Home Carboxys 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+)

3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+)

CAS No.:
16009-13-5
Catalog Number:
AG00HYL2
Molecular Formula:
C34H32ClFeN4O4
Molecular Weight:
651.9403
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
95%
In Stock USA
United States
$13
- +
5g
95%
In Stock USA
United States
$23
- +
25g
95%
In Stock USA
United States
$75
- +
100g
95%
In Stock USA
United States
$282
- +
500g
95%
In Stock USA
United States
$1225
- +
Product Description
Catalog Number:
AG00HYL2
Chemical Name:
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+)
CAS Number:
16009-13-5
Molecular Formula:
C34H32ClFeN4O4
Molecular Weight:
651.9403
MDL Number:
MFCD00010726
IUPAC Name:
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride
InChI:
InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3
InChI Key:
BTIJJDXEELBZFS-UHFFFAOYSA-K
SMILES:
C=Cc1c(C)c2n3c1C=C1C(=C(C4=[N+]1[Fe-2]13(Cl)[N+]3=C(C(=C(C3=C2)C)CCC(=O)O)C=c2n1c(=C4)c(c2CCC(=O)O)C)C=C)C
EC Number:
240-140-1
UNII:
743LRP9S7N
Properties
Complexity:
1010  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
651.146g/mol
Formal Charge:
0
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
651.949g/mol
Monoisotopic Mass:
651.146g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
102A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180201
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Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells. Chemico-biological interactions 20161225
Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Toxicology letters 20161215
Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Toxicology and applied pharmacology 20161115
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HO-1 expression control in the rat glomerulus. Biochemical and biophysical research communications 20150508
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The role of catechol-O-methyltransferase in catechol-enhanced erythroid differentiation of K562 cells. Toxicology and applied pharmacology 20131215
A functional link between heme oxygenase-1 and tristetraprolin in the anti-inflammatory effects of nicotine. Free radical biology & medicine 20131201
Changes in DNA methylation of erythroid-specific genes in K562 cells exposed to phenol and hydroquinone. Toxicology 20131004
Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. Pharmacological research 20131001
Electrochemical determination of microRNA-21 based on bio bar code and hemin/G-quadruplet DNAenzyme. The Analyst 20130621
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The role of DNA methylation in catechol-enhanced erythroid differentiation of K562 cells. Toxicology and applied pharmacology 20121115
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Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. International journal of molecular medicine 20121101
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Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides. Journal of medicinal chemistry 20121025
Investigating the interactions between cations, peroxidation substrates and G-quadruplex topology in DNAzyme peroxidation reactions using statistical testing. Analytica chimica acta 20121017
In vitro selection of highly efficient G-quadruplex-based DNAzymes. Analytical chemistry 20121002
Pharmacologic induction of heme oxygenase-1 plays a protective role in diabetic retinopathy in rats. Investigative ophthalmology & visual science 20120925
Micellar nanoreactors for hematin catalyzed synthesis of electrically conducting polypyrrole. Langmuir : the ACS journal of surfaces and colloids 20120918
Role of propionates in substrate binding to heme oxygenase from Neisseria meningitidis: a nuclear magnetic resonance study. Biochemistry 20120911
Involvement of heme oxygenase-1 in β-cyclodextrin-hemin complex-induced cucumber adventitious rooting process. Plant cell reports 20120901
Systematic interaction analysis of human lipocalin-type prostaglandin D synthase with small lipophilic ligands. The Biochemical journal 20120901
Haem oxygenase-1 is involved in salicylic acid-induced alleviation of oxidative stress due to cadmium stress in Medicago sativa. Journal of experimental botany 20120901
Insertion of an H-bonding residue into the distal pocket of the ferriheme protein nitrophorin 4: effect on nitrite-iron coordination and nitrite disproportionation. Chemistry & biodiversity 20120901
A reduced graphene oxide based electrochemical biosensor for tyrosine detection. Nanotechnology 20120824
Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents. Organic & biomolecular chemistry 20120821
Site E14 in hemoglobins and myoglobins: a key residue that affects hemin loss and lipid oxidation capacity. Journal of agricultural and food chemistry 20120808
The interaction between desferrioxamine and hemin: a potential toxicological implication. Toxicology in vitro : an international journal published in association with BIBRA 20120801
Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to β-hematin in acidic environment at malarial fever temperature. Experimental biology and medicine (Maywood, N.J.) 20120801
Nitric oxide is involved in hemin-induced cucumber adventitious rooting process. Journal of plant physiology 20120715
Selective isolation of G-quadruplexes by affinity chromatography. Journal of chromatography. A 20120713
Structural analysis of haemin demetallation by L-chain apoferritins. Journal of inorganic biochemistry 20120701
Heme oxygenase is involved in nitric oxide- and auxin-induced lateral root formation in rice. Plant cell reports 20120601
Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis. PLoS neglected tropical diseases 20120601
DNAzyme-based turn-on chemiluminescence assays in homogenous media. Biosensors & bioelectronics 20120515
Hemin/G-quadruplex simultaneously acts as NADH oxidase and HRP-mimicking DNAzyme for simple, sensitive pseudobienzyme electrochemical detection of thrombin. Chemical communications (Cambridge, England) 20120514
Role of globin moiety in the chemical structure of curing pigment. Journal of agricultural and food chemistry 20120509
Heme oxygenase-1 modulates thrombomodulin and activated protein C levels to attenuate lung injury in cecal ligation and puncture-induced acute lung injury mice. Experimental lung research 20120501
Colorimetric detection of cholesterol with G-quadruplex-based DNAzymes and ABTS2-. Analytica chimica acta 20120429
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circulation research 20120427
Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPARγ and NF-κB. World journal of gastroenterology 20120414
Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. American journal of physiology. Heart and circulatory physiology 20120401
Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention. Neurosurgical focus 20120401
Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 20120301
A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection. Molecular bioSystems 20120301
ZmHO-1, a maize haem oxygenase-1 gene, plays a role in determining lateral root development. Plant science : an international journal of experimental plant biology 20120301
Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis. Journal of cellular biochemistry 20120201
Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication. Toxicology in vitro : an international journal published in association with BIBRA 20120201
A novel label-free fluorescent sensor for the detection of potassium ion based on DNAzyme. Talanta 20120130
Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase. Toxicology 20120127
Label-free genotyping of cytochrome P450 2D6*10 using ligation-mediated strand displacement amplification with DNAzyme-based chemiluminescence detection. Analytica chimica acta 20120113
Isolation and characterization of a heme oxygenase-1 gene from Chinese cabbage. Molecular biotechnology 20120101
Functionalization of a protein surface with per-O-methylated β-cyclodextrin. Biopolymers 20120101
Determination of phenol by flow-injection with chemiluminescence detection based on the hemin-catalysed luminol-hydrogen peroxide reaction. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120101
Extracellular heme enhances the antimalarial activity of artemisinin. Biological & pharmaceutical bulletin 20120101
Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action. Malaria journal 20120101
Fuzheng Huayu recipe prevents nutritional fibrosing steatohepatitis in mice. Lipids in health and disease 20120101
Zymographic assay of oxidases using peroxidase or hemin entrapped in polyacrylamide gel. Methods in molecular biology (Clifton, N.J.) 20120101
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A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. PloS one 20120101
Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition. Malaria journal 20120101
Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC neuroscience 20120101
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Determination of hemin-binding characteristics of proteins by a combinatorial peptide library approach. Chembiochem : a European journal of chemical biology 20111216
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High glucose induced rat aorta vascular smooth muscle cell oxidative injury: involvement of protein tyrosine nitration. Journal of physiology and biochemistry 20111201
Characterization of human-type monoclonal antibodies against reduced form of hemin binding protein 35 from Porphyromonas gingivalis. Journal of periodontal research 20111201
Optimized refolding and characterization of S-peroxidase (CWPO_C of Populus alba) expressed in E. coli. Protein expression and purification 20111201
Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model. The Journal of pharmacology and experimental therapeutics 20111201
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Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study. Journal of inorganic biochemistry 20111201
Hemin/G-quadruplexes as DNAzymes for the fluorescent detection of DNA, aptamer-thrombin complexes, and probing the activity of glucose oxidase. The Analyst 20111107
Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension (Dallas, Tex. : 1979) 20111101
Hemin interaction with bare and 4,4'-thio-bis-benzene-thiolate covered n-GaAs (110) electrodes. Physical chemistry chemical physics : PCCP 20111014
Investigation of a deoxyribozyme as a biofuel cell catalyst. Journal of the American Chemical Society 20111012
The metabolism and toxicity of hemin in astrocytes. Glia 20111001
Enhanced hemeoxygenase activity in the rostral ventrolateral medulla mediates exaggerated hemin-evoked hypotension in the spontaneously hypertensive rat. The Journal of pharmacology and experimental therapeutics 20111001
α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism. Experimental cell research 20111001
Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. Inflammopharmacology 20111001
In vitro activity of deferoxamine against Porphyromonas gingivalis. FEMS microbiology letters 20111001
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Label-free fluorescent detection of thrombin using G-quadruplex-based DNAzyme as sensing platform. The Analyst 20110821
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Amplified surface plasmon resonance based DNA biosensors, aptasensors, and Hg2+ sensors using hemin/G-quadruplexes and Au nanoparticles. Chemistry (Weinheim an der Bergstrasse, Germany) 20110801
Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling. Cardiovascular research 20110715
Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury. American journal of physiology. Renal physiology 20110701
Protective effects of hemin in an experimental model of ventilator-induced lung injury. European journal of pharmacology 20110701
Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells. Toxicology letters 20110624
Postmortem interval of skeletal remains through the detection of intraosseal hemin traces. A comparison of UV-fluorescence, luminol, Hexagon-OBTI®, and Combur® tests. Forensic science international 20110615
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[Prevention of atherosclerotic plaque development by modulating heme oxygenase-1-endogenous carbon monoxide system in rabbit model]. Zhonghua bing li xue za zhi = Chinese journal of pathology 20110601
Heme oxygenase-1 is involved in the cytokinin-induced alleviation of senescence in detached wheat leaves during dark incubation. Journal of plant physiology 20110515
Panhematin provides a therapeutic benefit in experimental pancreatitis. Gut 20110501
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. Free radical biology & medicine 20110501
In vitro antimalarial activity of ICL670: a further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin. Experimental parasitology 20110501
Linear free energy relationships predict coordination and π-stacking interactions of small molecules with ferriprotoporphyrin IX. Journal of inorganic biochemistry 20110501
Participation of cell-surface hydrophobins for hemin binding in Helicobacter pylori. Folia microbiologica 20110501
