{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid
Title | Journal |
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Editor's Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats. | Toxicological sciences : an official journal of the Society of Toxicology 20170101 |
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals. | Mini reviews in medicinal chemistry 20170101 |
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. | Toxicology in vitro : an international journal published in association with BIBRA 20150201 |
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer. | European journal of medicinal chemistry 20140506 |
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates. | Toxicology 20130915 |
Anti-hepatitis B virus and anti-cancer activities of novel isoflavone analogs. | European journal of medicinal chemistry 20130401 |
Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation. | Transplant infectious disease : an official journal of the Transplantation Society 20121001 |
A case of adefovir-induced membranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease. | Clinical and experimental nephrology 20121001 |
Does genotype predict response to treatment in children infected with hepatitis B perinatally? | Journal of medical virology 20121001 |
The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection. | The Netherlands journal of medicine 20121001 |
Viral response at 6 months is associated with treatment outcome of adefovir add-on therapy for lamivudine-resistance. | Journal of gastroenterology and hepatology 20120901 |
Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). | Chemistry & biodiversity 20120901 |
Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir. | Liver international : official journal of the International Association for the Study of the Liver 20120801 |
Prolonged adefovir therapy associated Fanconi syndrome and interstitial nephritis in hepatitis B. | Internal medicine journal 20120801 |
Safety and efficacy of adefovir therapy for lamivudine-resistant hepatitis B virus infection in renal transplant recipients. | Journal of the Formosan Medical Association = Taiwan yi zhi 20120801 |
Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance. | Journal of medical virology 20120701 |
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120614 |
Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B. | Alimentary pharmacology & therapeutics 20120601 |
Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection. | Journal of viral hepatitis 20120601 |
In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates. | European journal of pharmacology 20120515 |
Efficacy of entecavir and adefovir combination therapy for patients with lamivudine- and entecavir-resistant chronic hepatitis B. | Digestive diseases and sciences 20120501 |
Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir. | Scandinavian journal of gastroenterology 20120401 |
Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy. | Clinics and research in hepatology and gastroenterology 20120401 |
[Hungarian consensus guideline for the diagnosis and treatment of B, C, and D viral hepatitis]. | Orvosi hetilap 20120311 |
Simple scoring system predicting genotypic resistance during rescue therapy for Lamivudine-resistant chronic hepatitis B. | Journal of clinical gastroenterology 20120301 |
Potent hepatitis B surface antigen response to treatment of hepatitis-B-e-antigen-positive chronic hepatitis B with α-interferon plus a nucleos(t)ide analog. | Journal of gastroenterology and hepatology 20120301 |
Antiviral efficacy of combination therapy with entecavir and adefovir for entecavir/lamivudine-resistant hepatitis B virus with or without adefovir resistance. | Journal of medical virology 20120301 |
Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis. | Alimentary pharmacology & therapeutics 20120301 |
Synthesis, anti-HBV activity and renal cell toxicity evaluation of mixed phosphonate prodrugs of adefovir. | European journal of medicinal chemistry 20120301 |
High efficacy of adefovir and entecavir combination therapy in patients with nucleoside-refractory hepatitis B. | The Korean journal of hepatology 20120301 |
A prospective clinical study in hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessation criteria for adefovir. | Archives of virology 20120201 |
The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment. | Liver international : official journal of the International Association for the Study of the Liver 20120201 |
Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages. | International immunopharmacology 20120201 |
[Efficacy of lamivudine and adefovir de novo combination therapy or after mono-therapy in chronic hepatitis B patients]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120201 |
Adefovir-based combination therapy with entecavir or lamivudine for patients with entecavir-refractory chronic hepatitis B. | Journal of medical virology 20120101 |
In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate. | Antiviral research 20120101 |
Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B. | Antiviral research 20120101 |
Risk factors of gene-resistant mutations in different nucleosides. | Hepato-gastroenterology 20120101 |
Entecavir plus adefovir combination treatment for chronic hepatitis B patients after failure of nucleoside/nucleotide analogues. | Antiviral therapy 20120101 |
Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment. | Antiviral therapy 20120101 |
HBV DNA level at 24 weeks is the best predictor of virological response to adefovir add-on therapy in patients with lamivudine resistance. | Antiviral therapy 20120101 |
High-resolution melting and real-time PCR for quantification and detection of drug-resistant HBV mutants in a single amplicon. | Antiviral therapy 20120101 |
Design and synthesis of novel 1',3'-dioxolane 5'-deoxyphosphonic acid purine analogues as potent antiviral agents. | Nucleosides, nucleotides & nucleic acids 20120101 |
Treatment response and evolution of HBV resistance during lamivudine plus adefovir or entecavir therapy in patients with adefovir-resistant mutants. | Antiviral therapy 20120101 |
[Prognosis analysis of hepatitis B virus recurrence after liver transplantation: a single-center study of 38 cases]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120101 |
[Evaluation of the safety of pregnancy initiated by chronic hepatitis B fathers while taking adefovir]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120101 |
Efficacy and adverse effects of the antiviral compound plerixafor in feline immunodeficiency virus-infected cats. | Journal of veterinary internal medicine 20120101 |
Reactivation of hepatitis B virus replication due to cytotoxic therapy: a five-year prospective study. | Tumori 20120101 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: adefovir monotherapy, adefovir plus lamivudine or entecavir combination therapy. | Internal medicine (Tokyo, Japan) 20120101 |
Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir. | Antiviral therapy 20120101 |
Comparison of entecavir and adefovir for the treatment of chronic hepatitis B. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20120101 |
Profile of users of drugs for the treatment of chronic hepatitis B available through the Brazilian Public Health System. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20120101 |
Does the antiviral therapy of patients with chronic hepatitis exert nephrotoxic effects? | Immunopharmacology and immunotoxicology 20111201 |
Adefovir induced hypophosphatemic osteomalacia. | Scandinavian journal of infectious diseases 20111201 |
Virologic response is not durable after adefovir discontinuation in lamivudine-resistant chronic hepatitis B patients. | The Korean journal of hepatology 20111201 |
Application of kinase bypass strategies to nucleoside antivirals. | Antiviral research 20111101 |
Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action. | Antimicrobial agents and chemotherapy 20111101 |
Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants. | Bioorganic & medicinal chemistry letters 20111101 |
Long-term adefovir plus lamivudine therapy does not decrease creatinine clearance in HBeAg-negative chronic hepatitis B patients. | Liver international : official journal of the International Association for the Study of the Liver 20111101 |
[Entecavir 1.0mg monotherapy or entecavir plus adefovir dipivoxil for patients with lamivudine-resistant chronic hepatitis B had suboptimal response to lamivudine plus adefovir dipivoxil]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20111101 |
Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir. | Journal of gastroenterology and hepatology 20111001 |
Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment. | Liver international : official journal of the International Association for the Study of the Liver 20111001 |
The efficacy of entecavir therapy in chronic hepatitis B patients with suboptimal response to adevofir. | Alimentary pharmacology & therapeutics 20111001 |
Management options for lamivudine-resistant chronic hepatitis B patients with suboptimal virological suppression by adefovir. | Alimentary pharmacology & therapeutics 20111001 |
Long-term efficacy of entecavir therapy in chronic hepatitis B patients with antiviral resistance to lamivudine and adefovir. | Journal of viral hepatitis 20111001 |
Long-term efficacy of entecavir in adefovir-refractory chronic hepatitis B patients with prior lamivudine resistance. | Journal of viral hepatitis 20111001 |
Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis. | Journal of clinical gastroenterology 20111001 |
Antiviral drugs for viruses other than human immunodeficiency virus. | Mayo Clinic proceedings 20111001 |
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication. | European journal of medicinal chemistry 20110901 |
[Clinical antiviral effects of Peg-IFNa-2a in patients with chronic hepatitis B]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110901 |
Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. | Journal of medicinal chemistry 20110825 |
Virological response to adefovir monotherapy and the risk of adefovir resistance. | World journal of gastroenterology 20110814 |
