Pralatrexate is an effective treatment for relapsed or refractory transformed mycosis fungoides: a subgroup efficacy analysis from the PROPEL study.

Clinical lymphoma, myeloma & leukemia 20120801

Evaluation of the OSCAR system for the production of monoclonal antibodies by CHO-K1 cells.

International journal of pharmaceutics 20120701

Cutaneous T-cell lymphoma's confounding nature.

Journal of the National Cancer Institute 20120606

Pralatrexate: a novel synthetic antifolate for relapsed or refractory peripheral T-cell lymphoma and other potential uses.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120601

Randomized phase 2b study of pralatrexate versus erlotinib in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC) after failure of prior platinum-based therapy.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120601

DNA synthesis as a therapeutic target: the first 65 years.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120601

Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate.

Molecules (Basel, Switzerland) 20120510

Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphoma.

Blood 20120503

Clinical development of new formulations of cytotoxics in solid tumors.

Current opinion in oncology 20120501

Sidney Farber and the treatment of childhood acute lymphoblastic leukemia with a chemotherapeutic agent.

Pediatric hematology and oncology 20120501

Teratogen update: methotrexate.

Birth defects research. Part A, Clinical and molecular teratology 20120401

Pralatrexate (Folotyn).

Skinmed 20120101

Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20111101

Efficacy and safety of CH-1504, a metabolically stable antifolate, in patients with active rheumatoid arthritis: results of a phase II multicenter randomized study.

The Journal of rheumatology 20110901

Evaluation of the pharmacokinetics, preclinical and clinical efficacy of pralatrexate for the treatment of T-cell lymphoma.

Expert opinion on drug metabolism & toxicology 20110901

Discontinued drugs 2010: rheumatology, allergy and dermatology, pulmonary.

Expert opinion on investigational drugs 20110901

Hematology: relapsed and refractory PTCL--into the therapeutic abyss.

Nature reviews. Clinical oncology 20110601

Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.

Bioorganic & medicinal chemistry letters 20110215

Single agent and combination studies of pralatrexate and molecular correlates of sensitivity.

British journal of cancer 20110118

Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.

Arthritis research & therapy 20110101

A new weapon against an old target.

Arthritis research & therapy 20110101

Folotyn (pralatrexate injection) for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma: U.S. Food and Drug Administration drug approval summary.

Clinical cancer research : an official journal of the American Association for Cancer Research 20101015

CH-1504, a metabolically inert antifolate for the potential treatment of rheumatoid arthritis.

IDrugs : the investigational drugs journal 20100801

Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research 20100715

Pralatrexate (Folotyn) for peripheral T-cell lymphoma.

The Medical letter on drugs and therapeutics 20100712

Pralatrexate: basic understanding and clinical development.

Expert opinion on pharmacotherapy 20100701

A proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation.

Journal of proteome research 20100604

Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.

Cancer chemotherapy and pharmacology 20100501

Novel agents in development for peripheral T-cell lymphoma.

Seminars in hematology 20100401

StatBite: FDA oncology drug product approvals in 2009.

Journal of the National Cancer Institute 20100224

Pralatrexate - from bench to bedside.

Drugs of today (Barcelona, Spain : 1998) 20100201

Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate.

Drug metabolism and pharmacokinetics 20100101

Pseudoaminopterin syndrome: clinical report with new characteristics.

American journal of medical genetics. Part A 20091201

Cancer research: from folate antagonism to molecular targets.

Best practice & research. Clinical haematology 20091201

FDA approves pralatrexate for treatment of rare lymphoma.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091101

Development and characterization of HAT-sensitive Ewing tumour cells for immunotherapy.

Anticancer research 20091101

Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.

Cancer chemotherapy and pharmacology 20091001

Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species.

Experimental parasitology 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090910

A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma.

Clinical pharmacology and therapeutics 20090801

Importance of early splenectomy in patients with hepatosplenic T-cell lymphoma and severe thrombocytopenia.

Annals of surgical oncology 20090701

Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions.

Blood 20090618

T-cell lymphomas.

Clinical advances in hematology & oncology : H&O 20090601

Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma.

British journal of haematology 20090501

Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.

Biochemical pharmacology 20090401

Pralatrexate, a new hope for aggressive T-cell lymphomas?

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20090401

Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity.

European journal of medicinal chemistry 20090201

Fetal methotrexate/aminopterin syndrome in an adult: a likely case with ectodermal abnormalities.

Clinical dysmorphology 20090101

Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.

Pediatric neurology 20090101

Optimizing chemotherapeutic strategies for peripheral T-cell lymphomas.

Clinical lymphoma & myeloma 20081201

Novel therapies for cutaneous T-cell lymphomas.

Clinical lymphoma & myeloma 20081201

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal of medicinal chemistry 20081113

Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.

Experimental parasitology 20081101

Novel therapies in peripheral T-cell lymphomas.

Current oncology reports 20080901

An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies.

Journal of immunological methods 20080731

Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies.

IDrugs : the investigational drugs journal 20080701

Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.

Cancer chemotherapy and pharmacology 20080601

Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

Parasitology research 20080501

CD4+ CD56+ hematodermic/plasmacytoid dendritic cell tumor with response to pralatrexate.

Journal of the American Academy of Dermatology 20080301

Two single-center, double-blind, randomized, placebo-controlled, phase I studies to investigate the tolerability and pharmacokinetics of CH-1504, an antifolate, in healthy male subjects.

