Home Aminos {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid

{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid

CAS No.:
106941-25-7
Catalog Number:
AG00HAW7
Molecular Formula:
C8H12N5O4P
Molecular Weight:
273.1857
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
97%
In Stock USA
United States
$13
- +
5g
97%
In Stock USA
United States
$25
- +
25g
97%
In Stock USA
United States
$88
- +
100g
97%
In Stock USA
United States
$250
- +
500g
97%
In Stock USA
United States
$757
- +
Product Description
Catalog Number:
AG00HAW7
Chemical Name:
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid
CAS Number:
106941-25-7
Molecular Formula:
C8H12N5O4P
Molecular Weight:
273.1857
MDL Number:
MFCD00866943
IUPAC Name:
2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
InChI:
InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
InChI Key:
SUPKOOSCJHTBAH-UHFFFAOYSA-N
SMILES:
Nc1ncnc2c1ncn2CCOCP(=O)(O)O
UNII:
6GQP90I798
Properties
Complexity:
327  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
273.063g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
273.189g/mol
Monoisotopic Mass:
273.063g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
136A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2  
Literature
Title Journal
Editor's Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats. Toxicological sciences : an official journal of the Society of Toxicology 20170101
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals. Mini reviews in medicinal chemistry 20170101
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicology in vitro : an international journal published in association with BIBRA 20150201
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer. European journal of medicinal chemistry 20140506
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates. Toxicology 20130915
Anti-hepatitis B virus and anti-cancer activities of novel isoflavone analogs. European journal of medicinal chemistry 20130401
Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation. Transplant infectious disease : an official journal of the Transplantation Society 20121001
A case of adefovir-induced membranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease. Clinical and experimental nephrology 20121001
Does genotype predict response to treatment in children infected with hepatitis B perinatally? Journal of medical virology 20121001
The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection. The Netherlands journal of medicine 20121001
Viral response at 6 months is associated with treatment outcome of adefovir add-on therapy for lamivudine-resistance. Journal of gastroenterology and hepatology 20120901
Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Chemistry & biodiversity 20120901
Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir. Liver international : official journal of the International Association for the Study of the Liver 20120801
Prolonged adefovir therapy associated Fanconi syndrome and interstitial nephritis in hepatitis B. Internal medicine journal 20120801
Safety and efficacy of adefovir therapy for lamivudine-resistant hepatitis B virus infection in renal transplant recipients. Journal of the Formosan Medical Association = Taiwan yi zhi 20120801
Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance. Journal of medical virology 20120701
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120614
Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B. Alimentary pharmacology & therapeutics 20120601
Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection. Journal of viral hepatitis 20120601
In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates. European journal of pharmacology 20120515
Efficacy of entecavir and adefovir combination therapy for patients with lamivudine- and entecavir-resistant chronic hepatitis B. Digestive diseases and sciences 20120501
Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir. Scandinavian journal of gastroenterology 20120401
Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy. Clinics and research in hepatology and gastroenterology 20120401
[Hungarian consensus guideline for the diagnosis and treatment of B, C, and D viral hepatitis]. Orvosi hetilap 20120311
Simple scoring system predicting genotypic resistance during rescue therapy for Lamivudine-resistant chronic hepatitis B. Journal of clinical gastroenterology 20120301
Potent hepatitis B surface antigen response to treatment of hepatitis-B-e-antigen-positive chronic hepatitis B with α-interferon plus a nucleos(t)ide analog. Journal of gastroenterology and hepatology 20120301
Antiviral efficacy of combination therapy with entecavir and adefovir for entecavir/lamivudine-resistant hepatitis B virus with or without adefovir resistance. Journal of medical virology 20120301
Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis. Alimentary pharmacology & therapeutics 20120301
Synthesis, anti-HBV activity and renal cell toxicity evaluation of mixed phosphonate prodrugs of adefovir. European journal of medicinal chemistry 20120301
High efficacy of adefovir and entecavir combination therapy in patients with nucleoside-refractory hepatitis B. The Korean journal of hepatology 20120301
A prospective clinical study in hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessation criteria for adefovir. Archives of virology 20120201
The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment. Liver international : official journal of the International Association for the Study of the Liver 20120201
Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages. International immunopharmacology 20120201
[Efficacy of lamivudine and adefovir de novo combination therapy or after mono-therapy in chronic hepatitis B patients]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120201
Adefovir-based combination therapy with entecavir or lamivudine for patients with entecavir-refractory chronic hepatitis B. Journal of medical virology 20120101
In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate. Antiviral research 20120101
Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B. Antiviral research 20120101
Risk factors of gene-resistant mutations in different nucleosides. Hepato-gastroenterology 20120101
Entecavir plus adefovir combination treatment for chronic hepatitis B patients after failure of nucleoside/nucleotide analogues. Antiviral therapy 20120101
Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment. Antiviral therapy 20120101
HBV DNA level at 24 weeks is the best predictor of virological response to adefovir add-on therapy in patients with lamivudine resistance. Antiviral therapy 20120101
High-resolution melting and real-time PCR for quantification and detection of drug-resistant HBV mutants in a single amplicon. Antiviral therapy 20120101
Design and synthesis of novel 1',3'-dioxolane 5'-deoxyphosphonic acid purine analogues as potent antiviral agents. Nucleosides, nucleotides & nucleic acids 20120101
Treatment response and evolution of HBV resistance during lamivudine plus adefovir or entecavir therapy in patients with adefovir-resistant mutants. Antiviral therapy 20120101
[Prognosis analysis of hepatitis B virus recurrence after liver transplantation: a single-center study of 38 cases]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120101
[Evaluation of the safety of pregnancy initiated by chronic hepatitis B fathers while taking adefovir]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120101
Efficacy and adverse effects of the antiviral compound plerixafor in feline immunodeficiency virus-infected cats. Journal of veterinary internal medicine 20120101
Reactivation of hepatitis B virus replication due to cytotoxic therapy: a five-year prospective study. Tumori 20120101
Rescue therapy for lamivudine-resistant chronic hepatitis B: adefovir monotherapy, adefovir plus lamivudine or entecavir combination therapy. Internal medicine (Tokyo, Japan) 20120101
Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir. Antiviral therapy 20120101
Comparison of entecavir and adefovir for the treatment of chronic hepatitis B. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20120101
Profile of users of drugs for the treatment of chronic hepatitis B available through the Brazilian Public Health System. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20120101
Does the antiviral therapy of patients with chronic hepatitis exert nephrotoxic effects? Immunopharmacology and immunotoxicology 20111201
Adefovir induced hypophosphatemic osteomalacia. Scandinavian journal of infectious diseases 20111201
Virologic response is not durable after adefovir discontinuation in lamivudine-resistant chronic hepatitis B patients. The Korean journal of hepatology 20111201
Application of kinase bypass strategies to nucleoside antivirals. Antiviral research 20111101
Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action. Antimicrobial agents and chemotherapy 20111101
Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants. Bioorganic & medicinal chemistry letters 20111101
Long-term adefovir plus lamivudine therapy does not decrease creatinine clearance in HBeAg-negative chronic hepatitis B patients. Liver international : official journal of the International Association for the Study of the Liver 20111101
[Entecavir 1.0mg monotherapy or entecavir plus adefovir dipivoxil for patients with lamivudine-resistant chronic hepatitis B had suboptimal response to lamivudine plus adefovir dipivoxil]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20111101
Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir. Journal of gastroenterology and hepatology 20111001
Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment. Liver international : official journal of the International Association for the Study of the Liver 20111001
The efficacy of entecavir therapy in chronic hepatitis B patients with suboptimal response to adevofir. Alimentary pharmacology & therapeutics 20111001