A biomimetic chitosan derivates: preparation, characterization and transdermal enhancement studies of N-arginine chitosan. | Molecules (Basel, Switzerland) 20110809 |
Defining virologic relapse in chronic hepatitis B. | Digestive diseases and sciences 20110801 |
Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B. | Infection 20110801 |
Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy. | Alimentary pharmacology & therapeutics 20110801 |
Randomised clinical trial: efficacy of peginterferon alfa-2a in HBeAg positive chronic hepatitis B patients with lamivudine resistance. | Alimentary pharmacology & therapeutics 20110801 |
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity. | Bioorganic & medicinal chemistry 20110801 |
[Efficacy of two nucleoside analogs to treat resistant HBeAg-negative chronic hepatitis B]. | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20110801 |
Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B. | Digestive diseases and sciences 20110701 |
Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study. | Hepatology (Baltimore, Md.) 20110701 |
Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array. | Journal of virological methods 20110701 |
Effect of antiviral therapy on the immunohistochemical expression of bcl-xL and bax protein in patients with HBeAg-negative chronic hepatitis B. | Journal of medical virology 20110701 |
Adefovir serum levels do not differ between responders and nonresponders. | Journal of viral hepatitis 20110701 |
Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B. | Journal of viral hepatitis 20110701 |
[Effect of shugan jianpi bushen recipe on splenic T lymphocytes and virus load in hepatitis B virus transgenic mice]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110701 |
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy. | Journal of viral hepatitis 20110601 |
Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs. | Scandinavian journal of gastroenterology 20110601 |
New prodrugs of Adefovir and Cidofovir. | Bioorganic & medicinal chemistry 20110601 |
Hepatitis: PEG-IFN for the treatment of hepatitis D. | Nature reviews. Gastroenterology & hepatology 20110601 |
[Safety and efficacy of Entecavir combined with Adefovir in patients with chronic hepatitis B who fail to respond to nucleoside analog treatment]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110601 |
[The past, present and future treatment for chronic hepatitis B]. | Nihon rinsho. Japanese journal of clinical medicine 20110501 |
[Prevention for the development of hepatitis B virus-related hepatocellular carcinoma by anti-viral treatment]. | Nihon rinsho. Japanese journal of clinical medicine 20110501 |
The level of HBV DNA at month 12 is an important predictor of virological breakthrough during adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance. | Digestive diseases and sciences 20110401 |
Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). | Biochemical pharmacology 20110401 |
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection. | Journal of viral hepatitis 20110401 |
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. | Bioorganic & medicinal chemistry 20110401 |
[Progress and perspectives in treatment of chronic hepatitis B]. | Nihon rinsho. Japanese journal of clinical medicine 20110401 |
[Improvement of health-related quality of life in chronic hepatitis B patients treated with entecavir or adefovir]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20110401 |
Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection. | Journal of general internal medicine 20110301 |
Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model. | American journal of physiology. Heart and circulatory physiology 20110301 |
1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac. | Biopharmaceutics & drug disposition 20110301 |
Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B. | Gut 20110201 |
Characteristics of adefovir resistance in patients with or without lamivudine-resistant hepatitis B virus treated with adefovir: a 4-year experience. | Liver international : official journal of the International Association for the Study of the Liver 20110201 |
[Treatment of patients with lamivudine-resistant chronic hepatitis B]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20110201 |
[Efficacy of entecavir and adefovir combination therapy in patients with chronic hepatitis B refractory to lamivudine and adefovir combination therapy]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20110201 |
Adefovir-induced Stevens-Johnson syndrome and toxic epidermal necrolysis overlap syndrome. | Singapore medical journal 20110201 |
Hypophosphatemic osteomalacia as a long-term complication after liver transplantation. | Transplantation 20110115 |
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. | Journal of medicinal chemistry 20110113 |
Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B. | Journal of hepatology 20110101 |
Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues. | Liver international : official journal of the International Association for the Study of the Liver 20110101 |
Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues. | Liver international : official journal of the International Association for the Study of the Liver 20110101 |
Hepatitis B virus resistance to antiviral drugs: where are we going? | Liver international : official journal of the International Association for the Study of the Liver 20110101 |
The impact of human immunodeficiency virus on viral hepatitis. | Liver international : official journal of the International Association for the Study of the Liver 20110101 |
Management of chronic hepatitis B patients: efficacy & limitation of nucleos(t)ide analogues. | The Indian journal of medical research 20110101 |
Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. | The Indian journal of medical research 20110101 |
Comparison of the 48-week efficacy between entecavir and adefovir in HBeAg-positive nucleos(t)ide-naïve Asian patients with chronic hepatitis B: a meta-analysis. | Virology journal 20110101 |
Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review. | Virology journal 20110101 |
On-treatment monitoring of liver fibrosis with transient elastography in chronic hepatitis B patients. | Antiviral therapy 20110101 |
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. | BMC biochemistry 20110101 |
[Current treatment of hepatitis B infection: where do the new nucleos(t)ide analogues fit in?]. | Gastroenterologia y hepatologia 20110101 |
Two patterns of alanine aminotransferase increase to predict long-term viral response in chronic hepatitis B patients: virus- or host-induced? | Antiviral therapy 20110101 |
Changes of serum levels of keratin-18 fragments in hepatitis B e antigen-negative chronic hepatitis B patients under oral antiviral therapy. | Antiviral therapy 20110101 |
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations. | BMC infectious diseases 20110101 |
[Reactivation of hepatitis B in a patient with spondyloarthritis after the suspension of methotrexate and efficacy of treatment with antivirals in association to adalimumab]. | Reumatologia clinica 20110101 |
Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment. | Virology journal 20110101 |
Lamivudine plus adefovir combination therapy versus entecavir monotherapy for lamivudine-resistant chronic hepatitis B: a systematic review and meta-analysis. | Virology journal 20110101 |
Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B. | Annals of hepatology 20110101 |
Rapid high-performance liquid chromatographic method for determination of adefovir in plasma using UV detection: application to pharmacokinetic studies. | Arzneimittel-Forschung 20110101 |
Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101 |
Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B. | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20101201 |
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery. | Antiviral research 20101201 |
Pharmacokinetics and efficacy of intravenous or intramuscular hepatitis B immunoglobulins in prophylaxis of hepatitis B after liver transplantation. | Minerva medica 20101201 |
[Efficacy of adefovir treatment in the lamivudine-resistant chronic hepatitis B patients]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20101201 |
Efficacy of adefovir add-on lamivudine rescue therapy compared with switching to entecavir monotherapy in patients with lamivudine-resistant chronic hepatitis B. | Journal of medical virology 20101101 |
High rate of adefovir-lamivudine combination therapy in nucleoside-naïve patients with chronic hepatitis B in France: results of a national survey in 1730 patients. | European journal of gastroenterology & hepatology 20101101 |
Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir. | Journal of hepatology 20100901 |
Question of ALT flare during switch to adefovir from lamivudine: A single center open-label, randomized, safety study (June 17, 2005 to February 5, 2009). | Journal of medical virology 20100901 |
[Long-term therapy for chronic hepatitis B in HIV co-infected patients]. | Gastroenterologie clinique et biologique 20100901 |
[Treatment has a positive impact on the long-term evolution of chronic hepatitis B]. | Gastroenterologie clinique et biologique 20100901 |
Long-term outcome of renal transplant recipients with chronic hepatitis B infection-impact of antiviral treatments. | Transplantation 20100815 |
Prevention of recurrent hepatitis B virus infection after liver transplantation: hepatitis B immunoglobulin, antiviral drugs, or both? Systematic review and meta-analysis. | Transplant infectious disease : an official journal of the Transplantation Society 20100801 |
Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B. | Antimicrobial agents and chemotherapy 20100801 |
Cost-effectiveness of nucleoside analog therapy for hepatitis B in China: a Markov analysis. | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100801 |
Acute hepatitis B infection associated with drug-resistant hepatitis B virus. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100801 |