Clinical therapeutics 20080101

Resistance of colorectal cancer cells to 5-FUdR and 5-FU caused by Mycoplasma infection.

Anticancer research 20080101

High-performance liquid chromatography separation of aminopterin-polyglutamates within red blood cells of children treated for acute lymphoblastic leukemia.

Translational research : the journal of laboratory and clinical medicine 20071201

A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis.

The British journal of dermatology 20071101

Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma.

British journal of haematology 20071101

Aminopterin might be safe in ALL.

The Lancet. Oncology 20071001

Phase II trial of 10-EDAM in the treatment of metastatic breast cancer.

Cancer chemotherapy and pharmacology 20070601

A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research 20070501

Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070401

Pralatrexate: an emerging new agent with activity in T-cell lymphomas.

Current opinion in oncology 20061101

Methotrexate-albumin and aminopterin-albumin effectively prevent experimental acute graft-versus-host disease.

Transplantation 20060827

Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization.

International journal of radiation oncology, biology, physics 20060801

Pharmacodynamic properties of methotrexate and Aminotrexate during weekly therapy.

Cancer chemotherapy and pharmacology 20060601

A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors.

Cancer chemotherapy and pharmacology 20060501

Controlled trial of methotrexate versus CH-1504 in the treatment of rheumatoid arthritis.

The Journal of rheumatology 20060501

In vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance.

Cell cycle (Georgetown, Tex.) 20060401

The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research 20060201

Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.

Journal of medicinal chemistry 20060126

Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids.

The Journal of biological chemistry 20051118

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.

Journal of medicinal chemistry 20051117

Phase II trial of oral aminopterin for adults and children with refractory acute leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research 20051115

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Journal of medicinal chemistry 20050811

Prediction of genotoxicity of chemical compounds by statistical learning methods.

Chemical research in toxicology 20050601

Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis.

Radiation research 20050301

Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.

Journal of medicinal chemistry 20041230

Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Journal of medicinal chemistry 20041230

Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.

Journal of medicinal chemistry 20041230

Pseudoaminopterin syndrome and trisomy 9.

American journal of medical genetics. Part A 20040715

Final results of a phase I and pharmacokinetic study of gamma-methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors.

Cancer chemotherapy and pharmacology 20040501

Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding.

Journal of cell science 20040401

10-propargyl-10-deazaaminopterin: an antifolate with activity in patients with previously treated non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research 20030601

Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression.

Leukemia & lymphoma 20030601

Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity.

Biochemical pharmacology 20030501

Molecular cloning and expression of the dihydrofolate reductase (DHFR) gene from adult buffalo fly (Haematobia irritans exigua): effects of antifolates.

Insect molecular biology 20030401

Metabolism of homocysteine-thiolactone in plants.

The Journal of biological chemistry 20030227

Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.

Journal of medicinal chemistry 20030213

Aminopterin-human serum albumin conjugate (AP-HSA): uptake and cytotoxic effects in tumor cell lines.

International journal of clinical pharmacology and therapeutics 20021201

Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.

Journal of medicinal chemistry 20021107

SycE allows secretion of YopE-DHFR hybrids by the Yersinia enterocolitica type III Ysc system.

Molecular microbiology 20021101

Fetal methotrexate and misoprostol exposure: the past revisited.

Teratology 20020801

Efficacy and tolerability of an aminopterin-albumin conjugate in tumor-bearing rats.

Anti-cancer drugs 20020701

Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate.

Journal of medicinal chemistry 20020425

Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors.

Biochemistry 20020108

Phase I trial of edatrexate in advanced breast and other cancers.

Cancer investigation 20020101

Spontaneous reactivation of the inactive X chromosome in mouse embryonal carcinoma cells.

Cytogenetic and genome research 20020101

A phase II trial of edatrexate, vinblastine, adriamycin, cisplastin, and filgrastim (EVAC/G-CSF) in patients with non-small-cell carcinoma of the lungs: a North Central Cancer Treatment Group Trial.

American journal of clinical oncology 20011201

Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.

Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

Requirement of de novo protein synthesis for aminopterin-induced apoptosis in a mouse myeloma cell line.

Immunology letters 20010702

Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin.

Clinical cancer research : an official journal of the American Association for Cancer Research 20010301

Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo.

European journal of medicinal chemistry 20010301

[Fetal aminopterin syndrome].

Ryoikibetsu shokogun shirizu 20010101

[Pseudoaminopterin syndrome].

Ryoikibetsu shokogun shirizu 20010101

Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.

Journal of medicinal chemistry 20001019

Developmental delay in fetal aminopterin/methotrexate syndrome.

Teratology 19990701

Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.

Journal of medicinal chemistry 19980423

Adult and two children with fetal methotrexate syndrome.

Teratology 19980201

Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy.

Investigational new drugs 19980101

Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.

Journal of medicinal chemistry 19950609

2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.

Journal of medicinal chemistry 19950303

Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.

Journal of medicinal chemistry 19940415

Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.

Cancer research 19920415

Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs.

Antimicrobial agents and chemotherapy 19910701

Inhibition of Pneumocystis dihydrofolate reductase by analogs of pyrimethamine, methotrexate and trimetrexate.

The Journal of protozoology 19910101

Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.

Antimicrobial agents and chemotherapy 19880701

Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.

Journal of medicinal chemistry 19880701

Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.

Hepatology (Baltimore, Md.) 19850101

Activity of sulfa drugs and dihydrofolate reductase inhibitors against Candida albicans.

Experientia 19820415

On the mechanism of action of aminopterin.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19500601