Fidarestat
| Title | Journal |
|---|---|
| X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. | Chemico-biological interactions 20130225 |
| Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition. | Journal of diabetes and its complications 20120901 |
| Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. | Biochemical pharmacology 20120401 |
| Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat. | PloS one 20120101 |
| Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in Lewis rats. | Investigative ophthalmology & visual science 20111001 |
| Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice. | Investigative ophthalmology & visual science 20111001 |
| Inhibition of aldose reductase prevents colon cancer metastasis. | Carcinogenesis 20110801 |
| Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells. | The Journal of biological chemistry 20110708 |
| Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold. | European journal of medicinal chemistry 20110501 |
| Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. | Angiogenesis 20110501 |
| Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma. | Respiratory research 20110101 |
| Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina. | International journal of molecular medicine 20100701 |
| Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats. | Yonsei medical journal 20100501 |
| The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice. | The Journal of pathology 20100401 |
| Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. | Current eye research 20100201 |
| Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review. | Journal of diabetes and its complications 20100101 |
| Aldose reductase inhibition prevents metaplasia of airway epithelial cells. | PloS one 20100101 |
| Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase. | Journal of molecular graphics & modelling 20090901 |
| Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase. | Journal of the American Chemical Society 20090812 |
| [Pathophysiology and treatment for diabetic neuropathy]. | Rinsho shinkeigaku = Clinical neurology 20090401 |
| Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. | Chemico-biological interactions 20090316 |
| Prevention of posterior capsular opacification through aldose reductase inhibition. | Investigative ophthalmology & visual science 20090201 |
| The aldose reductase inhibitor fidarestat suppresses ischemia-reperfusion-induced inflammatory response in rat retina. | Pharmacology 20090101 |
| Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. | International journal of molecular medicine 20080601 |
| Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism. | Journal of medicinal chemistry 20080313 |
| Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury. | Experimental eye research 20071101 |
| High-fat diet induced neuropathy of pre-diabetes and obesity: effects of 'healthy' diet and aldose reductase inhibition. | Diabetes 20071001 |
| Fidarestat improves cardiomyocyte contractile function in db/db diabetic obese mice through a histone deacetylase Sir2-dependent mechanism. | Journal of hypertension 20071001 |
| Deletion of aldose reductase leads to protection against cerebral ischemic injury. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070801 |
| Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites. | Cellular and molecular life sciences : CMLS 20070801 |
| Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. | Journal of diabetes and its complications 20070101 |
| Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat. | Diabetologia 20061201 |
| The role of polyol pathway in high glucose-induced endothelial cell damages. | Diabetes research and clinical practice 20060901 |
| High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32. | Journal of neurochemistry 20060701 |
| Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex. | Journal of medicinal chemistry 20050908 |
| Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity. | Journal of medicinal chemistry 20050825 |
| [Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor]. | Nihon rinsho. Japanese journal of clinical medicine 20050601 |
| [Role of aldose reductase in the progression of diabetic retinopathies]. | Nihon rinsho. Japanese journal of clinical medicine 20050601 |
| Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. | Diabetes 20050101 |
| Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice. | Diabetes 20041201 |
| High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. | Journal of medicinal chemistry 20040826 |
| Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase. | Diabetes 20040701 |
| Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors. | Proteins 20040601 |
| Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells. | Biochemical and biophysical research communications 20040206 |
| Effect of fidarestat and alpha-lipoic acid on diabetes-induced epineurial arteriole vascular dysfunction. | Experimental diabesity research 20040101 |
| Erythrocytic sorbitol contents in diabetic patients correlate with blood aldose reductase protein contents and plasma glucose levels, and are normalized by the potent aldose reductase inhibitor fidarestat (SNK-860). | Journal of diabetes and its complications 20040101 |
| [The inhibitory effect of aldose reductase inhibitor for proliferation in the lens epithelial cells of rat sugar cataract]. | Nippon Ganka Gakkai zasshi 20031001 |
| Fidarestat. Sanwa Kagaku/NC Curex/Sankyo. | Current opinion in investigational drugs (London, England : 2000) 20031001 |
| Apoptotic cell death in the lens epithelium of rat sugar cataract. | Experimental eye research 20030701 |
| Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. | Diabetes 20030301 |
| Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides. | Journal of medicinal chemistry 20030130 |
| Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats. | Journal of diabetes and its complications 20030101 |
| Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes. | Biochemical and biophysical research communications 20021129 |
| [Fidarestat (SNK-860)]. | Nihon rinsho. Japanese journal of clinical medicine 20020901 |
| Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients. | Journal of diabetes and its complications 20020101 |
| Fidarestat. Aldos, SK 860, SNK 860. | Drugs in R&D 20020101 |
| Aldose reductase inhibitors. | Journal of enzyme inhibition 20011201 |
| Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. | Diabetes care 20011001 |
| Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes. | Pharmacology 20010501 |
| A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography. | Journal of medicinal chemistry 20000615 |