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: comparison between entecavir 1.0 mg monotherapy, adefovir monotherapy and adefovir add-on lamivudine combination therapy. | Journal of gastroenterology and hepatology 20100801 |
The curative efficiency of tenofovir for patients with chronic hepatitis B after failure of nucleoside/nucleotide analogues. | Hepatology (Baltimore, Md.) 20100801 |
[Add on lamivudine to adefovir monotherapy for the treatment of lamivudine-resistant chronic hepatitis B patients]. | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20100801 |
[Design, synthesis and anti-hBV evaluation of adefovir mono-L-amino acid ester, mono non-steroidal anti-inflammatory drugs carboxylic ester prodrugs]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100801 |
[Treatment of chronic hepatitis B. High response rate in general practice]. | MMW Fortschritte der Medizin 20100722 |
Metal ion-binding properties of 9-[(2-phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antiviral nucleotide analogue 9-[(2-phosphonomethoxy)ethyl]adenine (PMEA). Steric guiding of metal ion-coordination by the purine-amino group. | Dalton transactions (Cambridge, England : 2003) 20100721 |
Naturally occurring hepatitis B virus (HBV) variants with primary resistance to antiviral therapy and S-mutants with potential primary resistance to adefovir in Argentina. | Antiviral research 20100701 |
[Effect of adefovir and lamivudine combination therapy on lamivudine resistance chronic hepatitis B patients for 48 weeks]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100701 |
Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro. | Antiviral research 20100601 |
Virologic response at 12 months of treatment predicts sustained antiviral efficacy in patients with adefovir-treated Lamivudine-resistant chronic hepatitis B. | Gut and liver 20100601 |
Antiviral treatment of chronic hepatitis B virus (HBV) infections. | Viruses 20100601 |
Avoiding and managing lamivudine resistance in chronic hepatitis B: current approaches and potential strategies including pegylated interferon. | Liver international : official journal of the International Association for the Study of the Liver 20100501 |
Hepatitis B genotypes and response to adefovir treatment in patients with HBV chronic infection. | The Journal of infection 20100501 |
[Serological and sociodemographic differences in HBV-patients with and without migration background]. | Zeitschrift fur Gastroenterologie 20100501 |
Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B infection. | Health technology assessment (Winchester, England) 20100501 |
[Comparison of the efficacy of 48 week-Entecavir therapy with that of Adefovir therapy for chronic hepatitis B patients]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100501 |
[Failure to treat hepatitis B virus infection with adefovir due to early selection of rtA181T mutation]. | Medicina clinica 20100410 |
Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion. | Liver international : official journal of the International Association for the Study of the Liver 20100401 |
Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues. | Journal of hepatology 20100401 |
[Genotype distribution of chronic hepatitis B and hepatitis C patients and investigation of the resistance patterns in hepatitis B cases]. | Mikrobiyoloji bulteni 20100401 |
Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application. | World journal of gastroenterology 20100314 |
Combination of Lamivudine and adefovir therapy in HBeAg-positive chronic hepatitis B patients with poor response to adefovir monotherapy. | Journal of viral hepatitis 20100301 |
Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B. | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20100301 |
Low efficacy of entecavir therapy in adefovir-refractory hepatitis B patients with prior lamivudine resistance. | Journal of viral hepatitis 20100301 |
Liver transplantation in bearers of hepatitis B associated or not with delta hepatitis in the age of the new antiviral drugs: is hyperimmune globulin still necessary? | Transplantation proceedings 20100301 |
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations. | Journal of Korean medical science 20100201 |
Viral resistance in hepatitis B: prevalence and management. | Current gastroenterology reports 20100201 |
Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives. | Journal of medicinal chemistry 20100128 |
[Protocol for the antiviral therapy of hepatitis B and D]. | Orvosi hetilap 20100103 |
Response to adefovir or entecavir in renal allograft recipients with hepatitic flare due to lamivudine-resistant hepatitis B. | Clinical transplantation 20100101 |
Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues. | Hepatology (Baltimore, Md.) 20100101 |
Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients. | Intervirology 20100101 |
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors. | Antiviral therapy 20100101 |
Overlap/switch to adefovir monotherapy for lamivudine-resistant patients who responded to combination therapy: a pilot controlled study. | Internal medicine (Tokyo, Japan) 20100101 |
Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case. | Virology journal 20100101 |
Long term survival and complications after liver transplantation in patients with chronic hepatitis B. | Annals of transplantation 20100101 |
A QSAR study on some series of anti-hepatitis B virus (HBV) agents. | Bioinformation 20100101 |
Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors. | Bioorganic & medicinal chemistry letters 20091215 |
Different models of HBeAg seroconversion predicated by on-treatment ALT and HBV DNA profiles. | Journal of viral hepatitis 20091201 |
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy. | Transplant infectious disease : an official journal of the Transplantation Society 20091201 |
Decrease in viral load at weeks 12 and 24 in patients with chronic hepatitis B treated with lamivudine or adefovir predicts virological response at week 48. | Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20091101 |
Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome. | Journal of hepatology 20091001 |
Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone. | Hepatology (Baltimore, Md.) 20091001 |
Lenalidomide-induced acute liver failure. | Blood transfusion = Trasfusione del sangue 20091001 |
Clinical outcome of lamivudine-resistant chronic hepatitis B patients with compensated cirrhosis under adefovir salvage treatment. Importance of HCC surveillance. | European journal of internal medicine 20090901 |
Stop codon read-through of a methylmalonic aciduria mutation. | Molecular genetics and metabolism 20090801 |
Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients. | Journal of gastroenterology and hepatology 20090801 |
[Factors associated with response to lamivudine: retrospective study of 233 patients with chronic hepatitis B]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090801 |
Early development of clevudine resistance during clevudine therapy in a patient with chronic hepatitis B who received prior lamivudine therapy. | Liver international : official journal of the International Association for the Study of the Liver 20090701 |
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo. | Antimicrobial agents and chemotherapy 20090701 |
Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues. | Current opinion in organ transplantation 20090601 |
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain. | Bioorganic & medicinal chemistry 20090601 |
Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare. | Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090601 |
[The antiviral treatment impacts on clinical outcomes of renal transplantation recipients with hepatitis B virus infection]. | Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20090601 |
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients. | The Journal of infectious diseases 20090501 |
Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy. | Joint, bone, spine : revue du rhumatisme 20090501 |
[Antiviral efficacy of lamivudine/adefovir combination therapy in chronic hepatitis b patients with resistance to lamivudine and adefovir consecutively]. | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20090501 |
[Treatment of hepatitis B virus resistant to lamivudine and adefovir]. | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20090501 |
The option of liver transplantation for hepatitis B: where are we? | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090501 |
Liver transplantation for hepatitis B virus. Pre-emptive and peri-operative prophylaxis. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090501 |
Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C. | The New England journal of medicine 20090430 |
[Telbivudine in the management of HIV/HBV coinfection. Treating hepatitis B without HIV trouble]. | MMW Fortschritte der Medizin 20090430 |
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. | Pharmaceutical research 20090401 |
Gene induction for the treatment of methylmalonic aciduria. | The journal of gene medicine 20090401 |
Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy. | Journal of hepatology 20090401 |
Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice. | Journal of hepatology 20090401 |
Decision analysis model for hepatitis B prophylaxis one year after liver transplantation. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20090401 |
Assessment of selective real-time PCR for quantitation of lamivudine and adefovir hepatitis B virus-resistant strains and comparison with direct sequencing and line probe assays. | Journal of virological methods 20090301 |
Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir. | Journal of medical virology 20090301 |
Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B. | Journal of medical virology 20090301 |
Chronic hepatitis B: early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides. | Journal of viral hepatitis 20090301 |
[Analysis of the cost-effectiveness of antiviral therapies in chronic hepatitis B patients in Korea]. | The Korean journal of hepatology 20090301 |
Hepatitis B in HIV patients: what is the current treatment and what are the challenges? | Journal of HIV therapy 20090301 |
