Phenotypic differences between fast and slow methionine sulfoximine-inbred mice: seizures, anxiety, and glutamine synthetase.

Epilepsy research 20120101

Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine.

The Journal of biological chemistry 20111230

A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells.

American journal of physiology. Cell physiology 20111001

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons.

Neurochemistry international 20110901

A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.

Liver international : official journal of the International Association for the Study of the Liver 20110901

Bioactive sulfoximines: syntheses and properties of Vioxx analogs.

Bioorganic & medicinal chemistry letters 20110815

Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model.

Investigative ophthalmology & visual science 20110801

Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1.

Microbial drug resistance (Larchmont, N.Y.) 20110801

Serotonergic neurotransmission plays a major role in the action of the glycogenic convulsant methionine sulfoximine.

Neuroscience research 20110701

Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis.

The European journal of neuroscience 20110701

Ring-closing metathesis of sulfoximine-substituted N-tethered trienes: modular asymmetric synthesis of medium-ring nitrogen heterocycles.

Chemistry (Weinheim an der Bergstrasse, Germany) 20110523

Cellular localization of glutamate and glutamine metabolism and transport pathways in the rat ciliary epithelium.

Investigative ophthalmology & visual science 20110518

Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal.

Biochemical pharmacology 20101101

Methionine sulfoximine may improve inflammation in autism, a novel hypothesized treatment for autism.

Archives of medical research 20101101

Brain glycogen and neurotransmitter levels in fast and slow methionine sulfoximine-selected mice.

Experimental neurology 20101001

Inhibition of glutamate/glutamine cycle in vivo results in decreased benzodiazepine binding and differentially regulated GABAergic subunit expression in the rat brain.

Epilepsia 20100801

Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.

Indian journal of experimental biology 20100801

Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.

Leukemia research 20100701

Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro.

Cellular and molecular neurobiology 20100701

Inhibition of glutamine synthetase during ammonia exposure in rainbow trout indicates a high reserve capacity to prevent brain ammonia toxicity.

The Journal of experimental biology 20100701

Methionine sulfoximine as a novel hypothesized treatment for Tourette's syndrome.

Journal of the neurological sciences 20100615

Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and rapamycin treatment in Saccharomyces cerevisiae.

The Journal of biological chemistry 20100604

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.

Journal of the neurological sciences 20100315

Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.

Epilepsia 20100101

The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study.

Experimental neurology 20091201

[Effect of glial cell metabolism on respiratory rhythmical discharge activity in neonatal rat medulla oblongata slices].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091201

Acute ammonia toxicity and the protective effects of methionine sulfoximine on the swamp eel, Monopterus albus.

Journal of experimental zoology. Part A, Ecological genetics and physiology 20091101

In vivo monitoring of extracellular 13N-glutamine derived from blood-borne 13N-ammonia in rat striatum using microdialysis with radio-LC method.

Journal of neuroscience methods 20091030

Glutamate metabolic pathways and retinal function.

Journal of neurochemistry 20091001

A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase.

Bioorganic & medicinal chemistry 20090915

Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels.

Glia 20090901

Regulation of glutamine synthetase 1 and amino acids transport in the phloem of young wheat plants.

Plant physiology and biochemistry : PPB 20090501

Altered fatty acid metabolism and composition in cultured astrocytes under hyperammonemic conditions.

Journal of neurochemistry 20090501

Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease.

Free radical biology & medicine 20090301

Epilepsy, regulation of brain energy metabolism and neurotransmission.

Current medicinal chemistry 20090301

C-C bond-forming desulfurizations of sulfoximines.

Organic letters 20080918

Inhibition of ammonium assimilation restores elongation of seminal rice roots repressed by high levels of exogenous ammonium.

Physiologia plantarum 20080901

Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats.

Brain : a journal of neurology 20080801

Exogenous ammonium inhibits petal pigmentation and expansion in Gerbera hybrida.