A label-free DNA reduced graphene oxide-based fluorescent sensor for highly sensitive and selective detection of hemin. Chemical communications (Cambridge, England) 20110428
Vesicular mixed gemini-SDS-hemin-imidazole complex as a peroxidase-like nano artificial enzyme. The journal of physical chemistry. B 20110428
Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity. Chemical communications (Cambridge, England) 20110421
Feruloylacetone as the model compound of half-curcumin: synthesis and antioxidant properties. European journal of medicinal chemistry 20110401
Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents. Bioorganic & medicinal chemistry 20110315
The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex. Journal of inorganic biochemistry 20110301
Beneficial effects of early (but not late) intervention of heme oxygenase-1 on bleomycin-induced pulmonary fibrosis in mice. Respiratory physiology & neurobiology 20110215
Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. Journal of medicinal chemistry 20110210
Quinolone compounds enhance delta-aminolevulinic acid-induced accumulation of protoporphyrin IX and photosensitivity of tumour cells. Journal of biochemistry 20110201
Hemin and magnesium-protoporphyrin IX induce global changes in gene expression in Chlamydomonas reinhardtii. Plant physiology 20110201
The mechanism of antimalarial action of [Au(CQ)(PPh(3))]PF(6): structural effects and increased drug lipophilicity enhance heme aggregation inhibition at lipid/water interfaces. Journal of inorganic biochemistry 20110201
Highly effective colorimetric and visual detection of ATP by a DNAzyme-aptamer sensor. Chemistry & biodiversity 20110201
Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. The Journal of biological chemistry 20110121
Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ). Bioorganic & medicinal chemistry letters 20110101
Combination of patch clamp and Raman spectroscopy for single-cell analysis. Analytical chemistry 20110101
Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice. Lipids in health and disease 20110101
Isoflurane preconditioning at clinically relevant doses induce protective effects of heme oxygenase-1 on hepatic ischemia reperfusion in rats. BMC gastroenterology 20110101
Heme oxygenase-1 overexpression fails to attenuate hypertension when the nitric oxide synthase system is not fully operative. Pharmacology 20110101
Hemoglobin expression in neurons and glia after intracerebral hemorrhage. Acta neurochirurgica. Supplement 20110101
Comparison of antioxidant effectiveness of lipoic acid and dihydrolipoic acid. Journal of biochemical and molecular toxicology 20110101
Genetic complexity of fusidic acid-resistant small colony variants (SCV) in Staphylococcus aureus. PloS one 20110101
Characterization of a wheat heme oxygenase-1 gene and its responses to different abiotic stresses. International journal of molecular sciences 20110101
Autoimmune reactivity of IgM acquired after oxidation. Redox report : communications in free radical research 20110101
Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells. Toxicology letters 20101215
Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity. The Journal of biological chemistry 20101210
Observation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2. Chemosphere 20101201
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorganic & medicinal chemistry 20101201
Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats. Antioxidants & redox signaling 20101115
Astrocyte-derived glutathione attenuates hemin-induced apoptosis in cerebral microvascular cells. Glia 20101115
Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins. Journal of molecular graphics & modelling 20101101
HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans. PLoS pathogens 20101101
Pro-healing potential of hemin: an inducer of heme oxygenase-1. European journal of pharmacology 20101025
Spatial monitoring of toxicity in HMOX-LacZ transgenic mice. Transgenic research 20101001
On the kinetics of formation of hemozoin, the malaria pigment. Journal of inorganic biochemistry 20101001
Gastroprotective effect of heme-oxygenase 1/biliverdin/CO pathway in ethanol-induced gastric damage in mice. European journal of pharmacology 20100910
Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100901
Ultrasensitive optical detection of hydrogen peroxide by triggered activation of horseradish peroxidase. The Analyst 20100901
ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer's disease. Journal of neurochemistry 20100901
Preparation and analytical application of mimetic enzyme hemin-loading magnetic silica nanotubes. Journal of nanoscience and nanotechnology 20100901
Hematin is an alternative catalyst to horseradish peroxidase for in situ hydrogelation of polymers with phenolic hydroxyl groups in vivo. Biomacromolecules 20100809
The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages. International journal for parasitology 20100801
The effect of curcumin on insulin release in rat-isolated pancreatic islets. Angiology 20100801
In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells. Cell biology international 20100801
Positive effects of ATP on G-quadruplex-hemin DNAzyme-mediated reactions. Analytical chemistry 20100715
Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: a possible additional mechanism of action for antimalarial activity. Experimental parasitology 20100701
Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme. American journal of physiology. Cell physiology 20100701
Molecular assay for screening and quantifying DNA in biological evidence: the modified Q-TAT assay. Journal of forensic sciences 20100701
A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans. Free radical research 20100701
Haemin-enhanced expression of haem oxygenase-1 stabilizes erythrocyte-induced vulnerable atherosclerotic plaques. British journal of pharmacology 20100701
[A study of the role of heme oxygenase-1 expression in ventilator induced lung injury and its mechanism in rats]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100701
A new small regulatory protein, HmuP, modulates haemin acquisition in Sinorhizobium meliloti. Microbiology (Reading, England) 20100601
Quantitative detection of Ag(+) and cysteine using G-quadruplex-hemin DNAzymes. The Analyst 20100601
Amplified biosensing using the horseradish peroxidase-mimicking DNAzyme as an electrocatalyst. Analytical chemistry 20100601
Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells. The Journal of biological chemistry 20100528
Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells. Free radical biology & medicine 20100515
c-FLIP is involved in erythropoietin-mediated protection of erythroid-differentiated cells from TNF-alpha-induced apoptosis. Cell biology international 20100504
Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation. Journal of neuroscience research 20100501
Analysis of HmsH and its role in plague biofilm formation. Microbiology (Reading, England) 20100501
In vitro selection of a photoresponsive RNA aptamer to hemin. Bioorganic & medicinal chemistry letters 20100501
[Acute intermittent porphyria and inappropriate ADH syndrome]. Revista espanola de anestesiologia y reanimacion 20100501
Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. Chemical research in toxicology 20100419
Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition. Biochemistry 20100413
Interactions of hemin with model erythrocyte membranes. The journal of physical chemistry. B 20100408
Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII. Blood 20100401
Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension (Dallas, Tex. : 1979) 20100401
miR-451 enhances erythroid differentiation in K562 cells. Leukemia & lymphoma 20100401
Heme oxygenase (HO)-1 protects from lipopolysaccharide (LPS)-mediated liver injury by inhibition of hepatic leukocyte accumulation and improvement of microvascular perfusion. Langenbeck's archives of surgery 20100401
Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes. Toxicology and applied pharmacology 20100315
Sonogel-carbon electrode based on hemin for detection of superoxide. Talanta 20100315
Histochemical application of a peroxidase DNAzyme with a covalently attached hemin cofactor. Analytical chemistry 20100315
Heme oxygenase-derived carbon monoxide modulates gonadotropin-releasing hormone release in immortalized hypothalamic neurons. Neuroscience letters 20100308
Membrane damage elicits an immunomodulatory program in Staphylococcus aureus. PLoS pathogens 20100301
Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice. Gastroenterology 20100201
A facile synthesis of deuteroporphyrins derivatives under ultrasound irradiation. Ultrasonics sonochemistry 20100201
Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 20100201
Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1. Journal of vascular surgery 20100201
Ag+ and cysteine quantitation based on G-quadruplex-hemin DNAzymes disruption by Ag+. Analytical chemistry 20100201
Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis. Journal of pediatric gastroenterology and nutrition 20100201
Hemin, a carbon monoxide donor, improves systemic vascular compliance by inhibiting the RhoA-Rhokinase pathway in spontaneous hypertensive rats. European journal of pharmacology 20100125
Myocardial dysfunction in early state of endotoxemia role of heme-oxygenase-1. The Journal of surgical research 20100101
The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin. Glia 20100101
The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension. American journal of physiology. Regulatory, integrative and comparative physiology 20100101
Potassium-sensitive G-quadruplex DNA for sensitive visible potassium detection. The Analyst 20100101
Characterization of hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis: its cellular distribution, thioredoxin activity and role in heme utilization. BMC microbiology 20100101
Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation. Journal of neuroinflammation 20100101
DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1. Respiratory research 20100101
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. Lipids in health and disease 20100101
Cigarette smoke-induced biochemical perturbations in human erythrocytes and attenuation by epigallocatechin-3-gallate--tea catechin. Pharmacological reports : PR 20100101
Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis. PloS one 20100101
Protective role of HO-1 for alcohol-dependent liver damage. Digestive diseases (Basel, Switzerland) 20100101
Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments. Journal of lipid research 20091201
Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability? European journal of medicinal chemistry 20091201
Heme reversibly damps PERIOD2 rhythms in mouse suprachiasmatic nucleus explants. Neuroscience 20091201
Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. Bioorganic & medicinal chemistry 20091201
Antimalarial acridines: synthesis, in vitro activity against P. falciparum and interaction with hematin. Bioorganic & medicinal chemistry 20091201
Anti-inflammatory effects of apigenin on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. International immunopharmacology 20091101
Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cells. American journal of physiology. Regulatory, integrative and comparative physiology 20091101
Haem oxygenase-1 induction protects against tumour necrosis factor alpha impairment of endothelial-dependent relaxation in rat isolated pulmonary artery. British journal of pharmacology 20091101
Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. Molecular cancer research : MCR 20091101
Investigation of 3,3',5,5'-tetramethylbenzidine as colorimetric substrate for a peroxidatic DNAzyme. Analytica chimica acta 20091005
The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner. Amino acids 20091001
Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions. Kidney international 20091001
Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase. The FEBS journal 20091001
Phenylalanine substitution at site B10 (L29F) inhibits metmyoglobin formation and myoglobin-mediated lipid oxidation in washed fish muscle: mechanistic implications. Journal of agricultural and food chemistry 20090909
Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase. Journal of the American Chemical Society 20090902
Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice. Free radical biology & medicine 20090901
1H and 13C NMR spectroscopic studies of the ferriheme resonances of three low-spin complexes of wild-type nitrophorin 2 and nitrophorin 2(V24E) as a function of pH. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090901
New insight into the influence of carob extract and gallic acid on hemin induced modulation of HT29 cell growth parameters. Toxicology in vitro : an international journal published in association with BIBRA 20090901
Sensitive and visual detection of adenosine by a rationally designed FokI-based biosensing strategy. Chemistry, an Asian journal 20090901
Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months. Journal of cardiac failure 20090901
Renoprotective potency of heme oxygenase-1 induction in rat renal ischemia-reperfusion. Inflammation & allergy drug targets 20090901
