Arterolane
| Title | Journal |
|---|---|
| Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120901 |
| Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes. | Journal of medicinal chemistry 20111208 |
| Pharmacokinetics and pharmacodynamics of arterolane maleate following multiple oral doses in adult patients with P. falciparum malaria. | Journal of clinical pharmacology 20111101 |
| Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine. | Journal of medicinal chemistry 20111013 |
| A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite. | ChemMedChem 20110307 |
| Comparative embryotoxicity of different antimalarial peroxides: in vitro study using the rat whole embryo culture model (WEC). | Reproductive toxicology (Elmsford, N.Y.) 20101201 |
| Arterolane, a new synthetic trioxolane for treatment of uncomplicated Plasmodium falciparum malaria: a phase II, multicenter, randomized, dose-finding clinical trial. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100915 |
| The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). | Journal of medicinal chemistry 20100114 |
| Development and validation of a headspace gas chromatographic method for the determination of residual solvents in arterolane (RBx11160) maleate bulk drug. | Journal of pharmacy & bioallied sciences 20100101 |
| Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001 |
| Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum. | Bioorganic & medicinal chemistry letters 20091001 |
| Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. | Bioorganic & medicinal chemistry letters 20090815 |
| Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. | Journal of medicinal chemistry 20090226 |
| In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum. | The Journal of antimicrobial chemotherapy 20081101 |
| Drug metabolism and pharmacokinetics. | Indian journal of pharmacology 20081001 |
| Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277. | Bioorganic & medicinal chemistry letters 20080301 |
| The future of artemisinins: natural, synthetic or recombinant? | Journal of biology 20080101 |
| In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277). | The American journal of tropical medicine and hygiene 20070601 |
| In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models. | Experimental parasitology 20070301 |
| Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75. | Experimental parasitology 20060701 |
| In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum. | The Journal of antimicrobial chemotherapy 20060701 |
| Infectious diseases. Source of new hope against malaria is in short supply. | Science (New York, N.Y.) 20050107 |
| [Artemisinin and successors]. | Pharmazie in unserer Zeit 20050101 |
| Synthetic antimalaria drug enters clinical trials. | The Lancet. Infectious diseases 20041001 |
| Identification of an antimalarial synthetic trioxolane drug development candidate. | Nature 20040819 |