4'-ethynyl-2-fluoro-2'-deoxyadenosine
| Title | Journal |
|---|---|
| MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture. | Antimicrobial agents and chemotherapy 20170801 |
| Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. | Antimicrobial agents and chemotherapy 20131201 |
| Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. | Retrovirology 20130101 |
| Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo. | Antimicrobial agents and chemotherapy 20120901 |
| Concise synthesis of the anti-HIV nucleoside EFdA. | Bioscience, biotechnology, and biochemistry 20120101 |
| Enantioselective total synthesis of the potent anti-HIV nucleoside EFdA. | Organic letters 20111007 |
| Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110311 |
| The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. | Cellular and molecular biology (Noisy-le-Grand, France) 20110212 |
| Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor. | The Journal of biological chemistry 20091218 |
| Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice. | Antimicrobial agents and chemotherapy 20090901 |
| 2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants. | The international journal of biochemistry & cell biology 20080101 |
| Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. | Antimicrobial agents and chemotherapy 20070801 |
| 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma. | Nucleosides, nucleotides & nucleic acids 20070101 |
| 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. | Chemical record (New York, N.Y.) 20060101 |
| 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma. | Nucleic acids symposium series (2004) 20060101 |