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients. | World journal of gastroenterology 20090214 |
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. | Antiviral research 20090201 |
Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study. | Journal of medical virology 20090201 |
Role of combination therapy in chronic hepatitis B. | Current gastroenterology reports 20090201 |
On-treatment monitoring of adefovir therapy in chronic hepatitis B: virologic response can be assessed at 24 weeks. | Journal of viral hepatitis 20090201 |
Hepatitis B therapy in children. | Expert review of gastroenterology & hepatology 20090201 |
[Atazanavir-induced nephrolithiasis]. | Enfermedades infecciosas y microbiologia clinica 20090201 |
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro. | Journal of medicinal chemistry 20090108 |
Serum HBsAg changes in HBeAg positive chronic hepatitis B patients with continuous viral load reductions during treatment with adefovir or peg-interferon-alpha-2a. | Antiviral research 20090101 |
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. | Antimicrobial agents and chemotherapy 20090101 |
Sensitivity and accuracy of an updated line probe assay (HBV DR v.3) in detecting mutations associated with hepatitis B antiviral resistance. | Journal of hepatology 20090101 |
Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir. | Hepatology (Baltimore, Md.) 20090101 |
Emergence of adefovir-resistant mutants after reversion to YMDD wild-type in lamivudine-resistant patients receiving adefovir monotherapy. | Journal of gastroenterology and hepatology 20090101 |
Renal side effects of adefovir in hepatitis B virus-(HBV) positive kidney allograft recipients. | Clinical nephrology 20090101 |
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues. | Liver international : official journal of the International Association for the Study of the Liver 20090101 |
On-treatment outcome prediction and adjustment during chronic hepatitis B therapy: now and future. | Antiviral therapy 20090101 |
Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues. | Antiviral chemistry & chemotherapy 20090101 |
Can antiviral therapy for chronic hepatitis B enhance the progression to hepatocellular carcinoma? | Antiviral therapy 20090101 |
Clinical usefulness of sequential hepatitis B virus DNA measurement (the roadmap concept) during adefovir treatment in lamivudine-resistant patients. | Antiviral therapy 20090101 |
Fatal lactic acidosis associated with the use of combination oral medications to treat reactivation of hepatitis B. | Journal of clinical gastroenterology 20090101 |
Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir. | Antiviral therapy 20090101 |
The significance of enzyme immunoassay for the assessment of hepatitis B virus core-related antigen following liver transplantation. | Internal medicine (Tokyo, Japan) 20090101 |
Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir. | Antiviral therapy 20090101 |
Evolution of hepatitis B virus mutation during entecavir rescue therapy in patients with antiviral resistance to lamivudine and adefovir. | Antiviral therapy 20090101 |
Determination of adefovir by LC-ESI-MS-MS and its application to a pharmacokinetic study in healthy Chinese volunteers. | Journal of chromatographic science 20090101 |
Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases. | Journal of molecular biology 20081212 |
Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers. | European journal of gastroenterology & hepatology 20081201 |
Failure of adefovir 20 mg to improve suboptimal response in lamivudine-resistant hepatitis B patients treated with adefovir 10 mg and lamivudine. | Journal of viral hepatitis 20081201 |
The discovery of antiviral agents: ten different compounds, ten different stories. | Medicinal research reviews 20081101 |
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101 |
Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy? | Journal of hepatology 20081101 |
A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis. | Hepatology (Baltimore, Md.) 20081101 |
[Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B]. | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20081101 |
[Chronic hepatitis B: current therapy]. | Bulletin de l'Academie nationale de medecine 20081101 |
Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient. | European journal of medical research 20081027 |
A review of telbivudine for the management of chronic hepatitis B virus infection. | Expert opinion on drug metabolism & toxicology 20081001 |
LB80380: a promising new drug for the treatment of chronic hepatitis B. | Expert opinion on investigational drugs 20081001 |
4'-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action. | Journal of medicinal chemistry 20080925 |
Hepatitis B virus genotype A2 harbours an L217R polymorphism which may account for a lower response to adefovir. | The Journal of antimicrobial chemotherapy 20080901 |
Continuous single motor unit electromyographic activity in adefovir associated myopathy. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20080901 |
What is the optimum dose of adefovir in the treatment of chronic hepatitis B infection? | Journal of hepatology 20080901 |
Entecavir therapy for adefovir-resistant hepatitis B virus infection in kidney and liver allograft recipients. | Transplantation 20080827 |
Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801 |
Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides. | Bioorganic & medicinal chemistry 20080715 |
Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis. | Liver international : official journal of the International Association for the Study of the Liver 20080701 |
Dynamics of lamivudine-resistant hepatitis B virus during adefovir monotherapy versus lamivudine plus adefovir combination therapy. | Journal of medical virology 20080701 |
[YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy]. | Mikrobiyoloji bulteni 20080701 |
Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4. | Cancer research 20080615 |
Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients. | World journal of gastroenterology 20080614 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). | Journal of medicinal chemistry 20080612 |
Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080601 |
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. | The Journal of pharmacology and experimental therapeutics 20080601 |
Evaluating anti-viral drug selection and treatment duration in HBeAg-negative chronic hepatitis B: a cost-effectiveness analysis. | Alimentary pharmacology & therapeutics 20080601 |
Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. | Gastroenterology 20080601 |
Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up. | Journal of hepatology 20080601 |
[Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients]. | MMW Fortschritte der Medizin 20080522 |
Evaluation of initial virological response to adefovir and development of adefovir-resistant mutations in patients with chronic hepatitis B. | Journal of viral hepatitis 20080501 |
6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. | Human mutation 20080501 |
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure. | Journal of hepatology 20080501 |
[Acute hepatitis B: is antiviral therapy indicated? Two case reports]. | Deutsche medizinische Wochenschrift (1946) 20080501 |
[Interferon in hepatitis B]. | Enfermedades infecciosas y microbiologia clinica 20080501 |
[Resistance in hepatitis B virus]. | Enfermedades infecciosas y microbiologia clinica 20080501 |
Viral persistence after liver transplantation for hepatitis B virus: a cross-sectional study. | Transplantation 20080427 |
Antibody to hepatitis B surface antigen trough levels and half-lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080401 |
Economic evaluation of chronic hepatitis B treatments in Taiwan. | Journal of gastroenterology and hepatology 20080401 |
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position. | Nucleosides, nucleotides & nucleic acids 20080401 |
Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B. | World journal of gastroenterology 20080321 |
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations. | Journal of hepatology 20080301 |
[Pharmacological agents for the treatment of chronic hepatitis B]. | Gastroenterologia y hepatologia 20080301 |
[Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine-resistant chronic hepatitis B patients]. | The Korean journal of hepatology 20080301 |
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B. | Journal of medicinal chemistry 20080214 |
Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression. | Journal of viral hepatitis 20080201 |
Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding. | Journal of enzyme inhibition and medicinal chemistry 20080201 |
Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future. | Reviews in medical virology 20080101 |
Prophylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 years. | Liver international : official journal of the International Association for the Study of the Liver 20080101 |
[Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20080101 |
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues. | Antiviral therapy 20080101 |
Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy. | The new microbiologica 20080101 |
[Treatment recommendations of chronic hepatitis B. Did the world escape us?]. | Przeglad epidemiologiczny 20080101 |
Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant. | Antiviral therapy 20080101 |
Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients. | Antiviral therapy 20080101 |
Living donor liver transplantation for hepatitis B associated liver diseases: a 10-year experience in a single center. | Hepato-gastroenterology 20080101 |
Pharmacotherapy of hepatitis B infection: a brief review. | Nephrology nursing journal : journal of the American Nephrology Nurses' Association 20080101 |
[Drugs treatment of hepatitis B]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20080101 |
Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. | Best practice & research. Clinical gastroenterology 20080101 |
Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues. | Best practice & research. Clinical gastroenterology 20080101 |
Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response. | Antiviral therapy 20080101 |
Successful treatment of an entecavir-resistant hepatitis B virus variant. | Journal of medical virology 20071201 |
Review article: Success and failure of nucleoside and nucleotide analogues in chronic hepatitis B. | Alimentary pharmacology & therapeutics 20071201 |
Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B. | Journal of HIV therapy 20071201 |
Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. | European journal of pharmacology 20071121 |
Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro. | Bioorganic & medicinal chemistry letters 20071115 |
[Attention-getting sexually transmitted diseases: Hepatitis B]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20071110 |
Redetection of HBV lamivudine-resistant mutations in a patient under entecavir therapy, who had been treated sequentially with nucleos(t)ide analogues. | Journal of medical virology 20071101 |
[Adefovir in reactivation of chemotherapy-induced hepatitis B in an anti-Hbc-positive patient]. | Gastroenterologia y hepatologia 20071101 |
Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients. | Gastroenterology 20071101 |
Hepatitis B: explosion of new knowledge. | Gastroenterology 20071101 |
Combination therapy in liver transplant recipients with hepatitis B virus without hepatitis B immune globulin. | Digestive diseases and sciences 20071001 |
Absence of a pharmacokinetic interaction between entecavir and adefovir. | Journal of clinical pharmacology 20071001 |
In vitro drug susceptibility analysis of hepatitis B virus clinical quasispecies populations. | Journal of clinical microbiology 20071001 |
Adefovir for lamivudine resistant HBV: more than meets the eye. | Journal of hepatology 20071001 |
[Indications for antiviral therapy for chronic hepatitis B]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071001 |
[Therapy for chronic hepatitis B: relationship between HBV genotype and efficacy or resistance of anti-viral therapy]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071001 |
[Recent therapies for hepatitis B (discussion)]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071001 |
[New German and American guidelines for therapy of hepatitis B. Discrepancies and similarities]. | Medizinische Klinik (Munich, Germany : 1983) 20070915 |
Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients. | Journal of hepatology 20070901 |
Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070901 |
Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B. | Journal of gastroenterology and hepatology 20070901 |
Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: a systematic review of economic evidence. | Journal of gastroenterology and hepatology 20070901 |
[Effect of initial virologic response to adefovir on the development of resistance to adefovir in lamivudine-resistant chronic hepatitis B]. | The Korean journal of hepatology 20070901 |
Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B. | World journal of gastroenterology 20070814 |
Does pre-treatment with lamivudine prime for adefovir resistance of hepatitis B virus infection? | The Journal of antimicrobial chemotherapy 20070801 |
Emergence of hepatitis B virus quasispecies with lower susceptibility to nucleos(t)ide analogues during lamivudine treatment. | The Journal of antimicrobial chemotherapy 20070801 |
Pradefovir, a liver-targeted prodrug of adefovir against HBV infection. | Current opinion in investigational drugs (London, England : 2000) 20070801 |
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. | Cancer research 20070715 |
Hepatitis B virus reactivation in a case of Waldenstrom's macroglobulinemia treated with chemotherapy and rituximab despite adefovir prophylaxis. | American journal of hematology 20070701 |
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. | Antiviral research 20070701 |
Optimal duration of therapy in HBV-related cirrhosis. | The Journal of antimicrobial chemotherapy 20070701 |
Pre- and post-treatment predictors of the early achievement of HBeAg loss in lamivudine-resistant patients receiving adefovir therapy. | Journal of gastroenterology and hepatology 20070701 |
HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA). | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615 |
Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients. | Expert opinion on investigational drugs 20070601 |
[An economic evaluation of different treatments for HBeAg-positive chronic hepatitis B in China]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20070601 |
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. | Veterinary microbiology 20070516 |
Tailoring antiviral therapy in chronic hepatitis B patients with lamivudine resistance. | Journal of hepatology 20070501 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. | Biochemical pharmacology 20070401 |
Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401 |
Hepatitis B virus resistance to adefovir in a nucleotide naive patient with chronic hepatitis B virus infection. | The Journal of antimicrobial chemotherapy 20070401 |
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). | Pharmaceutical research 20070401 |
Characteristics of patients with chronic hepatitis-B virus infection in an urban hospital. | Journal of the National Medical Association 20070401 |
[Advances in research of hepatitis B virus resistance to adefovir]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20070401 |
Recommendations for the treatment of chronic hepatitis B infection in children. | JPMA. The Journal of the Pakistan Medical Association 20070401 |
[A case of chronic hepatitis B with primary adefovir resistance]. | Mikrobiyoloji bulteni 20070401 |
Low risk of hepatitis B virus recurrence after withdrawal of long-term hepatitis B immunoglobulin in patients receiving maintenance nucleos(t)ide analogue therapy. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301 |
Treatment of chronic hepatitis B in HIV-infected patients in 2007. | Journal of HIV therapy 20070301 |
[Drugs for hepatitis B and C infection]. | Nihon rinsho. Japanese journal of clinical medicine 20070227 |
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. | Molecular pharmacology 20070201 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: when and how? | Hepatology (Baltimore, Md.) 20070201 |
Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity. | Bioorganic & medicinal chemistry letters 20070115 |
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. | The Journal of antimicrobial chemotherapy 20070101 |
Cross-study analysis of the relative efficacies of oral antiviral therapies for chronic hepatitis B infection in nucleoside-naive patients. | Clinical drug investigation 20070101 |
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. | Cancer research 20070101 |
Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma. | Internal medicine (Tokyo, Japan) 20070101 |
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. | Retrovirology 20070101 |
[The prophylaxis against post-liver-transplant hepatitis B re-infection]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101 |
Treatment of HIV/HBV coinfection: clinical and virologic issues. | AIDS reviews 20070101 |
Identification of 1-isopropylsulfonyl-2-amine benzimidazoles as a new class of inhibitors of hepatitis B virus. | European journal of medicinal chemistry 20070101 |
Chronic hepatitis B with advanced fibrosis or cirrhosis: impact of antiviral therapy. | Reviews in gastroenterological disorders 20070101 |
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. | Antiviral therapy 20070101 |
Cost effectiveness of entecavir versus lamivudine with adefovir salvage in HBeAg-positive chronic hepatitis B. | PharmacoEconomics 20070101 |
Dynamics of HBV DNA levels, HBV mutations and biochemical parameters during antiviral therapy in a patient with HBeAg-negative chronic hepatitis B. | Asian Pacific journal of allergy and immunology 20070101 |
Management and treatment of chronic hepatitis B virus: Belgian Association for the Study of the Liver (BASL) 2007 guidelines. | Acta gastro-enterologica Belgica 20070101 |
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. | Journal of medicinal chemistry 20061228 |
The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3. | American journal of physiology. Regulatory, integrative and comparative physiology 20061201 |
Nonresponse to adefovir: host or virus dependent? | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201 |
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen. | European journal of gastroenterology & hepatology 20061201 |
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3. | Neuro endocrinology letters 20061201 |
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir. | Xenobiotica; the fate of foreign compounds in biological systems 20061201 |
Hepatitis B virus treatment in HIV-infected patients. | Topics in HIV medicine : a publication of the International AIDS Society, USA 20061201 |
A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient. | AIDS (London, England) 20061114 |
Improved outcome of chronic hepatitis B after heart transplantation by long-term antiviral therapy. | Journal of viral hepatitis 20061101 |
Why adefovir is not yet available in Canada. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20061101 |
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro. | Antiviral research 20061001 |
Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061001 |
Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV. | Hepatology (Baltimore, Md.) 20061001 |
Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient. | Gastroenterology 20061001 |
[Managing resistance to analogue antiviral drugs in a decompensated cirrhosis patient]. | Gastroenterologie clinique et biologique 20061001 |
[Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients]. | Gastroenterologie clinique et biologique 20061001 |
[Managing lamivudine resistance in liver transplantation for hepatitis B liver disease]. | Gastroenterologie clinique et biologique 20061001 |
[Impact of resistance to analogue antivirals and therapeutic strategies in situations of dialysis, kidney transplantation, vasculitis, and preemptive treatments in immunosuppressed patients]. | Gastroenterologie clinique et biologique 20061001 |
