Home Other Building Blocks Yangonin

Yangonin

CAS No.:
500-62-9
Catalog Number:
AG019FT1
Molecular Formula:
C15H14O4
Molecular Weight:
258.2693
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$125
- +
5mg
≥98%
1 week
United States
$261
- +
10mg
≥98%
1 week
United States
$364
- +
25mg
≥98%
1 week
United States
$737
- +
Product Description
Catalog Number:
AG019FT1
Chemical Name:
Yangonin
CAS Number:
500-62-9
Molecular Formula:
C15H14O4
Molecular Weight:
258.2693
MDL Number:
MFCD00221733
IUPAC Name:
4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one
InChI:
InChI=1S/C15H14O4/c1-17-12-6-3-11(4-7-12)5-8-13-9-14(18-2)10-15(16)19-13/h3-10H,1-2H3/b8-5+
InChI Key:
XLHIYUYCSMZCCC-VMPITWQZSA-N
SMILES:
COc1ccc(cc1)/C=C/c1cc(OC)cc(=O)o1
UNII:
R970U49V3C
Properties
Complexity:
412  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
258.089g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
258.273g/mol
Monoisotopic Mass:
258.089g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
44.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro. Toxicology and applied pharmacology 20180601
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. Journal of pharmacological sciences 20120101
Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. Toxicological sciences : an official journal of the Society of Toxicology 20111201
Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro. Phytotherapy research : PTR 20110301
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts. PloS one 20110101
Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. International journal of toxicology 20090101
Permeability studies of Kavalactones using a Caco-2 cell monolayer model. Journal of clinical pharmacy and therapeutics 20070601
Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). Journal of agricultural and food chemistry 20060208
Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine : international journal of phytotherapy and phytopharmacology 20060201
Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard. Journal of AOAC International 20050101
Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones. Phytochemical analysis : PCA 20050101
In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones. Toxicological sciences : an official journal of the Society of Toxicology 20040501
Kava does not display metabolic toxicity in a homogeneous cellular assay. Planta medica 20040401
Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. Phytomedicine : international journal of phytotherapy and phytopharmacology 20040101
Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). Phytomedicine : international journal of phytotherapy and phytopharmacology 20030501
Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. Phytomedicine : international journal of phytotherapy and phytopharmacology 20020401
Interaction of various Piper methysticum cultivars with CNS receptors in vitro. Planta medica 20010601
Properties