Physiologia plantarum 20080601

A common transport system for methionine, L-methionine-DL-sulfoximine (MSX), and phosphinothricin (PPT) in the diazotrophic cyanobacterium Nostoc muscorum.

Current microbiology 20080501

Effect of glutamine synthesis inhibition with methionine sulfoximine on the nitric oxide-cyclic GMP pathway in the rat striatum treated acutely with ammonia: a microdialysis study.

Neurochemical research 20080201

Mechanisms of and defense against acute ammonia toxicity in the aquatic Chinese soft-shelled turtle, Pelodiscus sinensis.

Aquatic toxicology (Amsterdam, Netherlands) 20080131

Presence of a functional nitrate assimilation pathway in Mycobacterium smegmatis.

Microbial pathogenesis 20080101

The effect of ammonium on assimilatory nitrate reduction in the haloarchaeon Haloferax mediterranei.

Extremophiles : life under extreme conditions 20071101

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase.

Combinatorial chemistry & high throughput screening 20071101

The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.

Cancer chemotherapy and pharmacology 20071001

L-methionine sulfoximine as a novel selection agent for genetic transformation of orchids.

Journal of biotechnology 20070930

Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20070822

Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20070822

Poisoning by Cnestis ferruginea in Casamance (Senegal): an etiological approach.

Toxicon : official journal of the International Society on Toxinology 20070801

Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation.

The Journal of biological chemistry 20070622

Ammonia toxicity and tolerance in the brain of the African sharptooth catfish, Clarias gariepinus.

Aquatic toxicology (Amsterdam, Netherlands) 20070515

Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression.

Mutagenesis 20070501

Poly-beta-hydroxybutyrate accumulation in Nostoc muscorum: effects of metabolic inhibitors.

Journal of plant physiology 20070301

l-Methionine sulfoximine, but not phosphinothricin, is a substrate for an acetyltransferase (gene PA4866) from Pseudomonas aeruginosa: structural and functional studies.

Biochemistry 20070220

Saccharomyces cerevisiae Sit4 phosphatase is active irrespective of the nitrogen source provided, and Gln3 phosphorylation levels become nitrogen source-responsive in a sit4-deleted strain.

The Journal of biological chemistry 20061208

The three-dimensional structure of an eukaryotic glutamine synthetase: functional implications of its oligomeric structure.

Journal of structural biology 20061201

An octameric prokaryotic glutamine synthetase from the haloarchaeon Haloferax mediterranei.

FEMS microbiology letters 20061101

Development of transfection and high-producer screening protocols for the CHOK1SV cell system.

Molecular biotechnology 20061001

Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20060816

Effect of AmtB homologues on the post-translational regulation of nitrogenase activity in response to ammonium and energy signals in Rhodospirillum rubrum.

Microbiology (Reading, England) 20060701

Limitations to the development of humanized antibody producing Chinese hamster ovary cells using glutamine synthetase-mediated gene amplification.

Biotechnology progress 20060101

Synthesis and bioactivity of new phosphorylated R,R'-substituted sulfoximines.

Molecules (Basel, Switzerland) 20051130

All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.

Molecular microbiology 20051101

Development of a simple assay protocol for high-throughput screening of Mycobacterium tuberculosis glutamine synthetase for the identification of novel inhibitors.

Journal of biomolecular screening 20051001

Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).

Aquatic toxicology (Amsterdam, Netherlands) 20050815

Methionine sulfoximine treatment and carbon starvation elicit Snf1-independent phosphorylation of the transcription activator Gln3 in Saccharomyces cerevisiae.

The Journal of biological chemistry 20050722

Glutamine-dependent inhibition of pial arteriolar dilation to acetylcholine with and without hyperammonemia in the rat.

American journal of physiology. Regulatory, integrative and comparative physiology 20050601

An astrocyte toxin influences the pattern of breathing and the ventilatory response to hypercapnia in neonatal rats.

Respiratory physiology & neurobiology 20050512

Chronic and acute ammonia toxicity in mudskippers, Periophthalmodon schlosseri and Boleophthalmus boddaerti: brain ammonia and glutamine contents, and effects of methionine sulfoximine and MK801.