Development and validation of a sensitive LC-MS/MS method for the determination of adefovir in human serum and urine. | Journal of pharmaceutical and biomedical analysis 20060926 |
[Therapy of hepatitis B]. | Praxis 20060906 |
[Therapy of hepatitis B virus infection]. | Praxis 20060906 |
Favorable outcome of liver transplantation despite a high hepatitis B virus replication: beyond the limits? | Transplant infectious disease : an official journal of the Transplantation Society 20060901 |
New developments in the treatment of chronic hepatitis B. | Expert opinion on biological therapy 20060901 |
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer. | Antimicrobial agents and chemotherapy 20060901 |
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. | Hepatology (Baltimore, Md.) 20060901 |
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. | Hepatology (Baltimore, Md.) 20060801 |
Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives. | Journal of medicinal chemistry 20060727 |
Hepatitis B virus with primary resistance to adefovir. | The New England journal of medicine 20060720 |
Tubular transporters and clearance of adefovir. | European journal of pharmacology 20060701 |
A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B. | Hepatology (Baltimore, Md.) 20060701 |
Antiviral options for the treatment of chronic hepatitis B. | The Journal of antimicrobial chemotherapy 20060601 |
Antiviral treatment for chronic hepatitis B virus infection--immune modulation or viral suppression? | The Netherlands journal of medicine 20060601 |
Overlap lamivudine treatment in patients with chronic hepatitis B receiving adefovir for lamivudine-resistant viral mutants. | Journal of viral hepatitis 20060601 |
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. | Journal of biomedical science 20060501 |
First report of genotypic resistance to adefovir in chronic HBV in the Republic of Ireland. | The Journal of antimicrobial chemotherapy 20060501 |
Prophylactic strategies for hepatitis B patients undergoing liver transplant: a cost-effectiveness analysis. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20060501 |
Variant of hepatitis B virus with primary resistance to adefovir. | The New England journal of medicine 20060427 |
[Reactivation of hepatitis B treated with adefovir after infliximab administration]. | Medicina clinica 20060415 |
Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060401 |
Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis. | Journal of viral hepatitis 20060401 |
Adefovir therapy for lamivudine escape and hepatitis B virus reactivation after reduced intensity conditioning allogeneic stem cell transplantation. | Bone marrow transplantation 20060301 |
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine. | Antimicrobial agents and chemotherapy 20060301 |
Virologic response and resistance to adefovir in patients with chronic hepatitis B. | Journal of hepatology 20060201 |
Cellular and virological mechanisms of HBV drug resistance. | Journal of hepatology 20060201 |
Chronic hepatitis B: a critical appraisal of current approaches to therapy. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060201 |
Combination therapy for chronic hepatitis B: a one-two knockout punch, or a swing and a miss? | Gastroenterology 20060201 |
Replacement of tenofovir with adefovir may result in reactivation of hepatitis B virus replication. | Scandinavian journal of gastroenterology 20060201 |
[Treatment of chronic hepatitis B]. | Presse medicale (Paris, France : 1983) 20060201 |
[Liver transplantation for complications of hepatitis B]. | Presse medicale (Paris, France : 1983) 20060201 |
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver. | Current opinion in investigational drugs (London, England : 2000) 20060201 |
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine. | European journal of pharmacology 20060113 |
Introduction to chronic hepatitis B infection. | The American journal of gastroenterology 20060101 |
Therapeutic options for chronic hepatitis B: considerations and controversies. | The American journal of gastroenterology 20060101 |
Hepatitis B virus genotypes and response to antiviral therapy. | Clinical laboratory 20060101 |
Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues. | Annals of clinical microbiology and antimicrobials 20060101 |
In vitro comparison of antiviral drugs against feline herpesvirus 1. | BMC veterinary research 20060101 |
Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations. | Internal medicine (Tokyo, Japan) 20060101 |
Report from the 2nd International Workshop on HIV and Hepatitis Co-Infection, January 12-14, 2006, Amsterdam, Netherlands. Tenofovir or adefovir for hepatitis B. | TreatmentUpdate 20060101 |
Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases. | Antiviral therapy 20060101 |
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach. | Journal of medicinal chemistry 20051215 |
Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. | Journal of hepatology 20051201 |
Resistance to adefovir: a new challenge in the treatment of chronic hepatitis B. | Journal of hepatology 20051201 |
Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine. | Hepatology (Baltimore, Md.) 20051201 |
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir. | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201 |
[Drug therapy in chronic liver disease]. | Praxis 20051130 |
Risk of selecting K65R in antiretroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir. | AIDS (London, England) 20051118 |
Cost-effectiveness in hepatitis B. | Annals of internal medicine 20051115 |
Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatment. | Transplantation 20051115 |
Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir. | Journal of clinical pharmacology 20051101 |
[Tubular transporters OAT1 and MRP2 and clearance of adefovir]. | Nephrologie & therapeutique 20051101 |
[Clinical outcomes after discontinuation of Lamivudine in chronic hepatitis B patients with Lamivudine resistant HBV mutant]. | The Korean journal of hepatology 20050901 |
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). | The Journal of pharmacology and experimental therapeutics 20050801 |
Viral kinetics in patients with lamivudine-resistant hepatitis B during adefovir-lamivudine combination therapy. | Journal of hepatology 20050801 |
The risk of adefovir monotherapy in human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients. | Journal of hepatology 20050801 |
Adefovir-lamivudine combination therapy and hepatitis B viral kinetics. | Journal of hepatology 20050801 |
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. | The Journal of general virology 20050801 |
Understanding hepatitis B. | The Journal of the Association of Physicians of India 20050801 |
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution. | Inorganic chemistry 20050711 |
Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results. | Transplant international : official journal of the European Society for Organ Transplantation 20050701 |
Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine. | Hepatology (Baltimore, Md.) 20050701 |
Reactivation of viral replication after replacement of tenofovir by adefovir. | Hepatology (Baltimore, Md.) 20050701 |
Determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis B virus-related decompensated liver cirrhosis. | Journal of viral hepatitis 20050701 |
Chronic hepatitis B--treatment with nucleoside analogues. | The Medical journal of Malaysia 20050701 |
Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir. | Hepatology (Baltimore, Md.) 20050601 |
[Clinical and virologic characteristics and treatment for chronic hepatitis B: relation with HBV genotypes]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20050601 |
Summaries for patients. Antiviral regimens for chronic hepatitis B virus infection. | Annals of internal medicine 20050517 |
Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis. | Annals of internal medicine 20050517 |
Assessing the benefits and costs of new therapies for hepatitis B virus infection. | Annals of internal medicine 20050517 |
Spectrum of antiviral activity of o-(acetoxyphenyl)hept-2-ynyl sulphide (APHS). | International journal of antimicrobial agents 20050501 |
[Management of chronic hepatitis B]. | Praxis 20050420 |
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents. | Journal of the American Chemical Society 20050413 |
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). | Pharmacogenetics and genomics 20050401 |
[Chronic hepatitis B: which patients should be treated and how?]. | Gastroenterologie clinique et biologique 20050401 |
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides. | Antimicrobial agents and chemotherapy 20050301 |
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase. | Antimicrobial agents and chemotherapy 20050301 |
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities. | Antimicrobial agents and chemotherapy 20050301 |
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel. | AIDS (London, England) 20050218 |
Liver-targeted drug delivery using HepDirect prodrugs. | The Journal of pharmacology and experimental therapeutics 20050201 |
Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma. | Rapid communications in mass spectrometry : RCM 20050101 |
Cross-resistance testing of next-generation nucleoside and nucleotide analogues against lamivudine-resistant HBV. | Antiviral therapy 20050101 |
Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. | Rapid communications in mass spectrometry : RCM 20050101 |
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. | Nucleosides, nucleotides & nucleic acids 20050101 |
Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20041201 |
Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine. | Journal of inorganic biochemistry 20041201 |
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. | Hepatology (Baltimore, Md.) 20041201 |
The management of chronic viral hepatitis: a Canadian consensus conference 2004. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20041201 |