Management options for lamivudine-resistant chronic hepatitis B patients with suboptimal virological suppression by adefovir. Alimentary pharmacology & therapeutics 20111001
Long-term efficacy of entecavir therapy in chronic hepatitis B patients with antiviral resistance to lamivudine and adefovir. Journal of viral hepatitis 20111001
Long-term efficacy of entecavir in adefovir-refractory chronic hepatitis B patients with prior lamivudine resistance. Journal of viral hepatitis 20111001
Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis. Journal of clinical gastroenterology 20111001
Antiviral drugs for viruses other than human immunodeficiency virus. Mayo Clinic proceedings 20111001
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication. European journal of medicinal chemistry 20110901
[Clinical antiviral effects of Peg-IFNa-2a in patients with chronic hepatitis B]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110901
Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. Journal of medicinal chemistry 20110825
Virological response to adefovir monotherapy and the risk of adefovir resistance. World journal of gastroenterology 20110814
A biomimetic chitosan derivates: preparation, characterization and transdermal enhancement studies of N-arginine chitosan. Molecules (Basel, Switzerland) 20110809
Defining virologic relapse in chronic hepatitis B. Digestive diseases and sciences 20110801
Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B. Infection 20110801
Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy. Alimentary pharmacology & therapeutics 20110801
Randomised clinical trial: efficacy of peginterferon alfa-2a in HBeAg positive chronic hepatitis B patients with lamivudine resistance. Alimentary pharmacology & therapeutics 20110801
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity. Bioorganic & medicinal chemistry 20110801
[Efficacy of two nucleoside analogs to treat resistant HBeAg-negative chronic hepatitis B]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20110801
Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B. Digestive diseases and sciences 20110701
Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study. Hepatology (Baltimore, Md.) 20110701
Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array. Journal of virological methods 20110701
Effect of antiviral therapy on the immunohistochemical expression of bcl-xL and bax protein in patients with HBeAg-negative chronic hepatitis B. Journal of medical virology 20110701
Adefovir serum levels do not differ between responders and nonresponders. Journal of viral hepatitis 20110701
Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B. Journal of viral hepatitis 20110701
[Effect of shugan jianpi bushen recipe on splenic T lymphocytes and virus load in hepatitis B virus transgenic mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110701
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy. Journal of viral hepatitis 20110601
Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs. Scandinavian journal of gastroenterology 20110601
New prodrugs of Adefovir and Cidofovir. Bioorganic & medicinal chemistry 20110601
Hepatitis: PEG-IFN for the treatment of hepatitis D. Nature reviews. Gastroenterology & hepatology 20110601
[Safety and efficacy of Entecavir combined with Adefovir in patients with chronic hepatitis B who fail to respond to nucleoside analog treatment]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110601
[The past, present and future treatment for chronic hepatitis B]. Nihon rinsho. Japanese journal of clinical medicine 20110501
[Prevention for the development of hepatitis B virus-related hepatocellular carcinoma by anti-viral treatment]. Nihon rinsho. Japanese journal of clinical medicine 20110501
The level of HBV DNA at month 12 is an important predictor of virological breakthrough during adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance. Digestive diseases and sciences 20110401
Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochemical pharmacology 20110401
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection. Journal of viral hepatitis 20110401
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. Bioorganic & medicinal chemistry 20110401
[Progress and perspectives in treatment of chronic hepatitis B]. Nihon rinsho. Japanese journal of clinical medicine 20110401
[Improvement of health-related quality of life in chronic hepatitis B patients treated with entecavir or adefovir]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110401
Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection. Journal of general internal medicine 20110301
Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model. American journal of physiology. Heart and circulatory physiology 20110301
1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac. Biopharmaceutics & drug disposition 20110301
Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B. Gut 20110201
Characteristics of adefovir resistance in patients with or without lamivudine-resistant hepatitis B virus treated with adefovir: a 4-year experience. Liver international : official journal of the International Association for the Study of the Liver 20110201
[Treatment of patients with lamivudine-resistant chronic hepatitis B]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20110201
[Efficacy of entecavir and adefovir combination therapy in patients with chronic hepatitis B refractory to lamivudine and adefovir combination therapy]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20110201
Adefovir-induced Stevens-Johnson syndrome and toxic epidermal necrolysis overlap syndrome. Singapore medical journal 20110201
Hypophosphatemic osteomalacia as a long-term complication after liver transplantation. Transplantation 20110115
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. Journal of medicinal chemistry 20110113
Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B. Journal of hepatology 20110101
Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues. Liver international : official journal of the International Association for the Study of the Liver 20110101
Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues. Liver international : official journal of the International Association for the Study of the Liver 20110101
Hepatitis B virus resistance to antiviral drugs: where are we going? Liver international : official journal of the International Association for the Study of the Liver 20110101
The impact of human immunodeficiency virus on viral hepatitis. Liver international : official journal of the International Association for the Study of the Liver 20110101
Management of chronic hepatitis B patients: efficacy & limitation of nucleos(t)ide analogues. The Indian journal of medical research 20110101
Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. The Indian journal of medical research 20110101
Comparison of the 48-week efficacy between entecavir and adefovir in HBeAg-positive nucleos(t)ide-naïve Asian patients with chronic hepatitis B: a meta-analysis. Virology journal 20110101
Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review. Virology journal 20110101
On-treatment monitoring of liver fibrosis with transient elastography in chronic hepatitis B patients. Antiviral therapy 20110101
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC biochemistry 20110101
[Current treatment of hepatitis B infection: where do the new nucleos(t)ide analogues fit in?]. Gastroenterologia y hepatologia 20110101
Two patterns of alanine aminotransferase increase to predict long-term viral response in chronic hepatitis B patients: virus- or host-induced? Antiviral therapy 20110101
Changes of serum levels of keratin-18 fragments in hepatitis B e antigen-negative chronic hepatitis B patients under oral antiviral therapy. Antiviral therapy 20110101
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations. BMC infectious diseases 20110101
[Reactivation of hepatitis B in a patient with spondyloarthritis after the suspension of methotrexate and efficacy of treatment with antivirals in association to adalimumab]. Reumatologia clinica 20110101
Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment. Virology journal 20110101
Lamivudine plus adefovir combination therapy versus entecavir monotherapy for lamivudine-resistant chronic hepatitis B: a systematic review and meta-analysis. Virology journal 20110101
Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B. Annals of hepatology 20110101
Rapid high-performance liquid chromatographic method for determination of adefovir in plasma using UV detection: application to pharmacokinetic studies. Arzneimittel-Forschung 20110101
Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101
Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20101201
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery. Antiviral research 20101201
Pharmacokinetics and efficacy of intravenous or intramuscular hepatitis B immunoglobulins in prophylaxis of hepatitis B after liver transplantation. Minerva medica 20101201
[Efficacy of adefovir treatment in the lamivudine-resistant chronic hepatitis B patients]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20101201
Efficacy of adefovir add-on lamivudine rescue therapy compared with switching to entecavir monotherapy in patients with lamivudine-resistant chronic hepatitis B. Journal of medical virology 20101101
High rate of adefovir-lamivudine combination therapy in nucleoside-naïve patients with chronic hepatitis B in France: results of a national survey in 1730 patients. European journal of gastroenterology & hepatology 20101101
Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir. Journal of hepatology 20100901
Question of ALT flare during switch to adefovir from lamivudine: A single center open-label, randomized, safety study (June 17, 2005 to February 5, 2009). Journal of medical virology 20100901
[Long-term therapy for chronic hepatitis B in HIV co-infected patients]. Gastroenterologie clinique et biologique 20100901
