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RGB-286638

CAS No.:
784210-87-3
Catalog Number:
AG00G3PT
Molecular Formula:
C29H37Cl2N7O4
Molecular Weight:
618.5546
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$307
- +
10mg
98%
1 week
United States
$473
- +
50mg
98%
1 week
United States
$1890
- +
100mg
98%
1 week
United States
$3390
- +
Product Description
Catalog Number:
AG00G3PT
Chemical Name:
RGB-286638
CAS Number:
784210-87-3
Molecular Formula:
C29H37Cl2N7O4
Molecular Weight:
618.5546
MDL Number:
MFCD18633230
IUPAC Name:
1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea;dihydrochloride
InChI:
InChI=1S/C29H35N7O4.2ClH/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36;;/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38);2*1H
InChI Key:
WJVMGQMXUBAAPL-UHFFFAOYSA-N
SMILES:
COCCN1CCN(CC1)Cc1ccc(cc1)c1n[nH]c2c1C(=O)c1c2cccc1NC(=O)NN1CCOCC1.Cl.Cl
UNII:
478ZV54680
Properties
Complexity:
857  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
617.228g/mol
Formal Charge:
0
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
618.56g/mol
Monoisotopic Mass:
617.228g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
115A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20140915
Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia 20131201
Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry. Journal of pharmaceutical and biomedical analysis 20091205
Properties