Home Aminos 2-(2-amino-3-benzoylphenyl)acetamide

2-(2-amino-3-benzoylphenyl)acetamide

CAS No.:
78281-72-8
Catalog Number:
AG00G2B7
Molecular Formula:
C15H14N2O2
Molecular Weight:
254.2839
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
95%
In Stock USA
United States
$60
- +
100mg
95%
In Stock USA
United States
$133
- +
250mg
95%
In Stock USA
United States
$246
- +
1g
95%
In Stock USA
United States
$687
- +
Product Description
Catalog Number:
AG00G2B7
Chemical Name:
2-(2-amino-3-benzoylphenyl)acetamide
CAS Number:
78281-72-8
Molecular Formula:
C15H14N2O2
Molecular Weight:
254.2839
MDL Number:
MFCD08067732
IUPAC Name:
2-(2-amino-3-benzoylphenyl)acetamide
InChI:
InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChI Key:
QEFAQIPZVLVERP-UHFFFAOYSA-N
SMILES:
NC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
UNII:
0J9L7J6V8C
Properties
Complexity:
337  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
254.106g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
254.289g/mol
Monoisotopic Mass:
254.106g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
86.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.9  
Literature
Title Journal
Nepafenac: an ophthalmic nonsteroidal antiinflammatory drug for pain after cataract surgery. The Annals of pharmacotherapy 20130601
Prophylactic nepafenac and ketorolac versus placebo in preventing postoperative macular edema after uneventful phacoemulsification. Journal of cataract and refractive surgery 20120901
Role of topical nepafenac in prevention and treatment of macular edema after vitreoretinal surgery. Retina (Philadelphia, Pa.) 20120201
[Phase III open-label study of nepafenac ophthalmic suspension 0.1% for inflammation and ocular pain following ophthalmic surgery]. Nippon Ganka Gakkai zasshi 20120201
Prevention of post cataract-surgery cystoid macular edema with nepafenac. Journal of cataract and refractive surgery 20120101
Phototherapeutic keratectomy. Indian journal of ophthalmology 20120101
Emerging pharmacotherapies for diabetic macular edema. Experimental diabetes research 20120101
Update on twice-daily bromfenac sodium sesquihydrate to treat postoperative ocular inflammation following cataract extraction. Clinical ophthalmology (Auckland, N.Z.) 20120101
Topical steroid and non-steroidal anti-inflammatory drugs inhibit inflammatory cytokine expression on the ocular surface in the botulinum toxin B-induced murine dry eye model. Molecular vision 20120101
Comparison of bromfenac 0.09% QD to nepafenac 0.1% TID after cataract surgery: pilot evaluation of visual acuity, macular volume, and retinal thickness at a single site. Clinical ophthalmology (Auckland, N.Z.) 20120101
Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: a randomized trial. Indian journal of ophthalmology 20120101
Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. Clinical ophthalmology (Auckland, N.Z.) 20120101
Phase II placebo-controlled study of nepafenac ophthalmic suspension 0.1% for postoperative inflammation and ocular pain associated with cataract surgery in Japanese patients. Journal of ophthalmic inflammation and infection 20111201
A randomized comparison of to-aqueous penetration of ketorolac 0.45%, bromfenac 0.09% and nepafenac 0.1% in cataract patients undergoing phacoemulsification. Current medical research and opinion 20111201
Prostaglandin E2 inhibition of ketorolac 0.45%, bromfenac 0.09%, and nepafenac 0.1% in patients undergoing phacoemulsification. Advances in therapy 20111201
Nepafenac 0.1% versus fluorometholone 0.1% for preventing cystoid macular edema after cataract surgery. Journal of cataract and refractive surgery 20110901
Nepafenac for epiretinal membrane surgery. Ophthalmology 20110701
Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs. Clinical ophthalmology (Auckland, N.Z.) 20110101
Critical appraisal of ophthalmic ketorolac in treatment of pain and inflammation following cataract surgery. Clinical ophthalmology (Auckland, N.Z.) 20110101
Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury. PloS one 20110101
Evaluation of analgesic efficacy of bromfenac sodium ophthalmic solution 0.09% versus ketorolac tromethamine ophthalmic solution 0.5% following LASEK or Epi-LASIK. Clinical ophthalmology (Auckland, N.Z.) 20110101
Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy. Journal of ophthalmology 20110101
Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia. Molecular vision 20110101