[Treatment has a positive impact on the long-term evolution of chronic hepatitis B]. Gastroenterologie clinique et biologique 20100901
Long-term outcome of renal transplant recipients with chronic hepatitis B infection-impact of antiviral treatments. Transplantation 20100815
Prevention of recurrent hepatitis B virus infection after liver transplantation: hepatitis B immunoglobulin, antiviral drugs, or both? Systematic review and meta-analysis. Transplant infectious disease : an official journal of the Transplantation Society 20100801
Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B. Antimicrobial agents and chemotherapy 20100801
Cost-effectiveness of nucleoside analog therapy for hepatitis B in China: a Markov analysis. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100801
Acute hepatitis B infection associated with drug-resistant hepatitis B virus. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100801
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801
Rescue therapy for lamivudine-resistant chronic hepatitis B: comparison between entecavir 1.0 mg monotherapy, adefovir monotherapy and adefovir add-on lamivudine combination therapy. Journal of gastroenterology and hepatology 20100801
The curative efficiency of tenofovir for patients with chronic hepatitis B after failure of nucleoside/nucleotide analogues. Hepatology (Baltimore, Md.) 20100801
[Add on lamivudine to adefovir monotherapy for the treatment of lamivudine-resistant chronic hepatitis B patients]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20100801
[Design, synthesis and anti-hBV evaluation of adefovir mono-L-amino acid ester, mono non-steroidal anti-inflammatory drugs carboxylic ester prodrugs]. Yao xue xue bao = Acta pharmaceutica Sinica 20100801
[Treatment of chronic hepatitis B. High response rate in general practice]. MMW Fortschritte der Medizin 20100722
Metal ion-binding properties of 9-[(2-phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antiviral nucleotide analogue 9-[(2-phosphonomethoxy)ethyl]adenine (PMEA). Steric guiding of metal ion-coordination by the purine-amino group. Dalton transactions (Cambridge, England : 2003) 20100721
Naturally occurring hepatitis B virus (HBV) variants with primary resistance to antiviral therapy and S-mutants with potential primary resistance to adefovir in Argentina. Antiviral research 20100701
[Effect of adefovir and lamivudine combination therapy on lamivudine resistance chronic hepatitis B patients for 48 weeks]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100701
Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro. Antiviral research 20100601
Virologic response at 12 months of treatment predicts sustained antiviral efficacy in patients with adefovir-treated Lamivudine-resistant chronic hepatitis B. Gut and liver 20100601
Antiviral treatment of chronic hepatitis B virus (HBV) infections. Viruses 20100601
Avoiding and managing lamivudine resistance in chronic hepatitis B: current approaches and potential strategies including pegylated interferon. Liver international : official journal of the International Association for the Study of the Liver 20100501
Hepatitis B genotypes and response to adefovir treatment in patients with HBV chronic infection. The Journal of infection 20100501
[Serological and sociodemographic differences in HBV-patients with and without migration background]. Zeitschrift fur Gastroenterologie 20100501
Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B infection. Health technology assessment (Winchester, England) 20100501
[Comparison of the efficacy of 48 week-Entecavir therapy with that of Adefovir therapy for chronic hepatitis B patients]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100501
[Failure to treat hepatitis B virus infection with adefovir due to early selection of rtA181T mutation]. Medicina clinica 20100410
Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion. Liver international : official journal of the International Association for the Study of the Liver 20100401
Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues. Journal of hepatology 20100401
[Genotype distribution of chronic hepatitis B and hepatitis C patients and investigation of the resistance patterns in hepatitis B cases]. Mikrobiyoloji bulteni 20100401
Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application. World journal of gastroenterology 20100314
Combination of Lamivudine and adefovir therapy in HBeAg-positive chronic hepatitis B patients with poor response to adefovir monotherapy. Journal of viral hepatitis 20100301
Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20100301
Low efficacy of entecavir therapy in adefovir-refractory hepatitis B patients with prior lamivudine resistance. Journal of viral hepatitis 20100301
Liver transplantation in bearers of hepatitis B associated or not with delta hepatitis in the age of the new antiviral drugs: is hyperimmune globulin still necessary? Transplantation proceedings 20100301
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations. Journal of Korean medical science 20100201
Viral resistance in hepatitis B: prevalence and management. Current gastroenterology reports 20100201
Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives. Journal of medicinal chemistry 20100128
[Protocol for the antiviral therapy of hepatitis B and D]. Orvosi hetilap 20100103
Response to adefovir or entecavir in renal allograft recipients with hepatitic flare due to lamivudine-resistant hepatitis B. Clinical transplantation 20100101
Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues. Hepatology (Baltimore, Md.) 20100101
Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients. Intervirology 20100101
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors. Antiviral therapy 20100101
Overlap/switch to adefovir monotherapy for lamivudine-resistant patients who responded to combination therapy: a pilot controlled study. Internal medicine (Tokyo, Japan) 20100101
Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case. Virology journal 20100101
Long term survival and complications after liver transplantation in patients with chronic hepatitis B. Annals of transplantation 20100101
A QSAR study on some series of anti-hepatitis B virus (HBV) agents. Bioinformation 20100101
Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors. Bioorganic & medicinal chemistry letters 20091215
Different models of HBeAg seroconversion predicated by on-treatment ALT and HBV DNA profiles. Journal of viral hepatitis 20091201
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy. Transplant infectious disease : an official journal of the Transplantation Society 20091201
Decrease in viral load at weeks 12 and 24 in patients with chronic hepatitis B treated with lamivudine or adefovir predicts virological response at week 48. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20091101
Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome. Journal of hepatology 20091001
Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone. Hepatology (Baltimore, Md.) 20091001
Lenalidomide-induced acute liver failure. Blood transfusion = Trasfusione del sangue 20091001
Clinical outcome of lamivudine-resistant chronic hepatitis B patients with compensated cirrhosis under adefovir salvage treatment. Importance of HCC surveillance. European journal of internal medicine 20090901
Stop codon read-through of a methylmalonic aciduria mutation. Molecular genetics and metabolism 20090801
Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients. Journal of gastroenterology and hepatology 20090801
[Factors associated with response to lamivudine: retrospective study of 233 patients with chronic hepatitis B]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090801
Early development of clevudine resistance during clevudine therapy in a patient with chronic hepatitis B who received prior lamivudine therapy. Liver international : official journal of the International Association for the Study of the Liver 20090701
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo. Antimicrobial agents and chemotherapy 20090701
Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues. Current opinion in organ transplantation 20090601
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain. Bioorganic & medicinal chemistry 20090601
Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare. Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090601
[The antiviral treatment impacts on clinical outcomes of renal transplantation recipients with hepatitis B virus infection]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20090601
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients. The Journal of infectious diseases 20090501
Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy. Joint, bone, spine : revue du rhumatisme 20090501
[Antiviral efficacy of lamivudine/adefovir combination therapy in chronic hepatitis b patients with resistance to lamivudine and adefovir consecutively]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20090501
[Treatment of hepatitis B virus resistant to lamivudine and adefovir]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20090501
The option of liver transplantation for hepatitis B: where are we? Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090501
Liver transplantation for hepatitis B virus. Pre-emptive and peri-operative prophylaxis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090501
Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C. The New England journal of medicine 20090430
[Telbivudine in the management of HIV/HBV coinfection. Treating hepatitis B without HIV trouble]. MMW Fortschritte der Medizin 20090430
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. Pharmaceutical research 20090401
Gene induction for the treatment of methylmalonic aciduria. The journal of gene medicine 20090401
Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy. Journal of hepatology 20090401
Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice. Journal of hepatology 20090401
Decision analysis model for hepatitis B prophylaxis one year after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20090401
Assessment of selective real-time PCR for quantitation of lamivudine and adefovir hepatitis B virus-resistant strains and comparison with direct sequencing and line probe assays. Journal of virological methods 20090301
Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir. Journal of medical virology 20090301
Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B. Journal of medical virology 20090301
Chronic hepatitis B: early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides. Journal of viral hepatitis 20090301
[Analysis of the cost-effectiveness of antiviral therapies in chronic hepatitis B patients in Korea]. The Korean journal of hepatology 20090301
Hepatitis B in HIV patients: what is the current treatment and what are the challenges? Journal of HIV therapy 20090301
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients. World journal of gastroenterology 20090214
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. Antiviral research 20090201
Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study. Journal of medical virology 20090201
Role of combination therapy in chronic hepatitis B. Current gastroenterology reports 20090201
On-treatment monitoring of adefovir therapy in chronic hepatitis B: virologic response can be assessed at 24 weeks. Journal of viral hepatitis 20090201
Hepatitis B therapy in children. Expert review of gastroenterology & hepatology 20090201
[Atazanavir-induced nephrolithiasis]. Enfermedades infecciosas y microbiologia clinica 20090201
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro. Journal of medicinal chemistry 20090108
Serum HBsAg changes in HBeAg positive chronic hepatitis B patients with continuous viral load reductions during treatment with adefovir or peg-interferon-alpha-2a. Antiviral research 20090101
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrobial agents and chemotherapy 20090101
Sensitivity and accuracy of an updated line probe assay (HBV DR v.3) in detecting mutations associated with hepatitis B antiviral resistance. Journal of hepatology 20090101
Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir. Hepatology (Baltimore, Md.) 20090101
Emergence of adefovir-resistant mutants after reversion to YMDD wild-type in lamivudine-resistant patients receiving adefovir monotherapy. Journal of gastroenterology and hepatology 20090101
Renal side effects of adefovir in hepatitis B virus-(HBV) positive kidney allograft recipients. Clinical nephrology 20090101
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues. Liver international : official journal of the International Association for the Study of the Liver 20090101
On-treatment outcome prediction and adjustment during chronic hepatitis B therapy: now and future. Antiviral therapy 20090101
Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues. Antiviral chemistry & chemotherapy 20090101
Can antiviral therapy for chronic hepatitis B enhance the progression to hepatocellular carcinoma? Antiviral therapy 20090101
Clinical usefulness of sequential hepatitis B virus DNA measurement (the roadmap concept) during adefovir treatment in lamivudine-resistant patients. Antiviral therapy 20090101
Fatal lactic acidosis associated with the use of combination oral medications to treat reactivation of hepatitis B. Journal of clinical gastroenterology 20090101
Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir. Antiviral therapy 20090101
The significance of enzyme immunoassay for the assessment of hepatitis B virus core-related antigen following liver transplantation. Internal medicine (Tokyo, Japan) 20090101
Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir. Antiviral therapy 20090101
Evolution of hepatitis B virus mutation during entecavir rescue therapy in patients with antiviral resistance to lamivudine and adefovir. Antiviral therapy 20090101
Determination of adefovir by LC-ESI-MS-MS and its application to a pharmacokinetic study in healthy Chinese volunteers. Journal of chromatographic science 20090101
Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases. Journal of molecular biology 20081212
Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers. European journal of gastroenterology & hepatology 20081201
Failure of adefovir 20 mg to improve suboptimal response in lamivudine-resistant hepatitis B patients treated with adefovir 10 mg and lamivudine. Journal of viral hepatitis 20081201
The discovery of antiviral agents: ten different compounds, ten different stories. Medicinal research reviews 20081101
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101
Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy? Journal of hepatology 20081101
A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis. Hepatology (Baltimore, Md.) 20081101
[Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20081101
[Chronic hepatitis B: current therapy]. Bulletin de l'Academie nationale de medecine 20081101
Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient. European journal of medical research 20081027
A review of telbivudine for the management of chronic hepatitis B virus infection. Expert opinion on drug metabolism & toxicology 20081001
LB80380: a promising new drug for the treatment of chronic hepatitis B. Expert opinion on investigational drugs 20081001
4'-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action. Journal of medicinal chemistry 20080925
Hepatitis B virus genotype A2 harbours an L217R polymorphism which may account for a lower response to adefovir. The Journal of antimicrobial chemotherapy 20080901
Continuous single motor unit electromyographic activity in adefovir associated myopathy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20080901
What is the optimum dose of adefovir in the treatment of chronic hepatitis B infection? Journal of hepatology 20080901
Entecavir therapy for adefovir-resistant hepatitis B virus infection in kidney and liver allograft recipients. Transplantation 20080827
Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801
Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides. Bioorganic & medicinal chemistry 20080715
Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis. Liver international : official journal of the International Association for the Study of the Liver 20080701
Dynamics of lamivudine-resistant hepatitis B virus during adefovir monotherapy versus lamivudine plus adefovir combination therapy. Journal of medical virology 20080701
[YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy]. Mikrobiyoloji bulteni 20080701
Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4. Cancer research 20080615
Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients. World journal of gastroenterology 20080614
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. The Journal of pharmacology and experimental therapeutics 20080601
Evaluating anti-viral drug selection and treatment duration in HBeAg-negative chronic hepatitis B: a cost-effectiveness analysis. Alimentary pharmacology & therapeutics 20080601
Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. Gastroenterology 20080601
Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up. Journal of hepatology 20080601
[Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients]. MMW Fortschritte der Medizin 20080522
Evaluation of initial virological response to adefovir and development of adefovir-resistant mutations in patients with chronic hepatitis B. Journal of viral hepatitis 20080501
6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. Human mutation 20080501
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure. Journal of hepatology 20080501
[Acute hepatitis B: is antiviral therapy indicated? Two case reports]. Deutsche medizinische Wochenschrift (1946) 20080501
[Interferon in hepatitis B]. Enfermedades infecciosas y microbiologia clinica 20080501
[Resistance in hepatitis B virus]. Enfermedades infecciosas y microbiologia clinica 20080501
Viral persistence after liver transplantation for hepatitis B virus: a cross-sectional study. Transplantation 20080427
Antibody to hepatitis B surface antigen trough levels and half-lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080401
Economic evaluation of chronic hepatitis B treatments in Taiwan. Journal of gastroenterology and hepatology 20080401
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position. Nucleosides, nucleotides & nucleic acids 20080401
Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B. World journal of gastroenterology 20080321
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations. Journal of hepatology 20080301
[Pharmacological agents for the treatment of chronic hepatitis B]. Gastroenterologia y hepatologia 20080301
[Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine-resistant chronic hepatitis B patients]. The Korean journal of hepatology 20080301
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B. Journal of medicinal chemistry 20080214
Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression. Journal of viral hepatitis 20080201
Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding. Journal of enzyme inhibition and medicinal chemistry 20080201
Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future. Reviews in medical virology 20080101
Prophylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 years. Liver international : official journal of the International Association for the Study of the Liver 20080101
[Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20080101
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues. Antiviral therapy 20080101
Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy. The new microbiologica 20080101
[Treatment recommendations of chronic hepatitis B. Did the world escape us?]. Przeglad epidemiologiczny 20080101
Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant. Antiviral therapy 20080101
Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients. Antiviral therapy 20080101
Living donor liver transplantation for hepatitis B associated liver diseases: a 10-year experience in a single center. Hepato-gastroenterology 20080101
Pharmacotherapy of hepatitis B infection: a brief review. Nephrology nursing journal : journal of the American Nephrology Nurses' Association 20080101
[Drugs treatment of hepatitis B]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20080101
Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best practice & research. Clinical gastroenterology 20080101
Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues. Best practice & research. Clinical gastroenterology 20080101
Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. Antiviral therapy 20080101
Successful treatment of an entecavir-resistant hepatitis B virus variant. Journal of medical virology 20071201
Review article: Success and failure of nucleoside and nucleotide analogues in chronic hepatitis B. Alimentary pharmacology & therapeutics 20071201
Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B. Journal of HIV therapy 20071201
Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. European journal of pharmacology 20071121
Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro. Bioorganic & medicinal chemistry letters 20071115
[Attention-getting sexually transmitted diseases: Hepatitis B]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20071110
Redetection of HBV lamivudine-resistant mutations in a patient under entecavir therapy, who had been treated sequentially with nucleos(t)ide analogues. Journal of medical virology 20071101
[Adefovir in reactivation of chemotherapy-induced hepatitis B in an anti-Hbc-positive patient]. Gastroenterologia y hepatologia 20071101
Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients. Gastroenterology 20071101
Hepatitis B: explosion of new knowledge. Gastroenterology 20071101
Combination therapy in liver transplant recipients with hepatitis B virus without hepatitis B immune globulin. Digestive diseases and sciences 20071001
Absence of a pharmacokinetic interaction between entecavir and adefovir. Journal of clinical pharmacology 20071001
In vitro drug susceptibility analysis of hepatitis B virus clinical quasispecies populations. Journal of clinical microbiology 20071001
Adefovir for lamivudine resistant HBV: more than meets the eye. Journal of hepatology 20071001
[Indications for antiviral therapy for chronic hepatitis B]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071001
[Therapy for chronic hepatitis B: relationship between HBV genotype and efficacy or resistance of anti-viral therapy]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071001
[Recent therapies for hepatitis B (discussion)]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071001
[New German and American guidelines for therapy of hepatitis B. Discrepancies and similarities]. Medizinische Klinik (Munich, Germany : 1983) 20070915
Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients. Journal of hepatology 20070901
Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070901
Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B. Journal of gastroenterology and hepatology 20070901
Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: a systematic review of economic evidence. Journal of gastroenterology and hepatology 20070901
[Effect of initial virologic response to adefovir on the development of resistance to adefovir in lamivudine-resistant chronic hepatitis B]. The Korean journal of hepatology 20070901
Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B. World journal of gastroenterology 20070814
Does pre-treatment with lamivudine prime for adefovir resistance of hepatitis B virus infection? The Journal of antimicrobial chemotherapy 20070801
Emergence of hepatitis B virus quasispecies with lower susceptibility to nucleos(t)ide analogues during lamivudine treatment. The Journal of antimicrobial chemotherapy 20070801
Pradefovir, a liver-targeted prodrug of adefovir against HBV infection. Current opinion in investigational drugs (London, England : 2000) 20070801
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer research 20070715
Hepatitis B virus reactivation in a case of Waldenstrom's macroglobulinemia treated with chemotherapy and rituximab despite adefovir prophylaxis. American journal of hematology 20070701
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. Antiviral research 20070701
Optimal duration of therapy in HBV-related cirrhosis. The Journal of antimicrobial chemotherapy 20070701
Pre- and post-treatment predictors of the early achievement of HBeAg loss in lamivudine-resistant patients receiving adefovir therapy. Journal of gastroenterology and hepatology 20070701
HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients. Expert opinion on investigational drugs 20070601
[An economic evaluation of different treatments for HBeAg-positive chronic hepatitis B in China]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20070601
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. Veterinary microbiology 20070516
Tailoring antiviral therapy in chronic hepatitis B patients with lamivudine resistance. Journal of hepatology 20070501
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. Biochemical pharmacology 20070401
Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401
Hepatitis B virus resistance to adefovir in a nucleotide naive patient with chronic hepatitis B virus infection. The Journal of antimicrobial chemotherapy 20070401
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharmaceutical research 20070401
Characteristics of patients with chronic hepatitis-B virus infection in an urban hospital. Journal of the National Medical Association 20070401
[Advances in research of hepatitis B virus resistance to adefovir]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20070401
Recommendations for the treatment of chronic hepatitis B infection in children. JPMA. The Journal of the Pakistan Medical Association 20070401
[A case of chronic hepatitis B with primary adefovir resistance]. Mikrobiyoloji bulteni 20070401
Low risk of hepatitis B virus recurrence after withdrawal of long-term hepatitis B immunoglobulin in patients receiving maintenance nucleos(t)ide analogue therapy. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301
Treatment of chronic hepatitis B in HIV-infected patients in 2007. Journal of HIV therapy 20070301
[Drugs for hepatitis B and C infection]. Nihon rinsho. Japanese journal of clinical medicine 20070227
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Molecular pharmacology 20070201
Rescue therapy for lamivudine-resistant chronic hepatitis B: when and how? Hepatology (Baltimore, Md.) 20070201
Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity. Bioorganic & medicinal chemistry letters 20070115
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. The Journal of antimicrobial chemotherapy 20070101
Cross-study analysis of the relative efficacies of oral antiviral therapies for chronic hepatitis B infection in nucleoside-naive patients. Clinical drug investigation 20070101
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer research 20070101
Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma. Internal medicine (Tokyo, Japan) 20070101
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. Retrovirology 20070101
[The prophylaxis against post-liver-transplant hepatitis B re-infection]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101
Treatment of HIV/HBV coinfection: clinical and virologic issues. AIDS reviews 20070101
Identification of 1-isopropylsulfonyl-2-amine benzimidazoles as a new class of inhibitors of hepatitis B virus. European journal of medicinal chemistry 20070101
Chronic hepatitis B with advanced fibrosis or cirrhosis: impact of antiviral therapy. Reviews in gastroenterological disorders 20070101
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. Antiviral therapy 20070101
Cost effectiveness of entecavir versus lamivudine with adefovir salvage in HBeAg-positive chronic hepatitis B. PharmacoEconomics 20070101
Dynamics of HBV DNA levels, HBV mutations and biochemical parameters during antiviral therapy in a patient with HBeAg-negative chronic hepatitis B. Asian Pacific journal of allergy and immunology 20070101
Management and treatment of chronic hepatitis B virus: Belgian Association for the Study of the Liver (BASL) 2007 guidelines. Acta gastro-enterologica Belgica 20070101
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. Journal of medicinal chemistry 20061228
The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3. American journal of physiology. Regulatory, integrative and comparative physiology 20061201
Nonresponse to adefovir: host or virus dependent? Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen. European journal of gastroenterology & hepatology 20061201
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3. Neuro endocrinology letters 20061201
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir. Xenobiotica; the fate of foreign compounds in biological systems 20061201
Hepatitis B virus treatment in HIV-infected patients. Topics in HIV medicine : a publication of the International AIDS Society, USA 20061201
A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient. AIDS (London, England) 20061114
Improved outcome of chronic hepatitis B after heart transplantation by long-term antiviral therapy. Journal of viral hepatitis 20061101
Why adefovir is not yet available in Canada. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20061101
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro. Antiviral research 20061001
Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061001
Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV. Hepatology (Baltimore, Md.) 20061001
Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient. Gastroenterology 20061001
[Managing resistance to analogue antiviral drugs in a decompensated cirrhosis patient]. Gastroenterologie clinique et biologique 20061001
[Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients]. Gastroenterologie clinique et biologique 20061001
[Managing lamivudine resistance in liver transplantation for hepatitis B liver disease]. Gastroenterologie clinique et biologique 20061001
[Impact of resistance to analogue antivirals and therapeutic strategies in situations of dialysis, kidney transplantation, vasculitis, and preemptive treatments in immunosuppressed patients]. Gastroenterologie clinique et biologique 20061001
Development and validation of a sensitive LC-MS/MS method for the determination of adefovir in human serum and urine. Journal of pharmaceutical and biomedical analysis 20060926
[Therapy of hepatitis B]. Praxis 20060906
[Therapy of hepatitis B virus infection]. Praxis 20060906
Favorable outcome of liver transplantation despite a high hepatitis B virus replication: beyond the limits? Transplant infectious disease : an official journal of the Transplantation Society 20060901
New developments in the treatment of chronic hepatitis B. Expert opinion on biological therapy 20060901
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrobial agents and chemotherapy 20060901
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology (Baltimore, Md.) 20060901
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. Hepatology (Baltimore, Md.) 20060801
Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives. Journal of medicinal chemistry 20060727
Hepatitis B virus with primary resistance to adefovir. The New England journal of medicine 20060720
Tubular transporters and clearance of adefovir. European journal of pharmacology 20060701
A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B. Hepatology (Baltimore, Md.) 20060701
Antiviral options for the treatment of chronic hepatitis B. The Journal of antimicrobial chemotherapy 20060601
Antiviral treatment for chronic hepatitis B virus infection--immune modulation or viral suppression? The Netherlands journal of medicine 20060601
Overlap lamivudine treatment in patients with chronic hepatitis B receiving adefovir for lamivudine-resistant viral mutants. Journal of viral hepatitis 20060601
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. Journal of biomedical science 20060501
First report of genotypic resistance to adefovir in chronic HBV in the Republic of Ireland. The Journal of antimicrobial chemotherapy 20060501
Prophylactic strategies for hepatitis B patients undergoing liver transplant: a cost-effectiveness analysis. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20060501
Variant of hepatitis B virus with primary resistance to adefovir. The New England journal of medicine 20060427
[Reactivation of hepatitis B treated with adefovir after infliximab administration]. Medicina clinica 20060415
Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060401
Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis. Journal of viral hepatitis 20060401
Adefovir therapy for lamivudine escape and hepatitis B virus reactivation after reduced intensity conditioning allogeneic stem cell transplantation. Bone marrow transplantation 20060301
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine. Antimicrobial agents and chemotherapy 20060301
Virologic response and resistance to adefovir in patients with chronic hepatitis B. Journal of hepatology 20060201
Cellular and virological mechanisms of HBV drug resistance. Journal of hepatology 20060201
Chronic hepatitis B: a critical appraisal of current approaches to therapy. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060201
Combination therapy for chronic hepatitis B: a one-two knockout punch, or a swing and a miss? Gastroenterology 20060201
Replacement of tenofovir with adefovir may result in reactivation of hepatitis B virus replication. Scandinavian journal of gastroenterology 20060201
[Treatment of chronic hepatitis B]. Presse medicale (Paris, France : 1983) 20060201
[Liver transplantation for complications of hepatitis B]. Presse medicale (Paris, France : 1983) 20060201
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver. Current opinion in investigational drugs (London, England : 2000) 20060201
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine. European journal of pharmacology 20060113
Introduction to chronic hepatitis B infection. The American journal of gastroenterology 20060101
Therapeutic options for chronic hepatitis B: considerations and controversies. The American journal of gastroenterology 20060101
Hepatitis B virus genotypes and response to antiviral therapy. Clinical laboratory 20060101
Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues. Annals of clinical microbiology and antimicrobials 20060101
In vitro comparison of antiviral drugs against feline herpesvirus 1. BMC veterinary research 20060101
Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations. Internal medicine (Tokyo, Japan) 20060101
Report from the 2nd International Workshop on HIV and Hepatitis Co-Infection, January 12-14, 2006, Amsterdam, Netherlands. Tenofovir or adefovir for hepatitis B. TreatmentUpdate 20060101
Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases. Antiviral therapy 20060101
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach. Journal of medicinal chemistry 20051215
Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. Journal of hepatology 20051201
Resistance to adefovir: a new challenge in the treatment of chronic hepatitis B. Journal of hepatology 20051201
Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine. Hepatology (Baltimore, Md.) 20051201
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201
[Drug therapy in chronic liver disease]. Praxis 20051130
Risk of selecting K65R in antiretroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir. AIDS (London, England) 20051118
Cost-effectiveness in hepatitis B. Annals of internal medicine 20051115
Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatment. Transplantation 20051115
Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir. Journal of clinical pharmacology 20051101
[Tubular transporters OAT1 and MRP2 and clearance of adefovir]. Nephrologie & therapeutique 20051101
[Clinical outcomes after discontinuation of Lamivudine in chronic hepatitis B patients with Lamivudine resistant HBV mutant]. The Korean journal of hepatology 20050901
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). The Journal of pharmacology and experimental therapeutics 20050801
Viral kinetics in patients with lamivudine-resistant hepatitis B during adefovir-lamivudine combination therapy. Journal of hepatology 20050801
The risk of adefovir monotherapy in human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients. Journal of hepatology 20050801
Adefovir-lamivudine combination therapy and hepatitis B viral kinetics. Journal of hepatology 20050801
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. The Journal of general virology 20050801
Understanding hepatitis B. The Journal of the Association of Physicians of India 20050801
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution. Inorganic chemistry 20050711
Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results. Transplant international : official journal of the European Society for Organ Transplantation 20050701
Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine. Hepatology (Baltimore, Md.) 20050701
Reactivation of viral replication after replacement of tenofovir by adefovir. Hepatology (Baltimore, Md.) 20050701
Determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis B virus-related decompensated liver cirrhosis. Journal of viral hepatitis 20050701
Chronic hepatitis B--treatment with nucleoside analogues. The Medical journal of Malaysia 20050701
Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir. Hepatology (Baltimore, Md.) 20050601
[Clinical and virologic characteristics and treatment for chronic hepatitis B: relation with HBV genotypes]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20050601
Summaries for patients. Antiviral regimens for chronic hepatitis B virus infection. Annals of internal medicine 20050517
Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis. Annals of internal medicine 20050517
Assessing the benefits and costs of new therapies for hepatitis B virus infection. Annals of internal medicine 20050517
Spectrum of antiviral activity of o-(acetoxyphenyl)hept-2-ynyl sulphide (APHS). International journal of antimicrobial agents 20050501
[Management of chronic hepatitis B]. Praxis 20050420
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents. Journal of the American Chemical Society 20050413
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenetics and genomics 20050401
[Chronic hepatitis B: which patients should be treated and how?]. Gastroenterologie clinique et biologique 20050401
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides. Antimicrobial agents and chemotherapy 20050301
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase. Antimicrobial agents and chemotherapy 20050301
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities. Antimicrobial agents and chemotherapy 20050301
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel. AIDS (London, England) 20050218
Liver-targeted drug delivery using HepDirect prodrugs. The Journal of pharmacology and experimental therapeutics 20050201
Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma. Rapid communications in mass spectrometry : RCM 20050101
Cross-resistance testing of next-generation nucleoside and nucleotide analogues against lamivudine-resistant HBV. Antiviral therapy 20050101
Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. Rapid communications in mass spectrometry : RCM 20050101
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. Nucleosides, nucleotides & nucleic acids 20050101
Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20041201
Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine. Journal of inorganic biochemistry 20041201
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. Hepatology (Baltimore, Md.) 20041201
The management of chronic viral hepatitis: a Canadian consensus conference 2004. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20041201
Drug-induced renal failure in the ICU. The International journal of artificial organs 20041201
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state. The Journal of biological chemistry 20041119
Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment. AIDS (London, England) 20041119
Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells. Biochemical pharmacology 20041101
Adefovir treatment in posttransplant hepatitis B virus infection resistant to lamivudine plus hepatitis B virus immunoglobulin. Transplantation proceedings 20041101
Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. Antimicrobial agents and chemotherapy 20041001
[An attempt to approach an optional therapeutic regimen for chronic hepatitis B]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20041001
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity. Nucleosides, nucleotides & nucleic acids 20041001
[Active prevention and treatment of superinfection with HBV, HCV and HIV]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040901
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study. Bioorganic & medicinal chemistry letters 20040816
Prevention of hepatitis B virus reinfection after orthotopic liver transplantation. Hepatobiliary & pancreatic diseases international : HBPD INT 20040801
Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection. Expert review of anti-infective therapy 20040801
[Hepatitis B (acute and chronic)]. Praxis 20040728
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. Bioorganic & medicinal chemistry 20040615
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia. The Journal of pharmacology and experimental therapeutics 20040601
Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) by a quantitative real-time PCR assay. Antiviral research 20040601
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents. Antimicrobial agents and chemotherapy 20040601
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir. Antiviral therapy 20040601
A novel class of phosphonate nucleosides. 9-[(1-phosphonomethoxycyclopropyl)methyl]guanine as a potent and selective anti-HBV agent. Journal of medicinal chemistry 20040520
[Determination of adefovir dipivoxil and its degradation products by reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography 20040501
Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver. Journal of the American Chemical Society 20040428
Ultra sensitive method for the determination of 9-(2-phosphonylmethoxyethyl)adenine in human serum by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359. The Journal of infectious diseases 20040401
Metal ion complexes of antivirally active nucleotide analogues. Conclusions regarding their biological action. Chemical Society reviews 20040330
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. Biochemical and biophysical research communications 20040319
Antiretroviral therapy and HIV/hepatitis B virus coinfection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? Antiviral research 20040301
Rearrangement process occurring in the fragmentation of adefovir derivatives. Journal of mass spectrometry : JMS 20040201
In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector. Antiviral research 20040101
Rescue therapy for drug resistant hepatitis B: another argument for combination chemotherapy? Gastroenterology 20040101
[Adefovir dipivoxil-A new drug for hepatitis B]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20040101
Hepatitis B virus kinetics and mathematical modeling. Seminars in liver disease 20040101
The role of interferon therapy in hepatitis B. MedGenMed : Medscape general medicine 20040101
Hepatitis C virus in the setting of HIV or hepatitis B virus coinfection. Seminars in liver disease 20040101
Treatment of chronic viral hepatitis. Best practice & research. Clinical gastroenterology 20040101
Nickel(II), copper(II) and zinc(II) complexes of 9-[2- (phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-aza derivative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl] adenine (PMEA). Quantification of four isomeric species in aqueous solution. Bioinorganic chemistry and applications 20040101
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031215
Adefovir (Hepsera) for chronic hepatitis B infection. American family physician 20031215
Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. Journal of hepatology 20031201
Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes. Hepatology (Baltimore, Md.) 20031201
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. Journal of medicinal chemistry 20031106
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes. Toxicology and applied pharmacology 20031101
[Adefovir]. Revue de l'infirmiere 20031101
Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure. Transplantation 20031027
Current pharmacotherapy for the treatment of chronic hepatitis B. Expert opinion on pharmacotherapy 20031001
Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions. Antiviral research 20031001
Management of chronic hepatitis B in an HIV-positive patient with 3TC-resistant hepatitis B virus. AIDS patient care and STDs 20030901
[Hepatitis: associated diseases. Risk groups -- prevention -- treatment]. Praxis 20030813
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. The Journal of biological chemistry 20030808
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrobial agents and chemotherapy 20030701
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. Gastroenterology 20030701
Slowing the progression of chronic hepatitis B. Early antiviral therapy can help minimize complications. Postgraduate medicine 20030701
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.). Antiviral research 20030701
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Molecular pharmacology 20030501
[Viral hepatitis B/C and HIV. Therapy of double infections]. MMW Fortschritte der Medizin 20030428
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. The Journal of infectious diseases 20030401
Antiviral effect of adefovir in combination with a DNA vaccine in the duck hepatitis B virus infection model. Journal of hepatology 20030301
Management of patients with decompensated HBV cirrhosis. Seminars in liver disease 20030201
[Antiviral therapy for chronic viral hepatitis B and C]. Nihon rinsho. Japanese journal of clinical medicine 20030201
[Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry]. Yao xue xue bao = Acta pharmaceutica Sinica 20030201
Intrinsic acid-base properties of purine derivatives in aqueous solution and comparison of the acidifying effects of platinum(II) coordinated to N1 or N7: acidifying effects are reciprocal and the proton 'outruns' divalent metal ions. Inorganic chemistry 20030113
Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro. Hepatology (Baltimore, Md.) 20030101
Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells. Journal of viral hepatitis 20030101
In vitro activity of potential anti-poxvirus agents. Antiviral research 20030101
HIV and hepatitis B virus: options for managing coinfection. Topics in HIV medicine : a publication of the International AIDS Society, USA 20030101
Combination therapy for chronic hepatitis B. Journal of hepatology 20030101
Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others). Journal of hepatology 20030101
Current therapies for chronic hepatitis B. Annals of hepatology 20030101
Adefovir (Hepsera) for chronic hepatitis B infection. The Medical letter on drugs and therapeutics 20021209
Fanconi syndrome and renal failure induced by tenofovir: a first case report. American journal of kidney diseases : the official journal of the National Kidney Foundation 20021201
[Treatment of hepatitis B]. La Revue de medecine interne 20021201
Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures. Antimicrobial agents and chemotherapy 20021101
Antiviral activities of MCC-478, a novel and specific inhibitor of hepatitis B virus. Antimicrobial agents and chemotherapy 20020901
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. Hepatology (Baltimore, Md.) 20020901
Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine. The Journal of antimicrobial chemotherapy 20020901
Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrobial agents and chemotherapy 20020801
2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents. Journal of medicinal chemistry 20020704
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Antimicrobial agents and chemotherapy 20020701
Cidofovir in the treatment of poxvirus infections. Antiviral research 20020701
Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy. Journal of medical virology 20020501
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of medicinal chemistry 20020425
[New management strategies for hepatitis B]. Gastroenterologie clinique et biologique 20020201
Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails. Journal of acquired immune deficiency syndromes (1999) 20020101
Raman spectroscopy study of acid-base and structural properties of 9-[2-(phosphonomethoxy)ethyl]adenine in aqueous solutions. Biopolymers 20020101
Update on the management of chronic hepatitis B. Reviews in gastroenterological disorders 20020101
Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir. Gut 20011201
Nucleoside analogues for chronic hepatitis B. European journal of gastroenterology & hepatology 20011201
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. The Journal of pharmacology and experimental therapeutics 20011101
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs. Cancer research 20011101