General peroxidase activity of G-quadruplex-hemin complexes and its application in ligand screening. Biochemistry 20090825
Speciation of ferriprotoporphyrin IX in aqueous and mixed aqueous solution is controlled by solvent identity, pH, and salt concentration. Inorganic chemistry 20090817
Clotrimazole enhances lysis of human erythrocytes induced by t-BHP. Chemico-biological interactions 20090814
Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119. The Journal of biological chemistry 20090814
Involvement of methemoglobin (MetHb) formation and hemin loss in the pro-oxidant activity of fish hemoglobins. Journal of agricultural and food chemistry 20090812
Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning. Toxicology 20090803
Hemin-induced suicidal erythrocyte death. Annals of hematology 20090801
Bacteroides graminisolvens sp. nov., a xylanolytic anaerobe isolated from a methanogenic reactor treating cattle waste. International journal of systematic and evolutionary microbiology 20090801
VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression. The Journal of biological chemistry 20090724
Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo. Molecular pharmacology 20090701
Antioxidant sensors based on iron diethylenetriaminepentaacetic acid, hematin, and hemoglobin modified TiO2 nanoparticle printed electrodes. Analytical chemistry 20090701
Participation of the secreted dipeptidyl and tripeptidyl aminopeptidases in asaccharolytic growth of Porphyromonas gingivalis. Journal of periodontal research 20090601
Hemin promotes proliferation and differentiation of endothelial progenitor cells via activation of AKT and ERK. Journal of cellular physiology 20090601
Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats. Endocrinology 20090601
Post-transcriptional regulation of the expression of ferrochelatase by its variant mRNA. Journal of biochemistry 20090601
The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage. American journal of physiology. Gastrointestinal and liver physiology 20090601
Increasing expression of H- or L-ferritin protects cortical astrocytes from hemin toxicity. Free radical research 20090601
Upregulation of heme oxygenase-1 as a host mechanism for protection against nitric oxide-induced damage in human renal epithelial cells. Urology 20090501
Carbon monoxide produced by intrasinusoidally located haem-oxygenase-1 regulates the vascular tone in cirrhotic rat liver. Liver international : official journal of the International Association for the Study of the Liver 20090501
The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways. Endocrinology 20090501
Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes. American journal of physiology. Endocrinology and metabolism 20090501
Heterologous expression of the msp2 gene from Marasmius scorodonius. Archives of microbiology 20090501
Efficiency of methemoglobin, hemin and ferric citrate in catalyzing protein tyrosine nitration, protein oxidation and lipid peroxidation in a bovine serum albumin-liposome system: influence of pH. Journal of inorganic biochemistry 20090501
Fluorescent switch constructed based on hemin-sensitive anionic conjugated polymer and its applications in DNA-related sensors. Analytical chemistry 20090501
Bacillus anthracis HssRS signalling to HrtAB regulates haem resistance during infection. Molecular microbiology 20090501
Structural analysis of fish versus mammalian hemoglobins: effect of the heme pocket environment on autooxidation and hemin loss. Proteins 20090401
Hemin-H2O2-NO2(-) induced protein oxidation and tyrosine nitration are different from those of SIN-1: a study on glutamate dehydrogenase nitrative/oxidative modification. The international journal of biochemistry & cell biology 20090401
15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. Carcinogenesis 20090401
Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes. American journal of physiology. Endocrinology and metabolism 20090401
Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1. British journal of pharmacology 20090401
Influence of inorganic and organic iron compounds on parameters of cell growth and survival in human colon cells. Toxicology in vitro : an international journal published in association with BIBRA 20090401
Protective effect of hemin against cadmium-induced testicular damage in rats. Toxicology 20090329
A novel hemin-based organic phase artificial enzyme electrode and its application in different hydrophobicity organic solvents. Biosensors & bioelectronics 20090315
Label-free colorimetric detection of aqueous mercury ion (Hg2+) using Hg2+-modulated G-quadruplex-based DNAzymes. Analytical chemistry 20090315
Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H(2)S). Free radical biology & medicine 20090301
Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats. American journal of physiology. Renal physiology 20090301
The inhibitory effect of the proinflammatory cytokine TNFalpha on erythroid differentiation involves erythroid transcription factor modulation. International journal of oncology 20090301
Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores. Toxicology and applied pharmacology 20090215
Paralytic ileus and liver failure--an unusual presentation of advanced erythropoietic protoporphyria. Digestive diseases and sciences 20090201
Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20090201
A one-residue switch reverses the orientation of a heme b cofactor. Investigations of the ferriheme NO transporters nitrophorin 2 and 7 from the blood-feeding insect Rhodnius prolixus. Biochemistry 20090120
Reactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes: role for heme oxygenase-1 down-modulation. Chemico-biological interactions 20090115
Synthesis and application of a peroxidase-like molecularly imprinted polymer based on hemin for selective determination of serotonin in blood serum. Analytica chimica acta 20090112
Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells. Naunyn-Schmiedeberg's archives of pharmacology 20090101
MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells. Journal of cellular and molecular medicine 20090101
Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion. Hepatology (Baltimore, Md.) 20090101
Differences in response to fetal hemoglobin induction therapy in beta-thalassemia and sickle cell disease. Blood cells, molecules & diseases 20090101
A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. PloS one 20090101
Lidocaine: an inhibitor in the free-radical-induced hemolysis of erythrocytes. Journal of biochemical and molecular toxicology 20090101
Formation of heme-iron complexes with nitric oxide (NO) and peroxynitrite (ONOO-) after ultraviolet radiation as a protective mechanism in rat skin. In vivo (Athens, Greece) 20090101
Heme oxygenase-1 inducer hemin attenuates the progression of remnant kidney model. Nephron. Experimental nephrology 20090101
Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia. BMC molecular biology 20090101
Synthetic Plasmodium-like hemozoin activates the immune response: a morphology - function study. PloS one 20090101
Hemin counteracts the repression of Bcl-2 and NrF2 genes and the cell killing induced by imatinib in human Bcr-Abl(+) CML cells. Oncology research 20090101
Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke. Redox report : communications in free radical research 20090101
A Fok I/DNA machine that duplicates its analyte gene sequence. Journal of the American Chemical Society 20081224
Interaction of mitoxantrone with human serum albumin: spectroscopic and molecular modeling studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20081218
15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. Antioxidants & redox signaling 20081201
Inosine ameliorates the effects of hemin-induced oxidative stress in broilers. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081201
Carbon monoxide-induced stomatal closure involves generation of hydrogen peroxide in Vicia faba guard cells. Journal of integrative plant biology 20081201
Effect of feeding nitrite, ascorbate, hemin, and omeprazole on excretion of fecal total apparent N-nitroso compounds in mice. Chemical research in toxicology 20081201
Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action. Molecules (Basel, Switzerland) 20081120
Characterization of two TonB systems in marine fish pathogen Vibrio alginolyticus: their roles in iron utilization and virulence. Archives of microbiology 20081101
Heme-binding to the nuclear receptor retinoid X receptor alpha (RXRalpha) leads to the inhibition of the transcriptional activity. Gene 20081101
Interaction among heme oxygenase, nuclear factor-kappaB, and transcription activating factors in cardiac hypertrophy in hypertension. Hypertension (Dallas, Tex. : 1979) 20081101
Hemin treatment abrogates monocrotaline-induced pulmonary hypertension. Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101
Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes. Free radical biology & medicine 20081015
Electrospray-assisted laser desorption/ionization mass spectrometry for continuously monitoring the states of ongoing chemical reactions in organic or aqueous solution under ambient conditions. Analytical chemistry 20081015
Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents. Bioorganic & medicinal chemistry letters 20081015
Identification of heme uptake genes in the fish pathogen Aeromonas salmonicida subsp. salmonicida. Archives of microbiology 20081001
Heme oxygenase induction attenuates afferent arteriolar autoregulatory responses. American journal of physiology. Renal physiology 20081001
The heme oxygenase/carbon monoxide system is involved in the auxin-induced cucumber adventitious rooting process. Plant physiology 20081001
Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. American journal of physiology. Renal physiology 20081001
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. The American journal of pathology 20081001
Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression. Journal of medical microbiology 20081001
A Soret marker band for four-coordinate ferric heme proteins from absorption spectra of isolated Fe(III)-Heme+ and Fe(III)-Heme+(His) ions in vacuo. Journal of the American Chemical Society 20080910
Characterization of the microsomal cytochrome P450 2B4 O2 activation intermediates by cryoreduction and electron paramagnetic resonance. Biochemistry 20080909
Preparation of a DNA aptamer-Pt complex and its use in the colorimetric sensing of thrombin and anti-thrombin antibodies. Analytical chemistry 20080901
A new method for the study of G-quadruplex ligands. The Analyst 20080901
N,N-Bis(trifluoromethylquinolin-4-yl)diamino alkanes: synthesis and antimalarial activity. Medicinal chemistry (Shariqah (United Arab Emirates)) 20080901
BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. The Journal of biological chemistry 20080815
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin. Bioorganic & medicinal chemistry 20080815
HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes expression. The Journal of surgical research 20080801
Heme oxygenase-1 participates in the anti-inflammatory activity of taurine chloramine. Amino acids 20080801
Influence of heme oxygenase-1 on microcirculation after kidney transplantation. The Journal of surgical research 20080801
Assignment of the ferriheme resonances of high- and low-spin forms of the symmetrical hemin-reconstituted nitrophorins 1-4 by 1H and 13C NMR spectroscopy: the dynamics of heme ruffling deformations. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080801
The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials. Journal of inorganic biochemistry 20080801
Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. The Journal of allergy and clinical immunology 20080801
Effects of amino acids on malarial heme crystallization. Biological & pharmaceutical bulletin 20080801
[The protection of heme oxygenase-1 from acute cardiocyte injury in rats]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20080801
Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. Inorganic chemistry 20080707
Hemin inhibits cyclooxygenase-2 expression through nuclear factor-kappa B activation and ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin. Mutation research 20080703
[Change of JNK and c-Jun in lung injury associated with paraquat poisoning of rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20080701
The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2). Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601
Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. Journal of cellular physiology 20080601
Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Chemical research in toxicology 20080601
Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension. Journal of hypertension 20080601
[Effect of budesonide on the heme oxygenase-1 expression in lung tissues of rats with asthma]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601
Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2. Journal of cellular biochemistry 20080515
Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neuroscience letters 20080509
Fasciola hepatica: Surface tegumental responses to in vitro and in vivo treatment with the experimental fasciolicide OZ78. Experimental parasitology 20080501