[Progresses in antiinflamatory treatment in cataract surgery]. Oftalmologia (Bucharest, Romania : 1990) 20110101
Combination therapies in ophthalmology: implications for intravitreal delivery. Journal of ophthalmic & vision research 20110101
Nepafenac-assisted mydriasis in a rabbit model. Journal of cataract and refractive surgery 20101001
Topical nepafenac for treatment of exudative age-related macular degeneration. Acta ophthalmologica 20100301
The effects of nepafenac and amfenac on retinal angiogenesis. Brain research bulletin 20100215
NSAIDs in combination therapy for the treatment of chronic pseudophakic cystoid macular edema. Retina (Philadelphia, Pa.) 20100201
Impact of nepafenac 0.1% on macular thickness and postoperative visual acuity after cataract surgery in patients at low risk for cystoid macular oedema. Eye (London, England) 20100101
Diabetic cataract-pathogenesis, epidemiology and treatment. Journal of ophthalmology 20100101
Comparison of three strains of diabetic rats with respect to the rate at which retinopathy and tactile allodynia develop. Molecular vision 20100101
Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. Mediators of inflammation 20100101
Use of nepafenac (Nevanac) in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections. Clinical ophthalmology (Auckland, N.Z.) 20100101
Ocular pharmacokinetics of 0.45% ketorolac tromethamine. Clinical ophthalmology (Auckland, N.Z.) 20100101
Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress. Archives of biochemistry and biophysics 20091001
Vitreous nonsteroidal antiinflammatory drug concentrations and prostaglandin E2 levels in vitrectomy patients treated with ketorolac 0.4%, bromfenac 0.09%, and nepafenac 0.1%. Retina (Philadelphia, Pa.) 20091001
Nepafenac-associated bilateral corneal melt after photorefractive keratectomy. Cornea 20090901
Nepafenac dosing frequency for ocular pain and inflammation associated with cataract surgery. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090801
Nepafenac: new drug. After cataract surgery: just another NSAID eye drop. No better than other NSAID eye drops, and less convenient to use. Prescrire international 20090801
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20090401
Treatment of cystoid macular edema with the new-generation NSAID nepafenac 0.1%. Clinical ophthalmology (Auckland, N.Z.) 20090101
Management of ocular inflammation and pain following cataract surgery: focus on bromfenac ophthalmic solution. Clinical ophthalmology (Auckland, N.Z.) 20090101
Inhibition of surgically induced miosis and prevention of postoperative macular edema with nepafenac. Clinical ophthalmology (Auckland, N.Z.) 20090101
Intracameral dexamethasone reduces inflammation on the first postoperative day after cataract surgery in eyes with and without glaucoma. Clinical ophthalmology (Auckland, N.Z.) 20090101
Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy. Molecular vision 20090101
Etiology and treatment of the inflammatory causes of cystoid macular edema. Journal of inflammation research 20090101
Nepafenac dosing frequency for ocular pain and inflammation associated with cataract surgery. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201
Topical nepafenac in the treatment of diabetic macular edema. Clinical ophthalmology (Auckland, N.Z.) 20081201
Effect of nepafenac sodium 0.1% on delayed corneal epithelial healing and haze after photorefractive keratectomy: retrospective comparative study. Journal of cataract and refractive surgery 20080901
Re: Pharmacokinetics and pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. Journal of cataract and refractive surgery 20080801
Topical ocular delivery of NSAIDs. The AAPS journal 20080601
Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspension. Clinical ophthalmology (Auckland, N.Z.) 20080601
Amfenac increases the radiosensitivity of uveal melanoma cell lines. Eye (London, England) 20080501
Double-masked comparison of ketorolac tromethamine 0.4% versus nepafenac sodium 0.1% for postoperative healing rates and pain control in eyes undergoing surface ablation. Cornea 20080401
Double-masked comparison of ketorolac tromethamine 0.4% versus nepafenac sodium 0.1% for postoperative healing rates and pain control in eyes undergoing surface ablation. Cornea 20080401