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. Journal of medicinal chemistry 20011025
HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study. AIDS (London, England) 20010928
The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS (London, England) 20010907
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil. Antimicrobial agents and chemotherapy 20010901
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus. Molecular pharmacology 20010901
Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408. Journal of acquired immune deficiency syndromes (1999) 20010815
Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance. AIDS research and human retroviruses 20010810
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Human pathology 20010701
Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus. Antimicrobial agents and chemotherapy 20010601
Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus. The Journal of antimicrobial chemotherapy 20010601
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9. Chemistry (Weinheim an der Bergstrasse, Germany) 20010504
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA. Bioorganic & medicinal chemistry letters 20010423
[Current knowledge on chronic hepatitis B therapy]. Gastroenterologie clinique et biologique 20010401
Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9. Journal of inorganic biochemistry 20010301
[Current treatment of hepatitis B]. Gastroenterologia y hepatologia 20010201
Drug therapy for hepatitis B. Advances in internal medicine 20010101
Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo. Journal of hepatology 20010101
Preliver transplant viremic status and the choice of anti-HBV regimens. Transplantation proceedings 20010101
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation. Antiviral chemistry & chemotherapy 20010101
Kinetic studies of the degradation of oxycarbonyloxymethyl prodrug of Adefovir and Tenofovir in solution. Nucleosides, nucleotides & nucleic acids 20010101
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents. Nucleosides, nucleotides & nucleic acids 20010101
Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes. Nucleosides, nucleotides & nucleic acids 20010101
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides, nucleotides & nucleic acids 20010101
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. Reviews in medical virology 20010101
Low-dose adefovir for the treatment of chronic hepatitis B in HIV-infected people. GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20010101
In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas. Antiviral research 20001101
Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20000901
A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus. Antiviral research 20000901
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues. Antimicrobial agents and chemotherapy 20000801
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine. Antimicrobial agents and chemotherapy 20000701
Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC]. Antiviral chemistry & chemotherapy 20000701
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture. Journal of viral hepatitis 20000101
Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs. Antimicrobial agents and chemotherapy 19991201
Selective activity of various antiviral compounds against HHV-7 infection. Antiviral research 19990801
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. Journal of medicinal chemistry 19990617
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues. Biochemical pharmacology 19990615
Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors. The Journal of clinical investigation 19990615
Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro. The Journal of infectious diseases 19990101
Effect of acyclic nucleoside phosphonates on the HIV-1 integrase in vitro. Nucleosides & nucleotides 19990101
Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral research 19981201
Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nature neuroscience 19980901
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication. Antiviral chemistry & chemotherapy 19980501
Antiviral drug susceptibility of human herpesvirus 8. Antimicrobial agents and chemotherapy 19971201
Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses. Antiviral research 19971101
Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes. Journal of leukocyte biology 19970701
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine. Antimicrobial agents and chemotherapy 19970601
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes. Antiviral research 19970601
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice. Antimicrobial agents and chemotherapy 19970301
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability. Journal of medicinal chemistry 19961206
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Antiviral research 19961001
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro. Antimicrobial agents and chemotherapy 19960901
Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. Journal of medicinal chemistry 19960816
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109. Biochemical and biophysical research communications 19960814
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. Molecular pharmacology 19960801
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. Biochemical and biophysical research communications 19960215
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. Antimicrobial agents and chemotherapy 19960101
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. Antiviral research 19951201
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science (New York, N.Y.) 19951117
Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells. Antimicrobial agents and chemotherapy 19951101
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine. Antimicrobial agents and chemotherapy 19950801
Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds. Antimicrobial agents and chemotherapy 19950701
Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine. Antiviral research 19950601
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19950401
Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antiviral research 19950101
Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture. Antimicrobial agents and chemotherapy 19940901
Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates. Antimicrobial agents and chemotherapy 19940701
Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Journal of medicinal chemistry 19940610
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus. Virology 19931001
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates. Antimicrobial agents and chemotherapy 19931001
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors. Proceedings of the National Academy of Sciences of the United States of America 19930801
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection. Antiviral research 19930601
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5'-(4'-amino-1',2'- oxathiole-2',2'-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues. Molecular pharmacology 19930101
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150). Molecular pharmacology 19930101
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. Virology 19930101
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine. Antiviral research 19920901
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. Journal of medicinal chemistry 19920807
In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase. Molecular pharmacology 19920301
Chemotherapy of feline immunodeficiency virus infection. Journal of the American Veterinary Medical Association 19911115
Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes. Biochemical and biophysical research communications 19910715
Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Antiviral research 19910701
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models. Antiviral research 19910701
Cellular uptake of phosphonylmethoxyalkylpurine derivatives. Antiviral research 19910701
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo. Antiviral research 19910701
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America 19910601
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound. Proceedings of the National Academy of Sciences of the United States of America 19910215
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis. Antimicrobial agents and chemotherapy 19910201
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. The Journal of biological chemistry 19910105
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. AIDS (London, England) 19910101
Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation. Journal of medicinal chemistry 19900901
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. Antiviral research 19900601
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one. Journal of medicinal chemistry 19900501
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. Journal of medicinal chemistry 19900401
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19891201
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. Antimicrobial agents and chemotherapy 19891101
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine. Antimicrobial agents and chemotherapy 19890901
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. Antimicrobial agents and chemotherapy 19890201
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proceedings of the National Academy of Sciences of the United States of America 19890101
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrobial agents and chemotherapy 19881201
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Antimicrobial agents and chemotherapy 19880701
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral research 19871201
Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication. Antimicrobial agents and chemotherapy 19870901
Properties