Crystallization and preliminary characterization of a novel haem-binding protein of Streptomyces reticuli. Acta crystallographica. Section F, Structural biology and crystallization communications 20080501
[Effect of hemin on the lung development and pulmonary arterial structural remodeling in congenital diaphragmatic hernia: experiment with rats]. Zhonghua yi xue za zhi 20080408
High glucose induced human umbilical vein endothelial cell injury: involvement of protein tyrosine nitration. Molecular and cellular biochemistry 20080401
The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proceedings of the National Academy of Sciences of the United States of America 20080311
The protective effects of ginsenosides on human erythrocytes against hemin-induced hemolysis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301
Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress. Free radical biology & medicine 20080301
Electronic ground states of low-spin iron(III) porphyrinoids. Journal of inorganic biochemistry 20080301
Reduction of AHSP synthesis in hemin-induced K562 cells and EPO-induced CD34(+) cells leads to alpha-globin precipitation, impairment of normal hemoglobin production, and increased cell death. Experimental hematology 20080301
Protective effects of bilirubin against cyclophosphamide induced hemorrhagic cystitis in rats. The Journal of urology 20080301
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity. Journal of medicinal chemistry 20080227
GATA-1 binding sites in exon 1 direct erythroid-specific transcription of PPOX. Gene 20080215
Hemin, a heme oxygenase-1 inducer, improves aortic endothelial dysfunction in insulin resistant rats. Chinese medical journal 20080205
Apolipoprotein B binds ferritin by hemin-mediated binding: evidence of direct binding of apolipoprotein B and ferritin to hemin. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20080201
Antioxidative effect of melatonin on DNA and erythrocytes against free-radical-induced oxidation. Chemistry and physics of lipids 20080201
Effect of hemin and carbon monoxide releasing molecule (CORM-3) on cGMP in rat penile tissue. The journal of sexual medicine 20080201
Iron-chelator complexes as iron sources for early developing human erythroid precursors. Translational research : the journal of laboratory and clinical medicine 20080201
Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Free radical biology & medicine 20080201
H2O2/nitrite-induced post-translational modifications of human hemoglobin determined by mass spectrometry: redox regulation of tyrosine nitration and 3-nitrotyrosine reduction by antioxidants. Chembiochem : a European journal of chemical biology 20080125
Synthesis, characterization, and ab initio theoretical study of a molecularly imprinted polymer selective for biosensor materials. The journal of physical chemistry. A 20080117
Implication for using heme methyl hyperfine shifts as indicators of heme seating as related to stereoselectivity in the catabolism of heme by heme oxygenase: in-plane heme versus axial his rotation. Biochemistry 20080108
Protective effects of hemin pretreatment combined with ulinastatin on septic shock in rats. Chinese medical journal 20080105
Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB. Circulation research 20080104
Effects of dietary factors on iron uptake from ferritin by Caco-2 cells. The Journal of nutritional biochemistry 20080101
Epigenetic analysis of the human alpha- and beta-globin gene clusters. Blood cells, molecules & diseases 20080101
Heme rescues a two-component system Leptospira biflexa mutant. BMC microbiology 20080101
Iron chelators and free radical scavengers in naturally occurring polyhydroxylated 1,4-naphthoquinones. Hemoglobin 20080101
[Heme oxygenase activity in the tissues of the vessels and heart of rats under co-administration of NO-synthase inhibitor and hemin chloride]. Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101
Functional identification of HugZ, a heme oxygenase from Helicobacter pylori. BMC microbiology 20080101
Effects of glucose and nitrogen source concentration on batch fermentation kinetics of Lactococcus lactis under hemin-stimulated respirative condition. Biotechnology progress 20080101
Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer. British journal of cancer 20071217
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (New York, N.Y.) 20071214
Protective effects of heme oxygenase-1 against cyclophosphamide-induced haemorrhagic cystitis in rats. BJU international 20071201
Effects of heme oxygenase-1 inducer and inhibitor on experimental autoimmune uveoretinitis. Korean journal of ophthalmology : KJO 20071201
Bis-methionyl coordination in the crystal structure of the heme-binding domain of the streptococcal cell surface protein Shp. Journal of molecular biology 20071123
Enhanced catalytic DNAzyme for label-free colorimetric detection of DNA. Chemical communications (Cambridge, England) 20071107
Modulation of glyceraldehyde 3 phosphate dehydrogenase activity and tyr-phosphorylation of Band 3 in human erythrocytes treated with ferriprotoporphyrin IX. Biochemical pharmacology 20071101
A catalytically active molecularly imprinted polymer that mimics peroxidase based on hemin: application to the determination of p-aminophenol. Analytical and bioanalytical chemistry 20071101
Intermittent unexplained abdominal pain: is it porphyria? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071101
Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A. The Southeast Asian journal of tropical medicine and public health 20071101
Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. World journal of gastroenterology 20071028
Bis-methionine ligation to heme iron in the streptococcal cell surface protein Shp facilitates rapid hemin transfer to HtsA of the HtsABC transporter. The Journal of biological chemistry 20071026
Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury. American journal of physiology. Heart and circulatory physiology 20071001
Aptamer-based label-free method for hemin recognition and DNA assay by capillary electrophoresis with chemiluminescence detection. Analytical and bioanalytical chemistry 20071001
Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress. Hypertension (Dallas, Tex. : 1979) 20071001
The Aedes aegypti glutathione transferase family. Insect biochemistry and molecular biology 20071001
Post-translational modification of crystallins in vitreous body from experimental autoimmune uveitis of rats. Journal of proteome research 20071001
Susceptibility of oral obligate anaerobes to telithromycin, moxifloxacin and a number of commonly used antibacterials. Oral microbiology and immunology 20071001
Heme regulates exocrine peptidase precursor genes in zebrafish. Experimental biology and medicine (Maywood, N.J.) 20071001
Changes in the expression of cytochrome P450 genes in hemin-induced differentiated K562 cells. Biological & pharmaceutical bulletin 20071001
Effects of malaria heme products on red blood cell deformability. The American journal of tropical medicine and hygiene 20071001
Theoretical DFT study of fragmentation and association of heme and hemin. The journal of physical chemistry. A 20070927
Acute intermittent porphyria with peripheral neuropathy: a follow-up study after hematin treatment. Journal of the neurological sciences 20070915
A critical role for the co-repressor N-CoR in erythroid differentiation and heme synthesis. Cell research 20070901
Efficacy of metmyoglobin and hemin as a catalyst of lipid peroxidation determined by using a new testing system. Journal of agricultural and food chemistry 20070808
Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates. Arteriosclerosis, thrombosis, and vascular biology 20070801
Defense mechanism of heme oxygenase-1 against cytotoxic and receptor activator of nuclear factor-kappaB ligand inducing effects of hydrogen peroxide in human periodontal ligament cells. Journal of periodontal research 20070801
Upregulation of heme oxygenase-1 with hemin prevents D-galactosamine and lipopolysaccharide-induced acute hepatic injury in rats. Toxicology 20070731
Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells. Blood 20070715
Effect of haemin on growth, protein content and the antioxidant defence system in Trypanosoma cruzi. Parasitology 20070701
Overexpression in Escherichia coli and functional reconstitution of the liposome binding ferriheme protein nitrophorin 7 from the bloodsucking bug Rhodnius prolixus. Protein expression and purification 20070701
Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins. Biochemical pharmacology 20070630
Molecular cloning, expression, biochemical characteristics, and biomarker potential of theta class glutathione S-transferase (GST-T) from the polychaete Neanthes succinea. Aquatic toxicology (Amsterdam, Netherlands) 20070615
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. Journal of neuroscience research 20070601
Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601
Analysis of hemin effect on lactate reduction in Lactococcus lactis. Journal of bioscience and bioengineering 20070601
Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes. American journal of physiology. Cell physiology 20070501
Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers. The Journal of surgical research 20070501
Hypoxia inducible factor-1 modulates hemin-induced IL-8 secretion in microvascular endothelium. Microvascular research 20070501
The protective role of heme oxygenase-1 induction on testicular tissues after testicular torsion and detorsion. The Journal of urology 20070501
Media for the aerobic resuscitation of Campylobacter jejuni. Journal of food protection 20070501
[Cardioprotective effects of NOS and PKC under hemin induced ischemia/reperfusion injury in rat hearts]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070501
Curcumin reduces cold storage-induced damage in human cardiac myoblasts. Experimental & molecular medicine 20070430
Degradation of p22phox and inhibition of superoxide generation by Ehrlichia chaffeensis in human monocytes. Cellular microbiology 20070401
The novel antimalarial compound dioncophylline C forms a complex with heme in solution. ChemMedChem 20070401
JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. The Journal of biological chemistry 20070302
Cyclic nucleotide response element binding (CREB) protein activation is involved in K562 erythroleukemia cells differentiation. Journal of cellular biochemistry 20070301
Induction of heme oxygenase-1 improves impaired intestinal transit after burn injury. Surgery 20070301
Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium. Cancer research 20070201
[Protective role of endogenous carbon monoxide to lung and kidney tissues during septic shock]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201
The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligand. Journal of molecular biology 20070126
Assignment of the ferriheme resonances of the high-spin forms of nitrophorins 1 and 4 by 1H NMR spectroscopy: comparison to structural data obtained from X-ray crystallography. Inorganic chemistry 20070108
Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not mu-oxo dimer formation. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070101
Studies on PVP hydrogel-supported luminol chemiluminescence: 2. Luminometer calibration and potential analytical applications. Luminescence : the journal of biological and chemical luminescence 20070101
Studies on PVP hydrogel-supported luminol chemiluminescence: 1. Kinetic and mechanistic aspects using multivariate factorial analysis. Luminescence : the journal of biological and chemical luminescence 20070101
Effect of NO donor sodium nitroprusside on lipopolysaccharide induced acute lung injury in rats. Injury 20070101
Evaluation of different iron sources and their influence in biofilm formation by the dental pathogen Actinobacillus actinomycetemcomitans. Journal of medical microbiology 20070101
[Involvement of potassium channel in hemin-induced cardioprotection in rat hearts]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070101
[Nitric oxide/heme oxygenase-1 mediates the antioxidant effect of ACEI in rat aortic rings]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070101
[Regulation of the 26S proteasomes' endoribonuclease activity specificity in k562 cells under effect of differentiation and apoptosis inductors]. Tsitologiia 20070101
Kinetics of Lactococcus lactis growth and metabolite formation under aerobic and anaerobic conditions in the presence or absence of hemin. Biotechnology and bioengineering 20061220
[Protective effect of heme oxygenase-1 and its reaction product, carbon monoxide on acute liver injury induced by carbon tetrachloride in rats]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061218
Selective enhancement of cellular oxidative stress by chloroquine: implications for the treatment of glioblastoma multiforme. Neurosurgical focus 20061215
EspC, an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC), displays protease activity on human hemoglobin. FEMS microbiology letters 20061201