Drug-induced renal failure in the ICU. | The International journal of artificial organs 20041201 |
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state. | The Journal of biological chemistry 20041119 |
Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment. | AIDS (London, England) 20041119 |
Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells. | Biochemical pharmacology 20041101 |
Adefovir treatment in posttransplant hepatitis B virus infection resistant to lamivudine plus hepatitis B virus immunoglobulin. | Transplantation proceedings 20041101 |
Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. | Antimicrobial agents and chemotherapy 20041001 |
[An attempt to approach an optional therapeutic regimen for chronic hepatitis B]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20041001 |
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity. | Nucleosides, nucleotides & nucleic acids 20041001 |
[Active prevention and treatment of superinfection with HBV, HCV and HIV]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040901 |
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study. | Bioorganic & medicinal chemistry letters 20040816 |
Prevention of hepatitis B virus reinfection after orthotopic liver transplantation. | Hepatobiliary & pancreatic diseases international : HBPD INT 20040801 |
Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection. | Expert review of anti-infective therapy 20040801 |
[Hepatitis B (acute and chronic)]. | Praxis 20040728 |
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. | Bioorganic & medicinal chemistry 20040615 |
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia. | The Journal of pharmacology and experimental therapeutics 20040601 |
Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) by a quantitative real-time PCR assay. | Antiviral research 20040601 |
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents. | Antimicrobial agents and chemotherapy 20040601 |
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir. | Antiviral therapy 20040601 |
A novel class of phosphonate nucleosides. 9-[(1-phosphonomethoxycyclopropyl)methyl]guanine as a potent and selective anti-HBV agent. | Journal of medicinal chemistry 20040520 |
[Determination of adefovir dipivoxil and its degradation products by reversed-phase high performance liquid chromatography]. | Se pu = Chinese journal of chromatography 20040501 |
Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver. | Journal of the American Chemical Society 20040428 |
Ultra sensitive method for the determination of 9-(2-phosphonylmethoxyethyl)adenine in human serum by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425 |
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359. | The Journal of infectious diseases 20040401 |
Metal ion complexes of antivirally active nucleotide analogues. Conclusions regarding their biological action. | Chemical Society reviews 20040330 |
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. | Biochemical and biophysical research communications 20040319 |
Antiretroviral therapy and HIV/hepatitis B virus coinfection. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? | Antiviral research 20040301 |
Rearrangement process occurring in the fragmentation of adefovir derivatives. | Journal of mass spectrometry : JMS 20040201 |
In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector. | Antiviral research 20040101 |
Rescue therapy for drug resistant hepatitis B: another argument for combination chemotherapy? | Gastroenterology 20040101 |
[Adefovir dipivoxil-A new drug for hepatitis B]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20040101 |
Hepatitis B virus kinetics and mathematical modeling. | Seminars in liver disease 20040101 |
The role of interferon therapy in hepatitis B. | MedGenMed : Medscape general medicine 20040101 |
Hepatitis C virus in the setting of HIV or hepatitis B virus coinfection. | Seminars in liver disease 20040101 |
Treatment of chronic viral hepatitis. | Best practice & research. Clinical gastroenterology 20040101 |
Nickel(II), copper(II) and zinc(II) complexes of 9-[2- (phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-aza derivative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl] adenine (PMEA). Quantification of four isomeric species in aqueous solution. | Bioinorganic chemistry and applications 20040101 |
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031215 |
Adefovir (Hepsera) for chronic hepatitis B infection. | American family physician 20031215 |
Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. | Journal of hepatology 20031201 |
Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes. | Hepatology (Baltimore, Md.) 20031201 |
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. | Journal of medicinal chemistry 20031106 |
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes. | Toxicology and applied pharmacology 20031101 |
[Adefovir]. | Revue de l'infirmiere 20031101 |
Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure. | Transplantation 20031027 |
Current pharmacotherapy for the treatment of chronic hepatitis B. | Expert opinion on pharmacotherapy 20031001 |
Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions. | Antiviral research 20031001 |
Management of chronic hepatitis B in an HIV-positive patient with 3TC-resistant hepatitis B virus. | AIDS patient care and STDs 20030901 |
[Hepatitis: associated diseases. Risk groups -- prevention -- treatment]. | Praxis 20030813 |
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. | The Journal of biological chemistry 20030808 |
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. | Antimicrobial agents and chemotherapy 20030701 |
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. | Gastroenterology 20030701 |
Slowing the progression of chronic hepatitis B. Early antiviral therapy can help minimize complications. | Postgraduate medicine 20030701 |
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.). | Antiviral research 20030701 |
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. | Molecular pharmacology 20030501 |
[Viral hepatitis B/C and HIV. Therapy of double infections]. | MMW Fortschritte der Medizin 20030428 |
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy. | The Journal of infectious diseases 20030401 |
Antiviral effect of adefovir in combination with a DNA vaccine in the duck hepatitis B virus infection model. | Journal of hepatology 20030301 |
Management of patients with decompensated HBV cirrhosis. | Seminars in liver disease 20030201 |
[Antiviral therapy for chronic viral hepatitis B and C]. | Nihon rinsho. Japanese journal of clinical medicine 20030201 |
[Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry]. | Yao xue xue bao = Acta pharmaceutica Sinica 20030201 |
Intrinsic acid-base properties of purine derivatives in aqueous solution and comparison of the acidifying effects of platinum(II) coordinated to N1 or N7: acidifying effects are reciprocal and the proton 'outruns' divalent metal ions. | Inorganic chemistry 20030113 |
Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro. | Hepatology (Baltimore, Md.) 20030101 |
Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells. | Journal of viral hepatitis 20030101 |
In vitro activity of potential anti-poxvirus agents. | Antiviral research 20030101 |
HIV and hepatitis B virus: options for managing coinfection. | Topics in HIV medicine : a publication of the International AIDS Society, USA 20030101 |
Combination therapy for chronic hepatitis B. | Journal of hepatology 20030101 |
Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others). | Journal of hepatology 20030101 |
Current therapies for chronic hepatitis B. | Annals of hepatology 20030101 |
Adefovir (Hepsera) for chronic hepatitis B infection. | The Medical letter on drugs and therapeutics 20021209 |
Fanconi syndrome and renal failure induced by tenofovir: a first case report. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20021201 |
[Treatment of hepatitis B]. | La Revue de medecine interne 20021201 |
Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures. | Antimicrobial agents and chemotherapy 20021101 |
Antiviral activities of MCC-478, a novel and specific inhibitor of hepatitis B virus. | Antimicrobial agents and chemotherapy 20020901 |
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. | Hepatology (Baltimore, Md.) 20020901 |
Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine. | The Journal of antimicrobial chemotherapy 20020901 |
Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. | Antimicrobial agents and chemotherapy 20020801 |
2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents. | Journal of medicinal chemistry 20020704 |
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. | Antimicrobial agents and chemotherapy 20020701 |
Cidofovir in the treatment of poxvirus infections. | Antiviral research 20020701 |
Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy. | Journal of medical virology 20020501 |
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. | Journal of medicinal chemistry 20020425 |
[New management strategies for hepatitis B]. | Gastroenterologie clinique et biologique 20020201 |
Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails. | Journal of acquired immune deficiency syndromes (1999) 20020101 |
Raman spectroscopy study of acid-base and structural properties of 9-[2-(phosphonomethoxy)ethyl]adenine in aqueous solutions. | Biopolymers 20020101 |
Update on the management of chronic hepatitis B. | Reviews in gastroenterological disorders 20020101 |
Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir. | Gut 20011201 |
Nucleoside analogues for chronic hepatitis B. | European journal of gastroenterology & hepatology 20011201 |
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. | The Journal of pharmacology and experimental therapeutics 20011101 |
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs. | Cancer research 20011101 |
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. | Journal of medicinal chemistry 20011025 |
HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study. | AIDS (London, England) 20010928 |
The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. | AIDS (London, England) 20010907 |