The Journal of experimental biology 20050501

Accumulation of aluminum by primary cultured astrocytes from aluminum amino acid complex and its apoptotic effect.

Brain research 20050121

Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra.

Glia 20050101

Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats.

Neuroscience 20050101

Intracellular glutathione status regulates mouse bone marrow monocyte-derived macrophage differentiation and phagocytic activity.

Biochemical and biophysical research communications 20041203

Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.

Plant physiology and biochemistry : PPB 20041201

C(1)-symmetric sulfoximines as ligands in copper-catalyzed asymmetric Mukaiyama-type aldol reactions.

Angewandte Chemie (International ed. in English) 20041112

Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina.

Glia 20041001

Deletion of the Gibberella fujikuroi glutamine synthetase gene has significant impact on transcriptional control of primary and secondary metabolism.

Molecular microbiology 20040901

Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei: involvement of astrocytes in cerebral glucose-sensing in rats.

Journal of neuroendocrinology 20040501

Expression of cyanobacterial genes involved in heterocyst differentiation and dinitrogen fixation along a plant symbiosis development profile.

Molecular plant-microbe interactions : MPMI 20040401

Effects of methionine sulfoximine on the glutamine and glutamate content and cell volume in rat cerebral cortical slices: involvement of mechanisms not related to inhibition of glutamine synthesis.

Neurotoxicology 20040301

Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.

The journal of gene medicine 20040301

N-terminal extension of canine glutamine synthetase created by splicing alters its enzymatic property.

The Journal of biological chemistry 20040109

Possible roles of sulfur-containing amino acids in a chemoautotrophic bacterium-mollusc symbiosis.

The Biological bulletin 20031201

Feedback regulation of the ammonium transporter gene family AMT1 by glutamine in rice.

Plant & cell physiology 20031201

Nitrate uptake by the halotolerant cyanobacterium Aphanothece halophytica grown under non-stress and salt-stress conditions.

Current microbiology 20030901

Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain.

Experimental brain research 20030501

Methionine sulfoximine, an alternative selection for the bar marker in plants.

Journal of biotechnology 20030424

In vivo induction of insulin secretion by ornithine alpha-ketoglutarate: involvement of nitric oxide and glutamine.

Metabolism: clinical and experimental 20030301

Effects of ornithine alpha-ketoglutarate on insulin secretion in rat pancreatic islets: implication of nitric oxide synthase and glutamine synthetase pathways.

The British journal of nutrition 20030201

[Insertional inactivation of genes encoding eukaryotic type serine/threonine protein kinases in cyanobacterium Synechocystis sp. PCC 6803].

Mikrobiologiia 20030101

[Methionine sulfoximine and phosphinothricin--glutamine synthetase inhibitors and activators and their herbicidal activity (A review)].

Prikladnaia biokhimiia i mikrobiologiia 20030101

Glutamine synthetase enhances the clearance of extracellular glutamate by the neural retina.

Journal of neurochemistry 20021101

Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology.

Pediatric research 20020901

Regulation of amino acid uptake in conifers by exogenous and endogenous nitrogen.

Planta 20020801

Inhibition of glutamine synthetase in a549 cells during hyperoxia.

American journal of respiratory cell and molecular biology 20020701

Hyperammonemic encephalopathy.

Medicine 20020501

In vivo and in vitro glycogenic effects of methionine sulfoximine are different in two inbred strains of mice.

Brain research 20020308

Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines.

Clinical science (London, England : 1979) 20020301

Synergistic versus antagonistic actions of glutamate and glutathione: the role of excitotoxicity and oxidative stress in neuronal disease.

Cellular and molecular biology (Noisy-le-Grand, France) 20020301

Chronic inhibition of glutamine synthetase is not associated with impairment of learning and memory in mice.

Brain research bulletin 20020101

Effects of glutamine deprivation on protein synthesis in a model of human enterocytes in culture.