Heme oxygenase 1, nuclear factor E2-related factor 2, and nuclear factor kappaB are involved in hemin inhibition of type 2 cationic amino acid transporter expression and L-Arginine transport in stimulated macrophages. Anesthesiology 20061201
Heme oxygenase-1 mediates cytoprotection against nitric oxide-induced cytotoxicity via the cGMP pathway in human pulp cells. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20061201
How large is the [Fe(III)(protoporphyrin IX)]+ ion (hemin+) in the gas phase? The journal of physical chemistry. B 20061130
1H NMR Study of the influence of hemin vinyl-->methyl substitution on the interaction between the C-terminus and substrate and the 'aging' of the heme oxygenase from Neisseria meningitidis: induction of active site structural heterogeneity by a two-fold symmetric hemin. Biochemistry 20061121
Kinetics of beta-haematin formation from suspensions of haematin in aqueous benzoic acid. Dalton transactions (Cambridge, England : 2003) 20061114
Mass spectrometry studies of demetallation of haemin by recombinant horse L chain apoferritin and its mutant (E 53,56,57,60 Q). FEBS letters 20061113
Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochemical and biophysical research communications 20061110
Differential expression changes in K562 cells during the hemin-induced erythroid differentiation and the phorbol myristate acetate (PMA)-induced megakaryocytic differentiation. Molecular and cellular biochemistry 20061101
Hepatic expression of heme oxygenase-1 and antioxidant response element-mediated genes following administration of ethinyl estradiol to rats. Toxicology and applied pharmacology 20061101
Boronated protohaemins: synthesis and in vivo antitumour efficacy. Organic & biomolecular chemistry 20061021
The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP. The Journal of biological chemistry 20061020
Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. The Journal of biological chemistry 20061020
Mechanisms of heme protein-mediated lipid oxidation using hemoglobin and myoglobin variants in raw and heated washed muscle. Journal of agricultural and food chemistry 20061018
Purification and initial characterization of a novel Porphyromonas gingivalis HmuY protein expressed in Escherichia coli and insect cells. Protein expression and purification 20061001
Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension (Dallas, Tex. : 1979) 20061001
Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. British journal of pharmacology 20061001
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Molecular microbiology 20061001
The antioxidant role of a reagent, 2',7'-dichlorodihydrofluorescin diacetate, detecting reactive-oxygen species and blocking the induction of heme oxygenase-1 and preventing cytotoxicity. Journal of biochemistry 20061001
The use of nonsteroidal anti-inflammatory drugs and the occurrence of gastric lesions among patients undergoing upper endoscopy in a university hospital in Brazil. Clinics (Sao Paulo, Brazil) 20061001
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin. Biochemical and biophysical research communications 20060915
Proteasomal degradation regulates expression of porphobilinogen deaminase (PBGD) mutants of acute intermittent porphyria. Biochimica et biophysica acta 20060901
Nitric oxide inhibits, and carbon monoxide activates, islet acid alpha-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion. The Journal of endocrinology 20060901
[Fluorescence investigation on interaction between artemisinin (qinghaosu) and hemin and its analytical application]. Guang pu xue yu guang pu fen xi = Guang pu 20060901
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. The Journal of biological chemistry 20060811
Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. Journal of molecular biology 20060811
Immobilized hemin affinity chromatography as a probe for proteins having potentiality to bind with heme. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060807
Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritins. Journal of inorganic biochemistry 20060801
[Effect of endogenous carbon monoxide on the smooth muscle function of dog penile corpus cavernosum in vitro]. Zhonghua nan ke xue = National journal of andrology 20060801
Nitric oxide levels during erythroid differentiation in K562 cell line. Indian journal of biochemistry & biophysics 20060801
Study on the redox state dependent gamma(CH) vibrational modes of the c-type heme. Biopolymers 20060701
Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. Analytical biochemistry 20060701
Increased intracavernosal pressure response in hypertensive rats after chronic hemin treatment. The journal of sexual medicine 20060701
Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. Free radical research 20060701
A G316A mutation of manganese lipoxygenase augments hydroperoxide isomerase activity: mechanism of biosynthesis of epoxyalcohols. The Journal of biological chemistry 20060630
Iron-related transcriptomic variations in CaCo-2 cells, an in vitro model of intestinal absorptive cells. Physiological genomics 20060616
Studies with myoglobin variants indicate that released hemin is the primary promoter of lipid oxidation in washed fish muscle. Journal of agricultural and food chemistry 20060614
Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity. Oncogene 20060608
Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage. Neurobiology of disease 20060601
Inhibition of inflammatory nitric oxide production and epidermis damages by Saccharomycopsis Ferment Filtrate. Journal of dermatological science 20060601
Temporal responses in the disruption of iron regulation by manganese. Journal of neuroscience research 20060601
Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology 20060601
Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney. Amino acids 20060601
A protective role for heme oxygenase-1 in INS-1 cells and rat islets that are exposed to high glucose conditions. Journal of Korean medical science 20060601
Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury. Neuroscience letters 20060508
Interactions of quinoline antimalarials with hematin in solution. Journal of inorganic biochemistry 20060501
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite. Journal of lipid research 20060501
Global analysis of iron assimilation and fur regulation in Yersinia pestis. FEMS microbiology letters 20060501
Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. European journal of pharmacology 20060424
The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2-dependent phase II detoxifying genes and alters intracellular glutathione redox. Free radical biology & medicine 20060415
Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells. Molecular and cellular biology 20060401
Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes. Free radical biology & medicine 20060401
Vitamin E inhibits hemolysis induced by hemin as a membrane stabilizer. Biochemical pharmacology 20060314
JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells. Biochemical and biophysical research communications 20060310
The conserved active-site loop residues of ferrochelatase induce porphyrin conformational changes necessary for catalysis. Biochemistry 20060307
Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons. Molecular pharmacology 20060301
Long-term effect of heme oxygenase (HO)-1 induction in glomerular immune injury. The Journal of laboratory and clinical medicine 20060301
Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes. Mutation research 20060222
Phytol-modified heme in mesoporous silica: conjugates as models of hemoproteins. Biotechnology and bioengineering 20060220
Role of G proteins and ERK activation in hemin-induced erythroid differentiation of K562 cells. Life sciences 20060209
Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. The EMBO journal 20060208
Designing of the centers for adsorption of bile acids on a silica surface. Journal of colloid and interface science 20060201
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacological research 20060201
Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition. Protein science : a publication of the Protein Society 20060201
Iron acquisition systems for ferric hydroxamates, haemin and haemoglobin in Listeria monocytogenes. Molecular microbiology 20060201
Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein. Journal of cell science 20060115
Role of human cyclooxygenase-2 in the bioactivation of dapsone and sulfamethoxazole. Drug metabolism and disposition: the biological fate of chemicals 20060101
Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis. Free radical biology & medicine 20060101
A comparative study of the effects of hemin and bilirubin on bilateral renal ischemia reperfusion injury. Nephron. Experimental nephrology 20060101
Therapeutics in renal disease: the road ahead for antiproliferative targets. Nephron. Experimental nephrology 20060101
Hemin-mediated hemolysis in erythrocytes: effects of ascorbic acid and glutathione. Acta biochimica et biophysica Sinica 20060101
Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adducts. Chemical research in toxicology 20060101
Regulation of globin gene transcription by heme in erythroleukemia cells: analysis of putative heme regulatory motifs in the p45 NF-E2 transcription factor. Antioxidants & redox signaling 20060101
Soret spectral and bioinformatic approaches provide evidence for a critical role of the alpha -subunit in assembly of tetrameric hemoglobin. The protein journal 20060101
Hyperglycemia in streptozotocin-induced diabetes leads to persistent inflammation and tissue damage following uveitis due to reduced levels of ciliary body heme oxygenase-1. Mediators of inflammation 20060101
Lead-induced upregulation of the heme-regulated eukaryotic initiation factor 2alpha kinase is compromised by hemin in human K562 cells. Biochimica et biophysica acta 20051230
Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury. Journal of neuroscience research 20051215
Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B. The Journal of antimicrobial chemotherapy 20051201
O2 and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants. Journal of the American Chemical Society 20051116
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. The Journal of clinical investigation 20051101
Copper- and magnesium protoporphyrin complexes inhibit oxidative modification of LDL induced by hemin, transition metal ions and tyrosyl radicals. Free radical research 20051101
Aluminum ions stimulate the oxidizability of low density lipoprotein by Fe2+: implication in hemodialysis mediated atherogenic LDL modification. Free radical research 20051101
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. European journal of pharmacology 20051003
HO-1 induction in the guinea-pig stomach: protection of smooth muscle functional performance during cobalt-induced oxidative stress. Cellular and molecular biology (Noisy-le-Grand, France) 20051003
Monitoring circulatory heme level in hemin therapy for lowering blood pressure in rats. Cellular and molecular biology (Noisy-le-Grand, France) 20051003
Production and purification of human indoleamine 2,3-dioxygenase (HuIDO) protein in a baculovirus expression system and production and characterization of egg yolk antibody against the purified HuIDO. Immunology and cell biology 20051001
Mg-protoporphyrin IX and heme control HEMA, the gene encoding the first specific step of tetrapyrrole biosynthesis, in Chlamydomonas reinhardtii. Eukaryotic cell 20051001
Structural stabilities of recombinant scombridae fish myoglobins. Bioscience, biotechnology, and biochemistry 20051001
Characterization of the IgA1 protease from the Brazilian purpuric fever strain F3031 of Haemophilus influenzae biogroup aegyptius. FEMS microbiology letters 20050915
Apigenin decreases hemin-mediated heme oxygenase-1 induction. Free radical biology & medicine 20050915
Regulation of human erythrocyte glyceraldehyde-3-phosphate dehydrogenase by ferriprotoporphyrin IX. FEBS letters 20050912
Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design, construction, characterization, and pharmacology of metaquine. Journal of medicinal chemistry 20050825
Controlling reduction potentials of semiconductor-supported molecular catalysts for environmental remediation of organohalide pollutants. Environmental science & technology 20050815
Hemin induces active chloride secretion in Caco-2 cells. American journal of physiology. Gastrointestinal and liver physiology 20050801
Effect of bicarbonate on iron-mediated oxidation of low-density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America 20050726
Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum. The Journal of biological chemistry 20050715
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. The EMBO journal 20050706
The Chlamydomonas reinhardtii gtr gene encoding the tetrapyrrole biosynthetic enzyme glutamyl-trna reductase: structure of the gene and properties of the expressed enzyme. Plant molecular biology 20050701
Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury. Current neurovascular research 20050701
[Henry's law constant measurement for hydrogen peroxide using oxidative decoloration of BPR]. Guang pu xue yu guang pu fen xi = Guang pu 20050701