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil. | Antimicrobial agents and chemotherapy 20010901 |
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus. | Molecular pharmacology 20010901 |
Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408. | Journal of acquired immune deficiency syndromes (1999) 20010815 |
Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance. | AIDS research and human retroviruses 20010810 |
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. | Human pathology 20010701 |
Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus. | Antimicrobial agents and chemotherapy 20010601 |
Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus. | The Journal of antimicrobial chemotherapy 20010601 |
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9. | Chemistry (Weinheim an der Bergstrasse, Germany) 20010504 |
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA. | Bioorganic & medicinal chemistry letters 20010423 |
[Current knowledge on chronic hepatitis B therapy]. | Gastroenterologie clinique et biologique 20010401 |
Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9. | Journal of inorganic biochemistry 20010301 |
[Current treatment of hepatitis B]. | Gastroenterologia y hepatologia 20010201 |
Drug therapy for hepatitis B. | Advances in internal medicine 20010101 |
Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo. | Journal of hepatology 20010101 |
Preliver transplant viremic status and the choice of anti-HBV regimens. | Transplantation proceedings 20010101 |
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation. | Antiviral chemistry & chemotherapy 20010101 |
Kinetic studies of the degradation of oxycarbonyloxymethyl prodrug of Adefovir and Tenofovir in solution. | Nucleosides, nucleotides & nucleic acids 20010101 |
Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents. | Nucleosides, nucleotides & nucleic acids 20010101 |
Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides, ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes. | Nucleosides, nucleotides & nucleic acids 20010101 |
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. | Nucleosides, nucleotides & nucleic acids 20010101 |
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. | Reviews in medical virology 20010101 |
Low-dose adefovir for the treatment of chronic hepatitis B in HIV-infected people. | GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20010101 |
In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas. | Antiviral research 20001101 |
Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20000901 |
A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus. | Antiviral research 20000901 |
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues. | Antimicrobial agents and chemotherapy 20000801 |
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine. | Antimicrobial agents and chemotherapy 20000701 |
Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC]. | Antiviral chemistry & chemotherapy 20000701 |
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture. | Journal of viral hepatitis 20000101 |
Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs. | Antimicrobial agents and chemotherapy 19991201 |
Selective activity of various antiviral compounds against HHV-7 infection. | Antiviral research 19990801 |
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. | Journal of medicinal chemistry 19990617 |
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues. | Biochemical pharmacology 19990615 |
Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors. | The Journal of clinical investigation 19990615 |
Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro. | The Journal of infectious diseases 19990101 |
Effect of acyclic nucleoside phosphonates on the HIV-1 integrase in vitro. | Nucleosides & nucleotides 19990101 |
Comparison of antiviral compounds against human herpesvirus 6 and 7. | Antiviral research 19981201 |
Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. | Nature neuroscience 19980901 |
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication. | Antiviral chemistry & chemotherapy 19980501 |
Antiviral drug susceptibility of human herpesvirus 8. | Antimicrobial agents and chemotherapy 19971201 |
Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses. | Antiviral research 19971101 |
Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes. | Journal of leukocyte biology 19970701 |
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine. | Antimicrobial agents and chemotherapy 19970601 |
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes. | Antiviral research 19970601 |
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice. | Antimicrobial agents and chemotherapy 19970301 |
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability. | Journal of medicinal chemistry 19961206 |
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). | Antiviral research 19961001 |
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro. | Antimicrobial agents and chemotherapy 19960901 |
Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. | Journal of medicinal chemistry 19960816 |
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109. | Biochemical and biophysical research communications 19960814 |
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines. | Molecular pharmacology 19960801 |
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. | Biochemical and biophysical research communications 19960215 |
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. | Antimicrobial agents and chemotherapy 19960101 |
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. | Antiviral research 19951201 |
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. | Science (New York, N.Y.) 19951117 |
Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells. | Antimicrobial agents and chemotherapy 19951101 |
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine. | Antimicrobial agents and chemotherapy 19950801 |
Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds. | Antimicrobial agents and chemotherapy 19950701 |
Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine. | Antiviral research 19950601 |
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19950401 |
Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. | Antiviral research 19950101 |
Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture. | Antimicrobial agents and chemotherapy 19940901 |
Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates. | Antimicrobial agents and chemotherapy 19940701 |
Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). | Journal of medicinal chemistry 19940610 |
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus. | Virology 19931001 |
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates. | Antimicrobial agents and chemotherapy 19931001 |
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors. | Proceedings of the National Academy of Sciences of the United States of America 19930801 |
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection. | Antiviral research 19930601 |
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5'-(4'-amino-1',2'- oxathiole-2',2'-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues. | Molecular pharmacology 19930101 |
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150). | Molecular pharmacology 19930101 |
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. | Virology 19930101 |
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine. | Antiviral research 19920901 |
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. | Journal of medicinal chemistry 19920807 |
In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase. | Molecular pharmacology 19920301 |
Chemotherapy of feline immunodeficiency virus infection. | Journal of the American Veterinary Medical Association 19911115 |
Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes. | Biochemical and biophysical research communications 19910715 |
Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonylmethoxyethyl)adenine (PMEA). | Antiviral research 19910701 |
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models. | Antiviral research 19910701 |
Cellular uptake of phosphonylmethoxyalkylpurine derivatives. | Antiviral research 19910701 |
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo. | Antiviral research 19910701 |
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. | Proceedings of the National Academy of Sciences of the United States of America 19910601 |
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound. | Proceedings of the National Academy of Sciences of the United States of America 19910215 |
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis. | Antimicrobial agents and chemotherapy 19910201 |
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. | The Journal of biological chemistry 19910105 |
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. | AIDS (London, England) 19910101 |
Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation. | Journal of medicinal chemistry 19900901 |
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. | Antiviral research 19900601 |
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one. | Journal of medicinal chemistry 19900501 |
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. | Journal of medicinal chemistry 19900401 |
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19891201 |
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. | Antimicrobial agents and chemotherapy 19891101 |
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine. | Antimicrobial agents and chemotherapy 19890901 |
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. | Antimicrobial agents and chemotherapy 19890201 |
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. | Proceedings of the National Academy of Sciences of the United States of America 19890101 |
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. | Antimicrobial agents and chemotherapy 19881201 |
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. | Antimicrobial agents and chemotherapy 19880701 |
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. | Antiviral research 19871201 |
Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication. | Antimicrobial agents and chemotherapy 19870901 |