American journal of physiology. Gastrointestinal and liver physiology 20011201

Ammonia-induced production of free radicals in primary cultures of rat astrocytes.

Journal of neuroscience research 20011015

Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B.

Biochemistry 20010918

Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina.

Journal of neurophysiology 20010801

Association of glutathione with flowering in Arabidopsis thaliana.

Plant & cell physiology 20010501

Real time visualization of 13N-translocation in rice under different environmental conditions using positron emitting Ttacer imaging system.

Plant physiology 20010401

Modulation of the stress response during apoptosis and necrosis induction in cadmium-treated U-937 human promonocytic cells.

Biochimica et biophysica acta 20010205

Reversion in Chinese hamster lines amplified at the AMPD2 locus: spontaneous and benzamide-stimulated gradual loss of amplified alleles of marker genes.

Mutation research 19960117

Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity.

Biochemical pharmacology 19951026

Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress.

The Biochemical journal 19950715

Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells.

Cancer research 19950515

Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line.

International journal of cancer 19950504

Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.

AIDS research and human retroviruses 19940801

p-Dichlorobenzene-induced hepatotoxicity in mice depleted of glutathione by treatment with buthionine sulfoximine.

Toxicology 19940101

Nephrotoxicity and covalent binding of 1,1-dichloroethylene in buthionine sulphoximine-treated mice.

Archives of toxicology 19930101

Influence of modulators of epoxide metabolism on the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19920601

An improved model of acetaminophen-induced fulminant hepatic failure in dogs.

Hepatology (Baltimore, Md.) 19920201

The site specificity and sensitivity of the rat liver to butylated hydroxytoluene-induced damage.

Toxicology and applied pharmacology 19910315

Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19900301

1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH.

Archives of toxicology 19900101

Enhancement of cisplatin toxicity by buthionine sulfoximine, a glutathione-depleting agent, in mice.

Research communications in chemical pathology and pharmacology 19900101

Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice.

Japanese journal of pharmacology 19890901

Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice.

Research communications in chemical pathology and pharmacology 19890801

DNA synthesis in Alzheimer type II astrocytosis. The question of astrocytic proliferation and mitosis in experimentally induced hepatic encephalopathy.

Archives of neurology 19890801

Influence of buthionine sulfoximine on the lethality of ifosfamide and ifosfamide-induced urotoxicity in mice.

Research communications in chemical pathology and pharmacology 19890301

Astrocytic pathology of methionine sulfoximine-induced encephalopathy.

Acta neuropathologica 19890101

Suppression of methionine sulfoximine seizures by intranigral gamma-vinyl GABA injection.

European journal of pharmacology 19870604

Radiosensitizing effect of misonidazole in combination with an inhibitor of glutathione synthesis in murine tumors.

International journal of radiation oncology, biology, physics 19860901

Enhancement in the aerobic toxicity of misonidazole and SR-2508 by buthionine sulfoximine and 4-hydroxypyrazole: the role of hydrogen peroxide.

International journal of radiation oncology, biology, physics 19860701

Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.

Free radical research communications 19860101

Brain methylation and epileptogenesis: the case of methionine sulfoximine.

Annals of neurology 19840101

Anticonvulsant activity of glycylglycine and delta-aminovaleric acid: evidence for glutamine exchange in amino acid transport.

Journal of neurochemistry 19830401

Tryptophan availability, central serotonergic function and methionine sulphoximine-induced convulsions.

Neuropharmacology 19820101

Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions.

The Journal of biological chemistry 19780410

Inhibition by metyrapone of convulsions and storage of brain glycogen in mice induced by methionine sulfoximine (MSO).

Brain research 19770603

Effects of glutamate and sulphur containing amino acids on ammonia toxicity and methionine sulphoximine convulsions in mice.

Brain research 19760618

[Inhibitory effect of gamma aminobutyric acid (GABA) derivatives after intraspinal injection on epileptic convulsions caused by methionine sulfoximine].

Comptes rendus des seances de la Societe de biologie et de ses filiales 19720101