Guanidine hydrochloride denaturation of human serum albumin originates by local unfolding of some stable loops in domain III. Biochimica et biophysica acta 20050615
A spectrophotometric method for estimating hemin in biological systems. Analytical biochemistry 20050615
Three-dimensional structure of Plasmodium falciparum Ca2+ -ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6. Bioorganic & medicinal chemistry letters 20050615
Epileptic seizures cause extended postictal cerebral vascular dysfunction that is prevented by HO-1 overexpression. American journal of physiology. Heart and circulatory physiology 20050601
In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin. The Journal of antimicrobial chemotherapy 20050601
Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro. Toxicology and applied pharmacology 20050601
Nitric oxide-mediated nitrosation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline potentiated by hemin and myeloperoxidase. Chemical research in toxicology 20050601
Solution 1H NMR study of the accommodation of the side chain of n-butyl-etiohemin-I incorporated into the active site of cyano-metmyoglobin. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050501
Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050501
Creation of a new synthetic medium for culturing Helicobacter pylori. Bulletin of experimental biology and medicine 20050501
SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Blood 20050415
1,2,4-Triazino-[5,6b]indole derivatives: effects of the trifluoromethyl group on in vitro antimalarial activity. Bioorganic & medicinal chemistry 20050415
Destabilisation and subsequent lysis of human erythrocytes induced by Plasmodium falciparum haem products. European journal of haematology 20050401
Acute intermittent porphyria presenting as a diffuse encephalopathy. Annals of neurology 20050401
Design and synthesis of new antimalarial agents from 4-aminoquinoline. Bioorganic & medicinal chemistry 20050315
Recommendations for the diagnosis and treatment of the acute porphyrias. Annals of internal medicine 20050315
Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology 20050301
A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin. Journal of inorganic biochemistry 20050301
Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. Diabetes 20050301
Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock. Critical care medicine 20050301
The prospect of hemoglobin-based blood substitutes: Still a long stony road to go. Critical care medicine 20050301
Hemin potentiates nitric oxide-mediated nitrosation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to 2-nitrosoamino-3-methylimidazo[4,5-f]quinoline. Chemical research in toxicology 20050301
Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages. Journal of cellular physiology 20050201
Protein expressed by the ho2 gene of the cyanobacterium Synechocystis sp. PCC 6803 is a true heme oxygenase. Properties of the heme and enzyme complex. The FEBS journal 20050201
Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. Free radical biology & medicine 20050101
Redox regulation of p38 MAPK activation and expression of ICAM-1 and heme oxygenase-1 in human alveolar epithelial (A549) cells. Antioxidants & redox signaling 20050101
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity. Molecular pharmaceutics 20050101
A ligand function of glutathione S-transferase. Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101
Glucose-induced enhancement of hemin-catalyzed LDL oxidation in vitro and in vivo. Antioxidants & redox signaling 20050101
Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives. Arzneimittel-Forschung 20050101
Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process. American journal of physiology. Gastrointestinal and liver physiology 20041201
New eudesmane derivatives from Melampodium camphoratum from the Suriname rainforest. Journal of natural products 20041201
Pro-oxidant role of heme oxygenase in mediating glucose-induced endothelial cell damage. Free radical research 20041201
Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin. Biochemical and biophysical research communications 20041119
Overexpression of transglutaminase 2 accelerates the erythroid differentiation of human chronic myelogenous leukemia K562 cell line through PI3K/Akt signaling pathway. FEBS letters 20041119
Hemin/nitrite/H2O2 induces brain homogenate oxidation and nitration: effects of some flavonoids. Biochimica et biophysica acta 20041118
SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties. Biochemistry 20041109
Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. Biochemical and biophysical research communications 20041105
Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. Toxicology letters 20041102
Adenoviral transfer of the heme oxygenase-1 gene protects striatal astrocytes from heme-mediated oxidative injury. Neurobiology of disease 20041101
Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis. European journal of biochemistry 20041101
Calcium-dependent changes in potassium currents in guinea-pig coronary artery smooth muscle cells after acute cobalt loading in vivo. Pflugers Archiv : European journal of physiology 20041001
Susceptibility of skin cells to UVA-induced necrotic cell death reflects the intracellular level of labile iron. The Journal of investigative dermatology 20041001
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms-dependent biofilm formation in Yersinia pestis. Molecular microbiology 20041001
Secretion of ferritin by iron-laden macrophages and influence of lipoproteins. Free radical research 20041001
Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells. Molecular and cellular biochemistry 20041001
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Molecular cell 20040924
Erythroid-induced commitment of K562 cells results in clusters of differentially expressed genes enriched for specific transcription regulatory elements. Physiological genomics 20040916
Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells. Biochemical pharmacology 20040915
Mechanism of internal anal sphincter relaxation by CORM-1, authentic CO, and NANC nerve stimulation. American journal of physiology. Gastrointestinal and liver physiology 20040901
Silica-hemin composite nanoparticles as new biocatalyst to highly sensitive determination of glucose in human serum. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040901
1H NMR characterization of the solution active site structure of substrate-bound, cyanide-inhibited heme oxygenase from Neisseria meningitidis: comparison to crystal structures. Biochemistry 20040810
Serum antibodies against the hemoglobin-binding domain (HA2) of Porphyromonas gingivalis. Journal of periodontal research 20040801
Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis. Antioxidants & redox signaling 20040801
Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthase. Journal of biochemistry 20040801
Heme oxygenase inhibition reduces neuronal activation evoked by bicuculline in newborn pigs. Brain research 20040716
Rat liver glutathione S-transferase activity stimulation following acute cadmium or manganese intoxication. Toxicology 20040715
Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. The EMBO journal 20040707
De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1. Journal of the American Chemical Society 20040707
Heme oxygenase attenuates allergen-induced airway inflammation and hyperreactivity in guinea pigs. American journal of physiology. Lung cellular and molecular physiology 20040701
Heme oxygenase modulates hepatic leukocyte sequestration via changes in sinusoidal tone in systemic inflammation in mice. Microvascular research 20040701
Quenching of the intrinsic fluorescence of bovine serum albumin by chlorpromazine and hemin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040701
Heme-oxygenase-mediated iron accumulation in the liver. Canadian journal of physiology and pharmacology 20040701
Definition of an electronic profile of compounds with inhibitory activity against hematin aggregation in malaria parasite. Bioorganic & medicinal chemistry 20040615
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. The Journal of biological chemistry 20040604
Induction of calcium-activated potassium channel activity by hemin in human erythroleukemia cells. Life sciences 20040604
Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation. Journal of leukocyte biology 20040601
Susceptibility of low-density lipoprotein to oxidation and circulating cell adhesion molecules in young healthy adult offspring of parents with type 2 diabetes. Metabolism: clinical and experimental 20040601
In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes. Journal of medicinal chemistry 20040520
Quantitative determination of heme for forensic characterization of bacillus spores using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical chemistry 20040515
Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron. Biochemistry 20040511
Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. Journal of medicinal chemistry 20040506
Heme-iron increases levels of AP65-mediated adherence by Trichomonas vaginalis. Microbial pathogenesis 20040501
Xylella fastidiosa cultivation on a minimal solid defined medium. Current microbiology 20040501
Persistence of a Staphylococcus aureus small-colony variant under antibiotic pressure in vivo. FEMS immunology and medical microbiology 20040501
Unique features of recombinant heme oxygenase of Drosophila melanogaster compared with those of other heme oxygenases studied. European journal of biochemistry 20040501
Sources of variation in rates of in vitro ruminal protein degradation. Journal of dairy science 20040501
The effect of oxygen on the growth and physiology of Porphyromonas gingivalis. Oral microbiology and immunology 20040401
Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites. Biochemical pharmacology 20040401
Amplified chemiluminescence surface detection of DNA and telomerase activity using catalytic nucleic acid labels. Analytical chemistry 20040401
Chlorpromazine interactions to sera albumins. A study by the quenching of fluorescence. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040401
[Identification and analysis of expressed sequence tags related to K562 cells into erythroid differentiation]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20040401
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life sciences 20040305
Lighting up biochemiluminescence by the surface self-assembly of DNA-hemin complexes. Chembiochem : a European journal of chemical biology 20040305
Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arteriosclerosis, thrombosis, and vascular biology 20040301
Protease inhibitors modulate apoptosis in mesangial cells derived from a mouse model of HIVAN. Kidney international 20040301
Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells. Experimental hematology 20040301
Tertiary structure of human alpha1-acid glycoprotein (orosomucoid). Straightforward fluorescence experiments revealing the presence of a binding pocket. Carbohydrate research 20040225
Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics. Biochemical and biophysical research communications 20040206
Engineering peroxidase activity in myoglobin: the haem cavity structure and peroxide activation in the T67R/S92D mutant and its derivative reconstituted with protohaemin-l-histidine. The Biochemical journal 20040201
Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin. The Journal of biological chemistry 20040130
Intermediate formation at lower urea concentration in 'B' isomer of human serum albumin: a case study using domain specific ligands. Biochemical and biophysical research communications 20040130
Cellular genomic reporter assays for screening and evaluation of inducers of fetal hemoglobin. Human molecular genetics 20040115
Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells. Oncogene 20040115
Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX. Journal of inorganic biochemistry 20040101
Lysine-specific gingipain K and heme/hemoglobin receptor HmuR are involved in heme utilization in Porphyromonas gingivalis. Acta biochimica Polonica 20040101
ERK signaling pathway is differentially involved in erythroid differentiation of K562 cells depending on time and the inducing agent. Cell biology international 20040101
Effect of heme oxygenase-1 inducer hemin on chronic renal failure rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101
Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC neuroscience 20040101
Heme oxygenase-2 products activate IKCa: role of CO and iron in guinea pig portal vein smooth muscle cells. Journal of muscle research and cell motility 20040101
[False surgical acute abdomen with intermittent acute porphyria]. Chirurgia (Bucharest, Romania : 1990) 20040101
A cytochrome b562 variant with a c-type cytochrome CXXCH heme-binding motif as a probe of the Escherichia coli cytochrome c maturation system. The Journal of biological chemistry 20031226
Inhibitory effects of chlorophyllin, hemin and tetrakis(4-benzoic acid)porphyrin on oxidative DNA damage and mouse skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate as a possible anti-tumor promoting mechanism. Mutation research 20031209
