hydroxychalcones exhibit differential effects on XRE transactivation. Toxicology 20050214
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology 20031001
Electron ionization induced fragmentation of 4-hydroxychalcone derivatives. Rapid communications in mass spectrometry : RCM 20020101
Properties