Effects of topical nepafenac on corneal epithelial healing time and postoperative pain after PRK: a bilateral, prospective, randomized, masked trial. Journal of refractive surgery (Thorofare, N.J. : 1995) 20080401
Ketorolac versus nepafenac in cataract surgery. Journal of cataract and refractive surgery 20080301
Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery. Eye & contact lens 20080301
Topical nepafenac as an alternate treatment for cystoid macular edema in steroid responsive patients. Retina (Philadelphia, Pa.) 20080101
Cystoid and diabetic macular edema treated with nepafenac 0.1%. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071201
Re: Prostaglandin E(2) inhibition and aqueous concentration of ketorolac 0.4% and nepafenac 0.1% in patients undergoing phacoemulsification. American journal of ophthalmology 20071201
Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery. Clinical ophthalmology (Auckland, N.Z.) 20071201
Ketorolac tromethamine LS 0.4% versus nepafenac 0.1% in patients having cataract surgery. Prospective randomized double-masked clinical trial. Journal of cataract and refractive surgery 20071101
Nepafenac-associated corneal melt. Journal of cataract and refractive surgery 20071101
The use of a cyclooxygenase-2 inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma. Carcinogenesis 20070901
In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. Journal of cataract and refractive surgery 20070901
Incidence of visually significant pseudophakic macular edema after uneventful phacoemulsification in patients treated with nepafenac. Journal of cataract and refractive surgery 20070901
Case of corneal melting associated with the use of topical nepafenac. Cornea 20070901
Double-masked comparison of ketorolac tromethamine 0.4% versus nepafenac sodium 0.1% for postoperative healing rates and pain control in eyes undergoing surface ablation. Cornea 20070701
Prostaglandin E2 inhibition and aqueous concentration of ketorolac 0.4% (acular LS) and nepafenac 0.1% (nevanac) in patients undergoing phacoemulsification. American journal of ophthalmology 20070701
Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes 20070201
Effects of topical anti-inflammatory agents in a botulinum toxin B-induced mouse model of keratoconjunctivitis sicca. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070201
Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. Journal of cataract and refractive surgery 20070101
Comparative effects of the nonsteroidal anti-inflammatory drug nepafenac on corneal sensory nerve fibers responding to chemical irritation. Investigative ophthalmology & visual science 20070101
Double-masked study of the effects of nepafenac 0.1% and ketorolac 0.4% on corneal epithelial wound healing and pain after photorefractive keratectomy. Advances in therapy 20070101
The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. Journal of carcinogenesis 20070101
Effects of nonsteroidal ophthalmic drops on epithelial healing and pain in patients undergoing bilateral photorefractive keratectomy (PRK). Advances in therapy 20070101
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Experimental diabetes research 20070101
New drugs 06, part II. Nursing 20060801
The effect of a selective cyclooxygenase-2 (COX-2) inhibitor on the proliferation rate of retinoblastoma cell lines. Eye (London, England) 20060501
Comparison of the analgesic efficacy and safety of nepafenac ophthalmic suspension compared with diclofenac ophthalmic solution for ocular pain and photophobia after excimer laser surgery: a phase II, randomized, double-masked trial. Clinical therapeutics 20060401
Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac. Current medical research and opinion 20060201
New drugs: ramelteon, tipranavir, nepafenac, and deferasirox. Journal of the American Pharmacists Association : JAPhA 20060101
Nepafenac: a unique nonsteroidal prodrug. International ophthalmology clinics 20060101
Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Inflammation 20031001
Pharmacokinetics of topical ocular drug delivery: potential uses for the treatment of diseases of the posterior segment and beyond. Current drug metabolism 20030601
Topical nepafenac inhibits ocular neovascularization. Investigative ophthalmology & visual science 20030101
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation 20000801
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation 20000801
Properties