Evaluation of antiradical capacity by H2O2-hemin-induced luminol chemiluminescence. Journal of agricultural and food chemistry 20031203
Beneficial effects of heme oxygenase-1 up-regulation in the development of experimental inflammation induced by zymosan. The Journal of pharmacology and experimental therapeutics 20031201
Heme oxygenase in diabetes-induced oxidative stress in the heart. Journal of molecular and cellular cardiology 20031201
Spectrophotometric and ESI-MS/HPLC studies reveal a common mechanism for the reaction of various artemisinin analogues with hemin. Bioorganic & medicinal chemistry letters 20031117
Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells. American journal of physiology. Endocrinology and metabolism 20031101
Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. Biochemical pharmacology 20031101
Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. Carcinogenesis 20031001
Cre-mediated site-specific cassette exchange in erythroid cell. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20031001
Simplified method to assay total plasma peroxidase activity and ferriheme products in sickle cell anemia, with initial results in assessing clinical severity in a trial with citrulline therapy. Journal of pediatric hematology/oncology 20031001
Thermodynamics of heme binding to the HasA(SM) hemophore: effect of mutations at three key residues for heme uptake. Biochemistry 20030916
Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochemical pharmacology 20030915
Interaction of carbon monoxide and adenosine in the nucleus tractus solitarii of rats. Hypertension (Dallas, Tex. : 1979) 20030901
Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy. Blood 20030815
In vitro environmental regulation of Porphyromonas gingivalis growth and virulence. Oral microbiology and immunology 20030801
Leptospira spp. possess a complete haem biosynthetic pathway and are able to use exogenous haem sources. Molecular microbiology 20030801
Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning. Hepatology (Baltimore, Md.) 20030801
Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stress. Surgery 20030801
Induction of heme oxygenase-1 in monocytes suppresses angiotensin II-elicited chemotactic activity through inhibition of CCR2: role of bilirubin and carbon monoxide generated by the enzyme. Antioxidants & redox signaling 20030801
[Effect of differentiation inducer and heat stress on the expression of JWA protein and Hsp70 of K562 cells]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20030801
Coordination complex between haemin and parallel-quadruplexed d(TTAGGG). Chemical communications (Cambridge, England) 20030721
Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. The Journal of biological chemistry 20030718
Receptor-drug association studies in the inhibition of the hematin aggregation process of malaria. FEBS letters 20030717
Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth. Journal of medicinal chemistry 20030703
Role of constitutively expressed heme oxygenase-2 in the regulation of guinea pig coronary artery tone. Pflugers Archiv : European journal of physiology 20030701
Haemoglobin during pregnancy: relationship to erythropoietin and haematinic status. European journal of haematology 20030701
Hemin induces an iron-dependent, oxidative injury to human neuron-like cells. Journal of neuroscience research 20030701
Heme-oxygenase-1 mRNA expression affects hemorrhagic shock-induced leukocyte adherence. The Journal of trauma 20030701
Stereoselectivity of each of the three steps of the heme oxygenase reaction: hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin. Biochemistry 20030624
Chloroquine-induced masking of a lipid that promotes ferriprotoporphyrin IX dimerization in malaria. The Journal of biological chemistry 20030620
Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI. Biochemistry 20030603
Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway. The Biochemical journal 20030601
Age-related alterations in soluble guanylyl cyclase and cGMP pathway in spontaneously hypertensive rats. Journal of hypertension 20030601
Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 20030515
Binding and protection of porphyrins by glutathione S-transferases of Zea mays L. Biochimica et biophysica acta 20030502
Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood 20030501
Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Experimental biology and medicine (Maywood, N.J.) 20030501
Alterations in heme oxygenase/carbon monoxide system in pulmonary arteries in hypertension. Experimental biology and medicine (Maywood, N.J.) 20030501
The mysteries of hemoglobin degradation in Plasmodium falciparum-infected erythrocytes. Trends in parasitology 20030501
Tyrosine kinase is involved in hemin-induced pyresis. Archives of pharmacal research 20030501
The formation of the 7-carboxyheptyl radical from 13-hydroperoxy-9,11-octadecadienoic acid catalyzed by hemoglobin and myoglobin under anaerobic conditions. Journal of biochemistry 20030501
Carbon monoxide modulates the response of human basophils to FcepsilonRI stimulation through the heme oxygenase pathway. European journal of pharmacology 20030404
Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media. Parasitology research 20030401
Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1. Hepatology (Baltimore, Md.) 20030401
Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX. Antioxidants & redox signaling 20030401
[Study of hemin-induced gene expression in K562 cells]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030401
[A non-resonance surface-enhanced Raman spectroscopic study of hemin on a roughened silver electrode]. Guang pu xue yu guang pu fen xi = Guang pu 20030401
Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms. American journal of physiology. Renal physiology 20030301
The treatment of Plasmodium falciparum-infected erythrocytes with chloroquine leads to accumulation of ferriprotoporphyrin IX bound to particular parasite proteins and to the inhibition of the parasite's 6-phosphogluconate dehydrogenase. Parasite (Paris, France) 20030301
Construction and characterization of a chimeric myoglobin. Biochimica et biophysica acta 20030221
Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites. Archives of biochemistry and biophysics 20030215
Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-alpha-induced microcirculatory dysfunction and apoptotic cell death. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201
Level of haem oxygenase does not obligatorily reflect the sensitivity of PC12 cells to an oxidative shock induced by glutathione depletion. Journal of neurochemistry 20030201
Expression and characterization of cyanobacterium heme oxygenase, a key enzyme in the phycobilin synthesis. Properties of the heme complex of recombinant active enzyme. European journal of biochemistry 20030201
Role of hemin in the modulation of H2O2-mediated endothelial cell injury. Vascular pharmacology 20030201
Hemin: a possible cause of oxidative stress in blood circulation of beta-thalassemia/hemoglobin E disease. Free radical research 20030201
Assignment of heme resonances and determination of the electronic structures of high- and low-spin nitrophorin 2 by 1H and 13C NMR spectroscopy: an explanation of the order of heme methyl resonances in high-spin ferriheme proteins. Biochemistry 20030128
Role of heme oxygenase-1 in morphine-modulated apoptosis and migration of macrophages. The Journal of infectious diseases 20030101
Crystal structural analysis of human serum albumin complexed with hemin and fatty acid. BMC structural biology 20030101
The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2. Blood cells, molecules & diseases 20030101
Expression of HO-1 in chronic renal insufficiency. Rat kidney and implication. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101
Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox report : communications in free radical research 20030101
Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species of Plasmodium. Redox report : communications in free radical research 20030101
[Cardioprotective effect of heme oxygenase-1 induction by hemin on the isolated rat heart during ischemia--reperfusion]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101
Heme inhibits the mitochondrial import of coproporphyrinogen oxidase. Blood 20021215
Direct electron transfer between hemoglobin and a glassy carbon electrode facilitated by lipid-protected gold nanoparticles. Biochimica et biophysica acta 20021202
Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity. The international journal of biochemistry & cell biology 20021201
Development of sensitive fluorescent assays for embryonic and fetal hemoglobin inducers using the human beta -globin locus in erythropoietic cells. Blood 20021201
Bilirubin and ferritin as protectors against hemin-induced oxidative stress in rat liver. Cellular and molecular biology (Noisy-le-Grand, France) 20021201
Interaction of heme with nitroxyl or nitric oxide amplifies heme oxygenase-1 induction: involvement of the transcription factor Nrf2. Cellular and molecular biology (Noisy-le-Grand, France) 20021201
Effects of chronic administration of a heme oxygenase substrate or inhibitor on progression of the estrous cycle, pregnancy and lactation of Sprague-Dawley rats. Life sciences 20021129
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum. Journal of medicinal chemistry 20021107
Hemin, a heme oxygenase substrate analog, both inhibits and enhances neutrophil random migration and chemotaxis. Allergy 20021101
Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. Molecular pharmacology 20021101
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect. European journal of pharmacology 20021101
Interference of activated factor VII in apoptosis of erytholeukemic K562 cells. Comptes rendus biologies 20021101
Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparum. The Biochemical journal 20021015
Hemin induces neuroglobin expression in neural cells. Blood 20021001
Toward engineering the stability and hemin-binding properties of microsomal cytochromes b5 into rat outer mitochondrial membrane cytochrome b5: examining the influence of residues 25 and 71. Biochemistry 20021001
Binding and relaxometric properties of heme complexes with cyanogen bromide fragments of human serum albumin. Biophysical journal 20021001
Reductive activation of dioxygen by a myoglobin reconstituted with a flavohemin. Journal of the American Chemical Society 20020925
Molecular docking and 3-D-QSAR studies on the possible antimalarial mechanism of artemisinin analogues. Bioorganic & medicinal chemistry 20020901
Multilaboratory comparison of anaerobe susceptibility results using 3 different agar media. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020901
Stabilization of mast cells by heme oxygenase-1: an anti-inflammatory role. American journal of physiology. Heart and circulatory physiology 20020901
Post-transcriptional mechanisms control catalase synthesis during its light-induced turnover in rye leaves through the availability of the hemin cofactor and reversible changes of the translation efficiency of mRNA. The Plant journal : for cell and molecular biology 20020901
Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension (Dallas, Tex. : 1979) 20020901
Response of Staphylococcus aureus isolates from bovine mastitis to exogenous iron sources. Journal of dairy science 20020901
Enhancement of glutathione-dependent haemin degradation by ascorbic acid. Biochemical pharmacology 20020815
Solution structures of antimalarial drug-heme complexes. Biochemistry 20020813
Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives. Journal of medicinal chemistry 20020801
Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position. Journal of medicinal chemistry 20020801
Induction of heme oxygenase in guinea-pig stomach: roles in contraction and in single muscle cell ionic currents. Acta physiologica Scandinavica 20020801
Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. Antioxidants & redox signaling 20020801
Management of oxidative stress by heme oxygenase-1 in cisplatin-induced toxicity in renal tubular cells. Free radical research 20020801
Two novel assays for the detection of haemin-binding properties of antimalarials evaluated with compounds isolated from medicinal plants. The Journal of antimicrobial chemotherapy 20020701
Carbon monoxide regulates blood pressure cooperatively with nitric oxide in hypertensive rats. Heart and vessels 20020701
Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin. Toxicology and applied pharmacology 20020601
Carbon monoxide as a novel central pyrogenic mediator. Archives of pharmacal research 20020601
[The identification and cloning of human M961 full-length cDNA and its splicing isoform]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020601
Esterification of the propionate groups promotes alpha/beta hemoglobin chain homogeneity of CN-hemin binding. Biochemical and biophysical research communications 20020524
The role of endogenous heme oxygenase in the initiation of liver injury following limb ischemia/reperfusion. Journal of hepatology 20020501
