(4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid
| Title | Journal |
|---|---|
| Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH. | Human molecular genetics 20120915 |
| Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii. | Molecular and biochemical parasitology 20120801 |
| Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. | PLoS biology 20120401 |
| Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension. | Biochemical and biophysical research communications 20111028 |
| Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. | PLoS biology 20110801 |
| Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase. | Biochemistry 20110412 |
| Path finding methods accounting for stoichiometry in metabolic networks. | Genome biology 20110101 |
| Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry. | Analytical biochemistry 20100401 |
| Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis. | BMC systems biology 20100101 |
| [Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901 |
| Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli. | Biochemistry 20090804 |
| Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. | Nature chemical biology 20090801 |
| Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. | Biochemistry 20090203 |
| Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. | Biochemistry 20081014 |
| Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways. | The EMBO journal 20080917 |
| The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites. | Biochemistry 20080826 |
| Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium. | Microbiology (Reading, England) 20070801 |
| Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. | Biochemistry 20061219 |
| Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction. | Biochemistry 20060711 |
| Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis. | The Journal of biological chemistry 20060630 |
| 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus. | Biochemistry 20060613 |
| Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms. | Parasitology international 20060301 |
| Rate of promoter class turn-over in yeast evolution. | BMC evolutionary biology 20060101 |
| Immunotherapy for De Novo renal transplantation: what's in the pipeline? | Drugs 20060101 |
| Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits. | Journal of molecular biology 20050506 |
| Mechanism of the dihydroorotase reaction. | Biochemistry 20041228 |
| Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy. | Biochemistry 20040601 |
| Thorpe-Ingold effects in cyclizations to five-membered and six-membered rings containing planar segments. The rearrangement of N(1)-alkyl-substituted dihydroorotic acids to hydantoinacetic acids in base. | Organic & biomolecular chemistry 20040407 |
| Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. | Protein science : a publication of the Protein Society 20040401 |
| Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. | The Journal of biological chemistry 20030801 |
| Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea. | AIDS (London, England) 20030725 |
| Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration. | Parasitology international 20011101 |
| Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis. | Archives of biochemistry and biophysics 20010715 |
| Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila. | The Journal of biological chemistry 20010629 |