Utilization and cell-surface binding of hemin by Histoplasma capsulatum. Canadian journal of microbiology 20020501
Plasmodium falciparum histidine-rich protein-2 (PfHRP2) modulates the redox activity of ferri-protoporphyrin IX (FePPIX): peroxidase-like activity of the PfHRP2-FePPIX complex. The Journal of biological chemistry 20020426
Hemin-stimulated docking of cytochrome c to a hemin-DNA aptamer complex. Biochemistry 20020423
Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxidants & redox signaling 20020401
A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds. Experimental parasitology 20020401
DNA sensing on glassy carbon electrodes by using hemin as the electrochemical hybridization label. Analytical and bioanalytical chemistry 20020401
Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity. The Journal of biological chemistry 20020322
Effects of porphyrins and inorganic iron on the growth of Prevotella intermedia. FEMS microbiology letters 20020319
The atomic structure of human methemalbumin at 1.9 A. Biochemical and biophysical research communications 20020308
Novel phenothiazine antimalarials: synthesis, antimalarial activity, and inhibition of the formation of beta-haematin. Biochemical pharmacology 20020301
Supercritical fluid extraction and high-performance liquid chromatography-diode array-electrochemical detection of signature redox compounds from sand and soil samples. Analytical biochemistry 20020215
Concentration effects in myoglobin-catalyzed peroxidation of linoleate. Journal of agricultural and food chemistry 20020213
Alcohol-water as a novel medium for beta-hematin preparation. Archives of biochemistry and biophysics 20020201
Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Free radical biology & medicine 20020201
Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. Journal of neurosurgery 20020201
Exploration of the diaphorase activity of neutrophil NADPH oxidase. European journal of biochemistry 20020201
Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species. FEBS letters 20020130
A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. Biochemical and biophysical research communications 20020111
Methemoglobin contributes to the growth of human tumor cells. Life sciences 20020111
Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life sciences 20020104
Cytochrome c catalyses the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. The Biochemical journal 20020101
Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II. Hypertension (Dallas, Tex. : 1979) 20020101
Hematin is one of the cytotoxic factors in pancreatitis-associated ascitic fluid that causes hepatocellular injury. Surgery 20020101
Formation of a bioconjugate composed of hemin, smectite, and quaternary ammonium chloride that is soluble and active in hydrophobic media. Bioconjugate chemistry 20020101
Delta-aminolevulinic acid cytotoxic effects on human hepatocarcinoma cell lines. BMC cancer 20020101
Biomimetic synthesis of a water soluble conducting molecular complex of polyaniline and lignosulfonate. Biomacromolecules 20020101
Heme oxygenase-1 induction and dependent increase in ferritin. A protective antioxidant stratagem in hemin-treated rat brain. Developmental neuroscience 20020101
Glutathione inhibits the antischistosomal activity of artemether. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20020101
Hemoglobin components from trout (Salmo irideus): determination of their peroxidative activity. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20011201
Haeme oxygenase-1 and cardiac anaphylaxis. British journal of pharmacology 20011201
Effects of heme oxygenase system on the cyclooxygenase in the primary cultured hypothalamic cells. Archives of pharmacal research 20011201
Peroxidase activity of in vitro-selected 2'-amino RNAs. Biotechnology and bioengineering 20011120
Overexpression of heme oxygenase protects renal tubular cells against cold storage injury: studies using hemin induction and HO-1 gene transfer. Transplantation 20011115
Acetylphenylhydrazine induced haemoglobin oxidation in erythrocytes studied by Mössbauer spectroscopy. Biochimica et biophysica acta 20011107
Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation. Biochemistry 20011106
Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures. Journal of neurochemistry 20011101
Disturbance of cellular iron uptake and utilisation by aluminium. Journal of inorganic biochemistry 20011101
In vitro beta-hematin formation assays with plasma of mice infected with Plasmodium yoelii and other parasite preparations: comparative inhibition with quinoline and endoperoxide antimalarials. Life sciences 20011026
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. Journal of medicinal chemistry 20010913
A DNA oligonucleotide-hemin complex cleaves t-butyl hydroperoxide through a homolytic mechanism. Inorganic chemistry 20010910
Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform. FEBS letters 20010907
A novel heme protein, the Cu,Zn-superoxide dismutase from Haemophilus ducreyi. The Journal of biological chemistry 20010810
The homolytic and heterolytic fatty acid hydroperoxide lyase-like activities of hematin. Biochemical and biophysical research communications 20010810
Contribution of heat shock proteins to cell protection from complement-mediated lysis. International immunology 20010801
Reactive carbonyl formation by oxidative and non-oxidative pathways. Frontiers in bioscience : a journal and virtual library 20010801
Regulation of the 75-kDa subunit of mitochondrial complex I by iron. The Journal of biological chemistry 20010720
Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis. Neuroreport 20010703
Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. Haematologica 20010701
ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of molecular medicine (Berlin, Germany) 20010701
Short report: floxacrine analog WR 243251 inhibits hematin polymerization. The American journal of tropical medicine and hygiene 20010701
Effects of pelargonidine and a benzocaine analogue p-diethylaminoethyl benzoate on mitochondrial K(ATP) channel. Membrane & cell biology 20010701
Enzymatic properties of human hemalbumin. Biochimica et biophysica acta 20010611
Environmental regulation of recA gene expression in Porphyromonas gingivalis. Oral microbiology and immunology 20010601
Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways. The Biochemical journal 20010601
Histidine-rich protein 2 of the malaria parasite, Plasmodium falciparum, is involved in detoxification of the by-products of haemoglobin degradation. Molecular and biochemical parasitology 20010601
The role of haem oxygenase in renal vascular reactivity in normotensive and hypertensive rats. Journal of hypertension 20010601
Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010601
Biochemical characterisation of a hydrophobic ligand binding protein from the tapeworm Hymenolepis diminuta. International journal for parasitology 20010515
Diamidine compounds: selective uptake and targeting in Plasmodium falciparum. Molecular pharmacology 20010501
Abortive assembly of succinate-ubiquinone reductase (complex II) in a ferrochelatase-deficient mutant of Escherichia coli. Molecular genetics and genomics : MGG 20010501
Prooxidant activity of beta-hematin (synthetic malaria pigment) in arachidonic acid micelles and phospholipid large unilamellar vesicles. Biochemical pharmacology 20010415
Role of ERK activation in growth and erythroid differentiation of K562 cells. Experimental cell research 20010401
A new red-region substrate, tetra-substituted amino aluminium phthalocyanine, for the fluorimetric determination of H2O2 catalyzed by mimetic peroxidases. The Analyst 20010401
EPR studies of nitric oxide interactions of alkoxyl and peroxyl radicals in in vitro and ex vivo model systems. Antioxidants & redox signaling 20010401
Atherosclerosis: defeat of the defense? Circulation research 20010316
Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circulation research 20010316
Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries. Atherosclerosis 20010301
Effects of chlorhexidine digluconate and hydrogen peroxide on Porphyromonas gingivalis hemin binding and coaggregation with oral streptococci. Journal of oral science 20010301
New Heck-type reaction applied to the synthesis of protoporphyrin-IX derivatives. Organic letters 20010222
The peroxidase activity of a hemin--DNA oligonucleotide complex: free radical damage to specific guanine bases of the DNA. Journal of the American Chemical Society 20010221
Bioactivity of [6R]-5-formyltetrahydrofolate, an unusual isomer, in humans and Enterococcus hirae, and cytochrome c oxidation of 10-formytetrahydrofolate to 10-formyldihydrofolate. The Biochemical journal 20010215
Administration of heme arginate, but not hematin, caused anaphylactic shock. The American journal of medicine 20010215
The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro. Biochemical pharmacology 20010215
A functional link between heme oxygenase and cyclo-oxygenase activities in cortical rat astrocytes. Biochemical pharmacology 20010215
The two TonB systems of Vibrio cholerae: redundant and specific functions. Molecular microbiology 20010201
Haem regulation of the mitochondrial import of the Kluyveromyces lactis 5-aminolaevulinate synthase: an organelle approach. Yeast (Chichester, England) 20010115
Hemin (Fe(3+))-- and heme (Fe(2+))--smectite conjugates as a model of hemoprotein based on spectrophotometry. Bioconjugate chemistry 20010101
Evidence for a functional link between the heme oxygenase-carbon monoxide pathway and corticotropin-releasing hormone release from primary cultures of human trophoblast cells. The Journal of clinical endocrinology and metabolism 20010101
Artemether administered together with haemin damages schistosomes in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101
Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex. IUBMB life 20010101
Redox properties of local anesthetics: A structural determinant of closed channel blockers in BTX-modified Na+ channels. Membrane & cell biology 20010101
Chlorite-hemoprotein interaction as key role for the pharmacological activity of the chlorite-based drug WF10. Arzneimittel-Forschung 20010101
Heme oxygenase-1 regulates vascular tone of the peritoneum undergoing peritoneal dialysis. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20010101
p53-mediated differentiation of the erythroleukemia cell line K562. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20000601
Oxidative stress involvement in chemically induced differentiation of K562 cells. Free radical biology & medicine 20000101
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. The Journal of biological chemistry 19990910
Copper-induced apoptosis and immediate early gene expression in macrophages. Atherosclerosis 19990901
MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells. Biochemical and biophysical research communications 19990624
Suppression of heme oxygenase-1 mRNA expression by interferon-gamma in human glioblastoma cells. Journal of neurochemistry 19990601
8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization. Antimicrobial agents and chemotherapy 19990301
Effect of lindane and heptachlor on delta-aminolaevulinate synthase and its regulation. Archives of toxicology 19981101
Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride. Journal of biochemistry 19980901
NF kappa B-independent transcriptional induction of the human manganous superoxide dismutase gene. Archives of biochemistry and biophysics 19971215
Development of refractoriness of induced human heme oxygenase-1 gene expression to reinduction by UVA irradiation and hemin. Photochemistry and photobiology 19971001
Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors. Journal of neurochemistry 19960801
Effects of combinations of stem cell factor and hemin on erythropoiesis after azidothymidine treatment of immunosuppressed mice. European journal of haematology 19960801
Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases. Journal of medicinal chemistry 19960412
Cloning and expression of a cDNA for mu-class glutathione S-transferase from rabbit liver. Archives of biochemistry and biophysics 19950420
Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase zeta corresponds to a locus distinct from GST1, GST2, and GST3. Archives of biochemistry and biophysics 19910215
Purification of human erythrocyte proteolytic enzyme responsible for degradation of oxidant-damaged hemoglobin. Evidence for identifying as a member of the multicatalytic proteinase family. Biochimica et biophysica acta 19900301
Evidence suggesting that the two forms of heme oxygenase are products of different genes. The Journal of biological chemistry 19880305
Interaction of heme with a synthetic peptide mimicking the putative heme-binding site of histidine-rich glycoprotein. Biochemical and biophysical research communications 19871231
Effect of Griseofulvin on 5-aminolevulinate synthase and on ferrochelatase in mouse liver neoplastic nodules. Cancer research 19810401
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. The Journal of biological chemistry 19790210
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